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Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease

Toll-like receptors (TLRs) play an important part in the innate immune recognition of invading microorganisms, initiating sufficient immune responses. Growing amounts of data suggest that the ability of certain individuals to respond properly to TLR ligands may be impaired by single nucleotide polym... Full description

Journal Title: The Lancet infectious diseases 2005-03, Vol.5 (3), p.156-164
Main Author: Schröder, Nicolas WJ
Other Authors: Schumann, Ralf R
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: Elsevier Ltd
ID: ISSN: 1473-3099
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recordid: cdi_proquest_miscellaneous_67521567
title: Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease
format: Article
creator:
  • Schröder, Nicolas WJ
  • Schumann, Ralf R
subjects:
  • Adapter proteins
  • Arteriosclerosis
  • Atherosclerosis
  • Atherosclerosis (general aspects, experimental research)
  • Bacterial infections
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Cardiology. Vascular system
  • Case-Control Studies
  • Chromosomes
  • Communicable diseases
  • Communicable Diseases - genetics
  • Communicable Diseases - immunology
  • Cytokines
  • Diabetes
  • Diabetic neuropathy
  • Disease susceptibility
  • Gangrene
  • Genes
  • Genetic aspects
  • Genetic Variation
  • Genomes
  • Gram-positive bacteria
  • Heart attacks
  • Humans
  • Immune response
  • Immune system
  • Infections
  • Infectious diseases
  • Inflammatory diseases
  • Ligands
  • Lipopolysaccharides
  • Malaria
  • Medical research
  • Medical sciences
  • Medicine, Experimental
  • Membrane Glycoproteins - genetics
  • Membrane Glycoproteins - immunology
  • Membrane Glycoproteins - physiology
  • Microorganisms
  • Mortality
  • Pattern recognition
  • Polymorphism, Single Nucleotide - genetics
  • Polymorphism, Single Nucleotide - immunology
  • Polymorphism, Single Nucleotide - physiology
  • Proteins
  • Receptors
  • Receptors, Cell Surface - genetics
  • Receptors, Cell Surface - immunology
  • Receptors, Cell Surface - physiology
  • Sepsis
  • Signal transduction
  • Single nucleotide polymorphisms
  • Single-nucleotide polymorphism
  • TLR2 protein
  • TLR4 protein
  • Toll-Like Receptor 2
  • Toll-Like Receptor 4
  • Toll-Like Receptors
  • Tumor necrosis factor-TNF
ispartof: The Lancet infectious diseases, 2005-03, Vol.5 (3), p.156-164
description: Toll-like receptors (TLRs) play an important part in the innate immune recognition of invading microorganisms, initiating sufficient immune responses. Growing amounts of data suggest that the ability of certain individuals to respond properly to TLR ligands may be impaired by single nucleotide polymorphisms (SNPs) within TLR genes, resulting in an altered susceptibility to, or course of, infectious or inflammatory disease. Most studies have focused on two cosegregating SNPs—Asp299Gly and Thr399Ile—within the gene encoding TLR4, the receptor for bacterial lipopolysaccharide. These SNPs are present in approximately 10% of white individuals, and have been found to be positively correlated with several infectious diseases. However, these SNPs seem to protect from atherosclerosis and related diseases, which is reviewed in this article also. Meanwhile, SNPs of genes encoding other TLRs—eg, TLR2, which recognises a wide variety of microbial ligands—have been reported, and preliminary studies indicate an impact on susceptibility to infectious and inflammatory diseases as well. This review summarises and discusses the results obtained, and draws conclusions from these data.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1473-3099
fulltext: fulltext
issn:
  • 1473-3099
  • 1474-4457
url: Link


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descriptionToll-like receptors (TLRs) play an important part in the innate immune recognition of invading microorganisms, initiating sufficient immune responses. Growing amounts of data suggest that the ability of certain individuals to respond properly to TLR ligands may be impaired by single nucleotide polymorphisms (SNPs) within TLR genes, resulting in an altered susceptibility to, or course of, infectious or inflammatory disease. Most studies have focused on two cosegregating SNPs—Asp299Gly and Thr399Ile—within the gene encoding TLR4, the receptor for bacterial lipopolysaccharide. These SNPs are present in approximately 10% of white individuals, and have been found to be positively correlated with several infectious diseases. However, these SNPs seem to protect from atherosclerosis and related diseases, which is reviewed in this article also. Meanwhile, SNPs of genes encoding other TLRs—eg, TLR2, which recognises a wide variety of microbial ligands—have been reported, and preliminary studies indicate an impact on susceptibility to infectious and inflammatory diseases as well. This review summarises and discusses the results obtained, and draws conclusions from these data.
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subjectAdapter proteins ; Arteriosclerosis ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Bacterial infections ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Case-Control Studies ; Chromosomes ; Communicable diseases ; Communicable Diseases - genetics ; Communicable Diseases - immunology ; Cytokines ; Diabetes ; Diabetic neuropathy ; Disease susceptibility ; Gangrene ; Genes ; Genetic aspects ; Genetic Variation ; Genomes ; Gram-positive bacteria ; Heart attacks ; Humans ; Immune response ; Immune system ; Infections ; Infectious diseases ; Inflammatory diseases ; Ligands ; Lipopolysaccharides ; Malaria ; Medical research ; Medical sciences ; Medicine, Experimental ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - immunology ; Membrane Glycoproteins - physiology ; Microorganisms ; Mortality ; Pattern recognition ; Polymorphism, Single Nucleotide - genetics ; Polymorphism, Single Nucleotide - immunology ; Polymorphism, Single Nucleotide - physiology ; Proteins ; Receptors ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - immunology ; Receptors, Cell Surface - physiology ; Sepsis ; Signal transduction ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; TLR2 protein ; TLR4 protein ; Toll-Like Receptor 2 ; Toll-Like Receptor 4 ; Toll-Like Receptors ; Tumor necrosis factor-TNF
ispartofThe Lancet infectious diseases, 2005-03, Vol.5 (3), p.156-164
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descriptionToll-like receptors (TLRs) play an important part in the innate immune recognition of invading microorganisms, initiating sufficient immune responses. Growing amounts of data suggest that the ability of certain individuals to respond properly to TLR ligands may be impaired by single nucleotide polymorphisms (SNPs) within TLR genes, resulting in an altered susceptibility to, or course of, infectious or inflammatory disease. Most studies have focused on two cosegregating SNPs—Asp299Gly and Thr399Ile—within the gene encoding TLR4, the receptor for bacterial lipopolysaccharide. These SNPs are present in approximately 10% of white individuals, and have been found to be positively correlated with several infectious diseases. However, these SNPs seem to protect from atherosclerosis and related diseases, which is reviewed in this article also. Meanwhile, SNPs of genes encoding other TLRs—eg, TLR2, which recognises a wide variety of microbial ligands—have been reported, and preliminary studies indicate an impact on susceptibility to infectious and inflammatory diseases as well. This review summarises and discusses the results obtained, and draws conclusions from these data.
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1Arteriosclerosis
2Atherosclerosis
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4Bacterial infections
5Biological and medical sciences
6Blood and lymphatic vessels
7Cardiology. Vascular system
8Case-Control Studies
9Chromosomes
10Communicable diseases
11Communicable Diseases - genetics
12Communicable Diseases - immunology
13Cytokines
14Diabetes
15Diabetic neuropathy
16Disease susceptibility
17Gangrene
18Genes
19Genetic aspects
20Genetic Variation
21Genomes
22Gram-positive bacteria
23Heart attacks
24Humans
25Immune response
26Immune system
27Infections
28Infectious diseases
29Inflammatory diseases
30Ligands
31Lipopolysaccharides
32Malaria
33Medical research
34Medical sciences
35Medicine, Experimental
36Membrane Glycoproteins - genetics
37Membrane Glycoproteins - immunology
38Membrane Glycoproteins - physiology
39Microorganisms
40Mortality
41Pattern recognition
42Polymorphism, Single Nucleotide - genetics
43Polymorphism, Single Nucleotide - immunology
44Polymorphism, Single Nucleotide - physiology
45Proteins
46Receptors
47Receptors, Cell Surface - genetics
48Receptors, Cell Surface - immunology
49Receptors, Cell Surface - physiology
50Sepsis
51Signal transduction
52Single nucleotide polymorphisms
53Single-nucleotide polymorphism
54TLR2 protein
55TLR4 protein
56Toll-Like Receptor 2
57Toll-Like Receptor 4
58Toll-Like Receptors
59Tumor necrosis factor-TNF
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1Arteriosclerosis
2Atherosclerosis
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4Bacterial infections
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6Blood and lymphatic vessels
7Cardiology. Vascular system
8Case-Control Studies
9Chromosomes
10Communicable diseases
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12Communicable Diseases - immunology
13Cytokines
14Diabetes
15Diabetic neuropathy
16Disease susceptibility
17Gangrene
18Genes
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21Genomes
22Gram-positive bacteria
23Heart attacks
24Humans
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34Medical sciences
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abstractToll-like receptors (TLRs) play an important part in the innate immune recognition of invading microorganisms, initiating sufficient immune responses. Growing amounts of data suggest that the ability of certain individuals to respond properly to TLR ligands may be impaired by single nucleotide polymorphisms (SNPs) within TLR genes, resulting in an altered susceptibility to, or course of, infectious or inflammatory disease. Most studies have focused on two cosegregating SNPs—Asp299Gly and Thr399Ile—within the gene encoding TLR4, the receptor for bacterial lipopolysaccharide. These SNPs are present in approximately 10% of white individuals, and have been found to be positively correlated with several infectious diseases. However, these SNPs seem to protect from atherosclerosis and related diseases, which is reviewed in this article also. Meanwhile, SNPs of genes encoding other TLRs—eg, TLR2, which recognises a wide variety of microbial ligands—have been reported, and preliminary studies indicate an impact on susceptibility to infectious and inflammatory diseases as well. This review summarises and discusses the results obtained, and draws conclusions from these data.
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pmid15766650
doi10.1016/S1473-3099(05)01308-3