schliessen

Filtern

 

Bibliotheken

Glucose tolerance and vitamin D: Effects of treating vitamin D deficiency

Abstract Objective We investigated the effects of vitamin D treatment on plasma glucose, serum insulin, and insulin sensitivity in vitamin D–deficient individuals without diabetes mellitus. Methods Thirty-three adults with vitamin D insufficiency (serum 25-hydroxyvitamin D concentration ≤50 nmol/L)... Full description

Journal Title: Nutrition (Burbank Los Angeles County, Calif.), 2008, Vol.24 (10), p.950-956
Main Author: Tai, Kamilia, M.B.B.S
Other Authors: Need, Allan G., M.B.B.S., Ph.D , Horowitz, Michael, M.B.B.S., Ph.D , Chapman, Ian M., M.B.B.S., Ph.D
Format: Electronic Article Electronic Article
Language: English
Subjects:
men
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0899-9007
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_69530206
title: Glucose tolerance and vitamin D: Effects of treating vitamin D deficiency
format: Article
creator:
  • Tai, Kamilia, M.B.B.S
  • Need, Allan G., M.B.B.S., Ph.D
  • Horowitz, Michael, M.B.B.S., Ph.D
  • Chapman, Ian M., M.B.B.S., Ph.D
subjects:
  • Adult
  • adults
  • Aged
  • Area Under Curve
  • Biological and medical sciences
  • blood glucose
  • Blood Glucose - drug effects
  • Blood Glucose - metabolism
  • cholecalciferol
  • Clinical chemistry
  • Cohort Studies
  • Dextrose
  • Diabetes
  • diabetes mellitus
  • Diet therapy
  • Feeding. Feeding behavior
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Gastroenterology and Hepatology
  • Glucose
  • Glucose Intolerance - blood
  • Glucose Intolerance - epidemiology
  • Glucose tolerance
  • Glucose Tolerance Test
  • Humans
  • Insulin
  • Insulin - blood
  • Insulin - metabolism
  • Insulin resistance
  • Insulin Secretion
  • Insulin sensitivity
  • Male
  • men
  • metabolism
  • Middle Aged
  • nutrient reserves
  • nutrition assessment
  • nutritional intervention
  • nutritional status
  • Older people
  • Parathyroid Hormone - blood
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Vitamin D
  • Vitamin D - analogs & derivatives
  • Vitamin D - blood
  • Vitamin D - physiology
  • Vitamin D - therapeutic use
  • Vitamin D Deficiency - blood
  • Vitamin D Deficiency - drug therapy
  • Vitamin D Deficiency - physiopathology
  • vitamin deficiencies
  • Vitamins
  • women
  • Young Adult
ispartof: Nutrition (Burbank, Los Angeles County, Calif.), 2008, Vol.24 (10), p.950-956
description: Abstract Objective We investigated the effects of vitamin D treatment on plasma glucose, serum insulin, and insulin sensitivity in vitamin D–deficient individuals without diabetes mellitus. Methods Thirty-three adults with vitamin D insufficiency (serum 25-hydroxyvitamin D concentration ≤50 nmol/L) and without diabetes (12 with impaired glucose tolerance) were given two oral doses of 100 000 IU of cholecalciferol, 2 wk apart. Before the first dose and 2 wk after the second dose, a 75-g oral glucose tolerance test was performed. Plasma glucose, serum insulin, 25-hydroxyvitamin D, and parathyroid hormone concentrations were measured and insulin sensitivity was calculated from the oral glucose tolerance test. Results Mean serum 25-hydroxyvitamin D increased from 39.9 ± 1.5 (SEM) to 90.3 ± 4.3 nmol/L ( P < 0.0001) and mean serum parathyroid hormone decreased from 6.7 ± 1.2 to 4.5 ± 0.6 pmol/L ( P = 0.055). There was no change in blood glucose mean of 0–120 min (6.1 ± 0.3 before versus 6.2 ± 0.3 mmol/L, P = 0.63) or insulin mean of 0–120 min (47.8 ± 5.35 versus 48.9 ± 5.22 mU/L, P = 0.67) concentrations, and no change in insulin sensitivity (Avignon's insulin sensitivity index [SiM], P = 0.97; insulin sensitivity index at 0 and 120 min [ISI0,120 ], P = 0.74; Quantitative Insulin Sensitivity Check Index [QUICKI], P = 0.88; homeostasis model assessment [HOMA], P = 0.99) after vitamin D treatment. Results did not differ between subjects, with and without, impaired glucose tolerance. Conclusion In adults without diabetes, correction of vitamin D deficiency is not associated with any effect on blood glucose or insulin concentrations or insulin sensitivity as assessed during an oral glucose tolerance test. These observations do not support an association between glucose/insulin homeostasis and vitamin D, at least in the short term.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0899-9007
fulltext: fulltext
issn:
  • 0899-9007
  • 1873-1244
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.4824293
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_69530206
sourceformatXML
sourcesystemPC
galeidA191008587
sourcerecordidA191008587
originalsourceidFETCH-LOGICAL-c546t-1b04b5391c43dfa5302dbd569117bb76c7a8369290c40c0c9499596a81c6cc223
addsrcrecordideNp9kkFr3DAQhUVpabbb_oBeWkNJb3ZnLFm2WiiENE0DgR7SnIUsy4u2XimR7MD--8jdpUuXEnQwyO89zcw3hLxFKBCQf1oXbhqLEqApgBUA4hlZYFPTHEvGnpMFNELkAqA-Ia9iXAMACi5ekhNseEUp8gW5uhwm7aPJRj-YoJw2mXJd9mBHtbEu-_Y5u-h7o8eY-T4bg1GjdavD76wzvdXWOL19TV70aojmzf67JLffL36d_8ivf15enZ9d57pifMyxBdZWVKBmtOtVRaHs2q7iArFu25rrWjWUi1KAZqBBCyZEJbhqUHOty5Iuycdd7l3w95OJo9zYqM0wKGf8FCUXcybwJPxwJFz7KbhUm0TOWC3qEuGgWqnBSOt6Pwal50h5hgLTbKs00SUp_qNKpzMbq71LU0j3_xhwZ9DBxxhML--C3aiwlQhyhifXMsGTMzwJTCZ4yfNuX_DUbkx3cOxpJcHpXqCiVkM_87Lxry41XQvRzCOqjx7XCdhovUtV2-HJEt7vnL3yUq1CSr-9KQEpYEVrXs2NfdkpTGL8YE2Q8Q9_09mQ9kR23j6Z__XIrQfrbGrmt9maeAAkYylB3swbPC8wNJCYVkAfAWRA40s
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1644797210
display
typearticle
titleGlucose tolerance and vitamin D: Effects of treating vitamin D deficiency
sourceAlma/SFX Local Collection
creatorTai, Kamilia, M.B.B.S ; Need, Allan G., M.B.B.S., Ph.D ; Horowitz, Michael, M.B.B.S., Ph.D ; Chapman, Ian M., M.B.B.S., Ph.D
creatorcontribTai, Kamilia, M.B.B.S ; Need, Allan G., M.B.B.S., Ph.D ; Horowitz, Michael, M.B.B.S., Ph.D ; Chapman, Ian M., M.B.B.S., Ph.D
descriptionAbstract Objective We investigated the effects of vitamin D treatment on plasma glucose, serum insulin, and insulin sensitivity in vitamin D–deficient individuals without diabetes mellitus. Methods Thirty-three adults with vitamin D insufficiency (serum 25-hydroxyvitamin D concentration ≤50 nmol/L) and without diabetes (12 with impaired glucose tolerance) were given two oral doses of 100 000 IU of cholecalciferol, 2 wk apart. Before the first dose and 2 wk after the second dose, a 75-g oral glucose tolerance test was performed. Plasma glucose, serum insulin, 25-hydroxyvitamin D, and parathyroid hormone concentrations were measured and insulin sensitivity was calculated from the oral glucose tolerance test. Results Mean serum 25-hydroxyvitamin D increased from 39.9 ± 1.5 (SEM) to 90.3 ± 4.3 nmol/L ( P < 0.0001) and mean serum parathyroid hormone decreased from 6.7 ± 1.2 to 4.5 ± 0.6 pmol/L ( P = 0.055). There was no change in blood glucose mean of 0–120 min (6.1 ± 0.3 before versus 6.2 ± 0.3 mmol/L, P = 0.63) or insulin mean of 0–120 min (47.8 ± 5.35 versus 48.9 ± 5.22 mU/L, P = 0.67) concentrations, and no change in insulin sensitivity (Avignon's insulin sensitivity index [SiM], P = 0.97; insulin sensitivity index at 0 and 120 min [ISI0,120 ], P = 0.74; Quantitative Insulin Sensitivity Check Index [QUICKI], P = 0.88; homeostasis model assessment [HOMA], P = 0.99) after vitamin D treatment. Results did not differ between subjects, with and without, impaired glucose tolerance. Conclusion In adults without diabetes, correction of vitamin D deficiency is not associated with any effect on blood glucose or insulin concentrations or insulin sensitivity as assessed during an oral glucose tolerance test. These observations do not support an association between glucose/insulin homeostasis and vitamin D, at least in the short term.
identifier
0ISSN: 0899-9007
1EISSN: 1873-1244
2DOI: 10.1016/j.nut.2008.04.009
3PMID: 18653316
4CODEN: NUTRER
languageeng
publisherNew York, NY: Elsevier Inc
subjectAdult ; adults ; Aged ; Area Under Curve ; Biological and medical sciences ; blood glucose ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; cholecalciferol ; Clinical chemistry ; Cohort Studies ; Dextrose ; Diabetes ; diabetes mellitus ; Diet therapy ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Glucose ; Glucose Intolerance - blood ; Glucose Intolerance - epidemiology ; Glucose tolerance ; Glucose Tolerance Test ; Humans ; Insulin ; Insulin - blood ; Insulin - metabolism ; Insulin resistance ; Insulin Secretion ; Insulin sensitivity ; Male ; men ; metabolism ; Middle Aged ; nutrient reserves ; nutrition assessment ; nutritional intervention ; nutritional status ; Older people ; Parathyroid Hormone - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D - physiology ; Vitamin D - therapeutic use ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - drug therapy ; Vitamin D Deficiency - physiopathology ; vitamin deficiencies ; Vitamins ; women ; Young Adult
ispartofNutrition (Burbank, Los Angeles County, Calif.), 2008, Vol.24 (10), p.950-956
rights
0Elsevier Inc.
12008 Elsevier Inc.
22008 INIST-CNRS
3COPYRIGHT 2008 Elsevier B.V.
4Copyright Elsevier Limited Oct 2008
lds50peer_reviewed
citedbyFETCH-LOGICAL-c546t-1b04b5391c43dfa5302dbd569117bb76c7a8369290c40c0c9499596a81c6cc223
citesFETCH-LOGICAL-c546t-1b04b5391c43dfa5302dbd569117bb76c7a8369290c40c0c9499596a81c6cc223
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttps://agris.fao.org/agris-search/search.do?recordID=US201301537657$$DView record in FAO AGRIS
1$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20679982$$DView record in Pascal Francis
2$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18653316$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Tai, Kamilia, M.B.B.S
1Need, Allan G., M.B.B.S., Ph.D
2Horowitz, Michael, M.B.B.S., Ph.D
3Chapman, Ian M., M.B.B.S., Ph.D
title
0Glucose tolerance and vitamin D: Effects of treating vitamin D deficiency
1Nutrition (Burbank, Los Angeles County, Calif.)
addtitleNutrition
descriptionAbstract Objective We investigated the effects of vitamin D treatment on plasma glucose, serum insulin, and insulin sensitivity in vitamin D–deficient individuals without diabetes mellitus. Methods Thirty-three adults with vitamin D insufficiency (serum 25-hydroxyvitamin D concentration ≤50 nmol/L) and without diabetes (12 with impaired glucose tolerance) were given two oral doses of 100 000 IU of cholecalciferol, 2 wk apart. Before the first dose and 2 wk after the second dose, a 75-g oral glucose tolerance test was performed. Plasma glucose, serum insulin, 25-hydroxyvitamin D, and parathyroid hormone concentrations were measured and insulin sensitivity was calculated from the oral glucose tolerance test. Results Mean serum 25-hydroxyvitamin D increased from 39.9 ± 1.5 (SEM) to 90.3 ± 4.3 nmol/L ( P < 0.0001) and mean serum parathyroid hormone decreased from 6.7 ± 1.2 to 4.5 ± 0.6 pmol/L ( P = 0.055). There was no change in blood glucose mean of 0–120 min (6.1 ± 0.3 before versus 6.2 ± 0.3 mmol/L, P = 0.63) or insulin mean of 0–120 min (47.8 ± 5.35 versus 48.9 ± 5.22 mU/L, P = 0.67) concentrations, and no change in insulin sensitivity (Avignon's insulin sensitivity index [SiM], P = 0.97; insulin sensitivity index at 0 and 120 min [ISI0,120 ], P = 0.74; Quantitative Insulin Sensitivity Check Index [QUICKI], P = 0.88; homeostasis model assessment [HOMA], P = 0.99) after vitamin D treatment. Results did not differ between subjects, with and without, impaired glucose tolerance. Conclusion In adults without diabetes, correction of vitamin D deficiency is not associated with any effect on blood glucose or insulin concentrations or insulin sensitivity as assessed during an oral glucose tolerance test. These observations do not support an association between glucose/insulin homeostasis and vitamin D, at least in the short term.
subject
0Adult
1adults
2Aged
3Area Under Curve
4Biological and medical sciences
5blood glucose
6Blood Glucose - drug effects
7Blood Glucose - metabolism
8cholecalciferol
9Clinical chemistry
10Cohort Studies
11Dextrose
12Diabetes
13diabetes mellitus
14Diet therapy
15Feeding. Feeding behavior
16Female
17Fundamental and applied biological sciences. Psychology
18Gastroenterology and Hepatology
19Glucose
20Glucose Intolerance - blood
21Glucose Intolerance - epidemiology
22Glucose tolerance
23Glucose Tolerance Test
24Humans
25Insulin
26Insulin - blood
27Insulin - metabolism
28Insulin resistance
29Insulin Secretion
30Insulin sensitivity
31Male
32men
33metabolism
34Middle Aged
35nutrient reserves
36nutrition assessment
37nutritional intervention
38nutritional status
39Older people
40Parathyroid Hormone - blood
41Vertebrates: anatomy and physiology, studies on body, several organs or systems
42Vitamin D
43Vitamin D - analogs & derivatives
44Vitamin D - blood
45Vitamin D - physiology
46Vitamin D - therapeutic use
47Vitamin D Deficiency - blood
48Vitamin D Deficiency - drug therapy
49Vitamin D Deficiency - physiopathology
50vitamin deficiencies
51Vitamins
52women
53Young Adult
issn
00899-9007
11873-1244
fulltexttrue
rsrctypearticle
creationdate2008
recordtypearticle
recordideNp9kkFr3DAQhUVpabbb_oBeWkNJb3ZnLFm2WiiENE0DgR7SnIUsy4u2XimR7MD--8jdpUuXEnQwyO89zcw3hLxFKBCQf1oXbhqLEqApgBUA4hlZYFPTHEvGnpMFNELkAqA-Ia9iXAMACi5ekhNseEUp8gW5uhwm7aPJRj-YoJw2mXJd9mBHtbEu-_Y5u-h7o8eY-T4bg1GjdavD76wzvdXWOL19TV70aojmzf67JLffL36d_8ivf15enZ9d57pifMyxBdZWVKBmtOtVRaHs2q7iArFu25rrWjWUi1KAZqBBCyZEJbhqUHOty5Iuycdd7l3w95OJo9zYqM0wKGf8FCUXcybwJPxwJFz7KbhUm0TOWC3qEuGgWqnBSOt6Pwal50h5hgLTbKs00SUp_qNKpzMbq71LU0j3_xhwZ9DBxxhML--C3aiwlQhyhifXMsGTMzwJTCZ4yfNuX_DUbkx3cOxpJcHpXqCiVkM_87Lxry41XQvRzCOqjx7XCdhovUtV2-HJEt7vnL3yUq1CSr-9KQEpYEVrXs2NfdkpTGL8YE2Q8Q9_09mQ9kR23j6Z__XIrQfrbGrmt9maeAAkYylB3swbPC8wNJCYVkAfAWRA40s
startdate2008
enddate2008
creator
0Tai, Kamilia, M.B.B.S
1Need, Allan G., M.B.B.S., Ph.D
2Horowitz, Michael, M.B.B.S., Ph.D
3Chapman, Ian M., M.B.B.S., Ph.D
general
0Elsevier Inc
1[New York]: Elsevier Science Inc
2Elsevier
3Elsevier B.V
4Elsevier Limited
scope
0FBQ
1IQODW
2CGR
3CUY
4CVF
5ECM
6EIF
7NPM
8AAYXX
9CITATION
10BSHEE
113V.
127RQ
137RV
147TS
157U7
167X7
177XB
1888C
1988E
208AO
218C1
228FE
238FH
248FI
258FJ
268FK
278G5
28ABUWG
29AN0
30ASE
31AZQEC
32BBNVY
33BENPR
34BHPHI
35C1K
36DWQXO
37FPQ
38FYUFA
39GHDGH
40GNUQQ
41GUQSH
42HCIFZ
43K6X
44K9.
45KB0
46LK8
47M0S
48M0T
49M1P
50M2O
51M7P
52MBDVC
53NAPCQ
54PADUT
55PQEST
56PQQKQ
57PQUKI
58PRINS
59Q9U
607X8
sort
creationdate2008
titleGlucose tolerance and vitamin D: Effects of treating vitamin D deficiency
authorTai, Kamilia, M.B.B.S ; Need, Allan G., M.B.B.S., Ph.D ; Horowitz, Michael, M.B.B.S., Ph.D ; Chapman, Ian M., M.B.B.S., Ph.D
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c546t-1b04b5391c43dfa5302dbd569117bb76c7a8369290c40c0c9499596a81c6cc223
rsrctypearticles
prefilterarticles
languageeng
creationdate2008
topic
0Adult
1adults
2Aged
3Area Under Curve
4Biological and medical sciences
5blood glucose
6Blood Glucose - drug effects
7Blood Glucose - metabolism
8cholecalciferol
9Clinical chemistry
10Cohort Studies
11Dextrose
12Diabetes
13diabetes mellitus
14Diet therapy
15Feeding. Feeding behavior
16Female
17Fundamental and applied biological sciences. Psychology
18Gastroenterology and Hepatology
19Glucose
20Glucose Intolerance - blood
21Glucose Intolerance - epidemiology
22Glucose tolerance
23Glucose Tolerance Test
24Humans
25Insulin
26Insulin - blood
27Insulin - metabolism
28Insulin resistance
29Insulin Secretion
30Insulin sensitivity
31Male
32men
33metabolism
34Middle Aged
35nutrient reserves
36nutrition assessment
37nutritional intervention
38nutritional status
39Older people
40Parathyroid Hormone - blood
41Vertebrates: anatomy and physiology, studies on body, several organs or systems
42Vitamin D
43Vitamin D - analogs & derivatives
44Vitamin D - blood
45Vitamin D - physiology
46Vitamin D - therapeutic use
47Vitamin D Deficiency - blood
48Vitamin D Deficiency - drug therapy
49Vitamin D Deficiency - physiopathology
50vitamin deficiencies
51Vitamins
52women
53Young Adult
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Tai, Kamilia, M.B.B.S
1Need, Allan G., M.B.B.S., Ph.D
2Horowitz, Michael, M.B.B.S., Ph.D
3Chapman, Ian M., M.B.B.S., Ph.D
collection
0AGRIS
1Pascal-Francis
2Medline
3MEDLINE
4MEDLINE (Ovid)
5MEDLINE
6MEDLINE
7PubMed
8CrossRef
9Academic OneFile (A&I only)
10ProQuest Central (Corporate)
11Career & Technical Education Database
12Nursing & Allied Health Database
13Physical Education Index
14Toxicology Abstracts
15Health & Medical Collection
16ProQuest Central (purchase pre-March 2016)
17Healthcare Administration Database (Alumni)
18Medical Database (Alumni Edition)
19ProQuest Pharma Collection
20Public Health Database
21ProQuest SciTech Collection
22ProQuest Natural Science Collection
23Hospital Premium Collection
24Hospital Premium Collection (Alumni Edition)
25ProQuest Central (Alumni) (purchase pre-March 2016)
26Research Library (Alumni Edition)
27ProQuest Central (Alumni Edition)
28British Nursing Database
29British Nursing Index
30ProQuest Central Essentials
31Biological Science Collection
32ProQuest Central
33Natural Science Collection
34Environmental Sciences and Pollution Management
35ProQuest Central Korea
36British Nursing Index (BNI) (1985 to Present)
37Health Research Premium Collection
38Health Research Premium Collection (Alumni)
39ProQuest Central Student
40Research Library Prep
41SciTech Premium Collection
42British Nursing Index
43ProQuest Health & Medical Complete (Alumni)
44Nursing & Allied Health Database (Alumni Edition)
45ProQuest Biological Science Collection
46Health & Medical Collection (Alumni Edition)
47Healthcare Administration Database
48Medical Database
49Research Library
50Biological Science Database
51Research Library (Corporate)
52Nursing & Allied Health Premium
53Research Library China
54ProQuest One Academic Eastern Edition
55ProQuest One Academic
56ProQuest One Academic UKI Edition
57ProQuest Central China
58ProQuest Central Basic
59MEDLINE - Academic
jtitleNutrition (Burbank, Los Angeles County, Calif.)
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Tai, Kamilia, M.B.B.S
1Need, Allan G., M.B.B.S., Ph.D
2Horowitz, Michael, M.B.B.S., Ph.D
3Chapman, Ian M., M.B.B.S., Ph.D
formatjournal
genrearticle
ristypeJOUR
atitleGlucose tolerance and vitamin D: Effects of treating vitamin D deficiency
jtitleNutrition (Burbank, Los Angeles County, Calif.)
addtitleNutrition
date2008
risdate2008
volume24
issue10
spage950
epage956
pages950-956
issn0899-9007
eissn1873-1244
codenNUTRER
noteshttp://dx.doi.org/10.1016/j.nut.2008.04.009
abstractAbstract Objective We investigated the effects of vitamin D treatment on plasma glucose, serum insulin, and insulin sensitivity in vitamin D–deficient individuals without diabetes mellitus. Methods Thirty-three adults with vitamin D insufficiency (serum 25-hydroxyvitamin D concentration ≤50 nmol/L) and without diabetes (12 with impaired glucose tolerance) were given two oral doses of 100 000 IU of cholecalciferol, 2 wk apart. Before the first dose and 2 wk after the second dose, a 75-g oral glucose tolerance test was performed. Plasma glucose, serum insulin, 25-hydroxyvitamin D, and parathyroid hormone concentrations were measured and insulin sensitivity was calculated from the oral glucose tolerance test. Results Mean serum 25-hydroxyvitamin D increased from 39.9 ± 1.5 (SEM) to 90.3 ± 4.3 nmol/L ( P < 0.0001) and mean serum parathyroid hormone decreased from 6.7 ± 1.2 to 4.5 ± 0.6 pmol/L ( P = 0.055). There was no change in blood glucose mean of 0–120 min (6.1 ± 0.3 before versus 6.2 ± 0.3 mmol/L, P = 0.63) or insulin mean of 0–120 min (47.8 ± 5.35 versus 48.9 ± 5.22 mU/L, P = 0.67) concentrations, and no change in insulin sensitivity (Avignon's insulin sensitivity index [SiM], P = 0.97; insulin sensitivity index at 0 and 120 min [ISI0,120 ], P = 0.74; Quantitative Insulin Sensitivity Check Index [QUICKI], P = 0.88; homeostasis model assessment [HOMA], P = 0.99) after vitamin D treatment. Results did not differ between subjects, with and without, impaired glucose tolerance. Conclusion In adults without diabetes, correction of vitamin D deficiency is not associated with any effect on blood glucose or insulin concentrations or insulin sensitivity as assessed during an oral glucose tolerance test. These observations do not support an association between glucose/insulin homeostasis and vitamin D, at least in the short term.
copNew York, NY
pubElsevier Inc
pmid18653316
doi10.1016/j.nut.2008.04.009