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Association studies of genetic polymorphisms and complex disease

The strength of the association between a candidate gene polymorphism (allele) and a complex disease (measured as odds ratios in case-control studies) is used to try and gauge the importance of an underlying aetiology. The possible implications at the population level can be illustrated by the T594M... Full description

Journal Title: The Lancet (British edition) 2000-04-08, Vol.355 (9211), p.1278-1278
Main Author: Cappuccio, Francesco P
Other Authors: Sagnella, Giuseppe A , MacGregor, Graham A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Ltd
ID: ISSN: 0140-6736
Link: https://www.ncbi.nlm.nih.gov/pubmed/10770333
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title: Association studies of genetic polymorphisms and complex disease
format: Article
creator:
  • Cappuccio, Francesco P
  • Sagnella, Giuseppe A
  • MacGregor, Graham A
subjects:
  • Abridged Index Medicus
  • Cardiovascular Diseases - genetics
  • Case-Control Studies
  • Confounding Factors (Epidemiology)
  • Disease
  • Disease prevention
  • Health risk assessment
  • Humans
  • Hypertension
  • Odds Ratio
  • Polymorphism, Genetic
  • Population
ispartof: The Lancet (British edition), 2000-04-08, Vol.355 (9211), p.1278-1278
description: The strength of the association between a candidate gene polymorphism (allele) and a complex disease (measured as odds ratios in case-control studies) is used to try and gauge the importance of an underlying aetiology. The possible implications at the population level can be illustrated by the T594M polymorphism (of the β sub-unit of the epithelial sodium channel)2,3 and the C825T polymorphism (of the G-protein β3 subunit)4 that appear to be associated with blood pressure in black people. [...]a large effort in population-based molecular studies has produced rather modest results.5 There is a need for caution in investing disproportionate resources into large-scale genetic epidemiology, when a moderate investment in known modifiable environmental causes of complex diseases could lead to a substantial reduction of disease in the population—eg, cardiovascular disease.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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descriptionThe strength of the association between a candidate gene polymorphism (allele) and a complex disease (measured as odds ratios in case-control studies) is used to try and gauge the importance of an underlying aetiology. The possible implications at the population level can be illustrated by the T594M polymorphism (of the β sub-unit of the epithelial sodium channel)2,3 and the C825T polymorphism (of the G-protein β3 subunit)4 that appear to be associated with blood pressure in black people. [...]a large effort in population-based molecular studies has produced rather modest results.5 There is a need for caution in investing disproportionate resources into large-scale genetic epidemiology, when a moderate investment in known modifiable environmental causes of complex diseases could lead to a substantial reduction of disease in the population—eg, cardiovascular disease.
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subjectAbridged Index Medicus ; Cardiovascular Diseases - genetics ; Case-Control Studies ; Confounding Factors (Epidemiology) ; Disease ; Disease prevention ; Health risk assessment ; Humans ; Hypertension ; Odds Ratio ; Polymorphism, Genetic ; Population
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descriptionThe strength of the association between a candidate gene polymorphism (allele) and a complex disease (measured as odds ratios in case-control studies) is used to try and gauge the importance of an underlying aetiology. The possible implications at the population level can be illustrated by the T594M polymorphism (of the β sub-unit of the epithelial sodium channel)2,3 and the C825T polymorphism (of the G-protein β3 subunit)4 that appear to be associated with blood pressure in black people. [...]a large effort in population-based molecular studies has produced rather modest results.5 There is a need for caution in investing disproportionate resources into large-scale genetic epidemiology, when a moderate investment in known modifiable environmental causes of complex diseases could lead to a substantial reduction of disease in the population—eg, cardiovascular disease.
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abstractThe strength of the association between a candidate gene polymorphism (allele) and a complex disease (measured as odds ratios in case-control studies) is used to try and gauge the importance of an underlying aetiology. The possible implications at the population level can be illustrated by the T594M polymorphism (of the β sub-unit of the epithelial sodium channel)2,3 and the C825T polymorphism (of the G-protein β3 subunit)4 that appear to be associated with blood pressure in black people. [...]a large effort in population-based molecular studies has produced rather modest results.5 There is a need for caution in investing disproportionate resources into large-scale genetic epidemiology, when a moderate investment in known modifiable environmental causes of complex diseases could lead to a substantial reduction of disease in the population—eg, cardiovascular disease.
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pmid10770333
doi10.1016/S0140-6736(05)74711-5