schliessen

Filtern

 

Bibliotheken

Serum Cystatin C and Increased Coronary Heart Disease Prevalence in US Adults Without Chronic Kidney Disease

Previous studies indicated that serum cystatin C, a marker of renal function, was associated with cardiovascular disease (CVD). However, few data about this association are available for persons without chronic kidney disease or albuminuria. Data from 4,991 subjects in the Third National Health and... Full description

Journal Title: The American journal of cardiology 2008, Vol.102 (1), p.54-57
Main Author: Muntner, Paul, PhD
Other Authors: Mann, Devin, MD, MS , Winston, Jonathan, MD , Bansilal, Sameer, MD , Farkouh, Michael E., MD, MSc
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0002-9149
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_69234553
title: Serum Cystatin C and Increased Coronary Heart Disease Prevalence in US Adults Without Chronic Kidney Disease
format: Article
creator:
  • Muntner, Paul, PhD
  • Mann, Devin, MD, MS
  • Winston, Jonathan, MD
  • Bansilal, Sameer, MD
  • Farkouh, Michael E., MD, MSc
subjects:
  • Abridged Index Medicus
  • Adult
  • Adults
  • Albuminuria
  • Biological and medical sciences
  • Cardiology
  • Cardiology. Vascular system
  • Cardiovascular
  • Cardiovascular disease
  • Chronic Disease
  • Coronary Disease - blood
  • Coronary Disease - epidemiology
  • Coronary heart disease
  • Cross-Sectional Studies
  • Cystatin C
  • Cystatins - blood
  • Female
  • Glomerular Filtration Rate
  • Heart
  • Heart attacks
  • Humans
  • Kidney diseases
  • Kidney Diseases - blood
  • Kidney Diseases - complications
  • Kidneys
  • Male
  • Medical sciences
  • Nephrology
  • Nephrology. Urinary tract diseases
  • Nephropathies. Renovascular diseases. Renal failure
  • Nutrition
  • Prevalence
  • Renal failure
  • United States
  • Urinary system involvement in other diseases. Miscellaneous
ispartof: The American journal of cardiology, 2008, Vol.102 (1), p.54-57
description: Previous studies indicated that serum cystatin C, a marker of renal function, was associated with cardiovascular disease (CVD). However, few data about this association are available for persons without chronic kidney disease or albuminuria. Data from 4,991 subjects in the Third National Health and Nutrition Examination Survey with an estimated glomerular filtration rate ≥60 ml/min/1.73 m2 without micro- or macroalbuminuria were analyzed. Subjects were categorized into quartiles of serum cystatin C and compared for prevalence of CVD. CVD was defined as a history of myocardial infarction, angina, or stroke. After age standardization, prevalences of CVD from the lowest to highest quartile of serum cystatin C were 6.0%, 8.8%, 11.8%, and 16.7% (p-trend = 0.006). Also, age-standardized prevalences of myocardial infarction across quartiles of serum cystatin C were 1.9%, 4.4%, 6.6%, and 8.6%; age-standardized prevalences of angina were 2.4%, 4.4%, 4.2%, and 7.1%; and age-standardized prevalences of stroke were 2.5%, 1.6%, 3.5%, and 4.4% (each p-trend
language: eng
source:
identifier: ISSN: 0002-9149
fulltext: no_fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.4159997
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_cross
recordidTN_cdi_proquest_miscellaneous_69234553
sourceformatXML
sourcesystemPC
sourcerecordid69234553
originalsourceidFETCH-LOGICAL-c465t-43aa0436c253b64af8eafb53a61e921ce9e09ca369a56ced0af7846d0b7e1b3b0
addsrcrecordideNqFkt1r1EAUxYModlv9E5RBsG-73sl8JIOglPjRYkFhLT4ON5MbOms2qTNJYf97J-xaYV_6NNzh_A6Xc26WveKw4sD1u80KtxuHoVnlAOUK8hWY8km24GVhltxw8TRbAEC-NFyak-w0xk0aOVf6eXbCS1XkINQi69YUpi2rdnHE0fesYtg37Kp3gTBSw6ohDD2GHbskDCP75OP8z34EuseOekcsQTdrdtFM3RjZLz_eDtPIqtuEece--aan3T_sRfasxS7Sy8N7lt18-fyzulxef_96VV1cL53UalxKgQhSaJcrUWuJbUnY1kqg5mRy7sgQGIdCG1TaUQPYFqXUDdQF8VrUcJad733vwvBnojjarY-Oug57GqZotcmFVEok4Zsj4WaYQp92s7kAUUitiyRSe5ELQ4yBWnsX_DZlYjnYuQu7sYcu7NyFhdymLhL3-mA-1Vtq_lOH8JPg7UGA0WHXBuydjw-6HGRhoJiN3h8t4Pzc1tCPAX336Bof9zSlxO89BRudn5trfCA32mbwjzp8OHJwnU_tYvebdhQfIuM2JsCu57Obrw5KAKmlgr-Y4NKU
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid230374667
display
typearticle
titleSerum Cystatin C and Increased Coronary Heart Disease Prevalence in US Adults Without Chronic Kidney Disease
creatorMuntner, Paul, PhD ; Mann, Devin, MD, MS ; Winston, Jonathan, MD ; Bansilal, Sameer, MD ; Farkouh, Michael E., MD, MSc
creatorcontribMuntner, Paul, PhD ; Mann, Devin, MD, MS ; Winston, Jonathan, MD ; Bansilal, Sameer, MD ; Farkouh, Michael E., MD, MSc
descriptionPrevious studies indicated that serum cystatin C, a marker of renal function, was associated with cardiovascular disease (CVD). However, few data about this association are available for persons without chronic kidney disease or albuminuria. Data from 4,991 subjects in the Third National Health and Nutrition Examination Survey with an estimated glomerular filtration rate ≥60 ml/min/1.73 m2 without micro- or macroalbuminuria were analyzed. Subjects were categorized into quartiles of serum cystatin C and compared for prevalence of CVD. CVD was defined as a history of myocardial infarction, angina, or stroke. After age standardization, prevalences of CVD from the lowest to highest quartile of serum cystatin C were 6.0%, 8.8%, 11.8%, and 16.7% (p-trend = 0.006). Also, age-standardized prevalences of myocardial infarction across quartiles of serum cystatin C were 1.9%, 4.4%, 6.6%, and 8.6%; age-standardized prevalences of angina were 2.4%, 4.4%, 4.2%, and 7.1%; and age-standardized prevalences of stroke were 2.5%, 1.6%, 3.5%, and 4.4% (each p-trend <0.05). Each 1-SD higher serum cystatin C level was associated with a multivariate prevalence ratio of CVD of 1.55 (95% confidence interval [CI] 1.13 to 2.13), and multivariate-adjusted prevalence ratios were 1.44 (95% CI 1.01 to 2.07), 1.64 (95% CI 1.02 to 2.64), and 1.65 (95% CI 1.06 to 2.56) for myocardial infarction, angina, and stroke, respectively. In conclusion, a graded association exists between higher serum cystatin C and increased CVD prevalence in patients without established chronic kidney disease.
identifier
0ISSN: 0002-9149
1EISSN: 1879-1913
2DOI: 10.1016/j.amjcard.2008.02.098
3PMID: 18572035
4CODEN: AJCDAG
languageeng
publisherNew York, NY: Elsevier Inc
subjectAbridged Index Medicus ; Adult ; Adults ; Albuminuria ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Chronic Disease ; Coronary Disease - blood ; Coronary Disease - epidemiology ; Coronary heart disease ; Cross-Sectional Studies ; Cystatin C ; Cystatins - blood ; Female ; Glomerular Filtration Rate ; Heart ; Heart attacks ; Humans ; Kidney diseases ; Kidney Diseases - blood ; Kidney Diseases - complications ; Kidneys ; Male ; Medical sciences ; Nephrology ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nutrition ; Prevalence ; Renal failure ; United States ; Urinary system involvement in other diseases. Miscellaneous
ispartofThe American journal of cardiology, 2008, Vol.102 (1), p.54-57
rights
0Elsevier Inc.
12008 Elsevier Inc.
22008 INIST-CNRS
3Copyright Elsevier Sequoia S.A. Jul 1, 2008
lds50peer_reviewed
citedbyFETCH-LOGICAL-c465t-43aa0436c253b64af8eafb53a61e921ce9e09ca369a56ced0af7846d0b7e1b3b0
citesFETCH-LOGICAL-c465t-43aa0436c253b64af8eafb53a61e921ce9e09ca369a56ced0af7846d0b7e1b3b0
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20479078$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18572035$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Muntner, Paul, PhD
1Mann, Devin, MD, MS
2Winston, Jonathan, MD
3Bansilal, Sameer, MD
4Farkouh, Michael E., MD, MSc
title
0Serum Cystatin C and Increased Coronary Heart Disease Prevalence in US Adults Without Chronic Kidney Disease
1The American journal of cardiology
addtitleAm J Cardiol
descriptionPrevious studies indicated that serum cystatin C, a marker of renal function, was associated with cardiovascular disease (CVD). However, few data about this association are available for persons without chronic kidney disease or albuminuria. Data from 4,991 subjects in the Third National Health and Nutrition Examination Survey with an estimated glomerular filtration rate ≥60 ml/min/1.73 m2 without micro- or macroalbuminuria were analyzed. Subjects were categorized into quartiles of serum cystatin C and compared for prevalence of CVD. CVD was defined as a history of myocardial infarction, angina, or stroke. After age standardization, prevalences of CVD from the lowest to highest quartile of serum cystatin C were 6.0%, 8.8%, 11.8%, and 16.7% (p-trend = 0.006). Also, age-standardized prevalences of myocardial infarction across quartiles of serum cystatin C were 1.9%, 4.4%, 6.6%, and 8.6%; age-standardized prevalences of angina were 2.4%, 4.4%, 4.2%, and 7.1%; and age-standardized prevalences of stroke were 2.5%, 1.6%, 3.5%, and 4.4% (each p-trend <0.05). Each 1-SD higher serum cystatin C level was associated with a multivariate prevalence ratio of CVD of 1.55 (95% confidence interval [CI] 1.13 to 2.13), and multivariate-adjusted prevalence ratios were 1.44 (95% CI 1.01 to 2.07), 1.64 (95% CI 1.02 to 2.64), and 1.65 (95% CI 1.06 to 2.56) for myocardial infarction, angina, and stroke, respectively. In conclusion, a graded association exists between higher serum cystatin C and increased CVD prevalence in patients without established chronic kidney disease.
subject
0Abridged Index Medicus
1Adult
2Adults
3Albuminuria
4Biological and medical sciences
5Cardiology
6Cardiology. Vascular system
7Cardiovascular
8Cardiovascular disease
9Chronic Disease
10Coronary Disease - blood
11Coronary Disease - epidemiology
12Coronary heart disease
13Cross-Sectional Studies
14Cystatin C
15Cystatins - blood
16Female
17Glomerular Filtration Rate
18Heart
19Heart attacks
20Humans
21Kidney diseases
22Kidney Diseases - blood
23Kidney Diseases - complications
24Kidneys
25Male
26Medical sciences
27Nephrology
28Nephrology. Urinary tract diseases
29Nephropathies. Renovascular diseases. Renal failure
30Nutrition
31Prevalence
32Renal failure
33United States
34Urinary system involvement in other diseases. Miscellaneous
issn
00002-9149
11879-1913
fulltextfalse
rsrctypearticle
creationdate2008
recordtypearticle
recordideNqFkt1r1EAUxYModlv9E5RBsG-73sl8JIOglPjRYkFhLT4ON5MbOms2qTNJYf97J-xaYV_6NNzh_A6Xc26WveKw4sD1u80KtxuHoVnlAOUK8hWY8km24GVhltxw8TRbAEC-NFyak-w0xk0aOVf6eXbCS1XkINQi69YUpi2rdnHE0fesYtg37Kp3gTBSw6ohDD2GHbskDCP75OP8z34EuseOekcsQTdrdtFM3RjZLz_eDtPIqtuEece--aan3T_sRfasxS7Sy8N7lt18-fyzulxef_96VV1cL53UalxKgQhSaJcrUWuJbUnY1kqg5mRy7sgQGIdCG1TaUQPYFqXUDdQF8VrUcJad733vwvBnojjarY-Oug57GqZotcmFVEok4Zsj4WaYQp92s7kAUUitiyRSe5ELQ4yBWnsX_DZlYjnYuQu7sYcu7NyFhdymLhL3-mA-1Vtq_lOH8JPg7UGA0WHXBuydjw-6HGRhoJiN3h8t4Pzc1tCPAX336Bof9zSlxO89BRudn5trfCA32mbwjzp8OHJwnU_tYvebdhQfIuM2JsCu57Obrw5KAKmlgr-Y4NKU
startdate2008
enddate2008
creator
0Muntner, Paul, PhD
1Mann, Devin, MD, MS
2Winston, Jonathan, MD
3Bansilal, Sameer, MD
4Farkouh, Michael E., MD, MSc
general
0Elsevier Inc
1Elsevier
2Elsevier Limited
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
97QO
107TS
118FD
12FR3
13K9.
14P64
157X8
sort
creationdate2008
titleSerum Cystatin C and Increased Coronary Heart Disease Prevalence in US Adults Without Chronic Kidney Disease
authorMuntner, Paul, PhD ; Mann, Devin, MD, MS ; Winston, Jonathan, MD ; Bansilal, Sameer, MD ; Farkouh, Michael E., MD, MSc
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c465t-43aa0436c253b64af8eafb53a61e921ce9e09ca369a56ced0af7846d0b7e1b3b0
rsrctypearticles
prefilterarticles
languageeng
creationdate2008
topic
0Abridged Index Medicus
1Adult
2Adults
3Albuminuria
4Biological and medical sciences
5Cardiology
6Cardiology. Vascular system
7Cardiovascular
8Cardiovascular disease
9Chronic Disease
10Coronary Disease - blood
11Coronary Disease - epidemiology
12Coronary heart disease
13Cross-Sectional Studies
14Cystatin C
15Cystatins - blood
16Female
17Glomerular Filtration Rate
18Heart
19Heart attacks
20Humans
21Kidney diseases
22Kidney Diseases - blood
23Kidney Diseases - complications
24Kidneys
25Male
26Medical sciences
27Nephrology
28Nephrology. Urinary tract diseases
29Nephropathies. Renovascular diseases. Renal failure
30Nutrition
31Prevalence
32Renal failure
33United States
34Urinary system involvement in other diseases. Miscellaneous
toplevelpeer_reviewed
creatorcontrib
0Muntner, Paul, PhD
1Mann, Devin, MD, MS
2Winston, Jonathan, MD
3Bansilal, Sameer, MD
4Farkouh, Michael E., MD, MSc
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8Biotechnology Research Abstracts
9Physical Education Index
10Technology Research Database
11Engineering Research Database
12ProQuest Health & Medical Complete (Alumni)
13Biotechnology and BioEngineering Abstracts
14MEDLINE - Academic
jtitleThe American journal of cardiology
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Muntner, Paul, PhD
1Mann, Devin, MD, MS
2Winston, Jonathan, MD
3Bansilal, Sameer, MD
4Farkouh, Michael E., MD, MSc
formatjournal
genrearticle
ristypeJOUR
atitleSerum Cystatin C and Increased Coronary Heart Disease Prevalence in US Adults Without Chronic Kidney Disease
jtitleThe American journal of cardiology
addtitleAm J Cardiol
date2008
risdate2008
volume102
issue1
spage54
epage57
pages54-57
issn0002-9149
eissn1879-1913
codenAJCDAG
abstractPrevious studies indicated that serum cystatin C, a marker of renal function, was associated with cardiovascular disease (CVD). However, few data about this association are available for persons without chronic kidney disease or albuminuria. Data from 4,991 subjects in the Third National Health and Nutrition Examination Survey with an estimated glomerular filtration rate ≥60 ml/min/1.73 m2 without micro- or macroalbuminuria were analyzed. Subjects were categorized into quartiles of serum cystatin C and compared for prevalence of CVD. CVD was defined as a history of myocardial infarction, angina, or stroke. After age standardization, prevalences of CVD from the lowest to highest quartile of serum cystatin C were 6.0%, 8.8%, 11.8%, and 16.7% (p-trend = 0.006). Also, age-standardized prevalences of myocardial infarction across quartiles of serum cystatin C were 1.9%, 4.4%, 6.6%, and 8.6%; age-standardized prevalences of angina were 2.4%, 4.4%, 4.2%, and 7.1%; and age-standardized prevalences of stroke were 2.5%, 1.6%, 3.5%, and 4.4% (each p-trend <0.05). Each 1-SD higher serum cystatin C level was associated with a multivariate prevalence ratio of CVD of 1.55 (95% confidence interval [CI] 1.13 to 2.13), and multivariate-adjusted prevalence ratios were 1.44 (95% CI 1.01 to 2.07), 1.64 (95% CI 1.02 to 2.64), and 1.65 (95% CI 1.06 to 2.56) for myocardial infarction, angina, and stroke, respectively. In conclusion, a graded association exists between higher serum cystatin C and increased CVD prevalence in patients without established chronic kidney disease.
copNew York, NY
pubElsevier Inc
pmid18572035
doi10.1016/j.amjcard.2008.02.098