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Perivascular nitric oxide gradients normalize tumor vasculature

Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and norm... Full description

Journal Title: Nature medicine 2008-03, Vol.14 (3), p.255-257
Main Author: Fukumura, Dai
Other Authors: Kashiwagi, Satoshi , Tsukada, Kosuke , Xu, Lei , Miyazaki, Junichi , Kozin, Sergey V , Tyrrell, James A , Sessa, William C , Gerweck, Leo E , Jain, Rakesh K
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Nature Publishing Group
ID: ISSN: 1078-8956
Link: https://www.ncbi.nlm.nih.gov/pubmed/18278052
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title: Perivascular nitric oxide gradients normalize tumor vasculature
format: Article
creator:
  • Fukumura, Dai
  • Kashiwagi, Satoshi
  • Tsukada, Kosuke
  • Xu, Lei
  • Miyazaki, Junichi
  • Kozin, Sergey V
  • Tyrrell, James A
  • Sessa, William C
  • Gerweck, Leo E
  • Jain, Rakesh K
subjects:
  • Animals
  • Brain cancer
  • Cell Line, Tumor
  • Gene Silencing
  • Glioma - blood supply
  • Glioma - metabolism
  • Glioma - radiotherapy
  • Homeodomain Proteins - genetics
  • Homeodomain Proteins - metabolism
  • Humans
  • Inhibitor drugs
  • Mice
  • Mice, Knockout
  • Neoplasms, Experimental - enzymology
  • Neoplasms, Experimental - metabolism
  • Neoplasms, Experimental - radiotherapy
  • Nitric Oxide - metabolism
  • Nitric Oxide Synthase Type I - deficiency
  • Nitric Oxide Synthase Type I - genetics
  • Nitric Oxide Synthase Type I - metabolism
  • Nitric Oxide Synthase Type III - deficiency
  • Nitric Oxide Synthase Type III - genetics
  • Nitric Oxide Synthase Type III - metabolism
  • Oncology
  • Oxygen - metabolism
  • Rodents
  • Tumors
  • Veins & arteries
ispartof: Nature medicine, 2008-03, Vol.14 (3), p.255-257
description: Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.
language: eng
source:
identifier: ISSN: 1078-8956
fulltext: no_fulltext
issn:
  • 1078-8956
  • 1546-170X
url: Link


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titlePerivascular nitric oxide gradients normalize tumor vasculature
creatorFukumura, Dai ; Kashiwagi, Satoshi ; Tsukada, Kosuke ; Xu, Lei ; Miyazaki, Junichi ; Kozin, Sergey V ; Tyrrell, James A ; Sessa, William C ; Gerweck, Leo E ; Jain, Rakesh K
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descriptionNormalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.
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subjectAnimals ; Brain cancer ; Cell Line, Tumor ; Gene Silencing ; Glioma - blood supply ; Glioma - metabolism ; Glioma - radiotherapy ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Humans ; Inhibitor drugs ; Mice ; Mice, Knockout ; Neoplasms, Experimental - enzymology ; Neoplasms, Experimental - metabolism ; Neoplasms, Experimental - radiotherapy ; Nitric Oxide - metabolism ; Nitric Oxide Synthase Type I - deficiency ; Nitric Oxide Synthase Type I - genetics ; Nitric Oxide Synthase Type I - metabolism ; Nitric Oxide Synthase Type III - deficiency ; Nitric Oxide Synthase Type III - genetics ; Nitric Oxide Synthase Type III - metabolism ; Oncology ; Oxygen - metabolism ; Rodents ; Tumors ; Veins & arteries
ispartofNature medicine, 2008-03, Vol.14 (3), p.255-257
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16Nitric Oxide - metabolism
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18Nitric Oxide Synthase Type I - genetics
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24Oxygen - metabolism
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27Veins & arteries
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abstractNormalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.
copUnited States
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pmid18278052
doi10.1038/nm1730
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