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Plasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis

Bacterial sepsis is still a leading cause of neonatal morbidity and mortality. Early onset sepsis in particular, presents with a different clinical course and involves other pathogens than sepsis later in life. In this study, plasma concentrations and mRNA expression of granulocyte colony-stimulatin... Full description

Journal Title: Pediatric research 1998-10, Vol.44 (4), p.469-477
Main Author: Berner, R
Other Authors: Niemeyer, C M , Leititis, J U , Funke, A , Schwab, C , Rau, U , Richter, K , Tawfeek, M S , Clad, A , Brandis, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States
ID: ISSN: 0031-3998
Link: https://www.ncbi.nlm.nih.gov/pubmed/9773833
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title: Plasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis
format: Article
creator:
  • Berner, R
  • Niemeyer, C M
  • Leititis, J U
  • Funke, A
  • Schwab, C
  • Rau, U
  • Richter, K
  • Tawfeek, M S
  • Clad, A
  • Brandis, M
subjects:
  • Bacteremia - blood
  • Bacteremia - immunology
  • Blood Cells - immunology
  • Female
  • Fetal Blood
  • Gene Expression Regulation, Developmental
  • Germany
  • Granulocyte Colony-Stimulating Factor - blood
  • Granulocyte Colony-Stimulating Factor - genetics
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Interleukin-1 - blood
  • Interleukin-1 - genetics
  • Interleukin-6 - blood
  • Interleukin-6 - genetics
  • Interleukin-8 - blood
  • Interleukin-8 - genetics
  • Polymerase Chain Reaction
  • Pregnancy
  • Pregnancy Complications
  • Reference Values
  • RNA, Messenger - genetics
  • Transcription, Genetic
  • Tumor Necrosis Factor-alpha - genetics
  • Tumor Necrosis Factor-alpha - metabolism
ispartof: Pediatric research, 1998-10, Vol.44 (4), p.469-477
description: Bacterial sepsis is still a leading cause of neonatal morbidity and mortality. Early onset sepsis in particular, presents with a different clinical course and involves other pathogens than sepsis later in life. In this study, plasma concentrations and mRNA expression of granulocyte colony-stimulating factor (G-CSF), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 (sICAM-1) of neonates with early onset sepsis were evaluated in cord blood and during the first days of life. Irrespective of prematurity, plasma levels of G-CSF, TNF-alpha, IL-1beta, IL-6, and IL-8, but not sICAM-1, were excessively elevated in septic neonates when compared with both healthy infants and infants with clinically suspected but not confirmed sepsis. Compared with the corresponding maternal levels, neonatal cytokine cord plasma levels were likewise highly elevated, indicating the endogenous cytokine production by the neonate. With the exception of TNF-alpha, mRNA expression in blood cells from septic infants was, however, not more frequently detectable than in those from nonseptic patients. Cytokine levels decreased significantly within the first days of life, whereas levels of sICAM-1 and C-reactive protein increased during the same time period. In summary, in contrast to C-reactive protein and sICAM-1, cord blood plasma levels, but not the presence of mRNA, of G-CSF, TNF-alpha, IL-1beta, IL-6, and IL-8 can predict neonatal early onset sepsis with a high sensitivity and specificity. Cell types other than blood cells are likely to contribute considerably to the high cytokine production in septic newborns.
language: eng
source:
identifier: ISSN: 0031-3998
fulltext: no_fulltext
issn:
  • 0031-3998
  • 1530-0447
url: Link


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titlePlasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis
creatorBerner, R ; Niemeyer, C M ; Leititis, J U ; Funke, A ; Schwab, C ; Rau, U ; Richter, K ; Tawfeek, M S ; Clad, A ; Brandis, M
creatorcontribBerner, R ; Niemeyer, C M ; Leititis, J U ; Funke, A ; Schwab, C ; Rau, U ; Richter, K ; Tawfeek, M S ; Clad, A ; Brandis, M
descriptionBacterial sepsis is still a leading cause of neonatal morbidity and mortality. Early onset sepsis in particular, presents with a different clinical course and involves other pathogens than sepsis later in life. In this study, plasma concentrations and mRNA expression of granulocyte colony-stimulating factor (G-CSF), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 (sICAM-1) of neonates with early onset sepsis were evaluated in cord blood and during the first days of life. Irrespective of prematurity, plasma levels of G-CSF, TNF-alpha, IL-1beta, IL-6, and IL-8, but not sICAM-1, were excessively elevated in septic neonates when compared with both healthy infants and infants with clinically suspected but not confirmed sepsis. Compared with the corresponding maternal levels, neonatal cytokine cord plasma levels were likewise highly elevated, indicating the endogenous cytokine production by the neonate. With the exception of TNF-alpha, mRNA expression in blood cells from septic infants was, however, not more frequently detectable than in those from nonseptic patients. Cytokine levels decreased significantly within the first days of life, whereas levels of sICAM-1 and C-reactive protein increased during the same time period. In summary, in contrast to C-reactive protein and sICAM-1, cord blood plasma levels, but not the presence of mRNA, of G-CSF, TNF-alpha, IL-1beta, IL-6, and IL-8 can predict neonatal early onset sepsis with a high sensitivity and specificity. Cell types other than blood cells are likely to contribute considerably to the high cytokine production in septic newborns.
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subjectBacteremia - blood ; Bacteremia - immunology ; Blood Cells - immunology ; Female ; Fetal Blood ; Gene Expression Regulation, Developmental ; Germany ; Granulocyte Colony-Stimulating Factor - blood ; Granulocyte Colony-Stimulating Factor - genetics ; Humans ; Infant, Newborn ; Infant, Premature ; Interleukin-1 - blood ; Interleukin-1 - genetics ; Interleukin-6 - blood ; Interleukin-6 - genetics ; Interleukin-8 - blood ; Interleukin-8 - genetics ; Polymerase Chain Reaction ; Pregnancy ; Pregnancy Complications ; Reference Values ; RNA, Messenger - genetics ; Transcription, Genetic ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - metabolism
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7Tawfeek, M S
8Clad, A
9Brandis, M
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0Plasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis
1Pediatric research
addtitlePediatr Res
descriptionBacterial sepsis is still a leading cause of neonatal morbidity and mortality. Early onset sepsis in particular, presents with a different clinical course and involves other pathogens than sepsis later in life. In this study, plasma concentrations and mRNA expression of granulocyte colony-stimulating factor (G-CSF), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 (sICAM-1) of neonates with early onset sepsis were evaluated in cord blood and during the first days of life. Irrespective of prematurity, plasma levels of G-CSF, TNF-alpha, IL-1beta, IL-6, and IL-8, but not sICAM-1, were excessively elevated in septic neonates when compared with both healthy infants and infants with clinically suspected but not confirmed sepsis. Compared with the corresponding maternal levels, neonatal cytokine cord plasma levels were likewise highly elevated, indicating the endogenous cytokine production by the neonate. With the exception of TNF-alpha, mRNA expression in blood cells from septic infants was, however, not more frequently detectable than in those from nonseptic patients. Cytokine levels decreased significantly within the first days of life, whereas levels of sICAM-1 and C-reactive protein increased during the same time period. In summary, in contrast to C-reactive protein and sICAM-1, cord blood plasma levels, but not the presence of mRNA, of G-CSF, TNF-alpha, IL-1beta, IL-6, and IL-8 can predict neonatal early onset sepsis with a high sensitivity and specificity. Cell types other than blood cells are likely to contribute considerably to the high cytokine production in septic newborns.
subject
0Bacteremia - blood
1Bacteremia - immunology
2Blood Cells - immunology
3Female
4Fetal Blood
5Gene Expression Regulation, Developmental
6Germany
7Granulocyte Colony-Stimulating Factor - blood
8Granulocyte Colony-Stimulating Factor - genetics
9Humans
10Infant, Newborn
11Infant, Premature
12Interleukin-1 - blood
13Interleukin-1 - genetics
14Interleukin-6 - blood
15Interleukin-6 - genetics
16Interleukin-8 - blood
17Interleukin-8 - genetics
18Polymerase Chain Reaction
19Pregnancy
20Pregnancy Complications
21Reference Values
22RNA, Messenger - genetics
23Transcription, Genetic
24Tumor Necrosis Factor-alpha - genetics
25Tumor Necrosis Factor-alpha - metabolism
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4Schwab, C
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9Brandis, M
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titlePlasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis
authorBerner, R ; Niemeyer, C M ; Leititis, J U ; Funke, A ; Schwab, C ; Rau, U ; Richter, K ; Tawfeek, M S ; Clad, A ; Brandis, M
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8Granulocyte Colony-Stimulating Factor - genetics
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17Interleukin-8 - genetics
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25Tumor Necrosis Factor-alpha - metabolism
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8Clad, A
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8Clad, A
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atitlePlasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis
jtitlePediatric research
addtitlePediatr Res
date1998-10
risdate1998
volume44
issue4
spage469
epage477
pages469-477
issn0031-3998
eissn1530-0447
abstractBacterial sepsis is still a leading cause of neonatal morbidity and mortality. Early onset sepsis in particular, presents with a different clinical course and involves other pathogens than sepsis later in life. In this study, plasma concentrations and mRNA expression of granulocyte colony-stimulating factor (G-CSF), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 (sICAM-1) of neonates with early onset sepsis were evaluated in cord blood and during the first days of life. Irrespective of prematurity, plasma levels of G-CSF, TNF-alpha, IL-1beta, IL-6, and IL-8, but not sICAM-1, were excessively elevated in septic neonates when compared with both healthy infants and infants with clinically suspected but not confirmed sepsis. Compared with the corresponding maternal levels, neonatal cytokine cord plasma levels were likewise highly elevated, indicating the endogenous cytokine production by the neonate. With the exception of TNF-alpha, mRNA expression in blood cells from septic infants was, however, not more frequently detectable than in those from nonseptic patients. Cytokine levels decreased significantly within the first days of life, whereas levels of sICAM-1 and C-reactive protein increased during the same time period. In summary, in contrast to C-reactive protein and sICAM-1, cord blood plasma levels, but not the presence of mRNA, of G-CSF, TNF-alpha, IL-1beta, IL-6, and IL-8 can predict neonatal early onset sepsis with a high sensitivity and specificity. Cell types other than blood cells are likely to contribute considerably to the high cytokine production in septic newborns.
copUnited States
pmid9773833