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Apolipoprotein E Phenotype Regulates Cholesterol Absorption in Healthy 13-Month-Old Children–The STRIP Study

High serum cholesterol concentration is one of the key risk factors in development of atherosclerosis, which may begin early in life and later progress to symptomatic coronary heart disease. In adults, apoE polymorphism strongly influences cholesterol metabolism, as subjects with apoE 3/4 or 4/4 (co... Full description

Journal Title: Pediatric research 2001, Vol.50 (6), p.688-691
Main Author: TAMMI, Anne
Other Authors: RÖNNEMAA, Tapani , RASK-NISSILÄ, Leena , MIETTINEN, Tatu A , GYLLING, Helena , VALSTA, Liisa , VIIKARI, Jorma , VÄLIMÄKI, Ilkka , SIMELL, Olli
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0031-3998
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title: Apolipoprotein E Phenotype Regulates Cholesterol Absorption in Healthy 13-Month-Old Children–The STRIP Study
format: Article
creator:
  • TAMMI, Anne
  • RÖNNEMAA, Tapani
  • RASK-NISSILÄ, Leena
  • MIETTINEN, Tatu A
  • GYLLING, Helena
  • VALSTA, Liisa
  • VIIKARI, Jorma
  • VÄLIMÄKI, Ilkka
  • SIMELL, Olli
subjects:
  • Apolipoproteins E - genetics
  • Biological and medical sciences
  • Cholesterol - blood
  • Cholesterol - metabolism
  • Cholesterol, HDL
  • Disorders of blood lipids. Hyperlipoproteinemia
  • Energy Intake
  • Female
  • Homeostasis - genetics
  • Humans
  • Infant
  • Intestinal Absorption
  • Male
  • Medical sciences
  • Metabolic diseases
  • Phenotype
  • Reference Values
ispartof: Pediatric research, 2001, Vol.50 (6), p.688-691
description: High serum cholesterol concentration is one of the key risk factors in development of atherosclerosis, which may begin early in life and later progress to symptomatic coronary heart disease. In adults, apoE polymorphism strongly influences cholesterol metabolism, as subjects with apoE 3/4 or 4/4 (collectively called apoE4) phenotype absorb cholesterol effectively and thus also have higher cholesterol absorption-reflecting plant sterol concentrations in serum than subjects with other apoE phenotypes. Because of the inverse correlation of absorption and synthesis of cholesterol, concentrations of cholesterol synthesis-reflecting serum cholesterol precursor sterols are lower in subjects with apoE4 than in subjects with other phenotypes. To analyze whether apoE phenotype affects cholesterol absorption and synthesis in early childhood, we measured serum plant sterol (campesterol and sitosterol) and cholesterol precursor sterol (desmosterol and lathosterol) concentrations in healthy 13-month old children using gas-liquid chromatography. The 36 study children were participants in a randomized prospective trial (the Special Turku Coronary Risk Factor Intervention Project) aimed at decreasing exposure of the children to environmental atherosclerosis risk factors. The 16 apoE4 children had 30% to 50% higher cholesterol-adjusted campesterol and sitosterol concentrations in serum than the 20 apoE 3/3 children (p = 0.002 and p = 0.02, respectively). The concentrations of cholesterol precursor sterols in serum did not differ between the two groups of children. We conclude that the young apoE4 children may absorb cholesterol and plant sterols more effectively than the children with apoE 3/3 phenotype without compensatory reduction in endogenous synthesis of cholesterol.
language: eng
source:
identifier: ISSN: 0031-3998
fulltext: no_fulltext
issn:
  • 0031-3998
  • 1530-0447
url: Link


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titleApolipoprotein E Phenotype Regulates Cholesterol Absorption in Healthy 13-Month-Old Children–The STRIP Study
creatorTAMMI, Anne ; RÖNNEMAA, Tapani ; RASK-NISSILÄ, Leena ; MIETTINEN, Tatu A ; GYLLING, Helena ; VALSTA, Liisa ; VIIKARI, Jorma ; VÄLIMÄKI, Ilkka ; SIMELL, Olli
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descriptionHigh serum cholesterol concentration is one of the key risk factors in development of atherosclerosis, which may begin early in life and later progress to symptomatic coronary heart disease. In adults, apoE polymorphism strongly influences cholesterol metabolism, as subjects with apoE 3/4 or 4/4 (collectively called apoE4) phenotype absorb cholesterol effectively and thus also have higher cholesterol absorption-reflecting plant sterol concentrations in serum than subjects with other apoE phenotypes. Because of the inverse correlation of absorption and synthesis of cholesterol, concentrations of cholesterol synthesis-reflecting serum cholesterol precursor sterols are lower in subjects with apoE4 than in subjects with other phenotypes. To analyze whether apoE phenotype affects cholesterol absorption and synthesis in early childhood, we measured serum plant sterol (campesterol and sitosterol) and cholesterol precursor sterol (desmosterol and lathosterol) concentrations in healthy 13-month old children using gas-liquid chromatography. The 36 study children were participants in a randomized prospective trial (the Special Turku Coronary Risk Factor Intervention Project) aimed at decreasing exposure of the children to environmental atherosclerosis risk factors. The 16 apoE4 children had 30% to 50% higher cholesterol-adjusted campesterol and sitosterol concentrations in serum than the 20 apoE 3/3 children (p = 0.002 and p = 0.02, respectively). The concentrations of cholesterol precursor sterols in serum did not differ between the two groups of children. We conclude that the young apoE4 children may absorb cholesterol and plant sterols more effectively than the children with apoE 3/3 phenotype without compensatory reduction in endogenous synthesis of cholesterol.
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subjectApolipoproteins E - genetics ; Biological and medical sciences ; Cholesterol - blood ; Cholesterol - metabolism ; Cholesterol, HDL ; Disorders of blood lipids. Hyperlipoproteinemia ; Energy Intake ; Female ; Homeostasis - genetics ; Humans ; Infant ; Intestinal Absorption ; Male ; Medical sciences ; Metabolic diseases ; Phenotype ; Reference Values
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descriptionHigh serum cholesterol concentration is one of the key risk factors in development of atherosclerosis, which may begin early in life and later progress to symptomatic coronary heart disease. In adults, apoE polymorphism strongly influences cholesterol metabolism, as subjects with apoE 3/4 or 4/4 (collectively called apoE4) phenotype absorb cholesterol effectively and thus also have higher cholesterol absorption-reflecting plant sterol concentrations in serum than subjects with other apoE phenotypes. Because of the inverse correlation of absorption and synthesis of cholesterol, concentrations of cholesterol synthesis-reflecting serum cholesterol precursor sterols are lower in subjects with apoE4 than in subjects with other phenotypes. To analyze whether apoE phenotype affects cholesterol absorption and synthesis in early childhood, we measured serum plant sterol (campesterol and sitosterol) and cholesterol precursor sterol (desmosterol and lathosterol) concentrations in healthy 13-month old children using gas-liquid chromatography. The 36 study children were participants in a randomized prospective trial (the Special Turku Coronary Risk Factor Intervention Project) aimed at decreasing exposure of the children to environmental atherosclerosis risk factors. The 16 apoE4 children had 30% to 50% higher cholesterol-adjusted campesterol and sitosterol concentrations in serum than the 20 apoE 3/3 children (p = 0.002 and p = 0.02, respectively). The concentrations of cholesterol precursor sterols in serum did not differ between the two groups of children. We conclude that the young apoE4 children may absorb cholesterol and plant sterols more effectively than the children with apoE 3/3 phenotype without compensatory reduction in endogenous synthesis of cholesterol.
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authorTAMMI, Anne ; RÖNNEMAA, Tapani ; RASK-NISSILÄ, Leena ; MIETTINEN, Tatu A ; GYLLING, Helena ; VALSTA, Liisa ; VIIKARI, Jorma ; VÄLIMÄKI, Ilkka ; SIMELL, Olli
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6Energy Intake
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abstractHigh serum cholesterol concentration is one of the key risk factors in development of atherosclerosis, which may begin early in life and later progress to symptomatic coronary heart disease. In adults, apoE polymorphism strongly influences cholesterol metabolism, as subjects with apoE 3/4 or 4/4 (collectively called apoE4) phenotype absorb cholesterol effectively and thus also have higher cholesterol absorption-reflecting plant sterol concentrations in serum than subjects with other apoE phenotypes. Because of the inverse correlation of absorption and synthesis of cholesterol, concentrations of cholesterol synthesis-reflecting serum cholesterol precursor sterols are lower in subjects with apoE4 than in subjects with other phenotypes. To analyze whether apoE phenotype affects cholesterol absorption and synthesis in early childhood, we measured serum plant sterol (campesterol and sitosterol) and cholesterol precursor sterol (desmosterol and lathosterol) concentrations in healthy 13-month old children using gas-liquid chromatography. The 36 study children were participants in a randomized prospective trial (the Special Turku Coronary Risk Factor Intervention Project) aimed at decreasing exposure of the children to environmental atherosclerosis risk factors. The 16 apoE4 children had 30% to 50% higher cholesterol-adjusted campesterol and sitosterol concentrations in serum than the 20 apoE 3/3 children (p = 0.002 and p = 0.02, respectively). The concentrations of cholesterol precursor sterols in serum did not differ between the two groups of children. We conclude that the young apoE4 children may absorb cholesterol and plant sterols more effectively than the children with apoE 3/3 phenotype without compensatory reduction in endogenous synthesis of cholesterol.
copHagerstown, MD
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