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Glucose tolerance and vitamin D: Effects of treating vitamin D deficiency

Abstract Objective We investigated the effects of vitamin D treatment on plasma glucose, serum insulin, and insulin sensitivity in vitamin D–deficient individuals without diabetes mellitus. Methods Thirty-three adults with vitamin D insufficiency (serum 25-hydroxyvitamin D concentration ≤50 nmol/L)... Full description

Journal Title: Nutrition (Burbank Los Angeles County, Calif.), 2008, Vol.24 (10), p.950-956
Main Author: Tai, Kamilia, M.B.B.S
Other Authors: Need, Allan G., M.B.B.S., Ph.D , Horowitz, Michael, M.B.B.S., Ph.D , Chapman, Ian M., M.B.B.S., Ph.D
Format: Electronic Article Electronic Article
Language: English
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Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0899-9007
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title: Glucose tolerance and vitamin D: Effects of treating vitamin D deficiency
format: Article
creator:
  • Tai, Kamilia, M.B.B.S
  • Need, Allan G., M.B.B.S., Ph.D
  • Horowitz, Michael, M.B.B.S., Ph.D
  • Chapman, Ian M., M.B.B.S., Ph.D
subjects:
  • Adult
  • Aged
  • Area Under Curve
  • Biological and medical sciences
  • Blood Glucose - drug effects
  • Blood Glucose - metabolism
  • Clinical chemistry
  • Cohort Studies
  • Dextrose
  • Diabetes
  • Diet therapy
  • Feeding. Feeding behavior
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Gastroenterology and Hepatology
  • Glucose
  • Glucose Intolerance - blood
  • Glucose Intolerance - epidemiology
  • Glucose tolerance
  • Glucose Tolerance Test
  • Humans
  • Insulin
  • Insulin - blood
  • Insulin - metabolism
  • Insulin resistance
  • Insulin Secretion
  • Insulin sensitivity
  • Male
  • Middle Aged
  • Older people
  • Parathyroid Hormone - blood
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Vitamin D
  • Vitamin D - analogs & derivatives
  • Vitamin D - blood
  • Vitamin D - physiology
  • Vitamin D - therapeutic use
  • Vitamin D Deficiency - blood
  • Vitamin D Deficiency - drug therapy
  • Vitamin D Deficiency - physiopathology
  • Vitamins
  • Young Adult
ispartof: Nutrition (Burbank, Los Angeles County, Calif.), 2008, Vol.24 (10), p.950-956
description: Abstract Objective We investigated the effects of vitamin D treatment on plasma glucose, serum insulin, and insulin sensitivity in vitamin D–deficient individuals without diabetes mellitus. Methods Thirty-three adults with vitamin D insufficiency (serum 25-hydroxyvitamin D concentration ≤50 nmol/L) and without diabetes (12 with impaired glucose tolerance) were given two oral doses of 100 000 IU of cholecalciferol, 2 wk apart. Before the first dose and 2 wk after the second dose, a 75-g oral glucose tolerance test was performed. Plasma glucose, serum insulin, 25-hydroxyvitamin D, and parathyroid hormone concentrations were measured and insulin sensitivity was calculated from the oral glucose tolerance test. Results Mean serum 25-hydroxyvitamin D increased from 39.9 ± 1.5 (SEM) to 90.3 ± 4.3 nmol/L ( P < 0.0001) and mean serum parathyroid hormone decreased from 6.7 ± 1.2 to 4.5 ± 0.6 pmol/L ( P = 0.055). There was no change in blood glucose mean of 0–120 min (6.1 ± 0.3 before versus 6.2 ± 0.3 mmol/L, P = 0.63) or insulin mean of 0–120 min (47.8 ± 5.35 versus 48.9 ± 5.22 mU/L, P = 0.67) concentrations, and no change in insulin sensitivity (Avignon's insulin sensitivity index [SiM], P = 0.97; insulin sensitivity index at 0 and 120 min [ISI0,120 ], P = 0.74; Quantitative Insulin Sensitivity Check Index [QUICKI], P = 0.88; homeostasis model assessment [HOMA], P = 0.99) after vitamin D treatment. Results did not differ between subjects, with and without, impaired glucose tolerance. Conclusion In adults without diabetes, correction of vitamin D deficiency is not associated with any effect on blood glucose or insulin concentrations or insulin sensitivity as assessed during an oral glucose tolerance test. These observations do not support an association between glucose/insulin homeostasis and vitamin D, at least in the short term.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0899-9007
fulltext: fulltext
issn:
  • 0899-9007
  • 1873-1244
url: Link


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titleGlucose tolerance and vitamin D: Effects of treating vitamin D deficiency
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creatorTai, Kamilia, M.B.B.S ; Need, Allan G., M.B.B.S., Ph.D ; Horowitz, Michael, M.B.B.S., Ph.D ; Chapman, Ian M., M.B.B.S., Ph.D
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descriptionAbstract Objective We investigated the effects of vitamin D treatment on plasma glucose, serum insulin, and insulin sensitivity in vitamin D–deficient individuals without diabetes mellitus. Methods Thirty-three adults with vitamin D insufficiency (serum 25-hydroxyvitamin D concentration ≤50 nmol/L) and without diabetes (12 with impaired glucose tolerance) were given two oral doses of 100 000 IU of cholecalciferol, 2 wk apart. Before the first dose and 2 wk after the second dose, a 75-g oral glucose tolerance test was performed. Plasma glucose, serum insulin, 25-hydroxyvitamin D, and parathyroid hormone concentrations were measured and insulin sensitivity was calculated from the oral glucose tolerance test. Results Mean serum 25-hydroxyvitamin D increased from 39.9 ± 1.5 (SEM) to 90.3 ± 4.3 nmol/L ( P < 0.0001) and mean serum parathyroid hormone decreased from 6.7 ± 1.2 to 4.5 ± 0.6 pmol/L ( P = 0.055). There was no change in blood glucose mean of 0–120 min (6.1 ± 0.3 before versus 6.2 ± 0.3 mmol/L, P = 0.63) or insulin mean of 0–120 min (47.8 ± 5.35 versus 48.9 ± 5.22 mU/L, P = 0.67) concentrations, and no change in insulin sensitivity (Avignon's insulin sensitivity index [SiM], P = 0.97; insulin sensitivity index at 0 and 120 min [ISI0,120 ], P = 0.74; Quantitative Insulin Sensitivity Check Index [QUICKI], P = 0.88; homeostasis model assessment [HOMA], P = 0.99) after vitamin D treatment. Results did not differ between subjects, with and without, impaired glucose tolerance. Conclusion In adults without diabetes, correction of vitamin D deficiency is not associated with any effect on blood glucose or insulin concentrations or insulin sensitivity as assessed during an oral glucose tolerance test. These observations do not support an association between glucose/insulin homeostasis and vitamin D, at least in the short term.
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subjectAdult ; Aged ; Area Under Curve ; Biological and medical sciences ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Clinical chemistry ; Cohort Studies ; Dextrose ; Diabetes ; Diet therapy ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Glucose ; Glucose Intolerance - blood ; Glucose Intolerance - epidemiology ; Glucose tolerance ; Glucose Tolerance Test ; Humans ; Insulin ; Insulin - blood ; Insulin - metabolism ; Insulin resistance ; Insulin Secretion ; Insulin sensitivity ; Male ; Middle Aged ; Older people ; Parathyroid Hormone - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D - physiology ; Vitamin D - therapeutic use ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - drug therapy ; Vitamin D Deficiency - physiopathology ; Vitamins ; Young Adult
ispartofNutrition (Burbank, Los Angeles County, Calif.), 2008, Vol.24 (10), p.950-956
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descriptionAbstract Objective We investigated the effects of vitamin D treatment on plasma glucose, serum insulin, and insulin sensitivity in vitamin D–deficient individuals without diabetes mellitus. Methods Thirty-three adults with vitamin D insufficiency (serum 25-hydroxyvitamin D concentration ≤50 nmol/L) and without diabetes (12 with impaired glucose tolerance) were given two oral doses of 100 000 IU of cholecalciferol, 2 wk apart. Before the first dose and 2 wk after the second dose, a 75-g oral glucose tolerance test was performed. Plasma glucose, serum insulin, 25-hydroxyvitamin D, and parathyroid hormone concentrations were measured and insulin sensitivity was calculated from the oral glucose tolerance test. Results Mean serum 25-hydroxyvitamin D increased from 39.9 ± 1.5 (SEM) to 90.3 ± 4.3 nmol/L ( P < 0.0001) and mean serum parathyroid hormone decreased from 6.7 ± 1.2 to 4.5 ± 0.6 pmol/L ( P = 0.055). There was no change in blood glucose mean of 0–120 min (6.1 ± 0.3 before versus 6.2 ± 0.3 mmol/L, P = 0.63) or insulin mean of 0–120 min (47.8 ± 5.35 versus 48.9 ± 5.22 mU/L, P = 0.67) concentrations, and no change in insulin sensitivity (Avignon's insulin sensitivity index [SiM], P = 0.97; insulin sensitivity index at 0 and 120 min [ISI0,120 ], P = 0.74; Quantitative Insulin Sensitivity Check Index [QUICKI], P = 0.88; homeostasis model assessment [HOMA], P = 0.99) after vitamin D treatment. Results did not differ between subjects, with and without, impaired glucose tolerance. Conclusion In adults without diabetes, correction of vitamin D deficiency is not associated with any effect on blood glucose or insulin concentrations or insulin sensitivity as assessed during an oral glucose tolerance test. These observations do not support an association between glucose/insulin homeostasis and vitamin D, at least in the short term.
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29Older people
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35Vitamin D - physiology
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37Vitamin D Deficiency - blood
38Vitamin D Deficiency - drug therapy
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titleGlucose tolerance and vitamin D: Effects of treating vitamin D deficiency
authorTai, Kamilia, M.B.B.S ; Need, Allan G., M.B.B.S., Ph.D ; Horowitz, Michael, M.B.B.S., Ph.D ; Chapman, Ian M., M.B.B.S., Ph.D
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2Area Under Curve
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5Blood Glucose - metabolism
6Clinical chemistry
7Cohort Studies
8Dextrose
9Diabetes
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abstractAbstract Objective We investigated the effects of vitamin D treatment on plasma glucose, serum insulin, and insulin sensitivity in vitamin D–deficient individuals without diabetes mellitus. Methods Thirty-three adults with vitamin D insufficiency (serum 25-hydroxyvitamin D concentration ≤50 nmol/L) and without diabetes (12 with impaired glucose tolerance) were given two oral doses of 100 000 IU of cholecalciferol, 2 wk apart. Before the first dose and 2 wk after the second dose, a 75-g oral glucose tolerance test was performed. Plasma glucose, serum insulin, 25-hydroxyvitamin D, and parathyroid hormone concentrations were measured and insulin sensitivity was calculated from the oral glucose tolerance test. Results Mean serum 25-hydroxyvitamin D increased from 39.9 ± 1.5 (SEM) to 90.3 ± 4.3 nmol/L ( P < 0.0001) and mean serum parathyroid hormone decreased from 6.7 ± 1.2 to 4.5 ± 0.6 pmol/L ( P = 0.055). There was no change in blood glucose mean of 0–120 min (6.1 ± 0.3 before versus 6.2 ± 0.3 mmol/L, P = 0.63) or insulin mean of 0–120 min (47.8 ± 5.35 versus 48.9 ± 5.22 mU/L, P = 0.67) concentrations, and no change in insulin sensitivity (Avignon's insulin sensitivity index [SiM], P = 0.97; insulin sensitivity index at 0 and 120 min [ISI0,120 ], P = 0.74; Quantitative Insulin Sensitivity Check Index [QUICKI], P = 0.88; homeostasis model assessment [HOMA], P = 0.99) after vitamin D treatment. Results did not differ between subjects, with and without, impaired glucose tolerance. Conclusion In adults without diabetes, correction of vitamin D deficiency is not associated with any effect on blood glucose or insulin concentrations or insulin sensitivity as assessed during an oral glucose tolerance test. These observations do not support an association between glucose/insulin homeostasis and vitamin D, at least in the short term.
copNew York, NY
pubElsevier Inc
pmid18653316
doi10.1016/j.nut.2008.04.009