schliessen

Filtern

 

Bibliotheken

Effect of Statins on Noncholesterol Sterol Levels: Implications for Use of Plant Stanols and Sterols

Normal serum contains small amounts of noncholesterol sterols, including those reflecting cholesterol absorption and those that are markers of cholesterol synthesis. Absorption marker sterols include serum plant sterols, whereas cholesterol precursor sterols correlate with whole-body synthesis of ch... Full description

Journal Title: The American journal of cardiology 2005, Vol.96 (1), p.40-46
Main Author: Miettinen, Tatu A
Other Authors: Gylling, Helena
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0002-9149
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_67990909
title: Effect of Statins on Noncholesterol Sterol Levels: Implications for Use of Plant Stanols and Sterols
format: Article
creator:
  • Miettinen, Tatu A
  • Gylling, Helena
subjects:
  • Abridged Index Medicus
  • Biological and medical sciences
  • Cardiology. Vascular system
  • Chemical compounds
  • Cholesterol
  • Cholesterol, LDL - metabolism
  • Diet
  • Esters
  • Flowers & plants
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
  • Hypercholesterolemia - drug therapy
  • Intestinal Absorption
  • Medical sciences
  • Phytosterols
  • Phytosterols - pharmacology
  • Phytosterols - therapeutic use
  • Sitosterols - pharmacology
  • Sitosterols - therapeutic use
  • Sorption
  • Statins
  • Usage
ispartof: The American journal of cardiology, 2005, Vol.96 (1), p.40-46
description: Normal serum contains small amounts of noncholesterol sterols, including those reflecting cholesterol absorption and those that are markers of cholesterol synthesis. Absorption marker sterols include serum plant sterols, whereas cholesterol precursor sterols correlate with whole-body synthesis of cholesterol. Thus, serum noncholesterol sterols, and especially their ratios to cholesterol, can be used to evaluate the major features of cholesterol metabolism (ie, synthesis and absorption). Statin treatment reduces serum cholesterol precursors but increases serum plant sterols severalfold, especially in subjects with high-absorption marker sterol levels indicative of efficient cholesterol and sterol absorption in general. Statin therapy is most effective in subjects with high serum cholesterol precursor levels. In subjects with high-absorption sterol markers, dietary cholesterol absorption inhibition (eg, with plant stanol and sterol ester margarine) needs to be combined with a statin to achieve effective serum cholesterol reduction. However, whereas dietary plant stanol esters reduce statin-induced elevations of serum plant sterol levels, serum plant sterol levels remain elevated during dietary plant sterol ester consumption. The clinical implication of high serum plant sterol levels is under active investigation.
language: eng
source:
identifier: ISSN: 0002-9149
fulltext: no_fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.2180395
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_67990909
sourceformatXML
sourcesystemPC
galeidA195718023
sourcerecordidA195718023
originalsourceidFETCH-LOGICAL-c3649-add89882201ab38c5886a464f2c35c29cd0bed95eda8724014e793f908806c940
addsrcrecordideNqFklFrFDEUhYModl39Ccog6NuMycwkk-iDlFK1sKigfQ7Z5EYzZJJtMlvw35vpDhT6Uu7DJcl3DgdOEHpNcEMwYR_GRk2jVsk0Lca0wV2DiXiCNoQPoiaCdE_RBmPc1oL04gy9yHksR0Ioe47OCBWipYRukLm0FvRcRVv9mtXsQq5iqL7HoP9GD3mGFH15uVs7uAWfP1ZX08E7XeBYaBtTdZ1hMfjpVZgXmxB9rlQwqzC_RM-s8hlerXuLrr9c_r74Vu9-fL26ON_VumO9qJUxXHDetpiofcc15ZypnvW21R3VrdAG78EICkbxoe0x6WEQnRWYc8y06PEWvT_5HlK8OZb0cnJZgy-5IB6zZIMQeJktevsAHOMxhZJNth3uGKU9LVBzgv4oD9IFG-ekdBkDk9MxgHXl_pwIOhCOi26L6EmgU8w5gZWH5CaV_kmC5VKaHOVamlxKk7iTpbSie7OmOe4nMPeqtaUCvFsBlbXyNqmgXb7nhmJGGCvcpwcBtJvveirJnX80xueTupQMtw6SzNpB0GBcKl9EmugecfgPfDvJ7w
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid230365545
display
typearticle
titleEffect of Statins on Noncholesterol Sterol Levels: Implications for Use of Plant Stanols and Sterols
creatorMiettinen, Tatu A ; Gylling, Helena
creatorcontribMiettinen, Tatu A ; Gylling, Helena
descriptionNormal serum contains small amounts of noncholesterol sterols, including those reflecting cholesterol absorption and those that are markers of cholesterol synthesis. Absorption marker sterols include serum plant sterols, whereas cholesterol precursor sterols correlate with whole-body synthesis of cholesterol. Thus, serum noncholesterol sterols, and especially their ratios to cholesterol, can be used to evaluate the major features of cholesterol metabolism (ie, synthesis and absorption). Statin treatment reduces serum cholesterol precursors but increases serum plant sterols severalfold, especially in subjects with high-absorption marker sterol levels indicative of efficient cholesterol and sterol absorption in general. Statin therapy is most effective in subjects with high serum cholesterol precursor levels. In subjects with high-absorption sterol markers, dietary cholesterol absorption inhibition (eg, with plant stanol and sterol ester margarine) needs to be combined with a statin to achieve effective serum cholesterol reduction. However, whereas dietary plant stanol esters reduce statin-induced elevations of serum plant sterol levels, serum plant sterol levels remain elevated during dietary plant sterol ester consumption. The clinical implication of high serum plant sterol levels is under active investigation.
identifier
0ISSN: 0002-9149
1EISSN: 1879-1913
2DOI: 10.1016/j.amjcard.2005.03.019
3PMID: 15992515
4CODEN: AJCDAG
languageeng
publisherNew York, NY: Elsevier Inc
subjectAbridged Index Medicus ; Biological and medical sciences ; Cardiology. Vascular system ; Chemical compounds ; Cholesterol ; Cholesterol, LDL - metabolism ; Diet ; Esters ; Flowers & plants ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Hypercholesterolemia - drug therapy ; Intestinal Absorption ; Medical sciences ; Phytosterols ; Phytosterols - pharmacology ; Phytosterols - therapeutic use ; Sitosterols - pharmacology ; Sitosterols - therapeutic use ; Sorption ; Statins ; Usage
ispartofThe American journal of cardiology, 2005, Vol.96 (1), p.40-46
rights
02005 Elsevier Inc.
12005 INIST-CNRS
2COPYRIGHT 2005 Elsevier B.V.
3Copyright Elsevier Sequoia S.A. Jul 4, 2005
lds50peer_reviewed
citedbyFETCH-LOGICAL-c3649-add89882201ab38c5886a464f2c35c29cd0bed95eda8724014e793f908806c940
citesFETCH-LOGICAL-c3649-add89882201ab38c5886a464f2c35c29cd0bed95eda8724014e793f908806c940
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17005166$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15992515$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Miettinen, Tatu A
1Gylling, Helena
title
0Effect of Statins on Noncholesterol Sterol Levels: Implications for Use of Plant Stanols and Sterols
1The American journal of cardiology
addtitleAm J Cardiol
descriptionNormal serum contains small amounts of noncholesterol sterols, including those reflecting cholesterol absorption and those that are markers of cholesterol synthesis. Absorption marker sterols include serum plant sterols, whereas cholesterol precursor sterols correlate with whole-body synthesis of cholesterol. Thus, serum noncholesterol sterols, and especially their ratios to cholesterol, can be used to evaluate the major features of cholesterol metabolism (ie, synthesis and absorption). Statin treatment reduces serum cholesterol precursors but increases serum plant sterols severalfold, especially in subjects with high-absorption marker sterol levels indicative of efficient cholesterol and sterol absorption in general. Statin therapy is most effective in subjects with high serum cholesterol precursor levels. In subjects with high-absorption sterol markers, dietary cholesterol absorption inhibition (eg, with plant stanol and sterol ester margarine) needs to be combined with a statin to achieve effective serum cholesterol reduction. However, whereas dietary plant stanol esters reduce statin-induced elevations of serum plant sterol levels, serum plant sterol levels remain elevated during dietary plant sterol ester consumption. The clinical implication of high serum plant sterol levels is under active investigation.
subject
0Abridged Index Medicus
1Biological and medical sciences
2Cardiology. Vascular system
3Chemical compounds
4Cholesterol
5Cholesterol, LDL - metabolism
6Diet
7Esters
8Flowers & plants
9Humans
10Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
11Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
12Hypercholesterolemia - drug therapy
13Intestinal Absorption
14Medical sciences
15Phytosterols
16Phytosterols - pharmacology
17Phytosterols - therapeutic use
18Sitosterols - pharmacology
19Sitosterols - therapeutic use
20Sorption
21Statins
22Usage
issn
00002-9149
11879-1913
fulltextfalse
rsrctypearticle
creationdate2005
recordtypearticle
recordideNqFklFrFDEUhYModl39Ccog6NuMycwkk-iDlFK1sKigfQ7Z5EYzZJJtMlvw35vpDhT6Uu7DJcl3DgdOEHpNcEMwYR_GRk2jVsk0Lca0wV2DiXiCNoQPoiaCdE_RBmPc1oL04gy9yHksR0Ioe47OCBWipYRukLm0FvRcRVv9mtXsQq5iqL7HoP9GD3mGFH15uVs7uAWfP1ZX08E7XeBYaBtTdZ1hMfjpVZgXmxB9rlQwqzC_RM-s8hlerXuLrr9c_r74Vu9-fL26ON_VumO9qJUxXHDetpiofcc15ZypnvW21R3VrdAG78EICkbxoe0x6WEQnRWYc8y06PEWvT_5HlK8OZb0cnJZgy-5IB6zZIMQeJktevsAHOMxhZJNth3uGKU9LVBzgv4oD9IFG-ekdBkDk9MxgHXl_pwIOhCOi26L6EmgU8w5gZWH5CaV_kmC5VKaHOVamlxKk7iTpbSie7OmOe4nMPeqtaUCvFsBlbXyNqmgXb7nhmJGGCvcpwcBtJvveirJnX80xueTupQMtw6SzNpB0GBcKl9EmugecfgPfDvJ7w
startdate2005
enddate2005
creator
0Miettinen, Tatu A
1Gylling, Helena
general
0Elsevier Inc
1Elsevier
2Elsevier B.V
3Elsevier Limited
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
9BSHEE
107QO
117TS
128FD
13FR3
14K9.
15NAPCQ
16P64
177X8
sort
creationdate2005
titleEffect of Statins on Noncholesterol Sterol Levels: Implications for Use of Plant Stanols and Sterols
authorMiettinen, Tatu A ; Gylling, Helena
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c3649-add89882201ab38c5886a464f2c35c29cd0bed95eda8724014e793f908806c940
rsrctypearticles
prefilterarticles
languageeng
creationdate2005
topic
0Abridged Index Medicus
1Biological and medical sciences
2Cardiology. Vascular system
3Chemical compounds
4Cholesterol
5Cholesterol, LDL - metabolism
6Diet
7Esters
8Flowers & plants
9Humans
10Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
11Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
12Hypercholesterolemia - drug therapy
13Intestinal Absorption
14Medical sciences
15Phytosterols
16Phytosterols - pharmacology
17Phytosterols - therapeutic use
18Sitosterols - pharmacology
19Sitosterols - therapeutic use
20Sorption
21Statins
22Usage
toplevelpeer_reviewed
creatorcontrib
0Miettinen, Tatu A
1Gylling, Helena
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8Academic OneFile (A&I only)
9Biotechnology Research Abstracts
10Physical Education Index
11Technology Research Database
12Engineering Research Database
13ProQuest Health & Medical Complete (Alumni)
14Nursing & Allied Health Premium
15Biotechnology and BioEngineering Abstracts
16MEDLINE - Academic
jtitleThe American journal of cardiology
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Miettinen, Tatu A
1Gylling, Helena
formatjournal
genrearticle
ristypeJOUR
atitleEffect of Statins on Noncholesterol Sterol Levels: Implications for Use of Plant Stanols and Sterols
jtitleThe American journal of cardiology
addtitleAm J Cardiol
date2005
risdate2005
volume96
issue1
spage40
epage46
pages40-46
issn0002-9149
eissn1879-1913
codenAJCDAG
abstractNormal serum contains small amounts of noncholesterol sterols, including those reflecting cholesterol absorption and those that are markers of cholesterol synthesis. Absorption marker sterols include serum plant sterols, whereas cholesterol precursor sterols correlate with whole-body synthesis of cholesterol. Thus, serum noncholesterol sterols, and especially their ratios to cholesterol, can be used to evaluate the major features of cholesterol metabolism (ie, synthesis and absorption). Statin treatment reduces serum cholesterol precursors but increases serum plant sterols severalfold, especially in subjects with high-absorption marker sterol levels indicative of efficient cholesterol and sterol absorption in general. Statin therapy is most effective in subjects with high serum cholesterol precursor levels. In subjects with high-absorption sterol markers, dietary cholesterol absorption inhibition (eg, with plant stanol and sterol ester margarine) needs to be combined with a statin to achieve effective serum cholesterol reduction. However, whereas dietary plant stanol esters reduce statin-induced elevations of serum plant sterol levels, serum plant sterol levels remain elevated during dietary plant sterol ester consumption. The clinical implication of high serum plant sterol levels is under active investigation.
copNew York, NY
pubElsevier Inc
pmid15992515
doi10.1016/j.amjcard.2005.03.019