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Statin therapy and the acute inflammatory response after coronary artery bypass grafting

Preoperative statin therapy has been shown to improve cardiovascular outcome after coronary artery bypass grafting; however, the clinical gain achieved is in excess of the reduction of lipids. Brull et al demonstrate that statin therapy exerts a direct anti-inflammatory effect mediated through reduc... Full description

Journal Title: The American journal of cardiology 2001-08-15, Vol.88 (4), p.431-433
Main Author: Brull, David J
Other Authors: Sanders, Julie , Rumley, Ann , Lowe, Gordon D.O , Humphries, Steve E , Montgomery, Hugh E
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0002-9149
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title: Statin therapy and the acute inflammatory response after coronary artery bypass grafting
format: Article
creator:
  • Brull, David J
  • Sanders, Julie
  • Rumley, Ann
  • Lowe, Gordon D.O
  • Humphries, Steve E
  • Montgomery, Hugh E
subjects:
  • Abridged Index Medicus
  • Aged
  • Biological and medical sciences
  • Cardiovascular disease
  • Coronary Artery Bypass
  • Coronary Disease - blood
  • Coronary Disease - physiopathology
  • Coronary Disease - surgery
  • Female
  • General and cellular metabolism. Vitamins
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
  • Inflammation - drug therapy
  • Inflammation - physiopathology
  • Interleukin-6 - blood
  • Male
  • Medical sciences
  • Middle Aged
  • Pharmacology. Drug treatments
  • Postoperative Period
  • Prospective Studies
  • Surgery
  • Therapy
ispartof: The American journal of cardiology, 2001-08-15, Vol.88 (4), p.431-433
description: Preoperative statin therapy has been shown to improve cardiovascular outcome after coronary artery bypass grafting; however, the clinical gain achieved is in excess of the reduction of lipids. Brull et al demonstrate that statin therapy exerts a direct anti-inflammatory effect mediated through reduced interleukin-6 production.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0002-9149
fulltext: fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


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titleStatin therapy and the acute inflammatory response after coronary artery bypass grafting
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creatorBrull, David J ; Sanders, Julie ; Rumley, Ann ; Lowe, Gordon D.O ; Humphries, Steve E ; Montgomery, Hugh E
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descriptionPreoperative statin therapy has been shown to improve cardiovascular outcome after coronary artery bypass grafting; however, the clinical gain achieved is in excess of the reduction of lipids. Brull et al demonstrate that statin therapy exerts a direct anti-inflammatory effect mediated through reduced interleukin-6 production.
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subjectAbridged Index Medicus ; Aged ; Biological and medical sciences ; Cardiovascular disease ; Coronary Artery Bypass ; Coronary Disease - blood ; Coronary Disease - physiopathology ; Coronary Disease - surgery ; Female ; General and cellular metabolism. Vitamins ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Inflammation - drug therapy ; Inflammation - physiopathology ; Interleukin-6 - blood ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Postoperative Period ; Prospective Studies ; Surgery ; Therapy
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abstractPreoperative statin therapy has been shown to improve cardiovascular outcome after coronary artery bypass grafting; however, the clinical gain achieved is in excess of the reduction of lipids. Brull et al demonstrate that statin therapy exerts a direct anti-inflammatory effect mediated through reduced interleukin-6 production.
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