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Medical Management of Cronkhite-Canada Syndrome

We report the case of a patient with Cronkhite-Canada syndrome (CCS) successfully treated with combination medical therapy. This rare, noninherited gastrointestinal polyposis syndrome is associated with characteristic ectodermal abnormalities. The etiology and pathogenesis of CCS are not known. No m... Full description

Journal Title: Southern medical journal (Birmingham Ala.), 2002, Vol.95 (2), p.272-274
Main Author: WARD, Eric
Other Authors: WOLFSEN, Herbert C , NG, Christine
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0038-4348
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recordid: cdi_proquest_miscellaneous_71449476
title: Medical Management of Cronkhite-Canada Syndrome
format: Article
creator:
  • WARD, Eric
  • WOLFSEN, Herbert C
  • NG, Christine
subjects:
  • Abridged Index Medicus
  • Aged
  • Anti-Asthmatic Agents - therapeutic use
  • Anti-Infective Agents - therapeutic use
  • Anti-Inflammatory Agents - therapeutic use
  • Biological and medical sciences
  • Care and treatment
  • Cromolyn Sodium - therapeutic use
  • Diseases
  • Drug Therapy, Combination
  • Fluoroquinolones
  • Gastroenterology. Liver. Pancreas. Abdomen
  • Gastrointestinal diseases
  • Histamine H1 Antagonists - therapeutic use
  • Histamine H2 Antagonists - therapeutic use
  • Humans
  • Intestinal polyps
  • Intestinal Polyps - drug therapy
  • Intestinal Polyps - immunology
  • Intestinal Polyps - therapy
  • Loratadine - therapeutic use
  • Male
  • Medical sciences
  • Prednisone - therapeutic use
  • Ranitidine - therapeutic use
  • Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
  • Tumors
ispartof: Southern medical journal (Birmingham, Ala.), 2002, Vol.95 (2), p.272-274
description: We report the case of a patient with Cronkhite-Canada syndrome (CCS) successfully treated with combination medical therapy. This rare, noninherited gastrointestinal polyposis syndrome is associated with characteristic ectodermal abnormalities. The etiology and pathogenesis of CCS are not known. No medical therapy has been shown to be consistently effective, and the disease is usually fatal. The patient described herein was successfully treated with a novel combination regimen consisting of H1- and H2-receptor antagonists, cromolyn sodium, prednisone, and suppressive antibiotics. This regimen has resulted in sustained improvement in symptoms, and follow-up endoscopy has shown regression of the diffuse polyposis. Our patient's response to such therapy may provide insight into the optimal treatment for CCS.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0038-4348
fulltext: fulltext
issn:
  • 0038-4348
  • 1541-8243
url: Link


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descriptionWe report the case of a patient with Cronkhite-Canada syndrome (CCS) successfully treated with combination medical therapy. This rare, noninherited gastrointestinal polyposis syndrome is associated with characteristic ectodermal abnormalities. The etiology and pathogenesis of CCS are not known. No medical therapy has been shown to be consistently effective, and the disease is usually fatal. The patient described herein was successfully treated with a novel combination regimen consisting of H1- and H2-receptor antagonists, cromolyn sodium, prednisone, and suppressive antibiotics. This regimen has resulted in sustained improvement in symptoms, and follow-up endoscopy has shown regression of the diffuse polyposis. Our patient's response to such therapy may provide insight into the optimal treatment for CCS.
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subjectAbridged Index Medicus ; Aged ; Anti-Asthmatic Agents - therapeutic use ; Anti-Infective Agents - therapeutic use ; Anti-Inflammatory Agents - therapeutic use ; Biological and medical sciences ; Care and treatment ; Cromolyn Sodium - therapeutic use ; Diseases ; Drug Therapy, Combination ; Fluoroquinolones ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal diseases ; Histamine H1 Antagonists - therapeutic use ; Histamine H2 Antagonists - therapeutic use ; Humans ; Intestinal polyps ; Intestinal Polyps - drug therapy ; Intestinal Polyps - immunology ; Intestinal Polyps - therapy ; Loratadine - therapeutic use ; Male ; Medical sciences ; Prednisone - therapeutic use ; Ranitidine - therapeutic use ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors
ispartofSouthern medical journal (Birmingham, Ala.), 2002, Vol.95 (2), p.272-274
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abstractWe report the case of a patient with Cronkhite-Canada syndrome (CCS) successfully treated with combination medical therapy. This rare, noninherited gastrointestinal polyposis syndrome is associated with characteristic ectodermal abnormalities. The etiology and pathogenesis of CCS are not known. No medical therapy has been shown to be consistently effective, and the disease is usually fatal. The patient described herein was successfully treated with a novel combination regimen consisting of H1- and H2-receptor antagonists, cromolyn sodium, prednisone, and suppressive antibiotics. This regimen has resulted in sustained improvement in symptoms, and follow-up endoscopy has shown regression of the diffuse polyposis. Our patient's response to such therapy may provide insight into the optimal treatment for CCS.
copHagerstown, MD
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pmid11846261
doi10.1097/00007611-200202000-00025