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Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors

A population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance. A total of 1653 individuals aged 55 to 74 years participated in a population based survey in Southern Germany (KORA... Full description

Journal Title: Diabetologia 2002, Vol.45 (6), p.805-812
Main Author: MÜLLER, S
Other Authors: MARTIN, S , KOENIG, W , HANIFI-MOGHADDAM, P , RATHMANN, W , HAASTERT, B , GIANI, G , ILLIG, T , THORAND, B , KOLB, H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin: Springer
ID: ISSN: 0012-186X
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recordid: cdi_proquest_miscellaneous_71882904
title: Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors
format: Article
creator:
  • MÜLLER, S
  • MARTIN, S
  • KOENIG, W
  • HANIFI-MOGHADDAM, P
  • RATHMANN, W
  • HAASTERT, B
  • GIANI, G
  • ILLIG, T
  • THORAND, B
  • KOLB, H
subjects:
  • Acute-Phase Proteins - metabolism
  • Aged
  • Biological and medical sciences
  • Blood Glucose - metabolism
  • Blood Pressure
  • Diabetes Mellitus, Type 2 - blood
  • Diabetes Mellitus, Type 2 - immunology
  • Diabetes Mellitus, Type 2 - physiopathology
  • Diabetes. Impaired glucose tolerance
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Female
  • Glucose Intolerance - blood
  • Glucose Intolerance - immunology
  • Glucose Intolerance - physiopathology
  • Glucose Tolerance Test
  • Humans
  • Interleukin-6 - blood
  • Lipids - blood
  • Male
  • Medical sciences
  • Receptors, Tumor Necrosis Factor - blood
  • Reference Values
  • Tumor Necrosis Factor-alpha - metabolism
ispartof: Diabetologia, 2002, Vol.45 (6), p.805-812
description: A population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance. A total of 1653 individuals aged 55 to 74 years participated in a population based survey in Southern Germany (KORA Survey 2000). Those without a history of diabetes were subjected to an OGTT. Randomly selected subjects with IGT ( n=80) were compared with non-diabetic control subjects ( n=77) and patients with Type II diabetes ( n=152) of the same population-based sample after matching for age and sex. Immune parameters were analysed in serum with rigidly evaluated ELISA. Serum pro-inflammatory cytokine interleukin 6 (IL-6) concentrations were higher in subjects with IGT and Type II diabetes than in the control subjects (median 1.8 and 2.5 vs 0.8 pg/ml, p
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleImpaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors
creatorMÜLLER, S ; MARTIN, S ; KOENIG, W ; HANIFI-MOGHADDAM, P ; RATHMANN, W ; HAASTERT, B ; GIANI, G ; ILLIG, T ; THORAND, B ; KOLB, H
creatorcontribMÜLLER, S ; MARTIN, S ; KOENIG, W ; HANIFI-MOGHADDAM, P ; RATHMANN, W ; HAASTERT, B ; GIANI, G ; ILLIG, T ; THORAND, B ; KOLB, H
descriptionA population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance. A total of 1653 individuals aged 55 to 74 years participated in a population based survey in Southern Germany (KORA Survey 2000). Those without a history of diabetes were subjected to an OGTT. Randomly selected subjects with IGT ( n=80) were compared with non-diabetic control subjects ( n=77) and patients with Type II diabetes ( n=152) of the same population-based sample after matching for age and sex. Immune parameters were analysed in serum with rigidly evaluated ELISA. Serum pro-inflammatory cytokine interleukin 6 (IL-6) concentrations were higher in subjects with IGT and Type II diabetes than in the control subjects (median 1.8 and 2.5 vs 0.8 pg/ml, p<0.0001). Soluble IL-6 receptors potentiate IL-6 bioactivity and their concentrations were mildly increased in Type II diabetes ( p<0.05). These immune changes seem relevant because IL-6 dependent acute-phase proteins C-reactive protein, serum amyloid A protein and fibrinogen were also increased in IGT and Type II diabetes. Circulating concentrations of TNF-alpha and its two receptors sTNF-R60 and sTNF-R80 were not increased in IGT subjects compared with the control subjects. Our study shows systemic up-regulation of selected inflammatory mediators in patients with Type II diabetes and IGT. The pattern observed is non-random and fits with an IL-6 associated rather than TNF-alpha associated response.
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languageeng
publisherBerlin: Springer
subjectAcute-Phase Proteins - metabolism ; Aged ; Biological and medical sciences ; Blood Glucose - metabolism ; Blood Pressure ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - immunology ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Glucose Intolerance - blood ; Glucose Intolerance - immunology ; Glucose Intolerance - physiopathology ; Glucose Tolerance Test ; Humans ; Interleukin-6 - blood ; Lipids - blood ; Male ; Medical sciences ; Receptors, Tumor Necrosis Factor - blood ; Reference Values ; Tumor Necrosis Factor-alpha - metabolism
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descriptionA population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance. A total of 1653 individuals aged 55 to 74 years participated in a population based survey in Southern Germany (KORA Survey 2000). Those without a history of diabetes were subjected to an OGTT. Randomly selected subjects with IGT ( n=80) were compared with non-diabetic control subjects ( n=77) and patients with Type II diabetes ( n=152) of the same population-based sample after matching for age and sex. Immune parameters were analysed in serum with rigidly evaluated ELISA. Serum pro-inflammatory cytokine interleukin 6 (IL-6) concentrations were higher in subjects with IGT and Type II diabetes than in the control subjects (median 1.8 and 2.5 vs 0.8 pg/ml, p<0.0001). Soluble IL-6 receptors potentiate IL-6 bioactivity and their concentrations were mildly increased in Type II diabetes ( p<0.05). These immune changes seem relevant because IL-6 dependent acute-phase proteins C-reactive protein, serum amyloid A protein and fibrinogen were also increased in IGT and Type II diabetes. Circulating concentrations of TNF-alpha and its two receptors sTNF-R60 and sTNF-R80 were not increased in IGT subjects compared with the control subjects. Our study shows systemic up-regulation of selected inflammatory mediators in patients with Type II diabetes and IGT. The pattern observed is non-random and fits with an IL-6 associated rather than TNF-alpha associated response.
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4Blood Pressure
5Diabetes Mellitus, Type 2 - blood
6Diabetes Mellitus, Type 2 - immunology
7Diabetes Mellitus, Type 2 - physiopathology
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14Glucose Intolerance - immunology
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22Receptors, Tumor Necrosis Factor - blood
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24Tumor Necrosis Factor-alpha - metabolism
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abstractA population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance. A total of 1653 individuals aged 55 to 74 years participated in a population based survey in Southern Germany (KORA Survey 2000). Those without a history of diabetes were subjected to an OGTT. Randomly selected subjects with IGT ( n=80) were compared with non-diabetic control subjects ( n=77) and patients with Type II diabetes ( n=152) of the same population-based sample after matching for age and sex. Immune parameters were analysed in serum with rigidly evaluated ELISA. Serum pro-inflammatory cytokine interleukin 6 (IL-6) concentrations were higher in subjects with IGT and Type II diabetes than in the control subjects (median 1.8 and 2.5 vs 0.8 pg/ml, p<0.0001). Soluble IL-6 receptors potentiate IL-6 bioactivity and their concentrations were mildly increased in Type II diabetes ( p<0.05). These immune changes seem relevant because IL-6 dependent acute-phase proteins C-reactive protein, serum amyloid A protein and fibrinogen were also increased in IGT and Type II diabetes. Circulating concentrations of TNF-alpha and its two receptors sTNF-R60 and sTNF-R80 were not increased in IGT subjects compared with the control subjects. Our study shows systemic up-regulation of selected inflammatory mediators in patients with Type II diabetes and IGT. The pattern observed is non-random and fits with an IL-6 associated rather than TNF-alpha associated response.
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