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Lipid peroxidation and antioxidant vitamins prior to, during, and after correction of diabetic ketoacidosis

Oxidative stress plays an important role in the chronic complications of insulin-dependent diabetes mellitus (IDDM). Hyperketonemia, as well as hyperglycemia, is involved in the generation of oxygen-free radicals. We have studied the degree of oxidative stress in six patients before, during, and aft... Full description

Journal Title: Journal of diabetes and its complications 2002, Vol.16 (4), p.294-300
Main Author: Lee, Diana M
Other Authors: Hoffman, William H , Carl, G.F , Khichi, Mahmood , Cornwell, Philip E
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 1056-8727
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recordid: cdi_proquest_miscellaneous_71933802
title: Lipid peroxidation and antioxidant vitamins prior to, during, and after correction of diabetic ketoacidosis
format: Article
creator:
  • Lee, Diana M
  • Hoffman, William H
  • Carl, G.F
  • Khichi, Mahmood
  • Cornwell, Philip E
subjects:
  • Adolescent
  • Adult
  • Antioxidant vitamins
  • Antioxidants - metabolism
  • Ascorbic Acid - blood
  • Associated diseases and complications
  • Biological and medical sciences
  • Child
  • Diabetes
  • Diabetes Mellitus, Type 1 - complications
  • Diabetes Mellitus, Type 1 - physiopathology
  • Diabetes. Impaired glucose tolerance
  • Diabetic ketoacidosis
  • Diabetic Ketoacidosis - blood
  • Diabetic Ketoacidosis - drug therapy
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Fatty acids
  • Fatty Acids, Nonesterified - blood
  • Humans
  • Insulin - therapeutic use
  • Kinases
  • Lipid Peroxidation
  • Lipids
  • Medical sciences
  • Oxidation
  • Oxidative stress
  • Oxidative Stress - physiology
  • Time Factors
  • Vitamin A - blood
  • Vitamin C
  • Vitamin E
  • Vitamin E - blood
ispartof: Journal of diabetes and its complications, 2002, Vol.16 (4), p.294-300
description: Oxidative stress plays an important role in the chronic complications of insulin-dependent diabetes mellitus (IDDM). Hyperketonemia, as well as hyperglycemia, is involved in the generation of oxygen-free radicals. We have studied the degree of oxidative stress in six patients before, during, and after correction of diabetic ketoacidosis (DKA) by determining the plasma ratios of C20 and C18 fatty acids to C16 fatty acids in the cholesteryl esters of the lipoproteins as well as in the plasma concentrations of the antioxidant vitamins A, C, and E. Lipid peroxidation was slightly increased prior to treatment. However, the C20/C16 ratio at 120 h was significantly decreased in comparison to the ratio at pretreatment (P
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1056-8727
fulltext: fulltext
issn:
  • 1056-8727
  • 1873-460X
url: Link


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subjectAdolescent ; Adult ; Antioxidant vitamins ; Antioxidants - metabolism ; Ascorbic Acid - blood ; Associated diseases and complications ; Biological and medical sciences ; Child ; Diabetes ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diabetic ketoacidosis ; Diabetic Ketoacidosis - blood ; Diabetic Ketoacidosis - drug therapy ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty acids ; Fatty Acids, Nonesterified - blood ; Humans ; Insulin - therapeutic use ; Kinases ; Lipid Peroxidation ; Lipids ; Medical sciences ; Oxidation ; Oxidative stress ; Oxidative Stress - physiology ; Time Factors ; Vitamin A - blood ; Vitamin C ; Vitamin E ; Vitamin E - blood
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