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All-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992–1999

We compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK. We selected patients with type 1 diabetes (n=7,713), and for each of these diabetic subjects five age- and sex-matched control subjects without diabetes (n=38,518) fr... Full description

Journal Title: Diabetologia 2006, Vol.49 (4), p.660-666
Main Author: SOEDAMAH-MUTHU, S. S
Other Authors: FULLER, J. H , MULNIER, H. E , RALEIGH, V. S , LAWRENSON, R. A , COLHOUN, H. M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Cause of Death
Comparative analysis
Databases, Factual
Demography
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - mortality
Diabetes. Impaired glucose tolerance
Diabetics
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Family medicine
Family Practice
Female
Health aspects
Humans
Male
Medical sciences
Middle Aged
Mortality
Online databases
Physicians (General practice)
Public health
Resveratrol
Sex Characteristics
Type 1 diabetes
United Kingdom - epidemiology
Publisher: Berlin: Springer
ID: ISSN: 0012-186X
Zum Text:
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title: All-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992–1999
format: Article
creator:
  • SOEDAMAH-MUTHU, S. S
  • FULLER, J. H
  • MULNIER, H. E
  • RALEIGH, V. S
  • LAWRENSON, R. A
  • COLHOUN, H. M
subjects:
  • Adolescent
  • Adult
  • Aged
  • Biological and medical sciences
  • Cause of Death
  • Comparative analysis
  • Databases, Factual
  • Demography
  • Diabetes Mellitus, Type 1 - complications
  • Diabetes Mellitus, Type 1 - mortality
  • Diabetes. Impaired glucose tolerance
  • Diabetics
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Family medicine
  • Family Practice
  • Female
  • Health aspects
  • Humans
  • Male
  • Medical sciences
  • Middle Aged
  • Mortality
  • Online databases
  • Physicians (General practice)
  • Public health
  • Resveratrol
  • Sex Characteristics
  • Type 1 diabetes
  • United Kingdom - epidemiology
ispartof: Diabetologia, 2006, Vol.49 (4), p.660-666
description: We compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK. We selected patients with type 1 diabetes (n=7,713), and for each of these diabetic subjects five age- and sex-matched control subjects without diabetes (n=38,518) from the General Practice Research Database (GPRD). Baseline was 1 January 1992; subjects were followed until 1999. The GPRD is a large primary-care database containing morbidity and mortality data of a large sample representative of the UK population. Deaths occurring in the follow-up period were identified. The study comprised 208,178 person-years of follow-up. The prevalence of type 1 diabetes was 2.15/1,000 subjects in 1992 (mean age 33 years, SD 15). Annual mortality rates were 8.0 per 1,000 person-years (95% CI 7.2-8.9) in type 1 diabetic subjects compared with 2.4 per 1,000 person-years (95% CI 2.2-2.6) in those without diabetes (hazard ratio [HR]=3.7, 95% CI 3.2-4.3). The increased mortality rates in patients with type 1 diabetes were apparent across all age-bands. The HR was higher in women (HR=4.5, 95% CI 3.5-5.6 compared with non-diabetic women) than men (HR=3.3, 95% CI 2.7-4.0), such that the sex difference (p
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleAll-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992–1999
creatorSOEDAMAH-MUTHU, S. S ; FULLER, J. H ; MULNIER, H. E ; RALEIGH, V. S ; LAWRENSON, R. A ; COLHOUN, H. M
creatorcontribSOEDAMAH-MUTHU, S. S ; FULLER, J. H ; MULNIER, H. E ; RALEIGH, V. S ; LAWRENSON, R. A ; COLHOUN, H. M
descriptionWe compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK. We selected patients with type 1 diabetes (n=7,713), and for each of these diabetic subjects five age- and sex-matched control subjects without diabetes (n=38,518) from the General Practice Research Database (GPRD). Baseline was 1 January 1992; subjects were followed until 1999. The GPRD is a large primary-care database containing morbidity and mortality data of a large sample representative of the UK population. Deaths occurring in the follow-up period were identified. The study comprised 208,178 person-years of follow-up. The prevalence of type 1 diabetes was 2.15/1,000 subjects in 1992 (mean age 33 years, SD 15). Annual mortality rates were 8.0 per 1,000 person-years (95% CI 7.2-8.9) in type 1 diabetic subjects compared with 2.4 per 1,000 person-years (95% CI 2.2-2.6) in those without diabetes (hazard ratio [HR]=3.7, 95% CI 3.2-4.3). The increased mortality rates in patients with type 1 diabetes were apparent across all age-bands. The HR was higher in women (HR=4.5, 95% CI 3.5-5.6 compared with non-diabetic women) than men (HR=3.3, 95% CI 2.7-4.0), such that the sex difference (p<0.0001) in mortality in the non-diabetic population was abolished (p=0.3) in the type 1 diabetic patients. The predominant cause of death in patients with type 1 diabetes was cardiovascular disease. Despite advances in care, UK mortality rates in the past decade continue to be much greater in patients with type 1 diabetes than in those without diabetes.
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subjectAdolescent ; Adult ; Aged ; Biological and medical sciences ; Cause of Death ; Comparative analysis ; Databases, Factual ; Demography ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - mortality ; Diabetes. Impaired glucose tolerance ; Diabetics ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Family medicine ; Family Practice ; Female ; Health aspects ; Humans ; Male ; Medical sciences ; Middle Aged ; Mortality ; Online databases ; Physicians (General practice) ; Public health ; Resveratrol ; Sex Characteristics ; Type 1 diabetes ; United Kingdom - epidemiology
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descriptionWe compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK. We selected patients with type 1 diabetes (n=7,713), and for each of these diabetic subjects five age- and sex-matched control subjects without diabetes (n=38,518) from the General Practice Research Database (GPRD). Baseline was 1 January 1992; subjects were followed until 1999. The GPRD is a large primary-care database containing morbidity and mortality data of a large sample representative of the UK population. Deaths occurring in the follow-up period were identified. The study comprised 208,178 person-years of follow-up. The prevalence of type 1 diabetes was 2.15/1,000 subjects in 1992 (mean age 33 years, SD 15). Annual mortality rates were 8.0 per 1,000 person-years (95% CI 7.2-8.9) in type 1 diabetic subjects compared with 2.4 per 1,000 person-years (95% CI 2.2-2.6) in those without diabetes (hazard ratio [HR]=3.7, 95% CI 3.2-4.3). The increased mortality rates in patients with type 1 diabetes were apparent across all age-bands. The HR was higher in women (HR=4.5, 95% CI 3.5-5.6 compared with non-diabetic women) than men (HR=3.3, 95% CI 2.7-4.0), such that the sex difference (p<0.0001) in mortality in the non-diabetic population was abolished (p=0.3) in the type 1 diabetic patients. The predominant cause of death in patients with type 1 diabetes was cardiovascular disease. Despite advances in care, UK mortality rates in the past decade continue to be much greater in patients with type 1 diabetes than in those without diabetes.
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3Biological and medical sciences
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5Comparative analysis
6Databases, Factual
7Demography
8Diabetes Mellitus, Type 1 - complications
9Diabetes Mellitus, Type 1 - mortality
10Diabetes. Impaired glucose tolerance
11Diabetics
12Endocrine pancreas. Apud cells (diseases)
13Endocrinopathies
14Etiopathogenesis. Screening. Investigations. Target tissue resistance
15Family medicine
16Family Practice
17Female
18Health aspects
19Humans
20Male
21Medical sciences
22Middle Aged
23Mortality
24Online databases
25Physicians (General practice)
26Public health
27Resveratrol
28Sex Characteristics
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30United Kingdom - epidemiology
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titleAll-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992–1999
authorSOEDAMAH-MUTHU, S. S ; FULLER, J. H ; MULNIER, H. E ; RALEIGH, V. S ; LAWRENSON, R. A ; COLHOUN, H. M
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9Diabetes Mellitus, Type 1 - mortality
10Diabetes. Impaired glucose tolerance
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16Family Practice
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27Resveratrol
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atitleAll-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992–1999
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abstractWe compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK. We selected patients with type 1 diabetes (n=7,713), and for each of these diabetic subjects five age- and sex-matched control subjects without diabetes (n=38,518) from the General Practice Research Database (GPRD). Baseline was 1 January 1992; subjects were followed until 1999. The GPRD is a large primary-care database containing morbidity and mortality data of a large sample representative of the UK population. Deaths occurring in the follow-up period were identified. The study comprised 208,178 person-years of follow-up. The prevalence of type 1 diabetes was 2.15/1,000 subjects in 1992 (mean age 33 years, SD 15). Annual mortality rates were 8.0 per 1,000 person-years (95% CI 7.2-8.9) in type 1 diabetic subjects compared with 2.4 per 1,000 person-years (95% CI 2.2-2.6) in those without diabetes (hazard ratio [HR]=3.7, 95% CI 3.2-4.3). The increased mortality rates in patients with type 1 diabetes were apparent across all age-bands. The HR was higher in women (HR=4.5, 95% CI 3.5-5.6 compared with non-diabetic women) than men (HR=3.3, 95% CI 2.7-4.0), such that the sex difference (p<0.0001) in mortality in the non-diabetic population was abolished (p=0.3) in the type 1 diabetic patients. The predominant cause of death in patients with type 1 diabetes was cardiovascular disease. Despite advances in care, UK mortality rates in the past decade continue to be much greater in patients with type 1 diabetes than in those without diabetes.
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