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Chromosome 1p36 and 22qter deletions in paraffin block sections of intracranial meningiomas

Meningiomas are the most frequent benign tumors of the intracranial cavity. The classification and underlying pathogenetic mechanisms have been reported to be investigated by both pathological and genetic methods. In this study, we aimed to detect 1p36 and 22qter deletions by fluorescence in situ hy... Full description

Journal Title: Pathology oncology research 2005, Vol.11 (4), p.224-228
Main Author: Yilmaz, Zerrin
Other Authors: Sahin, Feride Iffet , Atalay, Basar , Ozen, Ozlem , Caner, Hakan , Bavbek, Murad , Demirhan, Beyhan , Altinörs, Nur
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Netherlands: Springer Nature B.V
ID: ISSN: 1219-4956
Link: https://www.ncbi.nlm.nih.gov/pubmed/16388319
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title: Chromosome 1p36 and 22qter deletions in paraffin block sections of intracranial meningiomas
format: Article
creator:
  • Yilmaz, Zerrin
  • Sahin, Feride Iffet
  • Atalay, Basar
  • Ozen, Ozlem
  • Caner, Hakan
  • Bavbek, Murad
  • Demirhan, Beyhan
  • Altinörs, Nur
subjects:
  • Adult
  • Aged
  • Chromosome Deletion
  • Chromosomes, Human, Pair 1 - genetics
  • Chromosomes, Human, Pair 22 - genetics
  • Data Interpretation, Statistical
  • Disease Progression
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Medical research
  • Meningeal Neoplasms - genetics
  • Meningioma - genetics
  • Middle Aged
ispartof: Pathology oncology research, 2005, Vol.11 (4), p.224-228
description: Meningiomas are the most frequent benign tumors of the intracranial cavity. The classification and underlying pathogenetic mechanisms have been reported to be investigated by both pathological and genetic methods. In this study, we aimed to detect 1p36 and 22qter deletions by fluorescence in situ hybridization (FISH) in archival materials of 50 intracranial meningioma patients. The clinical material consisted of paraffin-embedded tissue sections from 50 patients who were surgically treated and had histopathologic diagnosis of an intracranial meningioma. We observed 1p36 deletion in 23/50 (46%) and 22qter deletion in 33/50 (66%) patients. In addition, we observed 22qter deletion in 26/36 (72.2%) patients with meningothelial meningioma. This finding implies that 22qter deletion might play an important role in the pathogenesis of meningothelial meningioma. On the other hand, no alterations were documented in the frequency of these chromosomal alterations according to the grade of meningiomas, suggesting that malignant progression of these tumors depends on other, more relevant, genetic changes.
language: eng
source:
identifier: ISSN: 1219-4956
fulltext: no_fulltext
issn:
  • 1219-4956
  • 1532-2807
url: Link


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titleChromosome 1p36 and 22qter deletions in paraffin block sections of intracranial meningiomas
creatorYilmaz, Zerrin ; Sahin, Feride Iffet ; Atalay, Basar ; Ozen, Ozlem ; Caner, Hakan ; Bavbek, Murad ; Demirhan, Beyhan ; Altinörs, Nur
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descriptionMeningiomas are the most frequent benign tumors of the intracranial cavity. The classification and underlying pathogenetic mechanisms have been reported to be investigated by both pathological and genetic methods. In this study, we aimed to detect 1p36 and 22qter deletions by fluorescence in situ hybridization (FISH) in archival materials of 50 intracranial meningioma patients. The clinical material consisted of paraffin-embedded tissue sections from 50 patients who were surgically treated and had histopathologic diagnosis of an intracranial meningioma. We observed 1p36 deletion in 23/50 (46%) and 22qter deletion in 33/50 (66%) patients. In addition, we observed 22qter deletion in 26/36 (72.2%) patients with meningothelial meningioma. This finding implies that 22qter deletion might play an important role in the pathogenesis of meningothelial meningioma. On the other hand, no alterations were documented in the frequency of these chromosomal alterations according to the grade of meningiomas, suggesting that malignant progression of these tumors depends on other, more relevant, genetic changes.
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subjectAdult ; Aged ; Chromosome Deletion ; Chromosomes, Human, Pair 1 - genetics ; Chromosomes, Human, Pair 22 - genetics ; Data Interpretation, Statistical ; Disease Progression ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Medical research ; Meningeal Neoplasms - genetics ; Meningioma - genetics ; Middle Aged
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descriptionMeningiomas are the most frequent benign tumors of the intracranial cavity. The classification and underlying pathogenetic mechanisms have been reported to be investigated by both pathological and genetic methods. In this study, we aimed to detect 1p36 and 22qter deletions by fluorescence in situ hybridization (FISH) in archival materials of 50 intracranial meningioma patients. The clinical material consisted of paraffin-embedded tissue sections from 50 patients who were surgically treated and had histopathologic diagnosis of an intracranial meningioma. We observed 1p36 deletion in 23/50 (46%) and 22qter deletion in 33/50 (66%) patients. In addition, we observed 22qter deletion in 26/36 (72.2%) patients with meningothelial meningioma. This finding implies that 22qter deletion might play an important role in the pathogenesis of meningothelial meningioma. On the other hand, no alterations were documented in the frequency of these chromosomal alterations according to the grade of meningiomas, suggesting that malignant progression of these tumors depends on other, more relevant, genetic changes.
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titleChromosome 1p36 and 22qter deletions in paraffin block sections of intracranial meningiomas
authorYilmaz, Zerrin ; Sahin, Feride Iffet ; Atalay, Basar ; Ozen, Ozlem ; Caner, Hakan ; Bavbek, Murad ; Demirhan, Beyhan ; Altinörs, Nur
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abstractMeningiomas are the most frequent benign tumors of the intracranial cavity. The classification and underlying pathogenetic mechanisms have been reported to be investigated by both pathological and genetic methods. In this study, we aimed to detect 1p36 and 22qter deletions by fluorescence in situ hybridization (FISH) in archival materials of 50 intracranial meningioma patients. The clinical material consisted of paraffin-embedded tissue sections from 50 patients who were surgically treated and had histopathologic diagnosis of an intracranial meningioma. We observed 1p36 deletion in 23/50 (46%) and 22qter deletion in 33/50 (66%) patients. In addition, we observed 22qter deletion in 26/36 (72.2%) patients with meningothelial meningioma. This finding implies that 22qter deletion might play an important role in the pathogenesis of meningothelial meningioma. On the other hand, no alterations were documented in the frequency of these chromosomal alterations according to the grade of meningiomas, suggesting that malignant progression of these tumors depends on other, more relevant, genetic changes.
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doi10.1007/BF02893855