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Serum Cystatin C and Increased Coronary Heart Disease Prevalence in US Adults Without Chronic Kidney Disease

Previous studies indicated that serum cystatin C, a marker of renal function, was associated with cardiovascular disease (CVD). However, few data about this association are available for persons without chronic kidney disease or albuminuria. Data from 4,991 subjects in the Third National Health and... Full description

Journal Title: The American journal of cardiology 2008, Vol.102 (1), p.54-57
Main Author: Muntner, Paul, PhD
Other Authors: Mann, Devin, MD, MS , Winston, Jonathan, MD , Bansilal, Sameer, MD , Farkouh, Michael E., MD, MSc
Format: Electronic Article Electronic Article
Language: English
Subjects:
Abridged Index Medicus
Adult
Adults
Albuminuria
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Chronic Disease
Coronary Disease - blood
Coronary Disease - epidemiology
Coronary heart disease
Cross-Sectional Studies
Cystatin C
Cystatins - blood
Female
Glomerular Filtration Rate
Heart
Heart attacks
Humans
Kidney diseases
Kidney Diseases - blood
Kidney Diseases - complications
Kidneys
Male
Medical sciences
Nephrology
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Nutrition
Prevalence
Renal failure
United States
Urinary system involvement in other diseases. Miscellaneous
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0002-9149
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recordid: cdi_proquest_miscellaneous_69234553
title: Serum Cystatin C and Increased Coronary Heart Disease Prevalence in US Adults Without Chronic Kidney Disease
format: Article
creator:
  • Muntner, Paul, PhD
  • Mann, Devin, MD, MS
  • Winston, Jonathan, MD
  • Bansilal, Sameer, MD
  • Farkouh, Michael E., MD, MSc
subjects:
  • Abridged Index Medicus
  • Adult
  • Adults
  • Albuminuria
  • Biological and medical sciences
  • Cardiology
  • Cardiology. Vascular system
  • Cardiovascular
  • Cardiovascular disease
  • Chronic Disease
  • Coronary Disease - blood
  • Coronary Disease - epidemiology
  • Coronary heart disease
  • Cross-Sectional Studies
  • Cystatin C
  • Cystatins - blood
  • Female
  • Glomerular Filtration Rate
  • Heart
  • Heart attacks
  • Humans
  • Kidney diseases
  • Kidney Diseases - blood
  • Kidney Diseases - complications
  • Kidneys
  • Male
  • Medical sciences
  • Nephrology
  • Nephrology. Urinary tract diseases
  • Nephropathies. Renovascular diseases. Renal failure
  • Nutrition
  • Prevalence
  • Renal failure
  • United States
  • Urinary system involvement in other diseases. Miscellaneous
ispartof: The American journal of cardiology, 2008, Vol.102 (1), p.54-57
description: Previous studies indicated that serum cystatin C, a marker of renal function, was associated with cardiovascular disease (CVD). However, few data about this association are available for persons without chronic kidney disease or albuminuria. Data from 4,991 subjects in the Third National Health and Nutrition Examination Survey with an estimated glomerular filtration rate ≥60 ml/min/1.73 m2 without micro- or macroalbuminuria were analyzed. Subjects were categorized into quartiles of serum cystatin C and compared for prevalence of CVD. CVD was defined as a history of myocardial infarction, angina, or stroke. After age standardization, prevalences of CVD from the lowest to highest quartile of serum cystatin C were 6.0%, 8.8%, 11.8%, and 16.7% (p-trend = 0.006). Also, age-standardized prevalences of myocardial infarction across quartiles of serum cystatin C were 1.9%, 4.4%, 6.6%, and 8.6%; age-standardized prevalences of angina were 2.4%, 4.4%, 4.2%, and 7.1%; and age-standardized prevalences of stroke were 2.5%, 1.6%, 3.5%, and 4.4% (each p-trend
language: eng
source:
identifier: ISSN: 0002-9149
fulltext: no_fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


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titleSerum Cystatin C and Increased Coronary Heart Disease Prevalence in US Adults Without Chronic Kidney Disease
creatorMuntner, Paul, PhD ; Mann, Devin, MD, MS ; Winston, Jonathan, MD ; Bansilal, Sameer, MD ; Farkouh, Michael E., MD, MSc
creatorcontribMuntner, Paul, PhD ; Mann, Devin, MD, MS ; Winston, Jonathan, MD ; Bansilal, Sameer, MD ; Farkouh, Michael E., MD, MSc
descriptionPrevious studies indicated that serum cystatin C, a marker of renal function, was associated with cardiovascular disease (CVD). However, few data about this association are available for persons without chronic kidney disease or albuminuria. Data from 4,991 subjects in the Third National Health and Nutrition Examination Survey with an estimated glomerular filtration rate ≥60 ml/min/1.73 m2 without micro- or macroalbuminuria were analyzed. Subjects were categorized into quartiles of serum cystatin C and compared for prevalence of CVD. CVD was defined as a history of myocardial infarction, angina, or stroke. After age standardization, prevalences of CVD from the lowest to highest quartile of serum cystatin C were 6.0%, 8.8%, 11.8%, and 16.7% (p-trend = 0.006). Also, age-standardized prevalences of myocardial infarction across quartiles of serum cystatin C were 1.9%, 4.4%, 6.6%, and 8.6%; age-standardized prevalences of angina were 2.4%, 4.4%, 4.2%, and 7.1%; and age-standardized prevalences of stroke were 2.5%, 1.6%, 3.5%, and 4.4% (each p-trend <0.05). Each 1-SD higher serum cystatin C level was associated with a multivariate prevalence ratio of CVD of 1.55 (95% confidence interval [CI] 1.13 to 2.13), and multivariate-adjusted prevalence ratios were 1.44 (95% CI 1.01 to 2.07), 1.64 (95% CI 1.02 to 2.64), and 1.65 (95% CI 1.06 to 2.56) for myocardial infarction, angina, and stroke, respectively. In conclusion, a graded association exists between higher serum cystatin C and increased CVD prevalence in patients without established chronic kidney disease.
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languageeng
publisherNew York, NY: Elsevier Inc
subjectAbridged Index Medicus ; Adult ; Adults ; Albuminuria ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Chronic Disease ; Coronary Disease - blood ; Coronary Disease - epidemiology ; Coronary heart disease ; Cross-Sectional Studies ; Cystatin C ; Cystatins - blood ; Female ; Glomerular Filtration Rate ; Heart ; Heart attacks ; Humans ; Kidney diseases ; Kidney Diseases - blood ; Kidney Diseases - complications ; Kidneys ; Male ; Medical sciences ; Nephrology ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nutrition ; Prevalence ; Renal failure ; United States ; Urinary system involvement in other diseases. Miscellaneous
ispartofThe American journal of cardiology, 2008, Vol.102 (1), p.54-57
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0Serum Cystatin C and Increased Coronary Heart Disease Prevalence in US Adults Without Chronic Kidney Disease
1The American journal of cardiology
addtitleAm J Cardiol
descriptionPrevious studies indicated that serum cystatin C, a marker of renal function, was associated with cardiovascular disease (CVD). However, few data about this association are available for persons without chronic kidney disease or albuminuria. Data from 4,991 subjects in the Third National Health and Nutrition Examination Survey with an estimated glomerular filtration rate ≥60 ml/min/1.73 m2 without micro- or macroalbuminuria were analyzed. Subjects were categorized into quartiles of serum cystatin C and compared for prevalence of CVD. CVD was defined as a history of myocardial infarction, angina, or stroke. After age standardization, prevalences of CVD from the lowest to highest quartile of serum cystatin C were 6.0%, 8.8%, 11.8%, and 16.7% (p-trend = 0.006). Also, age-standardized prevalences of myocardial infarction across quartiles of serum cystatin C were 1.9%, 4.4%, 6.6%, and 8.6%; age-standardized prevalences of angina were 2.4%, 4.4%, 4.2%, and 7.1%; and age-standardized prevalences of stroke were 2.5%, 1.6%, 3.5%, and 4.4% (each p-trend <0.05). Each 1-SD higher serum cystatin C level was associated with a multivariate prevalence ratio of CVD of 1.55 (95% confidence interval [CI] 1.13 to 2.13), and multivariate-adjusted prevalence ratios were 1.44 (95% CI 1.01 to 2.07), 1.64 (95% CI 1.02 to 2.64), and 1.65 (95% CI 1.06 to 2.56) for myocardial infarction, angina, and stroke, respectively. In conclusion, a graded association exists between higher serum cystatin C and increased CVD prevalence in patients without established chronic kidney disease.
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0Abridged Index Medicus
1Adult
2Adults
3Albuminuria
4Biological and medical sciences
5Cardiology
6Cardiology. Vascular system
7Cardiovascular
8Cardiovascular disease
9Chronic Disease
10Coronary Disease - blood
11Coronary Disease - epidemiology
12Coronary heart disease
13Cross-Sectional Studies
14Cystatin C
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16Female
17Glomerular Filtration Rate
18Heart
19Heart attacks
20Humans
21Kidney diseases
22Kidney Diseases - blood
23Kidney Diseases - complications
24Kidneys
25Male
26Medical sciences
27Nephrology
28Nephrology. Urinary tract diseases
29Nephropathies. Renovascular diseases. Renal failure
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31Prevalence
32Renal failure
33United States
34Urinary system involvement in other diseases. Miscellaneous
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titleSerum Cystatin C and Increased Coronary Heart Disease Prevalence in US Adults Without Chronic Kidney Disease
authorMuntner, Paul, PhD ; Mann, Devin, MD, MS ; Winston, Jonathan, MD ; Bansilal, Sameer, MD ; Farkouh, Michael E., MD, MSc
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7Cardiovascular
8Cardiovascular disease
9Chronic Disease
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32Renal failure
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abstractPrevious studies indicated that serum cystatin C, a marker of renal function, was associated with cardiovascular disease (CVD). However, few data about this association are available for persons without chronic kidney disease or albuminuria. Data from 4,991 subjects in the Third National Health and Nutrition Examination Survey with an estimated glomerular filtration rate ≥60 ml/min/1.73 m2 without micro- or macroalbuminuria were analyzed. Subjects were categorized into quartiles of serum cystatin C and compared for prevalence of CVD. CVD was defined as a history of myocardial infarction, angina, or stroke. After age standardization, prevalences of CVD from the lowest to highest quartile of serum cystatin C were 6.0%, 8.8%, 11.8%, and 16.7% (p-trend = 0.006). Also, age-standardized prevalences of myocardial infarction across quartiles of serum cystatin C were 1.9%, 4.4%, 6.6%, and 8.6%; age-standardized prevalences of angina were 2.4%, 4.4%, 4.2%, and 7.1%; and age-standardized prevalences of stroke were 2.5%, 1.6%, 3.5%, and 4.4% (each p-trend <0.05). Each 1-SD higher serum cystatin C level was associated with a multivariate prevalence ratio of CVD of 1.55 (95% confidence interval [CI] 1.13 to 2.13), and multivariate-adjusted prevalence ratios were 1.44 (95% CI 1.01 to 2.07), 1.64 (95% CI 1.02 to 2.64), and 1.65 (95% CI 1.06 to 2.56) for myocardial infarction, angina, and stroke, respectively. In conclusion, a graded association exists between higher serum cystatin C and increased CVD prevalence in patients without established chronic kidney disease.
copNew York, NY
pubElsevier Inc
pmid18572035
doi10.1016/j.amjcard.2008.02.098