schliessen

Filtern

 

Bibliotheken

Cholesterol lowering with statins reduces exercise-induced myocardial ischemia in hypercholesterolemic patients with coronary artery disease

Coronary flow reserve is mainly influenced by the combination of luminal stenosis and vascular dilation capacity. Thus, after statin treatment, the reduction of ischemic threshold in patients submitted to exercise testing could be intensely influenced by angiographic severity. In this study, we veri... Full description

Journal Title: The American journal of cardiology 2001, Vol.88 (10), p.1134-1138
Main Author: Ramires, Jose Antonio F
Other Authors: Sposito, Andrei C , Mansur, Antonio P , Coelho, Otavio R , Maranhão, Mario , Cesar, Luis Antonio M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0002-9149
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_72266268
title: Cholesterol lowering with statins reduces exercise-induced myocardial ischemia in hypercholesterolemic patients with coronary artery disease
format: Article
creator:
  • Ramires, Jose Antonio F
  • Sposito, Andrei C
  • Mansur, Antonio P
  • Coelho, Otavio R
  • Maranhão, Mario
  • Cesar, Luis Antonio M
subjects:
  • Abridged Index Medicus
  • Adult
  • Aged
  • Anticholesteremic Agents - therapeutic use
  • Biological and medical sciences
  • Cardiovascular disease
  • Cholesterol
  • Coronary Angiography
  • Coronary Disease - classification
  • Coronary Disease - complications
  • Coronary vessels
  • Exercise Test
  • Female
  • General and cellular metabolism. Vitamins
  • Heart attacks
  • Humans
  • Hypercholesterolemia - complications
  • Hypercholesterolemia - diet therapy
  • Hypercholesterolemia - drug therapy
  • Male
  • Medical research
  • Medical sciences
  • Middle Aged
  • Myocardial Ischemia - etiology
  • Myocardial Ischemia - prevention & control
  • Pharmacology. Drug treatments
  • Pravastatin - therapeutic use
  • Simvastatin - therapeutic use
ispartof: The American journal of cardiology, 2001, Vol.88 (10), p.1134-1138
description: Coronary flow reserve is mainly influenced by the combination of luminal stenosis and vascular dilation capacity. Thus, after statin treatment, the reduction of ischemic threshold in patients submitted to exercise testing could be intensely influenced by angiographic severity. In this study, we verify the effect of statin treatment on exercise-induced myocardial ischemia in hypercholesterolemic patients with a broad range of coronary angiographic severities. Patients with 2 consecutive positive exercise tests, coronary stenosis ≥70%, total cholesterol ≥300 mg/dl, and triglycerides ≤200 mg/dl were randomly assigned to a 16-week treatment period with either diet alone (n = 39) or diet plus statins (simavastatin, n = 31 and pravastatin, n = 10). Statin-treated patients had a significant variation in total cholesterol (−46% vs −2.7%; p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0002-9149
fulltext: fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK1.927743
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_cross
recordidTN_cdi_proquest_miscellaneous_72266268
sourceformatXML
sourcesystemPC
sourcerecordid72266268
originalsourceidFETCH-LOGICAL-c409t-8db2b32c8e245b690c8c142962692438fb350522fd4a30910a055714f3e004823
addsrcrecordideNqFkU2LFDEQhoMo7rj6E5QgKHporXx0T8IeRAa_YMGDeg7pdLWTpaczJt2u8x_80dbsDA7sZU8hxVMPVfUy9lTAGwGiefsNAGRlhbavQLwGCdpU6h5bCLO0lbBC3WeL_8gZe1TKFX2FqJuH7EyIJShbmwX7u1qnAcuEOQ18SNeY4_iTX8dpzcvkpzgWnrGbAxaOfzCHWLCK477Q8c0uBZ-76AceS1jjJnoeR77ebQk8aake-JZcOE7loA4pp9HnHfeZkB3vSOsLPmYPej8UfHJ8z9mPjx--rz5Xl18_fVm9v6yCBjtVpmtlq2QwKHXdNhaCCUJL28jGSq1M36oaain7TnsFVoCHul4K3SsEOpNU5-zlwbvN6ddMY7oNLYDD4EdMc3FLKRuSGQKf3wKv0pxHms1JBaoxpqkJqg9QyKmUjL3b5rih7ZwAt8_K3WTl9kE4EO4mK6eo79lRPrcb7E5dx3AIeHEEfAl-6LMf6f4nTgvQWgniLm4NEOI-uzRO2cfhzjHeHbqRLv47YnYlUFQUcMwYJteleIfhH9C7xP4
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid230368865
display
typearticle
titleCholesterol lowering with statins reduces exercise-induced myocardial ischemia in hypercholesterolemic patients with coronary artery disease
sourceAlma/SFX Local Collection
creatorRamires, Jose Antonio F ; Sposito, Andrei C ; Mansur, Antonio P ; Coelho, Otavio R ; Maranhão, Mario ; Cesar, Luis Antonio M
creatorcontribRamires, Jose Antonio F ; Sposito, Andrei C ; Mansur, Antonio P ; Coelho, Otavio R ; Maranhão, Mario ; Cesar, Luis Antonio M
descriptionCoronary flow reserve is mainly influenced by the combination of luminal stenosis and vascular dilation capacity. Thus, after statin treatment, the reduction of ischemic threshold in patients submitted to exercise testing could be intensely influenced by angiographic severity. In this study, we verify the effect of statin treatment on exercise-induced myocardial ischemia in hypercholesterolemic patients with a broad range of coronary angiographic severities. Patients with 2 consecutive positive exercise tests, coronary stenosis ≥70%, total cholesterol ≥300 mg/dl, and triglycerides ≤200 mg/dl were randomly assigned to a 16-week treatment period with either diet alone (n = 39) or diet plus statins (simavastatin, n = 31 and pravastatin, n = 10). Statin-treated patients had a significant variation in total cholesterol (−46% vs −2.7%; p <0.01), low-density lipoprotein cholesterol (−58% vs 0.8%; p <0.01), and high-density cholesterol (+28% vs −6%; p <0.05) in comparison with the diet-only group. After 16 weeks of treatment, 36 patients (92%) in the diet group still had positive exercise tests, whereas only 7 patients (15%) of the statin group had a positive test (p <0.01). The proportion of positive tests was significantly reduced in subgroups of patients with 1-, 2-, or 3-vessel disease. Regarding the severity of coronary stenosis, the proportion of positive tests was significantly reduced in patients with stenosis between 70% and 90% and in patients with stenosis ≥90%. Moreover, the proportion of positive tests tended to decrease to a greater extent in patients with mild coronary disease. In conclusion, cholesterol-lowering treatment with statins reduces exercise-induced myocardial ischemia in hypercholesterolemic patients with mild or severe epicardial coronary stenosis.
identifier
0ISSN: 0002-9149
1EISSN: 1879-1913
2DOI: 10.1016/S0002-9149(01)02048-3
3PMID: 11703958
4CODEN: AJCDAG
languageeng
publisherNew York, NY: Elsevier Inc
subjectAbridged Index Medicus ; Adult ; Aged ; Anticholesteremic Agents - therapeutic use ; Biological and medical sciences ; Cardiovascular disease ; Cholesterol ; Coronary Angiography ; Coronary Disease - classification ; Coronary Disease - complications ; Coronary vessels ; Exercise Test ; Female ; General and cellular metabolism. Vitamins ; Heart attacks ; Humans ; Hypercholesterolemia - complications ; Hypercholesterolemia - diet therapy ; Hypercholesterolemia - drug therapy ; Male ; Medical research ; Medical sciences ; Middle Aged ; Myocardial Ischemia - etiology ; Myocardial Ischemia - prevention & control ; Pharmacology. Drug treatments ; Pravastatin - therapeutic use ; Simvastatin - therapeutic use
ispartofThe American journal of cardiology, 2001, Vol.88 (10), p.1134-1138
rights
02001 Excerpta Medica Inc.
12002 INIST-CNRS
2Copyright Elsevier Sequoia S.A. Nov 15, 2001
lds50peer_reviewed
citedbyFETCH-LOGICAL-c409t-8db2b32c8e245b690c8c142962692438fb350522fd4a30910a055714f3e004823
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14104431$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11703958$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Ramires, Jose Antonio F
1Sposito, Andrei C
2Mansur, Antonio P
3Coelho, Otavio R
4Maranhão, Mario
5Cesar, Luis Antonio M
title
0Cholesterol lowering with statins reduces exercise-induced myocardial ischemia in hypercholesterolemic patients with coronary artery disease
1The American journal of cardiology
addtitleAm J Cardiol
descriptionCoronary flow reserve is mainly influenced by the combination of luminal stenosis and vascular dilation capacity. Thus, after statin treatment, the reduction of ischemic threshold in patients submitted to exercise testing could be intensely influenced by angiographic severity. In this study, we verify the effect of statin treatment on exercise-induced myocardial ischemia in hypercholesterolemic patients with a broad range of coronary angiographic severities. Patients with 2 consecutive positive exercise tests, coronary stenosis ≥70%, total cholesterol ≥300 mg/dl, and triglycerides ≤200 mg/dl were randomly assigned to a 16-week treatment period with either diet alone (n = 39) or diet plus statins (simavastatin, n = 31 and pravastatin, n = 10). Statin-treated patients had a significant variation in total cholesterol (−46% vs −2.7%; p <0.01), low-density lipoprotein cholesterol (−58% vs 0.8%; p <0.01), and high-density cholesterol (+28% vs −6%; p <0.05) in comparison with the diet-only group. After 16 weeks of treatment, 36 patients (92%) in the diet group still had positive exercise tests, whereas only 7 patients (15%) of the statin group had a positive test (p <0.01). The proportion of positive tests was significantly reduced in subgroups of patients with 1-, 2-, or 3-vessel disease. Regarding the severity of coronary stenosis, the proportion of positive tests was significantly reduced in patients with stenosis between 70% and 90% and in patients with stenosis ≥90%. Moreover, the proportion of positive tests tended to decrease to a greater extent in patients with mild coronary disease. In conclusion, cholesterol-lowering treatment with statins reduces exercise-induced myocardial ischemia in hypercholesterolemic patients with mild or severe epicardial coronary stenosis.
subject
0Abridged Index Medicus
1Adult
2Aged
3Anticholesteremic Agents - therapeutic use
4Biological and medical sciences
5Cardiovascular disease
6Cholesterol
7Coronary Angiography
8Coronary Disease - classification
9Coronary Disease - complications
10Coronary vessels
11Exercise Test
12Female
13General and cellular metabolism. Vitamins
14Heart attacks
15Humans
16Hypercholesterolemia - complications
17Hypercholesterolemia - diet therapy
18Hypercholesterolemia - drug therapy
19Male
20Medical research
21Medical sciences
22Middle Aged
23Myocardial Ischemia - etiology
24Myocardial Ischemia - prevention & control
25Pharmacology. Drug treatments
26Pravastatin - therapeutic use
27Simvastatin - therapeutic use
issn
00002-9149
11879-1913
fulltexttrue
rsrctypearticle
creationdate2001
recordtypearticle
recordideNqFkU2LFDEQhoMo7rj6E5QgKHporXx0T8IeRAa_YMGDeg7pdLWTpaczJt2u8x_80dbsDA7sZU8hxVMPVfUy9lTAGwGiefsNAGRlhbavQLwGCdpU6h5bCLO0lbBC3WeL_8gZe1TKFX2FqJuH7EyIJShbmwX7u1qnAcuEOQ18SNeY4_iTX8dpzcvkpzgWnrGbAxaOfzCHWLCK477Q8c0uBZ-76AceS1jjJnoeR77ebQk8aake-JZcOE7loA4pp9HnHfeZkB3vSOsLPmYPej8UfHJ8z9mPjx--rz5Xl18_fVm9v6yCBjtVpmtlq2QwKHXdNhaCCUJL28jGSq1M36oaain7TnsFVoCHul4K3SsEOpNU5-zlwbvN6ddMY7oNLYDD4EdMc3FLKRuSGQKf3wKv0pxHms1JBaoxpqkJqg9QyKmUjL3b5rih7ZwAt8_K3WTl9kE4EO4mK6eo79lRPrcb7E5dx3AIeHEEfAl-6LMf6f4nTgvQWgniLm4NEOI-uzRO2cfhzjHeHbqRLv47YnYlUFQUcMwYJteleIfhH9C7xP4
startdate2001
enddate2001
creator
0Ramires, Jose Antonio F
1Sposito, Andrei C
2Mansur, Antonio P
3Coelho, Otavio R
4Maranhão, Mario
5Cesar, Luis Antonio M
general
0Elsevier Inc
1Elsevier
2Elsevier Limited
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
97QO
107TS
118FD
12FR3
13K9.
14NAPCQ
15P64
167X8
sort
creationdate2001
titleCholesterol lowering with statins reduces exercise-induced myocardial ischemia in hypercholesterolemic patients with coronary artery disease
authorRamires, Jose Antonio F ; Sposito, Andrei C ; Mansur, Antonio P ; Coelho, Otavio R ; Maranhão, Mario ; Cesar, Luis Antonio M
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c409t-8db2b32c8e245b690c8c142962692438fb350522fd4a30910a055714f3e004823
rsrctypearticles
prefilterarticles
languageeng
creationdate2001
topic
0Abridged Index Medicus
1Adult
2Aged
3Anticholesteremic Agents - therapeutic use
4Biological and medical sciences
5Cardiovascular disease
6Cholesterol
7Coronary Angiography
8Coronary Disease - classification
9Coronary Disease - complications
10Coronary vessels
11Exercise Test
12Female
13General and cellular metabolism. Vitamins
14Heart attacks
15Humans
16Hypercholesterolemia - complications
17Hypercholesterolemia - diet therapy
18Hypercholesterolemia - drug therapy
19Male
20Medical research
21Medical sciences
22Middle Aged
23Myocardial Ischemia - etiology
24Myocardial Ischemia - prevention & control
25Pharmacology. Drug treatments
26Pravastatin - therapeutic use
27Simvastatin - therapeutic use
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Ramires, Jose Antonio F
1Sposito, Andrei C
2Mansur, Antonio P
3Coelho, Otavio R
4Maranhão, Mario
5Cesar, Luis Antonio M
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8Biotechnology Research Abstracts
9Physical Education Index
10Technology Research Database
11Engineering Research Database
12ProQuest Health & Medical Complete (Alumni)
13Nursing & Allied Health Premium
14Biotechnology and BioEngineering Abstracts
15MEDLINE - Academic
jtitleThe American journal of cardiology
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Ramires, Jose Antonio F
1Sposito, Andrei C
2Mansur, Antonio P
3Coelho, Otavio R
4Maranhão, Mario
5Cesar, Luis Antonio M
formatjournal
genrearticle
ristypeJOUR
atitleCholesterol lowering with statins reduces exercise-induced myocardial ischemia in hypercholesterolemic patients with coronary artery disease
jtitleThe American journal of cardiology
addtitleAm J Cardiol
date2001
risdate2001
volume88
issue10
spage1134
epage1138
pages1134-1138
issn0002-9149
eissn1879-1913
codenAJCDAG
abstractCoronary flow reserve is mainly influenced by the combination of luminal stenosis and vascular dilation capacity. Thus, after statin treatment, the reduction of ischemic threshold in patients submitted to exercise testing could be intensely influenced by angiographic severity. In this study, we verify the effect of statin treatment on exercise-induced myocardial ischemia in hypercholesterolemic patients with a broad range of coronary angiographic severities. Patients with 2 consecutive positive exercise tests, coronary stenosis ≥70%, total cholesterol ≥300 mg/dl, and triglycerides ≤200 mg/dl were randomly assigned to a 16-week treatment period with either diet alone (n = 39) or diet plus statins (simavastatin, n = 31 and pravastatin, n = 10). Statin-treated patients had a significant variation in total cholesterol (−46% vs −2.7%; p <0.01), low-density lipoprotein cholesterol (−58% vs 0.8%; p <0.01), and high-density cholesterol (+28% vs −6%; p <0.05) in comparison with the diet-only group. After 16 weeks of treatment, 36 patients (92%) in the diet group still had positive exercise tests, whereas only 7 patients (15%) of the statin group had a positive test (p <0.01). The proportion of positive tests was significantly reduced in subgroups of patients with 1-, 2-, or 3-vessel disease. Regarding the severity of coronary stenosis, the proportion of positive tests was significantly reduced in patients with stenosis between 70% and 90% and in patients with stenosis ≥90%. Moreover, the proportion of positive tests tended to decrease to a greater extent in patients with mild coronary disease. In conclusion, cholesterol-lowering treatment with statins reduces exercise-induced myocardial ischemia in hypercholesterolemic patients with mild or severe epicardial coronary stenosis.
copNew York, NY
pubElsevier Inc
pmid11703958
doi10.1016/S0002-9149(01)02048-3