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Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential

Traditionally, neuronal operations in the cerebral cortex have been viewed as occurring through the interaction of synaptic potentials in the dendrite and soma, followed by the initiation of an action potential, typically in the axon. Propagation of this action potential to the synaptic terminals is... Full description

Journal Title: Nature 2006, Vol.441 (7094), p.761-765
Main Author: McCormick, David A
Other Authors: Shu, Yousheng , Hasenstaub, Andrea , Duque, Alvaro , Yu, Yuguo
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: London: Nature Publishing
ID: ISSN: 0028-0836
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recordid: cdi_proquest_miscellaneous_68050645
title: Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential
format: Article
creator:
  • McCormick, David A
  • Shu, Yousheng
  • Hasenstaub, Andrea
  • Duque, Alvaro
  • Yu, Yuguo
subjects:
  • Action Potentials - physiology
  • Animals
  • Axons - physiology
  • Biological and medical sciences
  • Central nervous system
  • Cerebral Cortex - cytology
  • Cerebral Cortex - physiology
  • Dendrites - physiology
  • Electrophysiology
  • Excitatory Postsynaptic Potentials - physiology
  • Ferrets - physiology
  • Fundamental and applied biological sciences. Psychology
  • Membrane Potentials - physiology
  • Neurons - cytology
  • Neurons - physiology
  • Presynaptic Terminals - physiology
  • Pyramidal Cells - cytology
  • Pyramidal Cells - physiology
  • Synapses - physiology
  • Synaptic Transmission
  • Vertebrates: nervous system and sense organs
ispartof: Nature, 2006, Vol.441 (7094), p.761-765
description: Traditionally, neuronal operations in the cerebral cortex have been viewed as occurring through the interaction of synaptic potentials in the dendrite and soma, followed by the initiation of an action potential, typically in the axon. Propagation of this action potential to the synaptic terminals is widely believed to be the only form of rapid communication of information between the soma and axonal synapses, and hence to postsynaptic neurons. Here we show that the voltage fluctuations associated with dendrosomatic synaptic activity propagate significant distances along the axon, and that modest changes in the somatic membrane potential of the presynaptic neuron modulate the amplitude and duration of axonal action potentials and, through a Ca2+-dependent mechanism, the average amplitude of the postsynaptic potential evoked by these spikes. These results indicate that synaptic activity in the dendrite and soma controls not only the pattern of action potentials generated, but also the amplitude of the synaptic potentials that these action potentials initiate in local cortical circuits, resulting in synaptic transmission that is a mixture of triggered and graded (analogue) signals.
language: eng
source:
identifier: ISSN: 0028-0836
fulltext: no_fulltext
issn:
  • 0028-0836
  • 1476-4687
  • 1476-4679
url: Link


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titleModulation of intracortical synaptic potentials by presynaptic somatic membrane potential
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descriptionTraditionally, neuronal operations in the cerebral cortex have been viewed as occurring through the interaction of synaptic potentials in the dendrite and soma, followed by the initiation of an action potential, typically in the axon. Propagation of this action potential to the synaptic terminals is widely believed to be the only form of rapid communication of information between the soma and axonal synapses, and hence to postsynaptic neurons. Here we show that the voltage fluctuations associated with dendrosomatic synaptic activity propagate significant distances along the axon, and that modest changes in the somatic membrane potential of the presynaptic neuron modulate the amplitude and duration of axonal action potentials and, through a Ca2+-dependent mechanism, the average amplitude of the postsynaptic potential evoked by these spikes. These results indicate that synaptic activity in the dendrite and soma controls not only the pattern of action potentials generated, but also the amplitude of the synaptic potentials that these action potentials initiate in local cortical circuits, resulting in synaptic transmission that is a mixture of triggered and graded (analogue) signals.
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subjectAction Potentials - physiology ; Animals ; Axons - physiology ; Biological and medical sciences ; Central nervous system ; Cerebral Cortex - cytology ; Cerebral Cortex - physiology ; Dendrites - physiology ; Electrophysiology ; Excitatory Postsynaptic Potentials - physiology ; Ferrets - physiology ; Fundamental and applied biological sciences. Psychology ; Membrane Potentials - physiology ; Neurons - cytology ; Neurons - physiology ; Presynaptic Terminals - physiology ; Pyramidal Cells - cytology ; Pyramidal Cells - physiology ; Synapses - physiology ; Synaptic Transmission ; Vertebrates: nervous system and sense organs
ispartofNature, 2006, Vol.441 (7094), p.761-765
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descriptionTraditionally, neuronal operations in the cerebral cortex have been viewed as occurring through the interaction of synaptic potentials in the dendrite and soma, followed by the initiation of an action potential, typically in the axon. Propagation of this action potential to the synaptic terminals is widely believed to be the only form of rapid communication of information between the soma and axonal synapses, and hence to postsynaptic neurons. Here we show that the voltage fluctuations associated with dendrosomatic synaptic activity propagate significant distances along the axon, and that modest changes in the somatic membrane potential of the presynaptic neuron modulate the amplitude and duration of axonal action potentials and, through a Ca2+-dependent mechanism, the average amplitude of the postsynaptic potential evoked by these spikes. These results indicate that synaptic activity in the dendrite and soma controls not only the pattern of action potentials generated, but also the amplitude of the synaptic potentials that these action potentials initiate in local cortical circuits, resulting in synaptic transmission that is a mixture of triggered and graded (analogue) signals.
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abstractTraditionally, neuronal operations in the cerebral cortex have been viewed as occurring through the interaction of synaptic potentials in the dendrite and soma, followed by the initiation of an action potential, typically in the axon. Propagation of this action potential to the synaptic terminals is widely believed to be the only form of rapid communication of information between the soma and axonal synapses, and hence to postsynaptic neurons. Here we show that the voltage fluctuations associated with dendrosomatic synaptic activity propagate significant distances along the axon, and that modest changes in the somatic membrane potential of the presynaptic neuron modulate the amplitude and duration of axonal action potentials and, through a Ca2+-dependent mechanism, the average amplitude of the postsynaptic potential evoked by these spikes. These results indicate that synaptic activity in the dendrite and soma controls not only the pattern of action potentials generated, but also the amplitude of the synaptic potentials that these action potentials initiate in local cortical circuits, resulting in synaptic transmission that is a mixture of triggered and graded (analogue) signals.
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