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The Relative Resistance of HIV Type 1-Infected Chimpanzees to AIDS Correlates with the Maintenance of Follicular Architecture and the Absence of Infiltration by CD8+ Cytotoxic T Lymphocytes

Lymphoid tissues are the focus of critical events in HIV pathogenesis. Persistent and high levels of virus production, extensive trapping of virus particles in germinal centers, and progressive degenerative changes in lymph node architecture are characteristics of progressive HIV-1 infection. Infilt... Full description

Journal Title: AIDS research and human retroviruses 1999, Vol.15 (4), p.365-373
Main Author: KOOPMAN, G
Other Authors: HAAKSMA, A. G. M , TEN VELDEN, J , HACK, C. E , HEENEY, J. L
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Larchmont, NY: Liebert
ID: ISSN: 0889-2229
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recordid: cdi_proquest_miscellaneous_69629171
title: The Relative Resistance of HIV Type 1-Infected Chimpanzees to AIDS Correlates with the Maintenance of Follicular Architecture and the Absence of Infiltration by CD8+ Cytotoxic T Lymphocytes
format: Article
creator:
  • KOOPMAN, G
  • HAAKSMA, A. G. M
  • TEN VELDEN, J
  • HACK, C. E
  • HEENEY, J. L
subjects:
  • Acquired Immunodeficiency Syndrome - immunology
  • Acquired Immunodeficiency Syndrome - pathology
  • AIDS/HIV
  • Animals
  • Biological and medical sciences
  • Experimental viral diseases and models
  • Granzymes
  • HIV-1 - immunology
  • Humans
  • Immunity, Innate - immunology
  • Infectious diseases
  • Lymph Nodes - cytology
  • Lymph Nodes - immunology
  • Lymph Nodes - virology
  • Medical sciences
  • Pan troglodytes
  • Serine Endopeptidases - analysis
  • T-Lymphocytes, Cytotoxic - immunology
  • Viral diseases
ispartof: AIDS research and human retroviruses, 1999, Vol.15 (4), p.365-373
description: Lymphoid tissues are the focus of critical events in HIV pathogenesis. Persistent and high levels of virus production, extensive trapping of virus particles in germinal centers, and progressive degenerative changes in lymph node architecture are characteristics of progressive HIV-1 infection. Infiltrates of granzyme B- and TIA-expressing CD8+ "cytotoxic" T lymphocytes (CTLs) precede involution of germinal centers in humans who develop AIDS. Similar to humans, HIV-1 infection in chimpanzees is active and persistent. However, in contrast to humans, they remain relatively resistant to AIDS. Lymph node biopsies from chimpanzees infected with HIV-1 or a related chimpanzee lentivirus were studied for the level and pattern of virus expression, changes in lymphoid architecture, CD8+ T cell infiltrates and the presence or absence of CTL markers. In stark contrast to HIV-1-infected humans, lymph nodes from infected chimpanzees had little virus deposition in germinal centers and a paucity of virus-expressing cells. Although some of the lymph nodes examined from infected animals had moderate follicular hyperplasia with infiltrating CD8+ T cells, none had evidence of follicular fragmentation. Most importantly, in marked contrast to infected humans, CD8+ T cells infiltrating the germinal center were negative for the CTL marker granzyme B. This evidence suggests that the infiltration of CD8+ CTLs into the germinal centers of lymph nodes may be a key determinant in AIDS pathogenesis.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0889-2229
fulltext: fulltext
issn:
  • 0889-2229
  • 1931-8405
url: Link


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titleThe Relative Resistance of HIV Type 1-Infected Chimpanzees to AIDS Correlates with the Maintenance of Follicular Architecture and the Absence of Infiltration by CD8+ Cytotoxic T Lymphocytes
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creatorKOOPMAN, G ; HAAKSMA, A. G. M ; TEN VELDEN, J ; HACK, C. E ; HEENEY, J. L
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descriptionLymphoid tissues are the focus of critical events in HIV pathogenesis. Persistent and high levels of virus production, extensive trapping of virus particles in germinal centers, and progressive degenerative changes in lymph node architecture are characteristics of progressive HIV-1 infection. Infiltrates of granzyme B- and TIA-expressing CD8+ "cytotoxic" T lymphocytes (CTLs) precede involution of germinal centers in humans who develop AIDS. Similar to humans, HIV-1 infection in chimpanzees is active and persistent. However, in contrast to humans, they remain relatively resistant to AIDS. Lymph node biopsies from chimpanzees infected with HIV-1 or a related chimpanzee lentivirus were studied for the level and pattern of virus expression, changes in lymphoid architecture, CD8+ T cell infiltrates and the presence or absence of CTL markers. In stark contrast to HIV-1-infected humans, lymph nodes from infected chimpanzees had little virus deposition in germinal centers and a paucity of virus-expressing cells. Although some of the lymph nodes examined from infected animals had moderate follicular hyperplasia with infiltrating CD8+ T cells, none had evidence of follicular fragmentation. Most importantly, in marked contrast to infected humans, CD8+ T cells infiltrating the germinal center were negative for the CTL marker granzyme B. This evidence suggests that the infiltration of CD8+ CTLs into the germinal centers of lymph nodes may be a key determinant in AIDS pathogenesis.
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subjectAcquired Immunodeficiency Syndrome - immunology ; Acquired Immunodeficiency Syndrome - pathology ; AIDS/HIV ; Animals ; Biological and medical sciences ; Experimental viral diseases and models ; Granzymes ; HIV-1 - immunology ; Humans ; Immunity, Innate - immunology ; Infectious diseases ; Lymph Nodes - cytology ; Lymph Nodes - immunology ; Lymph Nodes - virology ; Medical sciences ; Pan troglodytes ; Serine Endopeptidases - analysis ; T-Lymphocytes, Cytotoxic - immunology ; Viral diseases
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abstractLymphoid tissues are the focus of critical events in HIV pathogenesis. Persistent and high levels of virus production, extensive trapping of virus particles in germinal centers, and progressive degenerative changes in lymph node architecture are characteristics of progressive HIV-1 infection. Infiltrates of granzyme B- and TIA-expressing CD8+ "cytotoxic" T lymphocytes (CTLs) precede involution of germinal centers in humans who develop AIDS. Similar to humans, HIV-1 infection in chimpanzees is active and persistent. However, in contrast to humans, they remain relatively resistant to AIDS. Lymph node biopsies from chimpanzees infected with HIV-1 or a related chimpanzee lentivirus were studied for the level and pattern of virus expression, changes in lymphoid architecture, CD8+ T cell infiltrates and the presence or absence of CTL markers. In stark contrast to HIV-1-infected humans, lymph nodes from infected chimpanzees had little virus deposition in germinal centers and a paucity of virus-expressing cells. Although some of the lymph nodes examined from infected animals had moderate follicular hyperplasia with infiltrating CD8+ T cells, none had evidence of follicular fragmentation. Most importantly, in marked contrast to infected humans, CD8+ T cells infiltrating the germinal center were negative for the CTL marker granzyme B. This evidence suggests that the infiltration of CD8+ CTLs into the germinal centers of lymph nodes may be a key determinant in AIDS pathogenesis.
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pmid10082120
doi10.1089/088922299311330