schliessen

Filtern

 

Bibliotheken

The impact of male circumcision on HIV incidence and cost per infection prevented: a stochastic simulation model from Rakai, Uganda

To estimate the impact of male circumcision on HIV incidence, the number of procedures per HIV infection averted, and costs per infection averted. A stochastic simulation model with empirically derived parameters from a cohort in Rakai, Uganda was used to estimate HIV incidence, assuming that male c... Full description

Journal Title: AIDS (London) 2007, Vol.21 (7), p.845-850
Main Author: GRAY, Ronald H
Other Authors: XIANBIN LI , KIGOZI, Godfrey , SERWADDA, David , NALUGODA, Fred , WATYA, Stephen , REYNOLDS, Steven J , WAWER, Maria
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0269-9370
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_70343737
title: The impact of male circumcision on HIV incidence and cost per infection prevented: a stochastic simulation model from Rakai, Uganda
format: Article
creator:
  • GRAY, Ronald H
  • XIANBIN LI
  • KIGOZI, Godfrey
  • SERWADDA, David
  • NALUGODA, Fred
  • WATYA, Stephen
  • REYNOLDS, Steven J
  • WAWER, Maria
subjects:
  • Adolescent
  • Adult
  • AIDS/HIV
  • Biological and medical sciences
  • Circumcision, Male - economics
  • Cost-Benefit Analysis
  • Female
  • Health Care Costs - statistics & numerical data
  • HIV Infections - economics
  • HIV Infections - epidemiology
  • HIV Infections - prevention & control
  • HIV Infections - transmission
  • Human immunodeficiency virus
  • Human viral diseases
  • Humans
  • Immunodeficiencies
  • Immunodeficiencies. Immunoglobulinopathies
  • Immunopathology
  • Incidence
  • Infectious diseases
  • Male
  • Medical sciences
  • Middle Aged
  • Models, Statistical
  • Stochastic Processes
  • Uganda - epidemiology
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
ispartof: AIDS (London), 2007, Vol.21 (7), p.845-850
description: To estimate the impact of male circumcision on HIV incidence, the number of procedures per HIV infection averted, and costs per infection averted. A stochastic simulation model with empirically derived parameters from a cohort in Rakai, Uganda was used to estimate HIV incidence, assuming that male circumcision reduced the risks of HIV acquisition with rate ratios (RR) ranging from 0.3 to 0.6 in men, their female partners, and in both sexes combined, with circumcision coverage 0-100%. The reproductive number (R0) was also estimated. The number of HIV infections averted per circumcision was estimated from the incident cases in the absence of surgery minus the projected number of incident cases over 10 years following circumcision. The cost per procedure ($69.00) was used to estimate the cost per HIV infection averted. Baseline HIV incidence was 1.2/100 person-years. Male circumcision could markedly reduce HIV incidence in this population, particularly if there was preventative efficacy in both sexes. Under many scenarios, with RR < or = 0.5, circumcision could reduce R0 to < 1.0 and potentially abort the epidemic. The number of surgeries per infection averted over 10 years was 19-58, and the costs per infection averted was $1269-3911, depending on the efficacy of circumcision for either or both sexes, assuming 75% service coverage. However, behavioral disinhibition could offset any benefits of circumcision. Male circumcision could have substantial impact on the HIV epidemic and provide a cost-effective prevention strategy if benefits are not countered by behavioral disinhibition.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.4652452
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_cross
recordidTN_cdi_proquest_miscellaneous_70343737
sourceformatXML
sourcesystemPC
sourcerecordid19643820
originalsourceidFETCH-LOGICAL-1413t-771c5f08bdaff57c4ddae2d514b9b57c6ffc25cbc54b70a3d577e840851cf1ad0
addsrcrecordideNqFkU9rFTEUxYMo9ln9BiLZ6MqpySR5memutGoLBVFat8OdmxsbnX9NMkLXfnHT9kGhC4VASPidcy_nMPZaigMpWvvh69HJgeiFVKTqRsjGGq2fsI3UVlXGWPmUbUS9batWWbHHXqT0UwhhRNM8Z3vSammEajfsz8UV8TAugJnPno8wEMcQcR0xpDBPvJzTs-88TBgcTUgcJsdxTpkvFMu3J8y33BLpN02Z3CEHnvKMV5ByQJ7CuA5wh4yzo4H7OI_8G_yC8J5f_ihu8JI98zAkerW799nlp48Xx6fV-ZfPZ8dH55XUUuXKWonGi6Z34L2xqJ0Dqp2Rum_78t56j7XBHo3urQDljLXUaNEYiV6CE_vs3b3vEufrlVLuxpCQhgEmmtfUWaG0siWu_4Gy3WrV1KKA-h7EOKcUyXdLDCPEm06K7ralrrTUPW6pyN7s_Nd-JPcg2tVSgLc7ABLC4COU-NMD11itjFWFO3w0H0O-CztHCMO_t_gLhBGu3g
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid19643820
display
typearticle
titleThe impact of male circumcision on HIV incidence and cost per infection prevented: a stochastic simulation model from Rakai, Uganda
creatorGRAY, Ronald H ; XIANBIN LI ; KIGOZI, Godfrey ; SERWADDA, David ; NALUGODA, Fred ; WATYA, Stephen ; REYNOLDS, Steven J ; WAWER, Maria
creatorcontribGRAY, Ronald H ; XIANBIN LI ; KIGOZI, Godfrey ; SERWADDA, David ; NALUGODA, Fred ; WATYA, Stephen ; REYNOLDS, Steven J ; WAWER, Maria
descriptionTo estimate the impact of male circumcision on HIV incidence, the number of procedures per HIV infection averted, and costs per infection averted. A stochastic simulation model with empirically derived parameters from a cohort in Rakai, Uganda was used to estimate HIV incidence, assuming that male circumcision reduced the risks of HIV acquisition with rate ratios (RR) ranging from 0.3 to 0.6 in men, their female partners, and in both sexes combined, with circumcision coverage 0-100%. The reproductive number (R0) was also estimated. The number of HIV infections averted per circumcision was estimated from the incident cases in the absence of surgery minus the projected number of incident cases over 10 years following circumcision. The cost per procedure ($69.00) was used to estimate the cost per HIV infection averted. Baseline HIV incidence was 1.2/100 person-years. Male circumcision could markedly reduce HIV incidence in this population, particularly if there was preventative efficacy in both sexes. Under many scenarios, with RR < or = 0.5, circumcision could reduce R0 to < 1.0 and potentially abort the epidemic. The number of surgeries per infection averted over 10 years was 19-58, and the costs per infection averted was $1269-3911, depending on the efficacy of circumcision for either or both sexes, assuming 75% service coverage. However, behavioral disinhibition could offset any benefits of circumcision. Male circumcision could have substantial impact on the HIV epidemic and provide a cost-effective prevention strategy if benefits are not countered by behavioral disinhibition.
identifier
0ISSN: 0269-9370
1EISSN: 1473-5571
2DOI: 10.1097/QAD.0b013e3280187544
3PMID: 17415039
languageeng
publisherHagerstown, MD: Lippincott Williams & Wilkins
subjectAdolescent ; Adult ; AIDS/HIV ; Biological and medical sciences ; Circumcision, Male - economics ; Cost-Benefit Analysis ; Female ; Health Care Costs - statistics & numerical data ; HIV Infections - economics ; HIV Infections - epidemiology ; HIV Infections - prevention & control ; HIV Infections - transmission ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Incidence ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Models, Statistical ; Stochastic Processes ; Uganda - epidemiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids
ispartofAIDS (London), 2007, Vol.21 (7), p.845-850
rights2007 INIST-CNRS
lds50peer_reviewed
citedbyFETCH-LOGICAL-1413t-771c5f08bdaff57c4ddae2d514b9b57c6ffc25cbc54b70a3d577e840851cf1ad0
citesFETCH-LOGICAL-1413t-771c5f08bdaff57c4ddae2d514b9b57c6ffc25cbc54b70a3d577e840851cf1ad0
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18743573$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17415039$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0GRAY, Ronald H
1XIANBIN LI
2KIGOZI, Godfrey
3SERWADDA, David
4NALUGODA, Fred
5WATYA, Stephen
6REYNOLDS, Steven J
7WAWER, Maria
title
0The impact of male circumcision on HIV incidence and cost per infection prevented: a stochastic simulation model from Rakai, Uganda
1AIDS (London)
addtitleAIDS
descriptionTo estimate the impact of male circumcision on HIV incidence, the number of procedures per HIV infection averted, and costs per infection averted. A stochastic simulation model with empirically derived parameters from a cohort in Rakai, Uganda was used to estimate HIV incidence, assuming that male circumcision reduced the risks of HIV acquisition with rate ratios (RR) ranging from 0.3 to 0.6 in men, their female partners, and in both sexes combined, with circumcision coverage 0-100%. The reproductive number (R0) was also estimated. The number of HIV infections averted per circumcision was estimated from the incident cases in the absence of surgery minus the projected number of incident cases over 10 years following circumcision. The cost per procedure ($69.00) was used to estimate the cost per HIV infection averted. Baseline HIV incidence was 1.2/100 person-years. Male circumcision could markedly reduce HIV incidence in this population, particularly if there was preventative efficacy in both sexes. Under many scenarios, with RR < or = 0.5, circumcision could reduce R0 to < 1.0 and potentially abort the epidemic. The number of surgeries per infection averted over 10 years was 19-58, and the costs per infection averted was $1269-3911, depending on the efficacy of circumcision for either or both sexes, assuming 75% service coverage. However, behavioral disinhibition could offset any benefits of circumcision. Male circumcision could have substantial impact on the HIV epidemic and provide a cost-effective prevention strategy if benefits are not countered by behavioral disinhibition.
subject
0Adolescent
1Adult
2AIDS/HIV
3Biological and medical sciences
4Circumcision, Male - economics
5Cost-Benefit Analysis
6Female
7Health Care Costs - statistics & numerical data
8HIV Infections - economics
9HIV Infections - epidemiology
10HIV Infections - prevention & control
11HIV Infections - transmission
12Human immunodeficiency virus
13Human viral diseases
14Humans
15Immunodeficiencies
16Immunodeficiencies. Immunoglobulinopathies
17Immunopathology
18Incidence
19Infectious diseases
20Male
21Medical sciences
22Middle Aged
23Models, Statistical
24Stochastic Processes
25Uganda - epidemiology
26Viral diseases
27Viral diseases of the lymphoid tissue and the blood. Aids
issn
00269-9370
11473-5571
fulltextfalse
rsrctypearticle
creationdate2007
recordtypearticle
recordideNqFkU9rFTEUxYMo9ln9BiLZ6MqpySR5memutGoLBVFat8OdmxsbnX9NMkLXfnHT9kGhC4VASPidcy_nMPZaigMpWvvh69HJgeiFVKTqRsjGGq2fsI3UVlXGWPmUbUS9batWWbHHXqT0UwhhRNM8Z3vSammEajfsz8UV8TAugJnPno8wEMcQcR0xpDBPvJzTs-88TBgcTUgcJsdxTpkvFMu3J8y33BLpN02Z3CEHnvKMV5ByQJ7CuA5wh4yzo4H7OI_8G_yC8J5f_ihu8JI98zAkerW799nlp48Xx6fV-ZfPZ8dH55XUUuXKWonGi6Z34L2xqJ0Dqp2Rum_78t56j7XBHo3urQDljLXUaNEYiV6CE_vs3b3vEufrlVLuxpCQhgEmmtfUWaG0siWu_4Gy3WrV1KKA-h7EOKcUyXdLDCPEm06K7ralrrTUPW6pyN7s_Nd-JPcg2tVSgLc7ABLC4COU-NMD11itjFWFO3w0H0O-CztHCMO_t_gLhBGu3g
startdate2007
enddate2007
creator
0GRAY, Ronald H
1XIANBIN LI
2KIGOZI, Godfrey
3SERWADDA, David
4NALUGODA, Fred
5WATYA, Stephen
6REYNOLDS, Steven J
7WAWER, Maria
generalLippincott Williams & Wilkins
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
97T5
107U1
117U2
127U9
13C1K
14H94
157X8
sort
creationdate2007
titleThe impact of male circumcision on HIV incidence and cost per infection prevented: a stochastic simulation model from Rakai, Uganda
authorGRAY, Ronald H ; XIANBIN LI ; KIGOZI, Godfrey ; SERWADDA, David ; NALUGODA, Fred ; WATYA, Stephen ; REYNOLDS, Steven J ; WAWER, Maria
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1413t-771c5f08bdaff57c4ddae2d514b9b57c6ffc25cbc54b70a3d577e840851cf1ad0
rsrctypearticles
prefilterarticles
languageeng
creationdate2007
topic
0Adolescent
1Adult
2AIDS/HIV
3Biological and medical sciences
4Circumcision, Male - economics
5Cost-Benefit Analysis
6Female
7Health Care Costs - statistics & numerical data
8HIV Infections - economics
9HIV Infections - epidemiology
10HIV Infections - prevention & control
11HIV Infections - transmission
12Human immunodeficiency virus
13Human viral diseases
14Humans
15Immunodeficiencies
16Immunodeficiencies. Immunoglobulinopathies
17Immunopathology
18Incidence
19Infectious diseases
20Male
21Medical sciences
22Middle Aged
23Models, Statistical
24Stochastic Processes
25Uganda - epidemiology
26Viral diseases
27Viral diseases of the lymphoid tissue and the blood. Aids
toplevelpeer_reviewed
creatorcontrib
0GRAY, Ronald H
1XIANBIN LI
2KIGOZI, Godfrey
3SERWADDA, David
4NALUGODA, Fred
5WATYA, Stephen
6REYNOLDS, Steven J
7WAWER, Maria
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8Immunology Abstracts
9Risk Abstracts
10Safety Science and Risk
11Virology and AIDS Abstracts
12Environmental Sciences and Pollution Management
13AIDS and Cancer Research Abstracts
14MEDLINE - Academic
jtitleAIDS (London)
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0GRAY, Ronald H
1XIANBIN LI
2KIGOZI, Godfrey
3SERWADDA, David
4NALUGODA, Fred
5WATYA, Stephen
6REYNOLDS, Steven J
7WAWER, Maria
formatjournal
genrearticle
ristypeJOUR
atitleThe impact of male circumcision on HIV incidence and cost per infection prevented: a stochastic simulation model from Rakai, Uganda
jtitleAIDS (London)
addtitleAIDS
date2007
risdate2007
volume21
issue7
spage845
epage850
pages845-850
issn0269-9370
eissn1473-5571
abstractTo estimate the impact of male circumcision on HIV incidence, the number of procedures per HIV infection averted, and costs per infection averted. A stochastic simulation model with empirically derived parameters from a cohort in Rakai, Uganda was used to estimate HIV incidence, assuming that male circumcision reduced the risks of HIV acquisition with rate ratios (RR) ranging from 0.3 to 0.6 in men, their female partners, and in both sexes combined, with circumcision coverage 0-100%. The reproductive number (R0) was also estimated. The number of HIV infections averted per circumcision was estimated from the incident cases in the absence of surgery minus the projected number of incident cases over 10 years following circumcision. The cost per procedure ($69.00) was used to estimate the cost per HIV infection averted. Baseline HIV incidence was 1.2/100 person-years. Male circumcision could markedly reduce HIV incidence in this population, particularly if there was preventative efficacy in both sexes. Under many scenarios, with RR < or = 0.5, circumcision could reduce R0 to < 1.0 and potentially abort the epidemic. The number of surgeries per infection averted over 10 years was 19-58, and the costs per infection averted was $1269-3911, depending on the efficacy of circumcision for either or both sexes, assuming 75% service coverage. However, behavioral disinhibition could offset any benefits of circumcision. Male circumcision could have substantial impact on the HIV epidemic and provide a cost-effective prevention strategy if benefits are not countered by behavioral disinhibition.
copHagerstown, MD
pubLippincott Williams & Wilkins
pmid17415039
doi10.1097/QAD.0b013e3280187544