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Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU study

The amount and quality of fat in the diet could be of importance for development of insulin resistance and related metabolic disorders. Our aim was to determine whether a change in dietary fat quality alone could alter insulin action in humans. The KANWU study included 162 healthy subjects chosen at... Full description

Journal Title: Diabetologia 2001, Vol.44 (3), p.312-319
Main Author: VESSBY, B
Other Authors: UUSITUPA, M , CALVERT, G. D , MAFFETONE, A , PEDERSEN, E , GUSTAFSSON, I.-B , STORLIEN, L. H , HERMANSEN, K , RICCARDI, G , RIVELLESE, A. A , TAPSELL, L. C , NÄLSEN, C , BERGLUND, L , LOUHERANTA, A , RASMUSSEN, B. M
Format: Electronic Article Electronic Article
Language: English
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Publisher: Berlin: Springer
ID: ISSN: 0012-186X
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recordid: cdi_proquest_miscellaneous_70797635
title: Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU study
format: Article
creator:
  • VESSBY, B
  • UUSITUPA, M
  • CALVERT, G. D
  • MAFFETONE, A
  • PEDERSEN, E
  • GUSTAFSSON, I.-B
  • STORLIEN, L. H
  • HERMANSEN, K
  • RICCARDI, G
  • RIVELLESE, A. A
  • TAPSELL, L. C
  • NÄLSEN, C
  • BERGLUND, L
  • LOUHERANTA, A
  • RASMUSSEN, B. M
subjects:
  • Adult
  • Aged
  • Apolipoprotein A-I - blood
  • Apolipoproteins B - blood
  • Biological and medical sciences
  • Blood Glucose - drug effects
  • Blood Glucose - metabolism
  • Blood lipids
  • Cholesterol
  • Cholesterol - blood
  • Cholesterol, HDL - blood
  • Cholesterol, LDL - blood
  • Diabetes. Impaired glucose tolerance
  • Dietary fat
  • Dietary Fats - pharmacology
  • Dietary Fats, Unsaturated - pharmacology
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Fatty Acids, Monounsaturated - pharmacology
  • Fatty Acids, Omega-3 - pharmacology
  • Female
  • Fish Oils - pharmacology
  • Glucose Tolerance Test
  • Health aspects
  • Humans
  • Insulin
  • Insulin - blood
  • Insulin - metabolism
  • Insulin resistance
  • Insulin Secretion
  • Lipoprotein A
  • Lipoprotein(a) - blood
  • Low density lipoproteins
  • Male
  • Medical colleges
  • Medical sciences
  • Middle Aged
  • Monounsaturated fatty acids
  • Omega-3 fatty acids
  • Phospholipids - blood
  • Phospholipids - chemistry
  • Physiological aspects
  • Reference Values
  • Saturated fatty acids
  • Triglycerides - blood
  • Women
ispartof: Diabetologia, 2001, Vol.44 (3), p.312-319
description: The amount and quality of fat in the diet could be of importance for development of insulin resistance and related metabolic disorders. Our aim was to determine whether a change in dietary fat quality alone could alter insulin action in humans. The KANWU study included 162 healthy subjects chosen at random to receive a controlled, isoenergetic diet for 3 months containing either a high proportion of saturated (SAFA diet) or monounsaturated (MUFA diet) fatty acids. Within each group there was a second assignment at random to supplements with fish oil (3.6 g n-3 fatty acids/d) or placebo. Insulin sensitivity was significantly impaired on the saturated fatty acid diet (-10%, p = 0.03) but did not change on the monounsaturated fatty acid diet (+2%, NS) (p = 0.05 for difference between diets). Insulin secretion was not affected. The addition of n-3 fatty acids influenced neither insulin sensitivity nor insulin secretion. The favourable effects of substituting a monounsaturated fatty acid diet for a saturated fatty acid diet on insulin sensitivity were only seen at a total fat intake below median (37E%). Here, insulin sensitivity was 12.5% lower and 8.8% higher on the saturated fatty acid diet and monounsaturated fatty acid diet respectively (p = 0.03). Low density lipoprotein cholesterol (LDL) increased on the saturated fatty acid diet (+4.1%, p < 0.01) but decreased on the monounsaturated fatty acid diet (MUFA) (-5.2, p < 0.001), whereas lipoprotein (a) [Lp(a)] increased on a monounsaturated fatty acid diet by 12% (p < 0.001). A change of the proportions of dietary fatty acids, decreasing saturated fatty acid and increasing monounsaturated fatty acid, improves insulin sensitivity but has no effect on insulin secretion. A beneficial impact of the fat quality on insulin sensitivity is not seen in individuals with a high fat intake (> 37E%).
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleSubstituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU study
creatorVESSBY, B ; UUSITUPA, M ; CALVERT, G. D ; MAFFETONE, A ; PEDERSEN, E ; GUSTAFSSON, I.-B ; STORLIEN, L. H ; HERMANSEN, K ; RICCARDI, G ; RIVELLESE, A. A ; TAPSELL, L. C ; NÄLSEN, C ; BERGLUND, L ; LOUHERANTA, A ; RASMUSSEN, B. M
creatorcontribVESSBY, B ; UUSITUPA, M ; CALVERT, G. D ; MAFFETONE, A ; PEDERSEN, E ; GUSTAFSSON, I.-B ; STORLIEN, L. H ; HERMANSEN, K ; RICCARDI, G ; RIVELLESE, A. A ; TAPSELL, L. C ; NÄLSEN, C ; BERGLUND, L ; LOUHERANTA, A ; RASMUSSEN, B. M ; KANWU Study
descriptionThe amount and quality of fat in the diet could be of importance for development of insulin resistance and related metabolic disorders. Our aim was to determine whether a change in dietary fat quality alone could alter insulin action in humans. The KANWU study included 162 healthy subjects chosen at random to receive a controlled, isoenergetic diet for 3 months containing either a high proportion of saturated (SAFA diet) or monounsaturated (MUFA diet) fatty acids. Within each group there was a second assignment at random to supplements with fish oil (3.6 g n-3 fatty acids/d) or placebo. Insulin sensitivity was significantly impaired on the saturated fatty acid diet (-10%, p = 0.03) but did not change on the monounsaturated fatty acid diet (+2%, NS) (p = 0.05 for difference between diets). Insulin secretion was not affected. The addition of n-3 fatty acids influenced neither insulin sensitivity nor insulin secretion. The favourable effects of substituting a monounsaturated fatty acid diet for a saturated fatty acid diet on insulin sensitivity were only seen at a total fat intake below median (37E%). Here, insulin sensitivity was 12.5% lower and 8.8% higher on the saturated fatty acid diet and monounsaturated fatty acid diet respectively (p = 0.03). Low density lipoprotein cholesterol (LDL) increased on the saturated fatty acid diet (+4.1%, p < 0.01) but decreased on the monounsaturated fatty acid diet (MUFA) (-5.2, p < 0.001), whereas lipoprotein (a) [Lp(a)] increased on a monounsaturated fatty acid diet by 12% (p < 0.001). A change of the proportions of dietary fatty acids, decreasing saturated fatty acid and increasing monounsaturated fatty acid, improves insulin sensitivity but has no effect on insulin secretion. A beneficial impact of the fat quality on insulin sensitivity is not seen in individuals with a high fat intake (> 37E%).
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0ISSN: 0012-186X
1EISSN: 1432-0428
2DOI: 10.1007/s001250051620
3PMID: 11317662
languageeng
publisherBerlin: Springer
subjectAdult ; Aged ; Apolipoprotein A-I - blood ; Apolipoproteins B - blood ; Biological and medical sciences ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Blood lipids ; Cholesterol ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Diabetes. Impaired glucose tolerance ; Dietary fat ; Dietary Fats - pharmacology ; Dietary Fats, Unsaturated - pharmacology ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty Acids, Monounsaturated - pharmacology ; Fatty Acids, Omega-3 - pharmacology ; Female ; Fish Oils - pharmacology ; Glucose Tolerance Test ; Health aspects ; Humans ; Insulin ; Insulin - blood ; Insulin - metabolism ; Insulin resistance ; Insulin Secretion ; Lipoprotein A ; Lipoprotein(a) - blood ; Low density lipoproteins ; Male ; Medical colleges ; Medical sciences ; Middle Aged ; Monounsaturated fatty acids ; Omega-3 fatty acids ; Phospholipids - blood ; Phospholipids - chemistry ; Physiological aspects ; Reference Values ; Saturated fatty acids ; Triglycerides - blood ; Women
ispartofDiabetologia, 2001, Vol.44 (3), p.312-319
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0VESSBY, B
1UUSITUPA, M
2CALVERT, G. D
3MAFFETONE, A
4PEDERSEN, E
5GUSTAFSSON, I.-B
6STORLIEN, L. H
7HERMANSEN, K
8RICCARDI, G
9RIVELLESE, A. A
10TAPSELL, L. C
11NÄLSEN, C
12BERGLUND, L
13LOUHERANTA, A
14RASMUSSEN, B. M
15KANWU Study
title
0Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU study
1Diabetologia
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descriptionThe amount and quality of fat in the diet could be of importance for development of insulin resistance and related metabolic disorders. Our aim was to determine whether a change in dietary fat quality alone could alter insulin action in humans. The KANWU study included 162 healthy subjects chosen at random to receive a controlled, isoenergetic diet for 3 months containing either a high proportion of saturated (SAFA diet) or monounsaturated (MUFA diet) fatty acids. Within each group there was a second assignment at random to supplements with fish oil (3.6 g n-3 fatty acids/d) or placebo. Insulin sensitivity was significantly impaired on the saturated fatty acid diet (-10%, p = 0.03) but did not change on the monounsaturated fatty acid diet (+2%, NS) (p = 0.05 for difference between diets). Insulin secretion was not affected. The addition of n-3 fatty acids influenced neither insulin sensitivity nor insulin secretion. The favourable effects of substituting a monounsaturated fatty acid diet for a saturated fatty acid diet on insulin sensitivity were only seen at a total fat intake below median (37E%). Here, insulin sensitivity was 12.5% lower and 8.8% higher on the saturated fatty acid diet and monounsaturated fatty acid diet respectively (p = 0.03). Low density lipoprotein cholesterol (LDL) increased on the saturated fatty acid diet (+4.1%, p < 0.01) but decreased on the monounsaturated fatty acid diet (MUFA) (-5.2, p < 0.001), whereas lipoprotein (a) [Lp(a)] increased on a monounsaturated fatty acid diet by 12% (p < 0.001). A change of the proportions of dietary fatty acids, decreasing saturated fatty acid and increasing monounsaturated fatty acid, improves insulin sensitivity but has no effect on insulin secretion. A beneficial impact of the fat quality on insulin sensitivity is not seen in individuals with a high fat intake (> 37E%).
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2Apolipoprotein A-I - blood
3Apolipoproteins B - blood
4Biological and medical sciences
5Blood Glucose - drug effects
6Blood Glucose - metabolism
7Blood lipids
8Cholesterol
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10Cholesterol, HDL - blood
11Cholesterol, LDL - blood
12Diabetes. Impaired glucose tolerance
13Dietary fat
14Dietary Fats - pharmacology
15Dietary Fats, Unsaturated - pharmacology
16Endocrine pancreas. Apud cells (diseases)
17Endocrinopathies
18Etiopathogenesis. Screening. Investigations. Target tissue resistance
19Fatty Acids, Monounsaturated - pharmacology
20Fatty Acids, Omega-3 - pharmacology
21Female
22Fish Oils - pharmacology
23Glucose Tolerance Test
24Health aspects
25Humans
26Insulin
27Insulin - blood
28Insulin - metabolism
29Insulin resistance
30Insulin Secretion
31Lipoprotein A
32Lipoprotein(a) - blood
33Low density lipoproteins
34Male
35Medical colleges
36Medical sciences
37Middle Aged
38Monounsaturated fatty acids
39Omega-3 fatty acids
40Phospholipids - blood
41Phospholipids - chemistry
42Physiological aspects
43Reference Values
44Saturated fatty acids
45Triglycerides - blood
46Women
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3MAFFETONE, A
4PEDERSEN, E
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6STORLIEN, L. H
7HERMANSEN, K
8RICCARDI, G
9RIVELLESE, A. A
10TAPSELL, L. C
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titleSubstituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU study
authorVESSBY, B ; UUSITUPA, M ; CALVERT, G. D ; MAFFETONE, A ; PEDERSEN, E ; GUSTAFSSON, I.-B ; STORLIEN, L. H ; HERMANSEN, K ; RICCARDI, G ; RIVELLESE, A. A ; TAPSELL, L. C ; NÄLSEN, C ; BERGLUND, L ; LOUHERANTA, A ; RASMUSSEN, B. M
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1Aged
2Apolipoprotein A-I - blood
3Apolipoproteins B - blood
4Biological and medical sciences
5Blood Glucose - drug effects
6Blood Glucose - metabolism
7Blood lipids
8Cholesterol
9Cholesterol - blood
10Cholesterol, HDL - blood
11Cholesterol, LDL - blood
12Diabetes. Impaired glucose tolerance
13Dietary fat
14Dietary Fats - pharmacology
15Dietary Fats, Unsaturated - pharmacology
16Endocrine pancreas. Apud cells (diseases)
17Endocrinopathies
18Etiopathogenesis. Screening. Investigations. Target tissue resistance
19Fatty Acids, Monounsaturated - pharmacology
20Fatty Acids, Omega-3 - pharmacology
21Female
22Fish Oils - pharmacology
23Glucose Tolerance Test
24Health aspects
25Humans
26Insulin
27Insulin - blood
28Insulin - metabolism
29Insulin resistance
30Insulin Secretion
31Lipoprotein A
32Lipoprotein(a) - blood
33Low density lipoproteins
34Male
35Medical colleges
36Medical sciences
37Middle Aged
38Monounsaturated fatty acids
39Omega-3 fatty acids
40Phospholipids - blood
41Phospholipids - chemistry
42Physiological aspects
43Reference Values
44Saturated fatty acids
45Triglycerides - blood
46Women
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abstractThe amount and quality of fat in the diet could be of importance for development of insulin resistance and related metabolic disorders. Our aim was to determine whether a change in dietary fat quality alone could alter insulin action in humans. The KANWU study included 162 healthy subjects chosen at random to receive a controlled, isoenergetic diet for 3 months containing either a high proportion of saturated (SAFA diet) or monounsaturated (MUFA diet) fatty acids. Within each group there was a second assignment at random to supplements with fish oil (3.6 g n-3 fatty acids/d) or placebo. Insulin sensitivity was significantly impaired on the saturated fatty acid diet (-10%, p = 0.03) but did not change on the monounsaturated fatty acid diet (+2%, NS) (p = 0.05 for difference between diets). Insulin secretion was not affected. The addition of n-3 fatty acids influenced neither insulin sensitivity nor insulin secretion. The favourable effects of substituting a monounsaturated fatty acid diet for a saturated fatty acid diet on insulin sensitivity were only seen at a total fat intake below median (37E%). Here, insulin sensitivity was 12.5% lower and 8.8% higher on the saturated fatty acid diet and monounsaturated fatty acid diet respectively (p = 0.03). Low density lipoprotein cholesterol (LDL) increased on the saturated fatty acid diet (+4.1%, p < 0.01) but decreased on the monounsaturated fatty acid diet (MUFA) (-5.2, p < 0.001), whereas lipoprotein (a) [Lp(a)] increased on a monounsaturated fatty acid diet by 12% (p < 0.001). A change of the proportions of dietary fatty acids, decreasing saturated fatty acid and increasing monounsaturated fatty acid, improves insulin sensitivity but has no effect on insulin secretion. A beneficial impact of the fat quality on insulin sensitivity is not seen in individuals with a high fat intake (> 37E%).
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