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Adult socioeconomic position, C-reactive protein and interleukin-6 in the Whitehall II prospective study

Background Prior studies on the association of inflammatory markers, such as C-reactive protein (CRP) and interleukin-6 (IL-6), with socioeconomic position (SEP) have been cross-sectional. Thus, the question of whether socioeconomic differences in CRP and IL-6 change over time remains unanswered. We... Full description

Journal Title: European journal of epidemiology 2007-10-01, Vol.22 (10), p.675-683
Main Author: GIMENO, David
Other Authors: BRUNNER, Eric J , LOWE, Gordon D. O , RUMLEY, Ann , MARMOT, Michael G , FERRIE, Jane E
Format: Electronic Article Electronic Article
Language: English
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Publisher: Dordrecht: Springer
ID: ISSN: 0393-2990
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title: Adult socioeconomic position, C-reactive protein and interleukin-6 in the Whitehall II prospective study
format: Article
creator:
  • GIMENO, David
  • BRUNNER, Eric J
  • LOWE, Gordon D. O
  • RUMLEY, Ann
  • MARMOT, Michael G
  • FERRIE, Jane E
subjects:
  • Adult
  • Analysis
  • Behavior modeling
  • Biological and medical sciences
  • Body mass
  • Body mass index
  • Body size
  • C-reactive protein
  • C-Reactive Protein - analysis
  • C-Reactive Protein - immunology
  • CARDIOVASCULAR DISEASE
  • Cardiovascular diseases
  • Cholesterol
  • Civil service
  • Coronary artery disease
  • Cross-Sectional Studies
  • Cytokines
  • Epidemiology
  • Ethnicity
  • Female
  • General aspects
  • Health risks
  • High density lipoprotein
  • Humans
  • Immune system
  • Inflammation
  • Inflammatory diseases
  • Interleukin
  • Interleukin 6
  • Interleukin-6 - analysis
  • Interleukin-6 - immunology
  • Male
  • Medical research
  • Medical sciences
  • Medications
  • Middle Aged
  • Miscellaneous
  • Predisposing factors
  • Prospective Studies
  • Proteins
  • Public health. Hygiene
  • Public health. Hygiene-occupational medicine
  • Risk analysis
  • Risk factors
  • Risk taking
  • Social Class
  • Socioeconomic factors
  • Socioeconomics
  • Statistical analysis
ispartof: European journal of epidemiology, 2007-10-01, Vol.22 (10), p.675-683
description: Background Prior studies on the association of inflammatory markers, such as C-reactive protein (CRP) and interleukin-6 (IL-6), with socioeconomic position (SEP) have been cross-sectional. Thus, the question of whether socioeconomic differences in CRP and IL-6 change over time remains unanswered. We examined the relationship between SEP and changes over 12 years in CRP and IL-6. Methods Data were for 4,750 middle-aged (mean 49.0 years, SD 5.9) civil servants from phases 3 and 7 of the Whitehall II study. Adult SEP was based on last known Civil Service employment grade. Covariates included sociodemographics, behavioural and biological risk factors, presence of diseases/illnesses, prescribed medications, work-related factors, labour market status and early life factors. Results Steep socioeconomic gradients observed at Phase 3 (p < 0.001) persisted in both CRP and IL-6 12 years later after adjustment for other risk factors. Adjustment for behavioural (diet and smoking), biological (mainly body mass index and total: HDL cholesterol ratio) and early life factors resulted in considerable attenuation but the inverse socioeconomic gradients remained statistically significant. Although CRP and IL-6 concentrations increased substantially over the 12-year period at every level of SEP, CRP and IL-6 did not change differentially according to SEP. Conclusion Despite overall increases in CRP and IL6, relative differences by SEP remained unchanged so that socioeconomic gradients in both sexes persisted over the period observed.
language: eng
source:
identifier: ISSN: 0393-2990
fulltext: no_fulltext
issn:
  • 0393-2990
  • 1573-7284
url: Link


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titleAdult socioeconomic position, C-reactive protein and interleukin-6 in the Whitehall II prospective study
creatorGIMENO, David ; BRUNNER, Eric J ; LOWE, Gordon D. O ; RUMLEY, Ann ; MARMOT, Michael G ; FERRIE, Jane E
creatorcontribGIMENO, David ; BRUNNER, Eric J ; LOWE, Gordon D. O ; RUMLEY, Ann ; MARMOT, Michael G ; FERRIE, Jane E
descriptionBackground Prior studies on the association of inflammatory markers, such as C-reactive protein (CRP) and interleukin-6 (IL-6), with socioeconomic position (SEP) have been cross-sectional. Thus, the question of whether socioeconomic differences in CRP and IL-6 change over time remains unanswered. We examined the relationship between SEP and changes over 12 years in CRP and IL-6. Methods Data were for 4,750 middle-aged (mean 49.0 years, SD 5.9) civil servants from phases 3 and 7 of the Whitehall II study. Adult SEP was based on last known Civil Service employment grade. Covariates included sociodemographics, behavioural and biological risk factors, presence of diseases/illnesses, prescribed medications, work-related factors, labour market status and early life factors. Results Steep socioeconomic gradients observed at Phase 3 (p < 0.001) persisted in both CRP and IL-6 12 years later after adjustment for other risk factors. Adjustment for behavioural (diet and smoking), biological (mainly body mass index and total: HDL cholesterol ratio) and early life factors resulted in considerable attenuation but the inverse socioeconomic gradients remained statistically significant. Although CRP and IL-6 concentrations increased substantially over the 12-year period at every level of SEP, CRP and IL-6 did not change differentially according to SEP. Conclusion Despite overall increases in CRP and IL6, relative differences by SEP remained unchanged so that socioeconomic gradients in both sexes persisted over the period observed.
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subjectAdult ; Analysis ; Behavior modeling ; Biological and medical sciences ; Body mass ; Body mass index ; Body size ; C-reactive protein ; C-Reactive Protein - analysis ; C-Reactive Protein - immunology ; CARDIOVASCULAR DISEASE ; Cardiovascular diseases ; Cholesterol ; Civil service ; Coronary artery disease ; Cross-Sectional Studies ; Cytokines ; Epidemiology ; Ethnicity ; Female ; General aspects ; Health risks ; High density lipoprotein ; Humans ; Immune system ; Inflammation ; Inflammatory diseases ; Interleukin ; Interleukin 6 ; Interleukin-6 - analysis ; Interleukin-6 - immunology ; Male ; Medical research ; Medical sciences ; Medications ; Middle Aged ; Miscellaneous ; Predisposing factors ; Prospective Studies ; Proteins ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk analysis ; Risk factors ; Risk taking ; Social Class ; Socioeconomic factors ; Socioeconomics ; Statistical analysis
ispartofEuropean journal of epidemiology, 2007-10-01, Vol.22 (10), p.675-683
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descriptionBackground Prior studies on the association of inflammatory markers, such as C-reactive protein (CRP) and interleukin-6 (IL-6), with socioeconomic position (SEP) have been cross-sectional. Thus, the question of whether socioeconomic differences in CRP and IL-6 change over time remains unanswered. We examined the relationship between SEP and changes over 12 years in CRP and IL-6. Methods Data were for 4,750 middle-aged (mean 49.0 years, SD 5.9) civil servants from phases 3 and 7 of the Whitehall II study. Adult SEP was based on last known Civil Service employment grade. Covariates included sociodemographics, behavioural and biological risk factors, presence of diseases/illnesses, prescribed medications, work-related factors, labour market status and early life factors. Results Steep socioeconomic gradients observed at Phase 3 (p < 0.001) persisted in both CRP and IL-6 12 years later after adjustment for other risk factors. Adjustment for behavioural (diet and smoking), biological (mainly body mass index and total: HDL cholesterol ratio) and early life factors resulted in considerable attenuation but the inverse socioeconomic gradients remained statistically significant. Although CRP and IL-6 concentrations increased substantially over the 12-year period at every level of SEP, CRP and IL-6 did not change differentially according to SEP. Conclusion Despite overall increases in CRP and IL6, relative differences by SEP remained unchanged so that socioeconomic gradients in both sexes persisted over the period observed.
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authorGIMENO, David ; BRUNNER, Eric J ; LOWE, Gordon D. O ; RUMLEY, Ann ; MARMOT, Michael G ; FERRIE, Jane E
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abstractBackground Prior studies on the association of inflammatory markers, such as C-reactive protein (CRP) and interleukin-6 (IL-6), with socioeconomic position (SEP) have been cross-sectional. Thus, the question of whether socioeconomic differences in CRP and IL-6 change over time remains unanswered. We examined the relationship between SEP and changes over 12 years in CRP and IL-6. Methods Data were for 4,750 middle-aged (mean 49.0 years, SD 5.9) civil servants from phases 3 and 7 of the Whitehall II study. Adult SEP was based on last known Civil Service employment grade. Covariates included sociodemographics, behavioural and biological risk factors, presence of diseases/illnesses, prescribed medications, work-related factors, labour market status and early life factors. Results Steep socioeconomic gradients observed at Phase 3 (p < 0.001) persisted in both CRP and IL-6 12 years later after adjustment for other risk factors. Adjustment for behavioural (diet and smoking), biological (mainly body mass index and total: HDL cholesterol ratio) and early life factors resulted in considerable attenuation but the inverse socioeconomic gradients remained statistically significant. Although CRP and IL-6 concentrations increased substantially over the 12-year period at every level of SEP, CRP and IL-6 did not change differentially according to SEP. Conclusion Despite overall increases in CRP and IL6, relative differences by SEP remained unchanged so that socioeconomic gradients in both sexes persisted over the period observed.
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pmid17668278
doi10.1007/s10654-007-9171-9