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Physical exercise induces activation of NF-kappaB in human peripheral blood lymphocytes

Current understanding of nuclear factor-kappaB (NF-kappaB) activation is derived mostly from in vitro studies, and in vivo human data are limited. This study provides first evidence showing that physical exercise (80% maximal O2 consumption, 1 h) may trigger NF-kappaB activation, as determined by el... Full description

Journal Title: Antioxidants & redox signaling 2001-12, Vol.3 (6), p.1131-1137
Main Author: Vider, J
Other Authors: Laaksonen, D E , Kilk, A , Atalay, M , Lehtmaa, J , Zilmer, M , Sen, C K
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States
ID: ISSN: 1523-0864
Link: https://www.ncbi.nlm.nih.gov/pubmed/11813986
Zum Text:
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recordid: cdi_proquest_miscellaneous_72417527
title: Physical exercise induces activation of NF-kappaB in human peripheral blood lymphocytes
format: Article
creator:
  • Vider, J
  • Laaksonen, D E
  • Kilk, A
  • Atalay, M
  • Lehtmaa, J
  • Zilmer, M
  • Sen, C K
subjects:
  • Adult
  • Exercise
  • Humans
  • Lipid Peroxidation
  • Lymphocytes - metabolism
  • Male
  • NF-kappa B - blood
  • Receptors, Interleukin-2 - blood
  • Time Factors
  • Transcription Factor RelA
  • Tumor Necrosis Factor-alpha - biosynthesis
ispartof: Antioxidants & redox signaling, 2001-12, Vol.3 (6), p.1131-1137
description: Current understanding of nuclear factor-kappaB (NF-kappaB) activation is derived mostly from in vitro studies, and in vivo human data are limited. This study provides first evidence showing that physical exercise (80% maximal O2 consumption, 1 h) may trigger NF-kappaB activation, as determined by electrophoretic mobility shift assay, in peripheral blood lymphocytes of physically fit young men. Supershift assay showed that the NF-kappaB protein complex contained the transcriptionally active p65 protein. Plasma levels of NF-kappaB-directed gene products such as tumor necrosis factor-alpha and interleukin-2 receptor confirmed that physical exercise caused NF-kappaB transactivation. Exercise-induced NF-kappaB activation in lymphocytes was associated with elevated levels of lipid peroxidation by-products in the plasma.
language: eng
source:
identifier: ISSN: 1523-0864
fulltext: no_fulltext
issn:
  • 1523-0864
  • 1557-7716
url: Link


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titlePhysical exercise induces activation of NF-kappaB in human peripheral blood lymphocytes
creatorVider, J ; Laaksonen, D E ; Kilk, A ; Atalay, M ; Lehtmaa, J ; Zilmer, M ; Sen, C K
creatorcontribVider, J ; Laaksonen, D E ; Kilk, A ; Atalay, M ; Lehtmaa, J ; Zilmer, M ; Sen, C K
descriptionCurrent understanding of nuclear factor-kappaB (NF-kappaB) activation is derived mostly from in vitro studies, and in vivo human data are limited. This study provides first evidence showing that physical exercise (80% maximal O2 consumption, 1 h) may trigger NF-kappaB activation, as determined by electrophoretic mobility shift assay, in peripheral blood lymphocytes of physically fit young men. Supershift assay showed that the NF-kappaB protein complex contained the transcriptionally active p65 protein. Plasma levels of NF-kappaB-directed gene products such as tumor necrosis factor-alpha and interleukin-2 receptor confirmed that physical exercise caused NF-kappaB transactivation. Exercise-induced NF-kappaB activation in lymphocytes was associated with elevated levels of lipid peroxidation by-products in the plasma.
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subjectAdult ; Exercise ; Humans ; Lipid Peroxidation ; Lymphocytes - metabolism ; Male ; NF-kappa B - blood ; Receptors, Interleukin-2 - blood ; Time Factors ; Transcription Factor RelA ; Tumor Necrosis Factor-alpha - biosynthesis
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abstractCurrent understanding of nuclear factor-kappaB (NF-kappaB) activation is derived mostly from in vitro studies, and in vivo human data are limited. This study provides first evidence showing that physical exercise (80% maximal O2 consumption, 1 h) may trigger NF-kappaB activation, as determined by electrophoretic mobility shift assay, in peripheral blood lymphocytes of physically fit young men. Supershift assay showed that the NF-kappaB protein complex contained the transcriptionally active p65 protein. Plasma levels of NF-kappaB-directed gene products such as tumor necrosis factor-alpha and interleukin-2 receptor confirmed that physical exercise caused NF-kappaB transactivation. Exercise-induced NF-kappaB activation in lymphocytes was associated with elevated levels of lipid peroxidation by-products in the plasma.
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pmid11813986