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Changes in serum level and metabolism of cholesterol with plant stanol esters in postmenopausal women with and without coronary artery disease

Especially in women, serum cholesterol lowering with cholesterol malabsorption using plant sterol ester margarine has revealed controversial results. Accordingly, in this retrospective study, we evaluated whether plant stanol (3 g/d) ester margarine consumption for 6 and 12 weeks lowers serum choles... Full description

Journal Title: Menopause (New York N.Y.), 2006-03, Vol.13 (2), p.286-293
Main Author: Gylling, Helena
Other Authors: Rajaratnam, Radhakrishnan A , Vartiainen, Erkki , Puska, Pekka , Miettinen, Tatu A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States
ID: ISSN: 1072-3714
Link: https://www.ncbi.nlm.nih.gov/pubmed/16645542
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title: Changes in serum level and metabolism of cholesterol with plant stanol esters in postmenopausal women with and without coronary artery disease
format: Article
creator:
  • Gylling, Helena
  • Rajaratnam, Radhakrishnan A
  • Vartiainen, Erkki
  • Puska, Pekka
  • Miettinen, Tatu A
subjects:
  • Analysis of Variance
  • Cholesterol - blood
  • Cholesterol - metabolism
  • Coronary Artery Disease - blood
  • Coronary Artery Disease - metabolism
  • Female
  • Humans
  • Hypolipidemic Agents - administration & dosage
  • Middle Aged
  • Postmenopause - metabolism
  • Sitosterols - administration & dosage
ispartof: Menopause (New York, N.Y.), 2006-03, Vol.13 (2), p.286-293
description: Especially in women, serum cholesterol lowering with cholesterol malabsorption using plant sterol ester margarine has revealed controversial results. Accordingly, in this retrospective study, we evaluated whether plant stanol (3 g/d) ester margarine consumption for 6 and 12 weeks lowers serum cholesterol levels in mildly hypercholesterolemic women without (n = 38) and with (n = 22) coronary heart disease. The study population was selected from two of our earlier studies correspondingly matched for age, body mass index, and serum cholesterol and triglyceride levels. In addition, the long-term effect (12 months) of plant stanol ester with a dose reduction after 6 months (from 3-2 g stanol/d) was studied in the noncoronary group. At baseline, the coronary and noncoronary groups had similar serum lathosterol (synthesis marker) and campesterol and sitosterol (absorption markers) ratios to cholesterol, but high-density lipoprotein cholesterol was lower and serum squalene and desmosterol ratios to cholesterol were significantly higher in the coronary versus noncoronary groups. Short-term plant stanol ester consumption reduced serum cholesterol by 8.7% (P < 0.001) in the coronary group from the control margarine period, and in the noncoronary group by 11% from the control group (P < 0.001). The cholesterol-lowering effect sustained unchanged in the noncoronary subjects during one year consumption despite reduction of the plant stanol intake from 3 g/d to 2 g/d. Plant stanol ester margarine consumption effectively reduced serum cholesterol in postmenopausal women with and without coronary artery disease in short-term and for at least 1 year in the noncoronary group, suggesting that stanol ester margarine might be used in the long-term for cholesterol lowering in women.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1072-3714
fulltext: fulltext
issn:
  • 1072-3714
  • 1530-0374
url: Link


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descriptionEspecially in women, serum cholesterol lowering with cholesterol malabsorption using plant sterol ester margarine has revealed controversial results. Accordingly, in this retrospective study, we evaluated whether plant stanol (3 g/d) ester margarine consumption for 6 and 12 weeks lowers serum cholesterol levels in mildly hypercholesterolemic women without (n = 38) and with (n = 22) coronary heart disease. The study population was selected from two of our earlier studies correspondingly matched for age, body mass index, and serum cholesterol and triglyceride levels. In addition, the long-term effect (12 months) of plant stanol ester with a dose reduction after 6 months (from 3-2 g stanol/d) was studied in the noncoronary group. At baseline, the coronary and noncoronary groups had similar serum lathosterol (synthesis marker) and campesterol and sitosterol (absorption markers) ratios to cholesterol, but high-density lipoprotein cholesterol was lower and serum squalene and desmosterol ratios to cholesterol were significantly higher in the coronary versus noncoronary groups. Short-term plant stanol ester consumption reduced serum cholesterol by 8.7% (P < 0.001) in the coronary group from the control margarine period, and in the noncoronary group by 11% from the control group (P < 0.001). The cholesterol-lowering effect sustained unchanged in the noncoronary subjects during one year consumption despite reduction of the plant stanol intake from 3 g/d to 2 g/d. Plant stanol ester margarine consumption effectively reduced serum cholesterol in postmenopausal women with and without coronary artery disease in short-term and for at least 1 year in the noncoronary group, suggesting that stanol ester margarine might be used in the long-term for cholesterol lowering in women.
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subjectAnalysis of Variance ; Cholesterol - blood ; Cholesterol - metabolism ; Coronary Artery Disease - blood ; Coronary Artery Disease - metabolism ; Female ; Humans ; Hypolipidemic Agents - administration & dosage ; Middle Aged ; Postmenopause - metabolism ; Sitosterols - administration & dosage
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descriptionEspecially in women, serum cholesterol lowering with cholesterol malabsorption using plant sterol ester margarine has revealed controversial results. Accordingly, in this retrospective study, we evaluated whether plant stanol (3 g/d) ester margarine consumption for 6 and 12 weeks lowers serum cholesterol levels in mildly hypercholesterolemic women without (n = 38) and with (n = 22) coronary heart disease. The study population was selected from two of our earlier studies correspondingly matched for age, body mass index, and serum cholesterol and triglyceride levels. In addition, the long-term effect (12 months) of plant stanol ester with a dose reduction after 6 months (from 3-2 g stanol/d) was studied in the noncoronary group. At baseline, the coronary and noncoronary groups had similar serum lathosterol (synthesis marker) and campesterol and sitosterol (absorption markers) ratios to cholesterol, but high-density lipoprotein cholesterol was lower and serum squalene and desmosterol ratios to cholesterol were significantly higher in the coronary versus noncoronary groups. Short-term plant stanol ester consumption reduced serum cholesterol by 8.7% (P < 0.001) in the coronary group from the control margarine period, and in the noncoronary group by 11% from the control group (P < 0.001). The cholesterol-lowering effect sustained unchanged in the noncoronary subjects during one year consumption despite reduction of the plant stanol intake from 3 g/d to 2 g/d. Plant stanol ester margarine consumption effectively reduced serum cholesterol in postmenopausal women with and without coronary artery disease in short-term and for at least 1 year in the noncoronary group, suggesting that stanol ester margarine might be used in the long-term for cholesterol lowering in women.
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abstractEspecially in women, serum cholesterol lowering with cholesterol malabsorption using plant sterol ester margarine has revealed controversial results. Accordingly, in this retrospective study, we evaluated whether plant stanol (3 g/d) ester margarine consumption for 6 and 12 weeks lowers serum cholesterol levels in mildly hypercholesterolemic women without (n = 38) and with (n = 22) coronary heart disease. The study population was selected from two of our earlier studies correspondingly matched for age, body mass index, and serum cholesterol and triglyceride levels. In addition, the long-term effect (12 months) of plant stanol ester with a dose reduction after 6 months (from 3-2 g stanol/d) was studied in the noncoronary group. At baseline, the coronary and noncoronary groups had similar serum lathosterol (synthesis marker) and campesterol and sitosterol (absorption markers) ratios to cholesterol, but high-density lipoprotein cholesterol was lower and serum squalene and desmosterol ratios to cholesterol were significantly higher in the coronary versus noncoronary groups. Short-term plant stanol ester consumption reduced serum cholesterol by 8.7% (P < 0.001) in the coronary group from the control margarine period, and in the noncoronary group by 11% from the control group (P < 0.001). The cholesterol-lowering effect sustained unchanged in the noncoronary subjects during one year consumption despite reduction of the plant stanol intake from 3 g/d to 2 g/d. Plant stanol ester margarine consumption effectively reduced serum cholesterol in postmenopausal women with and without coronary artery disease in short-term and for at least 1 year in the noncoronary group, suggesting that stanol ester margarine might be used in the long-term for cholesterol lowering in women.
copUnited States
pmid16645542
doi10.1097/01.gme.0000174095.49029.56