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Pancreatic Glucose Uptake in Vivo in Men with Newly Diagnosed Type 1 Diabetes

Context: Due to the restricted accessibility of pancreatic tissue in living man, direct analysis of the events preceding development of autoimmune changes in the pancreas has been problematic. In vivo imaging of insulitis might markedly increase understanding of the events and timing of the events t... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2008-05, Vol.93 (5), p.1909-1914
Main Author: Kalliokoski, Teemu
Other Authors: Nuutila, Pirjo , Virtanen, Kirsi A , Iozzo, Patricia , Bucci, Marco , Svedström, Erkki , Roivainen, Anne , Någren, Kjell , Viljanen, Tapio , Minn, Heikki , Knuuti, Juhani , Rönnemaa, Tapani , Simell, Olli
Format: Electronic Article Electronic Article
Language: English
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Publisher: Bethesda, MD: Endocrine Society
ID: ISSN: 0021-972X
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recordid: cdi_proquest_miscellaneous_69193710
title: Pancreatic Glucose Uptake in Vivo in Men with Newly Diagnosed Type 1 Diabetes
format: Article
creator:
  • Kalliokoski, Teemu
  • Nuutila, Pirjo
  • Virtanen, Kirsi A
  • Iozzo, Patricia
  • Bucci, Marco
  • Svedström, Erkki
  • Roivainen, Anne
  • Någren, Kjell
  • Viljanen, Tapio
  • Minn, Heikki
  • Knuuti, Juhani
  • Rönnemaa, Tapani
  • Simell, Olli
subjects:
  • Abridged Index Medicus
  • Adult
  • Biological and medical sciences
  • Diabetes Mellitus, Type 1 - metabolism
  • Diabetes. Impaired glucose tolerance
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Feeding. Feeding behavior
  • Fluorodeoxyglucose F18
  • Fundamental and applied biological sciences. Psychology
  • Glucose - metabolism
  • Humans
  • Male
  • Medical sciences
  • Muscle, Skeletal - metabolism
  • Pancreas - metabolism
  • Positron-Emission Tomography
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Vertebrates: endocrinology
ispartof: The journal of clinical endocrinology and metabolism, 2008-05, Vol.93 (5), p.1909-1914
description: Context: Due to the restricted accessibility of pancreatic tissue in living man, direct analysis of the events preceding development of autoimmune changes in the pancreas has been problematic. In vivo imaging of insulitis might markedly increase understanding of the events and timing of the events that are necessary for the progression toward overt type 1 diabetes. Design: To evaluate possibilities to visualize insulitis in man in vivo with positron emission tomography, we studied 12 male patients (age 26 ± 7 yr) with newly diagnosed type 1 diabetes (duration range 0–7 months) and nine age- and sex-matched healthy controls after an overnight fast using 2-[18F]fluoro-2-deoxy-d-glucose and [11C]methionine. For definition of the regions of interest, pancreas was localized with magnetic resonance imaging or computed tomography-positron emission tomography. Results: Glucose uptake to the pancreas was markedly higher in the patients with type 1 diabetes than in the healthy controls (22.9 ± 6.4 vs. 17.8 ± 6.0 μmol/kg·min, P = 0.039). Glucose uptake to the pancreas of the patients was inversely associated with the duration of diabetes (r = −0.58; P = 0.024), so that in patients with newly diagnosed type 1 diabetes, glucose uptake was higher than in the healthy controls or patients with long duration of diabetes. Methionine uptake to the pancreas of the patients was similar as in the controls (3.7 ± 1.9 vs. 4.6 ± 2.4 μmol/kg·min, P = 0.21). Conclusions: In patients with type 1 diabetes, glucose uptake to the pancreas is enhanced at or soon after the time of diagnosis.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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titlePancreatic Glucose Uptake in Vivo in Men with Newly Diagnosed Type 1 Diabetes
creatorKalliokoski, Teemu ; Nuutila, Pirjo ; Virtanen, Kirsi A ; Iozzo, Patricia ; Bucci, Marco ; Svedström, Erkki ; Roivainen, Anne ; Någren, Kjell ; Viljanen, Tapio ; Minn, Heikki ; Knuuti, Juhani ; Rönnemaa, Tapani ; Simell, Olli
creatorcontribKalliokoski, Teemu ; Nuutila, Pirjo ; Virtanen, Kirsi A ; Iozzo, Patricia ; Bucci, Marco ; Svedström, Erkki ; Roivainen, Anne ; Någren, Kjell ; Viljanen, Tapio ; Minn, Heikki ; Knuuti, Juhani ; Rönnemaa, Tapani ; Simell, Olli
descriptionContext: Due to the restricted accessibility of pancreatic tissue in living man, direct analysis of the events preceding development of autoimmune changes in the pancreas has been problematic. In vivo imaging of insulitis might markedly increase understanding of the events and timing of the events that are necessary for the progression toward overt type 1 diabetes. Design: To evaluate possibilities to visualize insulitis in man in vivo with positron emission tomography, we studied 12 male patients (age 26 ± 7 yr) with newly diagnosed type 1 diabetes (duration range 0–7 months) and nine age- and sex-matched healthy controls after an overnight fast using 2-[18F]fluoro-2-deoxy-d-glucose and [11C]methionine. For definition of the regions of interest, pancreas was localized with magnetic resonance imaging or computed tomography-positron emission tomography. Results: Glucose uptake to the pancreas was markedly higher in the patients with type 1 diabetes than in the healthy controls (22.9 ± 6.4 vs. 17.8 ± 6.0 μmol/kg·min, P = 0.039). Glucose uptake to the pancreas of the patients was inversely associated with the duration of diabetes (r = −0.58; P = 0.024), so that in patients with newly diagnosed type 1 diabetes, glucose uptake was higher than in the healthy controls or patients with long duration of diabetes. Methionine uptake to the pancreas of the patients was similar as in the controls (3.7 ± 1.9 vs. 4.6 ± 2.4 μmol/kg·min, P = 0.21). Conclusions: In patients with type 1 diabetes, glucose uptake to the pancreas is enhanced at or soon after the time of diagnosis.
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subjectAbridged Index Medicus ; Adult ; Biological and medical sciences ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Feeding. Feeding behavior ; Fluorodeoxyglucose F18 ; Fundamental and applied biological sciences. Psychology ; Glucose - metabolism ; Humans ; Male ; Medical sciences ; Muscle, Skeletal - metabolism ; Pancreas - metabolism ; Positron-Emission Tomography ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology
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11Rönnemaa, Tapani
12Simell, Olli
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1The journal of clinical endocrinology and metabolism
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descriptionContext: Due to the restricted accessibility of pancreatic tissue in living man, direct analysis of the events preceding development of autoimmune changes in the pancreas has been problematic. In vivo imaging of insulitis might markedly increase understanding of the events and timing of the events that are necessary for the progression toward overt type 1 diabetes. Design: To evaluate possibilities to visualize insulitis in man in vivo with positron emission tomography, we studied 12 male patients (age 26 ± 7 yr) with newly diagnosed type 1 diabetes (duration range 0–7 months) and nine age- and sex-matched healthy controls after an overnight fast using 2-[18F]fluoro-2-deoxy-d-glucose and [11C]methionine. For definition of the regions of interest, pancreas was localized with magnetic resonance imaging or computed tomography-positron emission tomography. Results: Glucose uptake to the pancreas was markedly higher in the patients with type 1 diabetes than in the healthy controls (22.9 ± 6.4 vs. 17.8 ± 6.0 μmol/kg·min, P = 0.039). Glucose uptake to the pancreas of the patients was inversely associated with the duration of diabetes (r = −0.58; P = 0.024), so that in patients with newly diagnosed type 1 diabetes, glucose uptake was higher than in the healthy controls or patients with long duration of diabetes. Methionine uptake to the pancreas of the patients was similar as in the controls (3.7 ± 1.9 vs. 4.6 ± 2.4 μmol/kg·min, P = 0.21). Conclusions: In patients with type 1 diabetes, glucose uptake to the pancreas is enhanced at or soon after the time of diagnosis.
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1Adult
2Biological and medical sciences
3Diabetes Mellitus, Type 1 - metabolism
4Diabetes. Impaired glucose tolerance
5Endocrine pancreas. Apud cells (diseases)
6Endocrinopathies
7Etiopathogenesis. Screening. Investigations. Target tissue resistance
8Feeding. Feeding behavior
9Fluorodeoxyglucose F18
10Fundamental and applied biological sciences. Psychology
11Glucose - metabolism
12Humans
13Male
14Medical sciences
15Muscle, Skeletal - metabolism
16Pancreas - metabolism
17Positron-Emission Tomography
18Vertebrates: anatomy and physiology, studies on body, several organs or systems
19Vertebrates: endocrinology
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authorKalliokoski, Teemu ; Nuutila, Pirjo ; Virtanen, Kirsi A ; Iozzo, Patricia ; Bucci, Marco ; Svedström, Erkki ; Roivainen, Anne ; Någren, Kjell ; Viljanen, Tapio ; Minn, Heikki ; Knuuti, Juhani ; Rönnemaa, Tapani ; Simell, Olli
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4Diabetes. Impaired glucose tolerance
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6Endocrinopathies
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8Feeding. Feeding behavior
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10Fundamental and applied biological sciences. Psychology
11Glucose - metabolism
12Humans
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15Muscle, Skeletal - metabolism
16Pancreas - metabolism
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8Viljanen, Tapio
9Minn, Heikki
10Knuuti, Juhani
11Rönnemaa, Tapani
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abstractContext: Due to the restricted accessibility of pancreatic tissue in living man, direct analysis of the events preceding development of autoimmune changes in the pancreas has been problematic. In vivo imaging of insulitis might markedly increase understanding of the events and timing of the events that are necessary for the progression toward overt type 1 diabetes. Design: To evaluate possibilities to visualize insulitis in man in vivo with positron emission tomography, we studied 12 male patients (age 26 ± 7 yr) with newly diagnosed type 1 diabetes (duration range 0–7 months) and nine age- and sex-matched healthy controls after an overnight fast using 2-[18F]fluoro-2-deoxy-d-glucose and [11C]methionine. For definition of the regions of interest, pancreas was localized with magnetic resonance imaging or computed tomography-positron emission tomography. Results: Glucose uptake to the pancreas was markedly higher in the patients with type 1 diabetes than in the healthy controls (22.9 ± 6.4 vs. 17.8 ± 6.0 μmol/kg·min, P = 0.039). Glucose uptake to the pancreas of the patients was inversely associated with the duration of diabetes (r = −0.58; P = 0.024), so that in patients with newly diagnosed type 1 diabetes, glucose uptake was higher than in the healthy controls or patients with long duration of diabetes. Methionine uptake to the pancreas of the patients was similar as in the controls (3.7 ± 1.9 vs. 4.6 ± 2.4 μmol/kg·min, P = 0.21). Conclusions: In patients with type 1 diabetes, glucose uptake to the pancreas is enhanced at or soon after the time of diagnosis.
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