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First-pass metabolism of cyclosporin by the gut

Cyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin metabolites were readily detected in portal venous blood. Our findings indicate that the small intestine is... Full description

Journal Title: The Lancet (British edition) 1991-12-14, Vol.338 (8781), p.1488-1490
Main Author: Kolars, J.C
Other Authors: Watkins, P.B , Merion, R.M , Awni, W.M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: Elsevier Ltd
ID: ISSN: 0140-6736
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title: First-pass metabolism of cyclosporin by the gut
format: Article
creator:
  • Kolars, J.C
  • Watkins, P.B
  • Merion, R.M
  • Awni, W.M
subjects:
  • Abridged Index Medicus
  • Biological and medical sciences
  • Biological Availability
  • Cyclosporine
  • Cyclosporine - blood
  • Cyclosporine - metabolism
  • Cyclosporine - pharmacokinetics
  • Humans
  • Immunomodulators
  • Intestinal Absorption - drug effects
  • Intestine, Small - metabolism
  • Liver
  • Liver Transplantation
  • Medical research
  • Medical sciences
  • Metabolism
  • Pharmacology. Drug treatments
  • Physiological aspects
  • Portal Vein
  • Transplantation
  • Transplantation of organs, tissues, etc
  • Transplants & implants
ispartof: The Lancet (British edition), 1991-12-14, Vol.338 (8781), p.1488-1490
description: Cyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin metabolites were readily detected in portal venous blood. Our findings indicate that the small intestine is a major site of cyclosporin breakdown: such intestinal metabolism might help to explain the poor oral bioavailability and drug interactions of cyclosporin.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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descriptionCyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin metabolites were readily detected in portal venous blood. Our findings indicate that the small intestine is a major site of cyclosporin breakdown: such intestinal metabolism might help to explain the poor oral bioavailability and drug interactions of cyclosporin.
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subjectAbridged Index Medicus ; Biological and medical sciences ; Biological Availability ; Cyclosporine ; Cyclosporine - blood ; Cyclosporine - metabolism ; Cyclosporine - pharmacokinetics ; Humans ; Immunomodulators ; Intestinal Absorption - drug effects ; Intestine, Small - metabolism ; Liver ; Liver Transplantation ; Medical research ; Medical sciences ; Metabolism ; Pharmacology. Drug treatments ; Physiological aspects ; Portal Vein ; Transplantation ; Transplantation of organs, tissues, etc ; Transplants & implants
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abstractCyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin metabolites were readily detected in portal venous blood. Our findings indicate that the small intestine is a major site of cyclosporin breakdown: such intestinal metabolism might help to explain the poor oral bioavailability and drug interactions of cyclosporin.
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