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Decreased expression of IL-2 in central and effector CD4 memory cells during progression to AIDS in rhesus macaques

HIV-1 infection in humans has been reported to lead to a shift in the cytokine balance, with a relative decrease in T helper 1 type cytokines, especially IL-2. On the basis of the expression of CD45RA, in combination with homing markers CD62L or alpha4beta7, T helper cells can be sub-divided into na... Full description

Journal Title: AIDS (London) 2001, Vol.15 (18), p.2359-2369
Main Author: KOOPMAN, Gerrit
Other Authors: NIPHUIS, Henk , NEWMAN, Walter , KISHIMOTO, Takashi K , MAINO, Vernon C , HEENEY, Jonathan L
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
ID: ISSN: 0269-9370
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recordid: cdi_proquest_miscellaneous_72333660
title: Decreased expression of IL-2 in central and effector CD4 memory cells during progression to AIDS in rhesus macaques
format: Article
creator:
  • KOOPMAN, Gerrit
  • NIPHUIS, Henk
  • NEWMAN, Walter
  • KISHIMOTO, Takashi K
  • MAINO, Vernon C
  • HEENEY, Jonathan L
subjects:
  • AIDS/HIV
  • Animals
  • Biological and medical sciences
  • CD4 antigen
  • CD4-Positive T-Lymphocytes - immunology
  • Cytokines - metabolism
  • Disease Models, Animal
  • Disease Progression
  • Flow Cytometry - methods
  • Fundamental and applied biological sciences. Psychology
  • Human immunodeficiency virus
  • Human viral diseases
  • Humans
  • Immunologic Memory - immunology
  • Infectious diseases
  • Interleukin-2 - metabolism
  • Macaca mulatta
  • Medical sciences
  • Microbiology
  • Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
  • Simian Acquired Immunodeficiency Syndrome - immunology
  • Simian Acquired Immunodeficiency Syndrome - physiopathology
  • Simian Immunodeficiency Virus - immunology
  • T-Lymphocyte Subsets - immunology
  • T-Lymphocytes, Helper-Inducer - immunology
  • Viral diseases
  • Viral diseases of the lymphoid tissue and the blood. Aids
  • Virology
ispartof: AIDS (London), 2001, Vol.15 (18), p.2359-2369
description: HIV-1 infection in humans has been reported to lead to a shift in the cytokine balance, with a relative decrease in T helper 1 type cytokines, especially IL-2. On the basis of the expression of CD45RA, in combination with homing markers CD62L or alpha4beta7, T helper cells can be sub-divided into naive, activated naive, central memory and effector memory cells as well as gut-homing subpopulations. In addition, each subset may have the potential to express distinct cytokines. At present it is unclear whether the changes in cytokine expression observed in HIV-1-infected individuals are secondary to changes within the composition of CD4 T cell subsets or are caused by changes in cytokine expression within each subset. A new technique was developed to detect cytokine expression in phorbol 12-myristate 13-acetate/ionomycin-activated CD62L and alpha4beta7-expressing CD4 T cell subsets, using the protease inhibitor KD-IX-73-4. In SIV-infected macaques that develop AIDS a marked decrease in IL-2 expression was found within central, effector, or gut-homing memory cell subsets, whereas the expression of IL-2 in naive T cell subsets remained unaffected. This reduced IL-2 expression by memory cells and not a loss of the frequency of CD4 memory cells accounted for the reduced expression of IL-2 by CD4 T cells during SIV infection. As defined by the cell surface markers utilized, it appears that progression to AIDS is associated with functional impairment of memory cells, but not changes in lymphocyte circulation patterns.
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
url: Link


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titleDecreased expression of IL-2 in central and effector CD4 memory cells during progression to AIDS in rhesus macaques
creatorKOOPMAN, Gerrit ; NIPHUIS, Henk ; NEWMAN, Walter ; KISHIMOTO, Takashi K ; MAINO, Vernon C ; HEENEY, Jonathan L
creatorcontribKOOPMAN, Gerrit ; NIPHUIS, Henk ; NEWMAN, Walter ; KISHIMOTO, Takashi K ; MAINO, Vernon C ; HEENEY, Jonathan L
descriptionHIV-1 infection in humans has been reported to lead to a shift in the cytokine balance, with a relative decrease in T helper 1 type cytokines, especially IL-2. On the basis of the expression of CD45RA, in combination with homing markers CD62L or alpha4beta7, T helper cells can be sub-divided into naive, activated naive, central memory and effector memory cells as well as gut-homing subpopulations. In addition, each subset may have the potential to express distinct cytokines. At present it is unclear whether the changes in cytokine expression observed in HIV-1-infected individuals are secondary to changes within the composition of CD4 T cell subsets or are caused by changes in cytokine expression within each subset. A new technique was developed to detect cytokine expression in phorbol 12-myristate 13-acetate/ionomycin-activated CD62L and alpha4beta7-expressing CD4 T cell subsets, using the protease inhibitor KD-IX-73-4. In SIV-infected macaques that develop AIDS a marked decrease in IL-2 expression was found within central, effector, or gut-homing memory cell subsets, whereas the expression of IL-2 in naive T cell subsets remained unaffected. This reduced IL-2 expression by memory cells and not a loss of the frequency of CD4 memory cells accounted for the reduced expression of IL-2 by CD4 T cells during SIV infection. As defined by the cell surface markers utilized, it appears that progression to AIDS is associated with functional impairment of memory cells, but not changes in lymphocyte circulation patterns.
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languageeng
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subjectAIDS/HIV ; Animals ; Biological and medical sciences ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; Cytokines - metabolism ; Disease Models, Animal ; Disease Progression ; Flow Cytometry - methods ; Fundamental and applied biological sciences. Psychology ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunologic Memory - immunology ; Infectious diseases ; Interleukin-2 - metabolism ; Macaca mulatta ; Medical sciences ; Microbiology ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian Acquired Immunodeficiency Syndrome - physiopathology ; Simian Immunodeficiency Virus - immunology ; T-Lymphocyte Subsets - immunology ; T-Lymphocytes, Helper-Inducer - immunology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Virology
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0Decreased expression of IL-2 in central and effector CD4 memory cells during progression to AIDS in rhesus macaques
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descriptionHIV-1 infection in humans has been reported to lead to a shift in the cytokine balance, with a relative decrease in T helper 1 type cytokines, especially IL-2. On the basis of the expression of CD45RA, in combination with homing markers CD62L or alpha4beta7, T helper cells can be sub-divided into naive, activated naive, central memory and effector memory cells as well as gut-homing subpopulations. In addition, each subset may have the potential to express distinct cytokines. At present it is unclear whether the changes in cytokine expression observed in HIV-1-infected individuals are secondary to changes within the composition of CD4 T cell subsets or are caused by changes in cytokine expression within each subset. A new technique was developed to detect cytokine expression in phorbol 12-myristate 13-acetate/ionomycin-activated CD62L and alpha4beta7-expressing CD4 T cell subsets, using the protease inhibitor KD-IX-73-4. In SIV-infected macaques that develop AIDS a marked decrease in IL-2 expression was found within central, effector, or gut-homing memory cell subsets, whereas the expression of IL-2 in naive T cell subsets remained unaffected. This reduced IL-2 expression by memory cells and not a loss of the frequency of CD4 memory cells accounted for the reduced expression of IL-2 by CD4 T cells during SIV infection. As defined by the cell surface markers utilized, it appears that progression to AIDS is associated with functional impairment of memory cells, but not changes in lymphocyte circulation patterns.
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3CD4 antigen
4CD4-Positive T-Lymphocytes - immunology
5Cytokines - metabolism
6Disease Models, Animal
7Disease Progression
8Flow Cytometry - methods
9Fundamental and applied biological sciences. Psychology
10Human immunodeficiency virus
11Human viral diseases
12Humans
13Immunologic Memory - immunology
14Infectious diseases
15Interleukin-2 - metabolism
16Macaca mulatta
17Medical sciences
18Microbiology
19Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
20Simian Acquired Immunodeficiency Syndrome - immunology
21Simian Acquired Immunodeficiency Syndrome - physiopathology
22Simian Immunodeficiency Virus - immunology
23T-Lymphocyte Subsets - immunology
24T-Lymphocytes, Helper-Inducer - immunology
25Viral diseases
26Viral diseases of the lymphoid tissue and the blood. Aids
27Virology
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titleDecreased expression of IL-2 in central and effector CD4 memory cells during progression to AIDS in rhesus macaques
authorKOOPMAN, Gerrit ; NIPHUIS, Henk ; NEWMAN, Walter ; KISHIMOTO, Takashi K ; MAINO, Vernon C ; HEENEY, Jonathan L
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7Disease Progression
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14Infectious diseases
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19Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
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23T-Lymphocyte Subsets - immunology
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abstractHIV-1 infection in humans has been reported to lead to a shift in the cytokine balance, with a relative decrease in T helper 1 type cytokines, especially IL-2. On the basis of the expression of CD45RA, in combination with homing markers CD62L or alpha4beta7, T helper cells can be sub-divided into naive, activated naive, central memory and effector memory cells as well as gut-homing subpopulations. In addition, each subset may have the potential to express distinct cytokines. At present it is unclear whether the changes in cytokine expression observed in HIV-1-infected individuals are secondary to changes within the composition of CD4 T cell subsets or are caused by changes in cytokine expression within each subset. A new technique was developed to detect cytokine expression in phorbol 12-myristate 13-acetate/ionomycin-activated CD62L and alpha4beta7-expressing CD4 T cell subsets, using the protease inhibitor KD-IX-73-4. In SIV-infected macaques that develop AIDS a marked decrease in IL-2 expression was found within central, effector, or gut-homing memory cell subsets, whereas the expression of IL-2 in naive T cell subsets remained unaffected. This reduced IL-2 expression by memory cells and not a loss of the frequency of CD4 memory cells accounted for the reduced expression of IL-2 by CD4 T cells during SIV infection. As defined by the cell surface markers utilized, it appears that progression to AIDS is associated with functional impairment of memory cells, but not changes in lymphocyte circulation patterns.
copHagerstown, MD
pubLippincott Williams & Wilkins
pmid11740186
doi10.1097/00002030-200112070-00003