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LDL size and susceptibility to oxidation in experimental nephrosis

The aim of this study was to investigate the relationship between endothelial dysfunction and low density lipoprotein (LDL) size and susceptibility to oxidation in nephrotic rats with or without deficiency of vitamin E and selenium. Four groups of male Wistar rats were studied: control (C), vitamin... Full description

Journal Title: Molecular and cellular biochemistry 2001, Vol.220 (1-2), p.61-68
Main Author: Posadas-Sánchez, R
Other Authors: Posadas-Romero, C , Zamora-González, J , Hernández-Ono, A , Baños-Marhaber, G , Campos, O N , Pedraza-Chaverrí, J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Netherlands: Springer Nature B.V
ID: ISSN: 0300-8177
Link: https://www.ncbi.nlm.nih.gov/pubmed/11451384
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title: LDL size and susceptibility to oxidation in experimental nephrosis
format: Article
creator:
  • Posadas-Sánchez, R
  • Posadas-Romero, C
  • Zamora-González, J
  • Hernández-Ono, A
  • Baños-Marhaber, G
  • Campos, O N
  • Pedraza-Chaverrí, J
subjects:
  • Acetylcholine - pharmacology
  • Animals
  • Carbachol - pharmacology
  • Endothelium, Vascular - metabolism
  • Hypercholesterolemia - blood
  • Hypercholesterolemia - metabolism
  • Lipid Metabolism
  • Lipoproteins, LDL - blood
  • Lipoproteins, LDL - chemistry
  • Lipoproteins, LDL - metabolism
  • Low density lipoprotein
  • Male
  • Multivariate Analysis
  • Nephrosis - blood
  • Nephrotic Syndrome - blood
  • Nephrotic Syndrome - metabolism
  • Oxygen - metabolism
  • Rats
  • Rats, Wistar
  • Rodents
  • Selenium
  • Selenium - metabolism
  • Vasodilation
  • Vitamin E - blood
  • Vitamin E - metabolism
  • Vitamin E Deficiency - blood
ispartof: Molecular and cellular biochemistry, 2001, Vol.220 (1-2), p.61-68
description: The aim of this study was to investigate the relationship between endothelial dysfunction and low density lipoprotein (LDL) size and susceptibility to oxidation in nephrotic rats with or without deficiency of vitamin E and selenium. Four groups of male Wistar rats were studied: control (C), vitamin E and selenium deficient control (DefC), nephrotic (NS), and vitamin E and selenium deficient NS (DefNS). Nephrotic syndrome was induced by puromycin aminonucleoside. The molar ratio of vitamin E/LDL-cholesterol was significantly lower in DefNS, DefC rats, and NS vs. C rats. In comparison with control animals, vasodilation and LDL oxidability were significantly lower in nephrotic animals. LDL size was similar in all groups. Abnormal endothelial function in response to acetylcholine and carbachol was observed in NS animals compared to control rats. Relaxation response was inversely associated with an increase in LDL susceptibility to oxidation and with a lower molar ratio of vitamin E/LDL-c. LDL oxidability and LDL-c were the only variables independently associated with vasodilation. These results suggest that endothelial dysfunction of NS may be a consequence of the increased LDL susceptibility to oxidation, secondary to antioxidant deficiency.
language: eng
source:
identifier: ISSN: 0300-8177
fulltext: no_fulltext
issn:
  • 0300-8177
  • 1573-4919
url: Link


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titleLDL size and susceptibility to oxidation in experimental nephrosis
creatorPosadas-Sánchez, R ; Posadas-Romero, C ; Zamora-González, J ; Hernández-Ono, A ; Baños-Marhaber, G ; Campos, O N ; Pedraza-Chaverrí, J
creatorcontribPosadas-Sánchez, R ; Posadas-Romero, C ; Zamora-González, J ; Hernández-Ono, A ; Baños-Marhaber, G ; Campos, O N ; Pedraza-Chaverrí, J
descriptionThe aim of this study was to investigate the relationship between endothelial dysfunction and low density lipoprotein (LDL) size and susceptibility to oxidation in nephrotic rats with or without deficiency of vitamin E and selenium. Four groups of male Wistar rats were studied: control (C), vitamin E and selenium deficient control (DefC), nephrotic (NS), and vitamin E and selenium deficient NS (DefNS). Nephrotic syndrome was induced by puromycin aminonucleoside. The molar ratio of vitamin E/LDL-cholesterol was significantly lower in DefNS, DefC rats, and NS vs. C rats. In comparison with control animals, vasodilation and LDL oxidability were significantly lower in nephrotic animals. LDL size was similar in all groups. Abnormal endothelial function in response to acetylcholine and carbachol was observed in NS animals compared to control rats. Relaxation response was inversely associated with an increase in LDL susceptibility to oxidation and with a lower molar ratio of vitamin E/LDL-c. LDL oxidability and LDL-c were the only variables independently associated with vasodilation. These results suggest that endothelial dysfunction of NS may be a consequence of the increased LDL susceptibility to oxidation, secondary to antioxidant deficiency.
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subjectAcetylcholine - pharmacology ; Animals ; Carbachol - pharmacology ; Endothelium, Vascular - metabolism ; Hypercholesterolemia - blood ; Hypercholesterolemia - metabolism ; Lipid Metabolism ; Lipoproteins, LDL - blood ; Lipoproteins, LDL - chemistry ; Lipoproteins, LDL - metabolism ; Low density lipoprotein ; Male ; Multivariate Analysis ; Nephrosis - blood ; Nephrotic Syndrome - blood ; Nephrotic Syndrome - metabolism ; Oxygen - metabolism ; Rats ; Rats, Wistar ; Rodents ; Selenium ; Selenium - metabolism ; Vasodilation ; Vitamin E - blood ; Vitamin E - metabolism ; Vitamin E Deficiency - blood
ispartofMolecular and cellular biochemistry, 2001, Vol.220 (1-2), p.61-68
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descriptionThe aim of this study was to investigate the relationship between endothelial dysfunction and low density lipoprotein (LDL) size and susceptibility to oxidation in nephrotic rats with or without deficiency of vitamin E and selenium. Four groups of male Wistar rats were studied: control (C), vitamin E and selenium deficient control (DefC), nephrotic (NS), and vitamin E and selenium deficient NS (DefNS). Nephrotic syndrome was induced by puromycin aminonucleoside. The molar ratio of vitamin E/LDL-cholesterol was significantly lower in DefNS, DefC rats, and NS vs. C rats. In comparison with control animals, vasodilation and LDL oxidability were significantly lower in nephrotic animals. LDL size was similar in all groups. Abnormal endothelial function in response to acetylcholine and carbachol was observed in NS animals compared to control rats. Relaxation response was inversely associated with an increase in LDL susceptibility to oxidation and with a lower molar ratio of vitamin E/LDL-c. LDL oxidability and LDL-c were the only variables independently associated with vasodilation. These results suggest that endothelial dysfunction of NS may be a consequence of the increased LDL susceptibility to oxidation, secondary to antioxidant deficiency.
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0Acetylcholine - pharmacology
1Animals
2Carbachol - pharmacology
3Endothelium, Vascular - metabolism
4Hypercholesterolemia - blood
5Hypercholesterolemia - metabolism
6Lipid Metabolism
7Lipoproteins, LDL - blood
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13Nephrosis - blood
14Nephrotic Syndrome - blood
15Nephrotic Syndrome - metabolism
16Oxygen - metabolism
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20Selenium
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abstractThe aim of this study was to investigate the relationship between endothelial dysfunction and low density lipoprotein (LDL) size and susceptibility to oxidation in nephrotic rats with or without deficiency of vitamin E and selenium. Four groups of male Wistar rats were studied: control (C), vitamin E and selenium deficient control (DefC), nephrotic (NS), and vitamin E and selenium deficient NS (DefNS). Nephrotic syndrome was induced by puromycin aminonucleoside. The molar ratio of vitamin E/LDL-cholesterol was significantly lower in DefNS, DefC rats, and NS vs. C rats. In comparison with control animals, vasodilation and LDL oxidability were significantly lower in nephrotic animals. LDL size was similar in all groups. Abnormal endothelial function in response to acetylcholine and carbachol was observed in NS animals compared to control rats. Relaxation response was inversely associated with an increase in LDL susceptibility to oxidation and with a lower molar ratio of vitamin E/LDL-c. LDL oxidability and LDL-c were the only variables independently associated with vasodilation. These results suggest that endothelial dysfunction of NS may be a consequence of the increased LDL susceptibility to oxidation, secondary to antioxidant deficiency.
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pmid11451384
doi10.1023/A:1010874306937