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Myoepitheliomas of the skin and soft tissues. Report of 12 cases

We describe 12 cutaneous and soft tissue myoepitheliomas, most of them in elderly patients. Morphologically the cutaneous and soft tissue myoepitheliomas revealed the same spectrum as their salivary gland counterparts. They were composed of a mixture of spindle, epithelioid and clear myoepithelial c... Full description

Journal Title: Virchows Archiv : an international journal of pathology 1999, Vol.434 (5), p.393-400
Main Author: MICHAL, M
Other Authors: MIETTINEN, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin: Springer
ID: ISSN: 0945-6317
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recordid: cdi_proquest_miscellaneous_69855777
title: Myoepitheliomas of the skin and soft tissues. Report of 12 cases
format: Article
creator:
  • MICHAL, M
  • MIETTINEN, M
subjects:
  • Adult
  • Aged
  • Aged, 80 and over
  • Biological and medical sciences
  • Dermatology
  • Female
  • Humans
  • Immunohistochemistry
  • Keratins - analysis
  • Male
  • Medical sciences
  • Middle Aged
  • Myoepithelioma - chemistry
  • Myoepithelioma - pathology
  • S100 Proteins - analysis
  • Skin Neoplasms - chemistry
  • Skin Neoplasms - pathology
  • Soft Tissue Neoplasms - chemistry
  • Soft Tissue Neoplasms - pathology
  • Tumors of the skin and soft tissue. Premalignant lesions
ispartof: Virchows Archiv : an international journal of pathology, 1999, Vol.434 (5), p.393-400
description: We describe 12 cutaneous and soft tissue myoepitheliomas, most of them in elderly patients. Morphologically the cutaneous and soft tissue myoepitheliomas revealed the same spectrum as their salivary gland counterparts. They were composed of a mixture of spindle, epithelioid and clear myoepithelial cells. Immunohistochemically they were positive to keratins and S-100 protein and reacted inconsistently with antibodies to smooth muscle actin. Morphologically they lacked any folliculo-sebaceous or apocrine differentiation. We believe that they are related to the eccrine type of cutaneous mixed tumours. Most cases had a benign behaviour, but 1 tumour metastasized, and the patient died of the tumour. Myoepitheliomas of soft tissues should be distinguished from other neoplasms with epithelial differentiation and from ossifying fibromyxoid tumour of soft parts, parachordoma and extraskeletal myxoid chondrosarcoma.
language: eng
source:
identifier: ISSN: 0945-6317
fulltext: no_fulltext
issn:
  • 0945-6317
  • 1432-2307
url: Link


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titleMyoepitheliomas of the skin and soft tissues. Report of 12 cases
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descriptionWe describe 12 cutaneous and soft tissue myoepitheliomas, most of them in elderly patients. Morphologically the cutaneous and soft tissue myoepitheliomas revealed the same spectrum as their salivary gland counterparts. They were composed of a mixture of spindle, epithelioid and clear myoepithelial cells. Immunohistochemically they were positive to keratins and S-100 protein and reacted inconsistently with antibodies to smooth muscle actin. Morphologically they lacked any folliculo-sebaceous or apocrine differentiation. We believe that they are related to the eccrine type of cutaneous mixed tumours. Most cases had a benign behaviour, but 1 tumour metastasized, and the patient died of the tumour. Myoepitheliomas of soft tissues should be distinguished from other neoplasms with epithelial differentiation and from ossifying fibromyxoid tumour of soft parts, parachordoma and extraskeletal myxoid chondrosarcoma.
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subjectAdult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Dermatology ; Female ; Humans ; Immunohistochemistry ; Keratins - analysis ; Male ; Medical sciences ; Middle Aged ; Myoepithelioma - chemistry ; Myoepithelioma - pathology ; S100 Proteins - analysis ; Skin Neoplasms - chemistry ; Skin Neoplasms - pathology ; Soft Tissue Neoplasms - chemistry ; Soft Tissue Neoplasms - pathology ; Tumors of the skin and soft tissue. Premalignant lesions
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abstractWe describe 12 cutaneous and soft tissue myoepitheliomas, most of them in elderly patients. Morphologically the cutaneous and soft tissue myoepitheliomas revealed the same spectrum as their salivary gland counterparts. They were composed of a mixture of spindle, epithelioid and clear myoepithelial cells. Immunohistochemically they were positive to keratins and S-100 protein and reacted inconsistently with antibodies to smooth muscle actin. Morphologically they lacked any folliculo-sebaceous or apocrine differentiation. We believe that they are related to the eccrine type of cutaneous mixed tumours. Most cases had a benign behaviour, but 1 tumour metastasized, and the patient died of the tumour. Myoepitheliomas of soft tissues should be distinguished from other neoplasms with epithelial differentiation and from ossifying fibromyxoid tumour of soft parts, parachordoma and extraskeletal myxoid chondrosarcoma.
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