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Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn’s disease and histological findings

Summary Background  Faecal calprotectin and lactoferrin increasingly serve as surrogate markers of disease activity in IBD. Data on the correlation of these markers with simple endoscopic score for Crohn’s disease (SES‐CD) and with histological findings are as yet limited. Aim  To study the correlat... Full description

Journal Title: Alimentary pharmacology & therapeutics 2008, Vol.28 (10), p.1221-1229
Main Author: SIPPONEN, T.
Other Authors: KÄRKKÄINEN, P. , SAVILAHTI, E. , KOLHO, K.‐L. , NUUTINEN, H. , TURUNEN, U. , FÄRKKILÄ, M.
Format: Electronic Article Electronic Article
Language: English
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Publisher: Oxford, UK: Blackwell Publishing Ltd
ID: ISSN: 0269-2813
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title: Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn’s disease and histological findings
format: Article
creator:
  • SIPPONEN, T.
  • KÄRKKÄINEN, P.
  • SAVILAHTI, E.
  • KOLHO, K.‐L.
  • NUUTINEN, H.
  • TURUNEN, U.
  • FÄRKKILÄ, M.
subjects:
  • Adult
  • Aged
  • Biological and medical sciences
  • Biomarkers
  • Crohn Disease - diagnosis
  • Crohn Disease - pathology
  • Crohn's disease
  • Digestive system
  • Endoscopy, Gastrointestinal
  • Feces - chemistry
  • Female
  • Gastroenterology. Liver. Pancreas. Abdomen
  • Humans
  • Lactoferrin - analysis
  • Lactoferrins
  • Leukocyte L1 Antigen Complex - analysis
  • Male
  • Medical sciences
  • Middle Aged
  • Other diseases. Semiology
  • Pharmacology. Drug treatments
  • Predictive Value of Tests
  • Severity of Illness Index
  • Statistics as Topic
  • Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
  • Young Adult
ispartof: Alimentary pharmacology & therapeutics, 2008, Vol.28 (10), p.1221-1229
description: Summary Background  Faecal calprotectin and lactoferrin increasingly serve as surrogate markers of disease activity in IBD. Data on the correlation of these markers with simple endoscopic score for Crohn’s disease (SES‐CD) and with histological findings are as yet limited. Aim  To study the correlation of faecal calprotectin and lactoferrin with SES‐CD and histology. Methods  During 87 consecutive ileocolonoscopies, SES‐CD was calculated and biopsy specimens were obtained from the ileum, colon and rectum. Faecal calprotectin and lactoferrin were measured. Results  In ileocolonic or colonic disease, both faecal calprotectin and lactoferrin correlated significantly with colon SES‐CD (P 
language: eng
source:
identifier: ISSN: 0269-2813
fulltext: no_fulltext
issn:
  • 0269-2813
  • 1365-2036
url: Link


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titleCorrelation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn’s disease and histological findings
creatorSIPPONEN, T. ; KÄRKKÄINEN, P. ; SAVILAHTI, E. ; KOLHO, K.‐L. ; NUUTINEN, H. ; TURUNEN, U. ; FÄRKKILÄ, M.
creatorcontribSIPPONEN, T. ; KÄRKKÄINEN, P. ; SAVILAHTI, E. ; KOLHO, K.‐L. ; NUUTINEN, H. ; TURUNEN, U. ; FÄRKKILÄ, M.
descriptionSummary Background  Faecal calprotectin and lactoferrin increasingly serve as surrogate markers of disease activity in IBD. Data on the correlation of these markers with simple endoscopic score for Crohn’s disease (SES‐CD) and with histological findings are as yet limited. Aim  To study the correlation of faecal calprotectin and lactoferrin with SES‐CD and histology. Methods  During 87 consecutive ileocolonoscopies, SES‐CD was calculated and biopsy specimens were obtained from the ileum, colon and rectum. Faecal calprotectin and lactoferrin were measured. Results  In ileocolonic or colonic disease, both faecal calprotectin and lactoferrin correlated significantly with colon SES‐CD (P < 0.001) and colon histology (P < 0.001). In patients with normal calprotectin or lactoferrin levels, endoscopic and histology scores were significantly lower than in those with elevated concentrations (P < 0.001). In ileal CD, ileal SES‐CD correlated with histology (P < 0.001), but not with faecal calprotectin (P = 0.161) or lactoferrin (P = 0.448). Conclusion  In ileocolonic and colonic disease, endoscopic score SES‐CD and histological findings correlated significantly with faecal calprotectin and lactoferrin. A normal faecal‐marker concentration was a reliable surrogate marker for endoscopically and histologically inactive CD. Ileal endoscopic score and histological findings failed, however, to correlate with faecal markers.
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subjectAdult ; Aged ; Biological and medical sciences ; Biomarkers ; Crohn Disease - diagnosis ; Crohn Disease - pathology ; Crohn's disease ; Digestive system ; Endoscopy, Gastrointestinal ; Feces - chemistry ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Lactoferrin - analysis ; Lactoferrins ; Leukocyte L1 Antigen Complex - analysis ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Pharmacology. Drug treatments ; Predictive Value of Tests ; Severity of Illness Index ; Statistics as Topic ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Young Adult
ispartofAlimentary pharmacology & therapeutics, 2008, Vol.28 (10), p.1221-1229
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0Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn’s disease and histological findings
1Alimentary pharmacology & therapeutics
addtitleAliment Pharmacol Ther
descriptionSummary Background  Faecal calprotectin and lactoferrin increasingly serve as surrogate markers of disease activity in IBD. Data on the correlation of these markers with simple endoscopic score for Crohn’s disease (SES‐CD) and with histological findings are as yet limited. Aim  To study the correlation of faecal calprotectin and lactoferrin with SES‐CD and histology. Methods  During 87 consecutive ileocolonoscopies, SES‐CD was calculated and biopsy specimens were obtained from the ileum, colon and rectum. Faecal calprotectin and lactoferrin were measured. Results  In ileocolonic or colonic disease, both faecal calprotectin and lactoferrin correlated significantly with colon SES‐CD (P < 0.001) and colon histology (P < 0.001). In patients with normal calprotectin or lactoferrin levels, endoscopic and histology scores were significantly lower than in those with elevated concentrations (P < 0.001). In ileal CD, ileal SES‐CD correlated with histology (P < 0.001), but not with faecal calprotectin (P = 0.161) or lactoferrin (P = 0.448). Conclusion  In ileocolonic and colonic disease, endoscopic score SES‐CD and histological findings correlated significantly with faecal calprotectin and lactoferrin. A normal faecal‐marker concentration was a reliable surrogate marker for endoscopically and histologically inactive CD. Ileal endoscopic score and histological findings failed, however, to correlate with faecal markers.
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4Crohn Disease - diagnosis
5Crohn Disease - pathology
6Crohn's disease
7Digestive system
8Endoscopy, Gastrointestinal
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11Gastroenterology. Liver. Pancreas. Abdomen
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25Young Adult
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titleCorrelation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn’s disease and histological findings
authorSIPPONEN, T. ; KÄRKKÄINEN, P. ; SAVILAHTI, E. ; KOLHO, K.‐L. ; NUUTINEN, H. ; TURUNEN, U. ; FÄRKKILÄ, M.
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20Pharmacology. Drug treatments
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abstractSummary Background  Faecal calprotectin and lactoferrin increasingly serve as surrogate markers of disease activity in IBD. Data on the correlation of these markers with simple endoscopic score for Crohn’s disease (SES‐CD) and with histological findings are as yet limited. Aim  To study the correlation of faecal calprotectin and lactoferrin with SES‐CD and histology. Methods  During 87 consecutive ileocolonoscopies, SES‐CD was calculated and biopsy specimens were obtained from the ileum, colon and rectum. Faecal calprotectin and lactoferrin were measured. Results  In ileocolonic or colonic disease, both faecal calprotectin and lactoferrin correlated significantly with colon SES‐CD (P < 0.001) and colon histology (P < 0.001). In patients with normal calprotectin or lactoferrin levels, endoscopic and histology scores were significantly lower than in those with elevated concentrations (P < 0.001). In ileal CD, ileal SES‐CD correlated with histology (P < 0.001), but not with faecal calprotectin (P = 0.161) or lactoferrin (P = 0.448). Conclusion  In ileocolonic and colonic disease, endoscopic score SES‐CD and histological findings correlated significantly with faecal calprotectin and lactoferrin. A normal faecal‐marker concentration was a reliable surrogate marker for endoscopically and histologically inactive CD. Ileal endoscopic score and histological findings failed, however, to correlate with faecal markers.
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doi10.1111/j.1365-2036.2008.03835.x
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