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Randomised trials of HIV prevention

Many studies report increased condom use over time, which should be factored into power estimates.1,8-11 Pregnancy rates in the tenofovir trial were high, and treatment was interrupted during gestation or lactation because of concerns about fetal or infant toxicity.8 Treatment interruptions erode st... Full description

Journal Title: The Lancet (British edition) 2007, Vol.370 (9583), p.200-201
Main Author: Gray, Ronald H
Other Authors: Wawer, Maria J
Format: Electronic Article Electronic Article
Language: English
Subjects:
HIV
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Ltd
ID: ISSN: 0140-6736
Link: https://www.ncbi.nlm.nih.gov/pubmed/17631388
Zum Text:
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title: Randomised trials of HIV prevention
format: Article
creator:
  • Gray, Ronald H
  • Wawer, Maria J
subjects:
  • Abridged Index Medicus
  • Birth control
  • Circumcision
  • Clinical trials
  • Condoms - utilization
  • Contraceptive Devices, Female - utilization
  • Disease prevention
  • Female
  • Herpes viruses
  • HIV
  • HIV Infections - prevention & control
  • Human immunodeficiency virus
  • Humans
  • Internal Medicine
  • Intervention
  • Male
  • Methods
  • Pregnancy
  • Preventive medicine
  • Randomized Controlled Trials as Topic
  • Reproductive health
  • Safe Sex
  • Sexual behavior
  • Studies
  • Treatment Failure
  • Treatment Refusal
ispartof: The Lancet (British edition), 2007, Vol.370 (9583), p.200-201
description: Many studies report increased condom use over time, which should be factored into power estimates.1,8-11 Pregnancy rates in the tenofovir trial were high, and treatment was interrupted during gestation or lactation because of concerns about fetal or infant toxicity.8 Treatment interruptions erode study power and do not realistically represent circumstances of future programmatic use in which women who are not using a contraceptive are likely to conceive.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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descriptionMany studies report increased condom use over time, which should be factored into power estimates.1,8-11 Pregnancy rates in the tenofovir trial were high, and treatment was interrupted during gestation or lactation because of concerns about fetal or infant toxicity.8 Treatment interruptions erode study power and do not realistically represent circumstances of future programmatic use in which women who are not using a contraceptive are likely to conceive.
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subjectAbridged Index Medicus ; Birth control ; Circumcision ; Clinical trials ; Condoms - utilization ; Contraceptive Devices, Female - utilization ; Disease prevention ; Female ; Herpes viruses ; HIV ; HIV Infections - prevention & control ; Human immunodeficiency virus ; Humans ; Internal Medicine ; Intervention ; Male ; Methods ; Pregnancy ; Preventive medicine ; Randomized Controlled Trials as Topic ; Reproductive health ; Safe Sex ; Sexual behavior ; Studies ; Treatment Failure ; Treatment Refusal
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abstractMany studies report increased condom use over time, which should be factored into power estimates.1,8-11 Pregnancy rates in the tenofovir trial were high, and treatment was interrupted during gestation or lactation because of concerns about fetal or infant toxicity.8 Treatment interruptions erode study power and do not realistically represent circumstances of future programmatic use in which women who are not using a contraceptive are likely to conceive.
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pmid17631388
doi10.1016/S0140-6736(07)61058-7