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Frequency of C3435T polymorphism of MDR1 gene in African people

The variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C... Full description

Journal Title: The Lancet (British edition) 2001, Vol.358 (9279), p.383-384
Main Author: Schaeffeler, Elke
Other Authors: Eichelbaum, Michel , Brinkmann, Ulrich , Penger, Anja , Asante-Poku, Steven , Zanger, Ulrich M , Schwab, Matthias
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: Elsevier Ltd
ID: ISSN: 0140-6736
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recordid: cdi_proquest_miscellaneous_71128457
title: Frequency of C3435T polymorphism of MDR1 gene in African people
format: Article
creator:
  • Schaeffeler, Elke
  • Eichelbaum, Michel
  • Brinkmann, Ulrich
  • Penger, Anja
  • Asante-Poku, Steven
  • Zanger, Ulrich M
  • Schwab, Matthias
subjects:
  • Abridged Index Medicus
  • African Americans
  • African Continental Ancestry Group
  • Africans
  • Antineoplastic agents
  • Asian Continental Ancestry Group
  • ATP-Binding Cassette, Sub-Family B, Member 1 - genetics
  • Bioavailability
  • Biological and medical sciences
  • Black people
  • Cells
  • Demographic aspects
  • Drug resistance
  • Drug therapy
  • Epithelial cells
  • European Continental Ancestry Group
  • Gene expression
  • Gene Frequency
  • Gene mutations
  • Gene polymorphism
  • General aspects
  • Genes
  • Genes, MDR - genetics
  • Genetic aspects
  • Genetic polymorphisms
  • Genotype
  • Ghana
  • Glycoproteins
  • Humans
  • Infectious diseases
  • Intestine
  • Lymphoid cells
  • MDR1 protein
  • Medical colleges
  • Medical sciences
  • Minority & ethnic groups
  • Mutation
  • P-Glycoprotein
  • Pharmacogenetics
  • Pharmacology. Drug treatments
  • Physiological aspects
  • Plasmodium falciparum
  • Polymorphism
  • Polymorphism, Genetic
  • Protease inhibitors
  • Proteases
  • Proteinase inhibitors
  • Proteins
  • Random Allocation
  • Salmonella Typhi
  • Substrate inhibition
  • Tropical diseases
  • Viral infections
  • White people
ispartof: The Lancet (British edition), 2001, Vol.358 (9279), p.383-384
description: The variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype. We compared allele frequencies of the C3435T polymorphism in random samples of west African, African American, white, and Japanese people. We recorded a significantly higher frequency of the C/C genotype in West Africans and African Americans (142 of 172 [83%] and 25 of 41 [61%], respectively), than in white people (139 of 537 [26%]) (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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creatorSchaeffeler, Elke ; Eichelbaum, Michel ; Brinkmann, Ulrich ; Penger, Anja ; Asante-Poku, Steven ; Zanger, Ulrich M ; Schwab, Matthias
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descriptionThe variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype. We compared allele frequencies of the C3435T polymorphism in random samples of west African, African American, white, and Japanese people. We recorded a significantly higher frequency of the C/C genotype in West Africans and African Americans (142 of 172 [83%] and 25 of 41 [61%], respectively), than in white people (139 of 537 [26%]) (p<0·0001). These findings could affect use of drugs that are P-glycoprotein substrates (such as HIV-1 protease inhibitors and ciclosporin) in African populations.
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languageeng
publisherLondon: Elsevier Ltd
subjectAbridged Index Medicus ; African Americans ; African Continental Ancestry Group ; Africans ; Antineoplastic agents ; Asian Continental Ancestry Group ; ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ; Bioavailability ; Biological and medical sciences ; Black people ; Cells ; Demographic aspects ; Drug resistance ; Drug therapy ; Epithelial cells ; European Continental Ancestry Group ; Gene expression ; Gene Frequency ; Gene mutations ; Gene polymorphism ; General aspects ; Genes ; Genes, MDR - genetics ; Genetic aspects ; Genetic polymorphisms ; Genotype ; Ghana ; Glycoproteins ; Humans ; Infectious diseases ; Intestine ; Lymphoid cells ; MDR1 protein ; Medical colleges ; Medical sciences ; Minority & ethnic groups ; Mutation ; P-Glycoprotein ; Pharmacogenetics ; Pharmacology. Drug treatments ; Physiological aspects ; Plasmodium falciparum ; Polymorphism ; Polymorphism, Genetic ; Protease inhibitors ; Proteases ; Proteinase inhibitors ; Proteins ; Random Allocation ; Salmonella Typhi ; Substrate inhibition ; Tropical diseases ; Viral infections ; White people
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descriptionThe variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype. We compared allele frequencies of the C3435T polymorphism in random samples of west African, African American, white, and Japanese people. We recorded a significantly higher frequency of the C/C genotype in West Africans and African Americans (142 of 172 [83%] and 25 of 41 [61%], respectively), than in white people (139 of 537 [26%]) (p<0·0001). These findings could affect use of drugs that are P-glycoprotein substrates (such as HIV-1 protease inhibitors and ciclosporin) in African populations.
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4Antineoplastic agents
5Asian Continental Ancestry Group
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44Protease inhibitors
45Proteases
46Proteinase inhibitors
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49Salmonella Typhi
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51Tropical diseases
52Viral infections
53White people
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abstractThe variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype. We compared allele frequencies of the C3435T polymorphism in random samples of west African, African American, white, and Japanese people. We recorded a significantly higher frequency of the C/C genotype in West Africans and African Americans (142 of 172 [83%] and 25 of 41 [61%], respectively), than in white people (139 of 537 [26%]) (p<0·0001). These findings could affect use of drugs that are P-glycoprotein substrates (such as HIV-1 protease inhibitors and ciclosporin) in African populations.
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pubElsevier Ltd
pmid11502320
doi10.1016/S0140-6736(01)05579-9