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All-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992–1999

We compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK. We selected patients with type 1 diabetes (n=7,713), and for each of these diabetic subjects five age- and sex-matched control subjects without diabetes (n=38,518) fr... Full description

Journal Title: Diabetologia 2006, Vol.49 (4), p.660-666
Main Author: SOEDAMAH-MUTHU, S. S
Other Authors: FULLER, J. H , MULNIER, H. E , RALEIGH, V. S , LAWRENSON, R. A , COLHOUN, H. M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin: Springer
ID: ISSN: 0012-186X
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title: All-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992–1999
format: Article
creator:
  • SOEDAMAH-MUTHU, S. S
  • FULLER, J. H
  • MULNIER, H. E
  • RALEIGH, V. S
  • LAWRENSON, R. A
  • COLHOUN, H. M
subjects:
  • Adolescent
  • Adult
  • Aged
  • Biological and medical sciences
  • Cause of Death
  • Comparative analysis
  • Databases, Factual
  • Demography
  • Diabetes Mellitus, Type 1 - complications
  • Diabetes Mellitus, Type 1 - mortality
  • Diabetes. Impaired glucose tolerance
  • Diabetics
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Family medicine
  • Family Practice
  • Female
  • Health aspects
  • Humans
  • Male
  • Medical sciences
  • Middle Aged
  • Mortality
  • Online databases
  • Physicians (General practice)
  • Public health
  • Resveratrol
  • Sex Characteristics
  • Type 1 diabetes
  • United Kingdom - epidemiology
ispartof: Diabetologia, 2006, Vol.49 (4), p.660-666
description: We compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK. We selected patients with type 1 diabetes (n=7,713), and for each of these diabetic subjects five age- and sex-matched control subjects without diabetes (n=38,518) from the General Practice Research Database (GPRD). Baseline was 1 January 1992; subjects were followed until 1999. The GPRD is a large primary-care database containing morbidity and mortality data of a large sample representative of the UK population. Deaths occurring in the follow-up period were identified. The study comprised 208,178 person-years of follow-up. The prevalence of type 1 diabetes was 2.15/1,000 subjects in 1992 (mean age 33 years, SD 15). Annual mortality rates were 8.0 per 1,000 person-years (95% CI 7.2-8.9) in type 1 diabetic subjects compared with 2.4 per 1,000 person-years (95% CI 2.2-2.6) in those without diabetes (hazard ratio [HR]=3.7, 95% CI 3.2-4.3). The increased mortality rates in patients with type 1 diabetes were apparent across all age-bands. The HR was higher in women (HR=4.5, 95% CI 3.5-5.6 compared with non-diabetic women) than men (HR=3.3, 95% CI 2.7-4.0), such that the sex difference (p
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleAll-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992–1999
creatorSOEDAMAH-MUTHU, S. S ; FULLER, J. H ; MULNIER, H. E ; RALEIGH, V. S ; LAWRENSON, R. A ; COLHOUN, H. M
creatorcontribSOEDAMAH-MUTHU, S. S ; FULLER, J. H ; MULNIER, H. E ; RALEIGH, V. S ; LAWRENSON, R. A ; COLHOUN, H. M
descriptionWe compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK. We selected patients with type 1 diabetes (n=7,713), and for each of these diabetic subjects five age- and sex-matched control subjects without diabetes (n=38,518) from the General Practice Research Database (GPRD). Baseline was 1 January 1992; subjects were followed until 1999. The GPRD is a large primary-care database containing morbidity and mortality data of a large sample representative of the UK population. Deaths occurring in the follow-up period were identified. The study comprised 208,178 person-years of follow-up. The prevalence of type 1 diabetes was 2.15/1,000 subjects in 1992 (mean age 33 years, SD 15). Annual mortality rates were 8.0 per 1,000 person-years (95% CI 7.2-8.9) in type 1 diabetic subjects compared with 2.4 per 1,000 person-years (95% CI 2.2-2.6) in those without diabetes (hazard ratio [HR]=3.7, 95% CI 3.2-4.3). The increased mortality rates in patients with type 1 diabetes were apparent across all age-bands. The HR was higher in women (HR=4.5, 95% CI 3.5-5.6 compared with non-diabetic women) than men (HR=3.3, 95% CI 2.7-4.0), such that the sex difference (p<0.0001) in mortality in the non-diabetic population was abolished (p=0.3) in the type 1 diabetic patients. The predominant cause of death in patients with type 1 diabetes was cardiovascular disease. Despite advances in care, UK mortality rates in the past decade continue to be much greater in patients with type 1 diabetes than in those without diabetes.
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subjectAdolescent ; Adult ; Aged ; Biological and medical sciences ; Cause of Death ; Comparative analysis ; Databases, Factual ; Demography ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - mortality ; Diabetes. Impaired glucose tolerance ; Diabetics ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Family medicine ; Family Practice ; Female ; Health aspects ; Humans ; Male ; Medical sciences ; Middle Aged ; Mortality ; Online databases ; Physicians (General practice) ; Public health ; Resveratrol ; Sex Characteristics ; Type 1 diabetes ; United Kingdom - epidemiology
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descriptionWe compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK. We selected patients with type 1 diabetes (n=7,713), and for each of these diabetic subjects five age- and sex-matched control subjects without diabetes (n=38,518) from the General Practice Research Database (GPRD). Baseline was 1 January 1992; subjects were followed until 1999. The GPRD is a large primary-care database containing morbidity and mortality data of a large sample representative of the UK population. Deaths occurring in the follow-up period were identified. The study comprised 208,178 person-years of follow-up. The prevalence of type 1 diabetes was 2.15/1,000 subjects in 1992 (mean age 33 years, SD 15). Annual mortality rates were 8.0 per 1,000 person-years (95% CI 7.2-8.9) in type 1 diabetic subjects compared with 2.4 per 1,000 person-years (95% CI 2.2-2.6) in those without diabetes (hazard ratio [HR]=3.7, 95% CI 3.2-4.3). The increased mortality rates in patients with type 1 diabetes were apparent across all age-bands. The HR was higher in women (HR=4.5, 95% CI 3.5-5.6 compared with non-diabetic women) than men (HR=3.3, 95% CI 2.7-4.0), such that the sex difference (p<0.0001) in mortality in the non-diabetic population was abolished (p=0.3) in the type 1 diabetic patients. The predominant cause of death in patients with type 1 diabetes was cardiovascular disease. Despite advances in care, UK mortality rates in the past decade continue to be much greater in patients with type 1 diabetes than in those without diabetes.
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5Comparative analysis
6Databases, Factual
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8Diabetes Mellitus, Type 1 - complications
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10Diabetes. Impaired glucose tolerance
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12Endocrine pancreas. Apud cells (diseases)
13Endocrinopathies
14Etiopathogenesis. Screening. Investigations. Target tissue resistance
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20Male
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22Middle Aged
23Mortality
24Online databases
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abstractWe compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK. We selected patients with type 1 diabetes (n=7,713), and for each of these diabetic subjects five age- and sex-matched control subjects without diabetes (n=38,518) from the General Practice Research Database (GPRD). Baseline was 1 January 1992; subjects were followed until 1999. The GPRD is a large primary-care database containing morbidity and mortality data of a large sample representative of the UK population. Deaths occurring in the follow-up period were identified. The study comprised 208,178 person-years of follow-up. The prevalence of type 1 diabetes was 2.15/1,000 subjects in 1992 (mean age 33 years, SD 15). Annual mortality rates were 8.0 per 1,000 person-years (95% CI 7.2-8.9) in type 1 diabetic subjects compared with 2.4 per 1,000 person-years (95% CI 2.2-2.6) in those without diabetes (hazard ratio [HR]=3.7, 95% CI 3.2-4.3). The increased mortality rates in patients with type 1 diabetes were apparent across all age-bands. The HR was higher in women (HR=4.5, 95% CI 3.5-5.6 compared with non-diabetic women) than men (HR=3.3, 95% CI 2.7-4.0), such that the sex difference (p<0.0001) in mortality in the non-diabetic population was abolished (p=0.3) in the type 1 diabetic patients. The predominant cause of death in patients with type 1 diabetes was cardiovascular disease. Despite advances in care, UK mortality rates in the past decade continue to be much greater in patients with type 1 diabetes than in those without diabetes.
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