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Enhancement of memory function in aged mice by a novel derivative of xanomeline

In age-related cognitive deficits and Alzheimer's disease (AD), one of the most common pathological changes appears to be the loss of cholinergic neurons in the forebrain and the depletion of cortical cholinergic axons [1]. Accordingly, attempts have been made to generate therapies that aim to rever... Full description

Journal Title: Cell research 2008, Vol.18 (11), p.1151-1153
Main Author: Cui, Yihui
Other Authors: Wang, Dong , Si, Wen , Lv, Wen , Niu, Yan , Lei, Xiaoping , Hu, Yinhe , Cao, Xiaohua
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: England: Nature Publishing Group
ID: ISSN: 1001-0602
Link: https://www.ncbi.nlm.nih.gov/pubmed/18936783
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title: Enhancement of memory function in aged mice by a novel derivative of xanomeline
format: Article
creator:
  • Cui, Yihui
  • Wang, Dong
  • Si, Wen
  • Lv, Wen
  • Niu, Yan
  • Lei, Xiaoping
  • Hu, Yinhe
  • Cao, Xiaohua
subjects:
  • Aging - metabolism
  • Animals
  • Memory - drug effects
  • Mice
  • Muscarinic Agonists - pharmacology
  • Neuronal Plasticity - drug effects
  • Pyridines - chemical synthesis
  • Pyridines - chemistry
  • Pyridines - pharmacology
  • Receptor, Muscarinic M1 - metabolism
  • Thiadiazoles - chemical synthesis
  • Thiadiazoles - chemistry
  • Thiadiazoles - pharmacology
  • 死亡
  • 研究
  • 细胞
  • 衰老
ispartof: Cell research, 2008, Vol.18 (11), p.1151-1153
description: In age-related cognitive deficits and Alzheimer's disease (AD), one of the most common pathological changes appears to be the loss of cholinergic neurons in the forebrain and the depletion of cortical cholinergic axons [1]. Accordingly, attempts have been made to generate therapies that aim to reverse the cognitive deficits associated with AD and aging by direct stimulation of mAChRs with specific agonists.
language: eng
source:
identifier: ISSN: 1001-0602
fulltext: no_fulltext
issn:
  • 1001-0602
  • 1748-7838
url: Link


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descriptionIn age-related cognitive deficits and Alzheimer's disease (AD), one of the most common pathological changes appears to be the loss of cholinergic neurons in the forebrain and the depletion of cortical cholinergic axons [1]. Accordingly, attempts have been made to generate therapies that aim to reverse the cognitive deficits associated with AD and aging by direct stimulation of mAChRs with specific agonists.
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subjectAging - metabolism ; Animals ; Memory - drug effects ; Mice ; Muscarinic Agonists - pharmacology ; Neuronal Plasticity - drug effects ; Pyridines - chemical synthesis ; Pyridines - chemistry ; Pyridines - pharmacology ; Receptor, Muscarinic M1 - metabolism ; Thiadiazoles - chemical synthesis ; Thiadiazoles - chemistry ; Thiadiazoles - pharmacology ; 死亡 ; 研究 ; 细胞 ; 衰老
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authorCui, Yihui ; Wang, Dong ; Si, Wen ; Lv, Wen ; Niu, Yan ; Lei, Xiaoping ; Hu, Yinhe ; Cao, Xiaohua
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abstractIn age-related cognitive deficits and Alzheimer's disease (AD), one of the most common pathological changes appears to be the loss of cholinergic neurons in the forebrain and the depletion of cortical cholinergic axons [1]. Accordingly, attempts have been made to generate therapies that aim to reverse the cognitive deficits associated with AD and aging by direct stimulation of mAChRs with specific agonists.
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doi10.1038/cr.2008.292
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