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Perivascular nitric oxide gradients normalize tumor vasculature

Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and norm... Full description

Journal Title: Nature medicine 2008-03, Vol.14 (3), p.255-257
Main Author: Fukumura, Dai
Other Authors: Kashiwagi, Satoshi , Tsukada, Kosuke , Xu, Lei , Miyazaki, Junichi , Kozin, Sergey V , Tyrrell, James A , Sessa, William C , Gerweck, Leo E , Jain, Rakesh K
Format: Electronic Article Electronic Article
Language: English
Subjects:
Animals
Brain cancer
Cell Line, Tumor
Gene Silencing
Glioma - blood supply
Glioma - metabolism
Glioma - radiotherapy
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Humans
Inhibitor drugs
Mice
Mice, Knockout
Neoplasms, Experimental - enzymology
Neoplasms, Experimental - metabolism
Neoplasms, Experimental - radiotherapy
Nitric Oxide - metabolism
Nitric Oxide Synthase Type I - deficiency
Nitric Oxide Synthase Type I - genetics
Nitric Oxide Synthase Type I - metabolism
Nitric Oxide Synthase Type III - deficiency
Nitric Oxide Synthase Type III - genetics
Nitric Oxide Synthase Type III - metabolism
Oncology
Oxygen - metabolism
Rodents
Tumors
Veins & arteries
Publisher: United States: Nature Publishing Group
ID: ISSN: 1078-8956
Link: https://www.ncbi.nlm.nih.gov/pubmed/18278052
Zum Text:
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recordid: cdi_proquest_miscellaneous_70368900
title: Perivascular nitric oxide gradients normalize tumor vasculature
format: Article
creator:
  • Fukumura, Dai
  • Kashiwagi, Satoshi
  • Tsukada, Kosuke
  • Xu, Lei
  • Miyazaki, Junichi
  • Kozin, Sergey V
  • Tyrrell, James A
  • Sessa, William C
  • Gerweck, Leo E
  • Jain, Rakesh K
subjects:
  • Animals
  • Brain cancer
  • Cell Line, Tumor
  • Gene Silencing
  • Glioma - blood supply
  • Glioma - metabolism
  • Glioma - radiotherapy
  • Homeodomain Proteins - genetics
  • Homeodomain Proteins - metabolism
  • Humans
  • Inhibitor drugs
  • Mice
  • Mice, Knockout
  • Neoplasms, Experimental - enzymology
  • Neoplasms, Experimental - metabolism
  • Neoplasms, Experimental - radiotherapy
  • Nitric Oxide - metabolism
  • Nitric Oxide Synthase Type I - deficiency
  • Nitric Oxide Synthase Type I - genetics
  • Nitric Oxide Synthase Type I - metabolism
  • Nitric Oxide Synthase Type III - deficiency
  • Nitric Oxide Synthase Type III - genetics
  • Nitric Oxide Synthase Type III - metabolism
  • Oncology
  • Oxygen - metabolism
  • Rodents
  • Tumors
  • Veins & arteries
ispartof: Nature medicine, 2008-03, Vol.14 (3), p.255-257
description: Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.
language: eng
source:
identifier: ISSN: 1078-8956
fulltext: no_fulltext
issn:
  • 1078-8956
  • 1546-170X
url: Link


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titlePerivascular nitric oxide gradients normalize tumor vasculature
creatorFukumura, Dai ; Kashiwagi, Satoshi ; Tsukada, Kosuke ; Xu, Lei ; Miyazaki, Junichi ; Kozin, Sergey V ; Tyrrell, James A ; Sessa, William C ; Gerweck, Leo E ; Jain, Rakesh K
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descriptionNormalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.
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subjectAnimals ; Brain cancer ; Cell Line, Tumor ; Gene Silencing ; Glioma - blood supply ; Glioma - metabolism ; Glioma - radiotherapy ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Humans ; Inhibitor drugs ; Mice ; Mice, Knockout ; Neoplasms, Experimental - enzymology ; Neoplasms, Experimental - metabolism ; Neoplasms, Experimental - radiotherapy ; Nitric Oxide - metabolism ; Nitric Oxide Synthase Type I - deficiency ; Nitric Oxide Synthase Type I - genetics ; Nitric Oxide Synthase Type I - metabolism ; Nitric Oxide Synthase Type III - deficiency ; Nitric Oxide Synthase Type III - genetics ; Nitric Oxide Synthase Type III - metabolism ; Oncology ; Oxygen - metabolism ; Rodents ; Tumors ; Veins & arteries
ispartofNature medicine, 2008-03, Vol.14 (3), p.255-257
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descriptionNormalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.
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12Mice, Knockout
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1Brain cancer
2Cell Line, Tumor
3Gene Silencing
4Glioma - blood supply
5Glioma - metabolism
6Glioma - radiotherapy
7Homeodomain Proteins - genetics
8Homeodomain Proteins - metabolism
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10Inhibitor drugs
11Mice
12Mice, Knockout
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14Neoplasms, Experimental - metabolism
15Neoplasms, Experimental - radiotherapy
16Nitric Oxide - metabolism
17Nitric Oxide Synthase Type I - deficiency
18Nitric Oxide Synthase Type I - genetics
19Nitric Oxide Synthase Type I - metabolism
20Nitric Oxide Synthase Type III - deficiency
21Nitric Oxide Synthase Type III - genetics
22Nitric Oxide Synthase Type III - metabolism
23Oncology
24Oxygen - metabolism
25Rodents
26Tumors
27Veins & arteries
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7Sessa, William C
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abstractNormalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.
copUnited States
pubNature Publishing Group
pmid18278052
doi10.1038/nm1730
tpages3