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Prevalence of Kaposi Sarcoma-Associated Herpesvirus Compared With Selected Sexually Transmitted Diseases in Adolescents and Young Adults in Rural Rakai District, Uganda

Background: Kaposi sarcoma-associated herpesvirus (KSHV) is transmitted by routes such as homosexual intercourse and is associated with HIV infection in industrialized countries. However, there is little information about its transmission in developing countries where Kaposi sarcoma is an endemic di... Full description

Journal Title: Sexually transmitted diseases 2001, Vol.28 (2), p.77-81
Main Author: Wawer, M J
Other Authors: Eng, S M , Serwadda, D , Sewankambo, N K , Kiwanuka, N , Li, C , Gray, R H
Format: Electronic Article Electronic Article
Language: English
Subjects:
STD
Quelle: Alma/SFX Local Collection
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0148-5717
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title: Prevalence of Kaposi Sarcoma-Associated Herpesvirus Compared With Selected Sexually Transmitted Diseases in Adolescents and Young Adults in Rural Rakai District, Uganda
format: Article
creator:
  • Wawer, M J
  • Eng, S M
  • Serwadda, D
  • Sewankambo, N K
  • Kiwanuka, N
  • Li, C
  • Gray, R H
subjects:
  • Adolescent
  • Adult
  • Age Factors
  • Antibodies, Viral - blood
  • Biological and medical sciences
  • Cohort Studies
  • Comparative analysis
  • Developing countries
  • Female
  • Fluorescent Antibody Technique, Direct
  • Herpes viruses
  • Herpesviridae Infections - epidemiology
  • Herpesviridae Infections - transmission
  • Herpesvirus 8, Human - immunology
  • Herpesvirus 8, Human - isolation & purification
  • HIV Infections - epidemiology
  • Homosexuality
  • Human herpesvirus 8
  • Human viral diseases
  • Humans
  • Immunoblotting
  • Infectious diseases
  • Kaposis sarcoma
  • LDCs
  • Male
  • Medical sciences
  • Rural Health
  • Sarcoma, Kaposi - epidemiology
  • Sarcoma, Kaposi - virology
  • Seroepidemiologic Studies
  • Sexuality
  • Sexually transmitted diseases
  • Sexually Transmitted Diseases - epidemiology
  • Sexually Transmitted Diseases - transmission
  • STD
  • Syphilis - epidemiology
  • Teenagers
  • Uganda
  • Uganda - epidemiology
  • Viral diseases
  • Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
  • Young adults
ispartof: Sexually transmitted diseases, 2001, Vol.28 (2), p.77-81
description: Background: Kaposi sarcoma-associated herpesvirus (KSHV) is transmitted by routes such as homosexual intercourse and is associated with HIV infection in industrialized countries. However, there is little information about its transmission in developing countries where Kaposi sarcoma is an endemic disease. Goal: To examine KSHV seroprevalence in young adults in a general, rural Ugandan population, and to compare this prevalence with rates of known sexually transmitted infections. Study Design: The seroprevalence of KSHV was compared with the epidemiology of sexually transmitted diseases in 523 sexually active subjects aged 15 to 29 years who were randomly selected from a general population cohort in rural Rakai District, Uganda. Participants provided in-home interview data and specimens. Sera were tested for KSHV using immunofluorescence assay and immunoblot for lytically expressed recombinant KSHV ORF65.2. Sera were also tested for HIV type 1, herpes simplex virus type 2, and syphilis. Results: The prevalence of KSHV was significantly higher in participants 15 to 19 years compared with older persons 25 to 29 years (45.0% and 36.1%, respectively; adjusted odds ratio, 0.48; 95% CI, 0.28-0.82). In contrast, herpes simplex virus type 2 and HIV type 1 prevalence increased with age. Kaposi sarcoma-associated herpesvirus serostatus was not associated with HIV type 1, syphilis, herpes simplex virus type 2, or number of sexual partners. Homosexual and anal intercourse were reported by less than 1% of participants. Conclusions: Kaposi sarcoma-associated herpesvirus does not appear to be a heterosexually transmitted infection in rural Uganda.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0148-5717
fulltext: fulltext
issn:
  • 0148-5717
  • 1537-4521
url: Link


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titlePrevalence of Kaposi Sarcoma-Associated Herpesvirus Compared With Selected Sexually Transmitted Diseases in Adolescents and Young Adults in Rural Rakai District, Uganda
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creatorWawer, M J ; Eng, S M ; Serwadda, D ; Sewankambo, N K ; Kiwanuka, N ; Li, C ; Gray, R H
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descriptionBackground: Kaposi sarcoma-associated herpesvirus (KSHV) is transmitted by routes such as homosexual intercourse and is associated with HIV infection in industrialized countries. However, there is little information about its transmission in developing countries where Kaposi sarcoma is an endemic disease. Goal: To examine KSHV seroprevalence in young adults in a general, rural Ugandan population, and to compare this prevalence with rates of known sexually transmitted infections. Study Design: The seroprevalence of KSHV was compared with the epidemiology of sexually transmitted diseases in 523 sexually active subjects aged 15 to 29 years who were randomly selected from a general population cohort in rural Rakai District, Uganda. Participants provided in-home interview data and specimens. Sera were tested for KSHV using immunofluorescence assay and immunoblot for lytically expressed recombinant KSHV ORF65.2. Sera were also tested for HIV type 1, herpes simplex virus type 2, and syphilis. Results: The prevalence of KSHV was significantly higher in participants 15 to 19 years compared with older persons 25 to 29 years (45.0% and 36.1%, respectively; adjusted odds ratio, 0.48; 95% CI, 0.28-0.82). In contrast, herpes simplex virus type 2 and HIV type 1 prevalence increased with age. Kaposi sarcoma-associated herpesvirus serostatus was not associated with HIV type 1, syphilis, herpes simplex virus type 2, or number of sexual partners. Homosexual and anal intercourse were reported by less than 1% of participants. Conclusions: Kaposi sarcoma-associated herpesvirus does not appear to be a heterosexually transmitted infection in rural Uganda.
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languageeng
publisherHagerstown, MD: Lippincott Williams & Wilkins
subjectAdolescent ; Adult ; Age Factors ; Antibodies, Viral - blood ; Biological and medical sciences ; Cohort Studies ; Comparative analysis ; Developing countries ; Female ; Fluorescent Antibody Technique, Direct ; Herpes viruses ; Herpesviridae Infections - epidemiology ; Herpesviridae Infections - transmission ; Herpesvirus 8, Human - immunology ; Herpesvirus 8, Human - isolation & purification ; HIV Infections - epidemiology ; Homosexuality ; Human herpesvirus 8 ; Human viral diseases ; Humans ; Immunoblotting ; Infectious diseases ; Kaposis sarcoma ; LDCs ; Male ; Medical sciences ; Rural Health ; Sarcoma, Kaposi - epidemiology ; Sarcoma, Kaposi - virology ; Seroepidemiologic Studies ; Sexuality ; Sexually transmitted diseases ; Sexually Transmitted Diseases - epidemiology ; Sexually Transmitted Diseases - transmission ; STD ; Syphilis - epidemiology ; Teenagers ; Uganda ; Uganda - epidemiology ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye ; Young adults
ispartofSexually transmitted diseases, 2001, Vol.28 (2), p.77-81
rights
0Copyright © 2001 American Sexually Transmitted Diseases Association
12002 INIST-CNRS
2COPYRIGHT 2001 American Venereal Disease Association
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descriptionBackground: Kaposi sarcoma-associated herpesvirus (KSHV) is transmitted by routes such as homosexual intercourse and is associated with HIV infection in industrialized countries. However, there is little information about its transmission in developing countries where Kaposi sarcoma is an endemic disease. Goal: To examine KSHV seroprevalence in young adults in a general, rural Ugandan population, and to compare this prevalence with rates of known sexually transmitted infections. Study Design: The seroprevalence of KSHV was compared with the epidemiology of sexually transmitted diseases in 523 sexually active subjects aged 15 to 29 years who were randomly selected from a general population cohort in rural Rakai District, Uganda. Participants provided in-home interview data and specimens. Sera were tested for KSHV using immunofluorescence assay and immunoblot for lytically expressed recombinant KSHV ORF65.2. Sera were also tested for HIV type 1, herpes simplex virus type 2, and syphilis. Results: The prevalence of KSHV was significantly higher in participants 15 to 19 years compared with older persons 25 to 29 years (45.0% and 36.1%, respectively; adjusted odds ratio, 0.48; 95% CI, 0.28-0.82). In contrast, herpes simplex virus type 2 and HIV type 1 prevalence increased with age. Kaposi sarcoma-associated herpesvirus serostatus was not associated with HIV type 1, syphilis, herpes simplex virus type 2, or number of sexual partners. Homosexual and anal intercourse were reported by less than 1% of participants. Conclusions: Kaposi sarcoma-associated herpesvirus does not appear to be a heterosexually transmitted infection in rural Uganda.
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4Biological and medical sciences
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35Syphilis - epidemiology
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titlePrevalence of Kaposi Sarcoma-Associated Herpesvirus Compared With Selected Sexually Transmitted Diseases in Adolescents and Young Adults in Rural Rakai District, Uganda
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9Fluorescent Antibody Technique, Direct
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abstractBackground: Kaposi sarcoma-associated herpesvirus (KSHV) is transmitted by routes such as homosexual intercourse and is associated with HIV infection in industrialized countries. However, there is little information about its transmission in developing countries where Kaposi sarcoma is an endemic disease. Goal: To examine KSHV seroprevalence in young adults in a general, rural Ugandan population, and to compare this prevalence with rates of known sexually transmitted infections. Study Design: The seroprevalence of KSHV was compared with the epidemiology of sexually transmitted diseases in 523 sexually active subjects aged 15 to 29 years who were randomly selected from a general population cohort in rural Rakai District, Uganda. Participants provided in-home interview data and specimens. Sera were tested for KSHV using immunofluorescence assay and immunoblot for lytically expressed recombinant KSHV ORF65.2. Sera were also tested for HIV type 1, herpes simplex virus type 2, and syphilis. Results: The prevalence of KSHV was significantly higher in participants 15 to 19 years compared with older persons 25 to 29 years (45.0% and 36.1%, respectively; adjusted odds ratio, 0.48; 95% CI, 0.28-0.82). In contrast, herpes simplex virus type 2 and HIV type 1 prevalence increased with age. Kaposi sarcoma-associated herpesvirus serostatus was not associated with HIV type 1, syphilis, herpes simplex virus type 2, or number of sexual partners. Homosexual and anal intercourse were reported by less than 1% of participants. Conclusions: Kaposi sarcoma-associated herpesvirus does not appear to be a heterosexually transmitted infection in rural Uganda.
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pubLippincott Williams & Wilkins
pmid11234789
doi10.1097/00007435-200102000-00003