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The Transcription Factor Yin Yang 1 Is Essential for Oligodendrocyte Progenitor Differentiation

The progression of progenitors to oligodendrocytes requires proliferative arrest and the activation of a transcriptional program of differentiation. While regulation of cell cycle exit has been extensively characterized, the molecular mechanisms responsible for the initiation of differentiation rema... Full description

Journal Title: Neuron 2007, Vol.55 (2), p.217-230
Main Author: He, Ye
Other Authors: Dupree, Jeff , Wang, Ju , Sandoval, Juan , Li, Jiadong , Liu, Huifei , Shi, Yang , Nave, Klaus Armin , Casaccia-Bonnefil, Patrizia
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0896-6273
Link: https://www.ncbi.nlm.nih.gov/pubmed/17640524
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recordid: cdi_proquest_miscellaneous_70745317
title: The Transcription Factor Yin Yang 1 Is Essential for Oligodendrocyte Progenitor Differentiation
format: Article
creator:
  • He, Ye
  • Dupree, Jeff
  • Wang, Ju
  • Sandoval, Juan
  • Li, Jiadong
  • Liu, Huifei
  • Shi, Yang
  • Nave, Klaus Armin
  • Casaccia-Bonnefil, Patrizia
subjects:
  • Animals
  • Article
  • Ataxia
  • Cell cycle
  • Cell Cycle - genetics
  • Cell Cycle - physiology
  • Cell Differentiation - physiology
  • Cell Lineage - physiology
  • DEVBIO
  • DNA
  • embryonic structures
  • Gene expression
  • Gene Expression Regulation, Developmental - physiology
  • Mice
  • Mice, Knockout
  • Mice, Mutant Strains
  • MOLNEURO
  • Myelin Sheath - metabolism
  • Nerve Fibers, Myelinated - metabolism
  • Neuroscience(all)
  • Oligodendroglia - cytology
  • Oligodendroglia - metabolism
  • Proteins
  • Rodents
  • Software
  • Statistical methods
  • Stem Cells - cytology
  • Stem Cells - metabolism
  • Studies
  • Transcription factors
  • Transcription, Genetic - physiology
  • YY1 Transcription Factor - metabolism
ispartof: Neuron, 2007, Vol.55 (2), p.217-230
description: The progression of progenitors to oligodendrocytes requires proliferative arrest and the activation of a transcriptional program of differentiation. While regulation of cell cycle exit has been extensively characterized, the molecular mechanisms responsible for the initiation of differentiation remain ill-defined. Here, we identify the transcription factor Yin Yang 1 (YY1) as a critical regulator of oligodendrocyte progenitor differentiation. Conditional ablation of yy1 in the oligodendrocyte lineage in vivo induces a phenotype characterized by defective myelination, ataxia, and tremor. At the cellular level, lack of yy1 arrests differentiation of oligodendrocyte progenitors after they exit from the cell cycle. At the molecular level, YY1 acts as a lineage-specific repressor of transcriptional inhibitors of myelin gene expression (Tcf4 and Id4), by recruiting histone deacetylase-1 to their promoters during oligodendrocyte differentiation. Thus, we identify YY1 as an essential component of the transcriptional network regulating the transition of oligodendrocyte progenitors from cell cycle exit to differentiation.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0896-6273
fulltext: fulltext
issn:
  • 0896-6273
  • 1097-4199
url: Link


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descriptionThe progression of progenitors to oligodendrocytes requires proliferative arrest and the activation of a transcriptional program of differentiation. While regulation of cell cycle exit has been extensively characterized, the molecular mechanisms responsible for the initiation of differentiation remain ill-defined. Here, we identify the transcription factor Yin Yang 1 (YY1) as a critical regulator of oligodendrocyte progenitor differentiation. Conditional ablation of yy1 in the oligodendrocyte lineage in vivo induces a phenotype characterized by defective myelination, ataxia, and tremor. At the cellular level, lack of yy1 arrests differentiation of oligodendrocyte progenitors after they exit from the cell cycle. At the molecular level, YY1 acts as a lineage-specific repressor of transcriptional inhibitors of myelin gene expression (Tcf4 and Id4), by recruiting histone deacetylase-1 to their promoters during oligodendrocyte differentiation. Thus, we identify YY1 as an essential component of the transcriptional network regulating the transition of oligodendrocyte progenitors from cell cycle exit to differentiation.
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subjectAnimals ; Article ; Ataxia ; Cell cycle ; Cell Cycle - genetics ; Cell Cycle - physiology ; Cell Differentiation - physiology ; Cell Lineage - physiology ; DEVBIO ; DNA ; embryonic structures ; Gene expression ; Gene Expression Regulation, Developmental - physiology ; Mice ; Mice, Knockout ; Mice, Mutant Strains ; MOLNEURO ; Myelin Sheath - metabolism ; Nerve Fibers, Myelinated - metabolism ; Neuroscience(all) ; Oligodendroglia - cytology ; Oligodendroglia - metabolism ; Proteins ; Rodents ; Software ; Statistical methods ; Stem Cells - cytology ; Stem Cells - metabolism ; Studies ; Transcription factors ; Transcription, Genetic - physiology ; YY1 Transcription Factor - metabolism
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descriptionThe progression of progenitors to oligodendrocytes requires proliferative arrest and the activation of a transcriptional program of differentiation. While regulation of cell cycle exit has been extensively characterized, the molecular mechanisms responsible for the initiation of differentiation remain ill-defined. Here, we identify the transcription factor Yin Yang 1 (YY1) as a critical regulator of oligodendrocyte progenitor differentiation. Conditional ablation of yy1 in the oligodendrocyte lineage in vivo induces a phenotype characterized by defective myelination, ataxia, and tremor. At the cellular level, lack of yy1 arrests differentiation of oligodendrocyte progenitors after they exit from the cell cycle. At the molecular level, YY1 acts as a lineage-specific repressor of transcriptional inhibitors of myelin gene expression (Tcf4 and Id4), by recruiting histone deacetylase-1 to their promoters during oligodendrocyte differentiation. Thus, we identify YY1 as an essential component of the transcriptional network regulating the transition of oligodendrocyte progenitors from cell cycle exit to differentiation.
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abstractThe progression of progenitors to oligodendrocytes requires proliferative arrest and the activation of a transcriptional program of differentiation. While regulation of cell cycle exit has been extensively characterized, the molecular mechanisms responsible for the initiation of differentiation remain ill-defined. Here, we identify the transcription factor Yin Yang 1 (YY1) as a critical regulator of oligodendrocyte progenitor differentiation. Conditional ablation of yy1 in the oligodendrocyte lineage in vivo induces a phenotype characterized by defective myelination, ataxia, and tremor. At the cellular level, lack of yy1 arrests differentiation of oligodendrocyte progenitors after they exit from the cell cycle. At the molecular level, YY1 acts as a lineage-specific repressor of transcriptional inhibitors of myelin gene expression (Tcf4 and Id4), by recruiting histone deacetylase-1 to their promoters during oligodendrocyte differentiation. Thus, we identify YY1 as an essential component of the transcriptional network regulating the transition of oligodendrocyte progenitors from cell cycle exit to differentiation.
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doi10.1016/j.neuron.2007.06.029
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