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Frequency of C3435T polymorphism of MDR1 gene in African people

The variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C... Full description

Journal Title: The Lancet (British edition) 2001, Vol.358 (9279), p.383-384
Main Author: Schaeffeler, Elke
Other Authors: Eichelbaum, Michel , Brinkmann, Ulrich , Penger, Anja , Asante-Poku, Steven , Zanger, Ulrich M , Schwab, Matthias
Format: Electronic Article Electronic Article
Language: English
Subjects:
Abridged Index Medicus
African Americans
African Continental Ancestry Group
Africans
Antineoplastic agents
Asian Continental Ancestry Group
ATP-Binding Cassette, Sub-Family B, Member 1 - genetics
Bioavailability
Biological and medical sciences
Black people
Cells
Demographic aspects
Drug resistance
Drug therapy
Epithelial cells
European Continental Ancestry Group
Gene expression
Gene Frequency
Gene mutations
Gene polymorphism
General aspects
Genes
Genes, MDR - genetics
Genetic aspects
Genetic polymorphisms
Genotype
Ghana
Glycoproteins
Humans
Infectious diseases
Intestine
Lymphoid cells
MDR1 protein
Medical colleges
Medical sciences
Minority & ethnic groups
Mutation
P-Glycoprotein
Pharmacogenetics
Pharmacology. Drug treatments
Physiological aspects
Plasmodium falciparum
Polymorphism
Polymorphism, Genetic
Protease inhibitors
Proteases
Proteinase inhibitors
Proteins
Random Allocation
Salmonella Typhi
Substrate inhibition
Tropical diseases
Viral infections
White people
Quelle: Alma/SFX Local Collection
Publisher: London: Elsevier Ltd
ID: ISSN: 0140-6736
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recordid: cdi_proquest_miscellaneous_71128457
title: Frequency of C3435T polymorphism of MDR1 gene in African people
format: Article
creator:
  • Schaeffeler, Elke
  • Eichelbaum, Michel
  • Brinkmann, Ulrich
  • Penger, Anja
  • Asante-Poku, Steven
  • Zanger, Ulrich M
  • Schwab, Matthias
subjects:
  • Abridged Index Medicus
  • African Americans
  • African Continental Ancestry Group
  • Africans
  • Antineoplastic agents
  • Asian Continental Ancestry Group
  • ATP-Binding Cassette, Sub-Family B, Member 1 - genetics
  • Bioavailability
  • Biological and medical sciences
  • Black people
  • Cells
  • Demographic aspects
  • Drug resistance
  • Drug therapy
  • Epithelial cells
  • European Continental Ancestry Group
  • Gene expression
  • Gene Frequency
  • Gene mutations
  • Gene polymorphism
  • General aspects
  • Genes
  • Genes, MDR - genetics
  • Genetic aspects
  • Genetic polymorphisms
  • Genotype
  • Ghana
  • Glycoproteins
  • Humans
  • Infectious diseases
  • Intestine
  • Lymphoid cells
  • MDR1 protein
  • Medical colleges
  • Medical sciences
  • Minority & ethnic groups
  • Mutation
  • P-Glycoprotein
  • Pharmacogenetics
  • Pharmacology. Drug treatments
  • Physiological aspects
  • Plasmodium falciparum
  • Polymorphism
  • Polymorphism, Genetic
  • Protease inhibitors
  • Proteases
  • Proteinase inhibitors
  • Proteins
  • Random Allocation
  • Salmonella Typhi
  • Substrate inhibition
  • Tropical diseases
  • Viral infections
  • White people
ispartof: The Lancet (British edition), 2001, Vol.358 (9279), p.383-384
description: The variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype. We compared allele frequencies of the C3435T polymorphism in random samples of west African, African American, white, and Japanese people. We recorded a significantly higher frequency of the C/C genotype in West Africans and African Americans (142 of 172 [83%] and 25 of 41 [61%], respectively), than in white people (139 of 537 [26%]) (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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creatorSchaeffeler, Elke ; Eichelbaum, Michel ; Brinkmann, Ulrich ; Penger, Anja ; Asante-Poku, Steven ; Zanger, Ulrich M ; Schwab, Matthias
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descriptionThe variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype. We compared allele frequencies of the C3435T polymorphism in random samples of west African, African American, white, and Japanese people. We recorded a significantly higher frequency of the C/C genotype in West Africans and African Americans (142 of 172 [83%] and 25 of 41 [61%], respectively), than in white people (139 of 537 [26%]) (p<0·0001). These findings could affect use of drugs that are P-glycoprotein substrates (such as HIV-1 protease inhibitors and ciclosporin) in African populations.
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languageeng
publisherLondon: Elsevier Ltd
subjectAbridged Index Medicus ; African Americans ; African Continental Ancestry Group ; Africans ; Antineoplastic agents ; Asian Continental Ancestry Group ; ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ; Bioavailability ; Biological and medical sciences ; Black people ; Cells ; Demographic aspects ; Drug resistance ; Drug therapy ; Epithelial cells ; European Continental Ancestry Group ; Gene expression ; Gene Frequency ; Gene mutations ; Gene polymorphism ; General aspects ; Genes ; Genes, MDR - genetics ; Genetic aspects ; Genetic polymorphisms ; Genotype ; Ghana ; Glycoproteins ; Humans ; Infectious diseases ; Intestine ; Lymphoid cells ; MDR1 protein ; Medical colleges ; Medical sciences ; Minority & ethnic groups ; Mutation ; P-Glycoprotein ; Pharmacogenetics ; Pharmacology. Drug treatments ; Physiological aspects ; Plasmodium falciparum ; Polymorphism ; Polymorphism, Genetic ; Protease inhibitors ; Proteases ; Proteinase inhibitors ; Proteins ; Random Allocation ; Salmonella Typhi ; Substrate inhibition ; Tropical diseases ; Viral infections ; White people
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descriptionThe variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype. We compared allele frequencies of the C3435T polymorphism in random samples of west African, African American, white, and Japanese people. We recorded a significantly higher frequency of the C/C genotype in West Africans and African Americans (142 of 172 [83%] and 25 of 41 [61%], respectively), than in white people (139 of 537 [26%]) (p<0·0001). These findings could affect use of drugs that are P-glycoprotein substrates (such as HIV-1 protease inhibitors and ciclosporin) in African populations.
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0Abridged Index Medicus
1African Americans
2African Continental Ancestry Group
3Africans
4Antineoplastic agents
5Asian Continental Ancestry Group
6ATP-Binding Cassette, Sub-Family B, Member 1 - genetics
7Bioavailability
8Biological and medical sciences
9Black people
10Cells
11Demographic aspects
12Drug resistance
13Drug therapy
14Epithelial cells
15European Continental Ancestry Group
16Gene expression
17Gene Frequency
18Gene mutations
19Gene polymorphism
20General aspects
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27Glycoproteins
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33Medical colleges
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36Mutation
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42Polymorphism
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44Protease inhibitors
45Proteases
46Proteinase inhibitors
47Proteins
48Random Allocation
49Salmonella Typhi
50Substrate inhibition
51Tropical diseases
52Viral infections
53White people
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titleFrequency of C3435T polymorphism of MDR1 gene in African people
authorSchaeffeler, Elke ; Eichelbaum, Michel ; Brinkmann, Ulrich ; Penger, Anja ; Asante-Poku, Steven ; Zanger, Ulrich M ; Schwab, Matthias
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1African Americans
2African Continental Ancestry Group
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4Antineoplastic agents
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1Eichelbaum, Michel
2Brinkmann, Ulrich
3Penger, Anja
4Asante-Poku, Steven
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atitleFrequency of C3435T polymorphism of MDR1 gene in African people
jtitleThe Lancet (British edition)
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date2001-08-04
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volume358
issue9279
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pages383-384
issn0140-6736
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abstractThe variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype. We compared allele frequencies of the C3435T polymorphism in random samples of west African, African American, white, and Japanese people. We recorded a significantly higher frequency of the C/C genotype in West Africans and African Americans (142 of 172 [83%] and 25 of 41 [61%], respectively), than in white people (139 of 537 [26%]) (p<0·0001). These findings could affect use of drugs that are P-glycoprotein substrates (such as HIV-1 protease inhibitors and ciclosporin) in African populations.
copLondon
pubElsevier Ltd
pmid11502320
doi10.1016/S0140-6736(01)05579-9