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Are antisarcolemmal (ASAs) and antimyolemmal antibodies (AMLAs) “natural” antibodies?

Antisarcolemmal (ASAs) and in particular antimyolemmal antibodies (AMLAs) are a serologic hallmark of inflammatory heart muscle disease and its sequelae. Since they may also occur to a much lesser incidence with increasing age, it was examined whether they also possess properties of “natural antibod... Full description

Journal Title: Basic research in cardiology 1991, Vol.86, p.101-114
Main Author: Maisch, Bernhard
Other Authors: Drude, L. , Hengstenberg, C. , Herzum, M. , Hufnagel, G. , Kochsiek, K. , Schmaltz, A. , Schönian, U. , Schwab, M. D.
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Heidelberg: Steinkopff
ID: ISSN: 0300-8428
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recordid: cdi_proquest_miscellaneous_72643130
title: Are antisarcolemmal (ASAs) and antimyolemmal antibodies (AMLAs) “natural” antibodies?
format: Article
creator:
  • Maisch, Bernhard
  • Drude, L.
  • Hengstenberg, C.
  • Herzum, M.
  • Hufnagel, G.
  • Kochsiek, K.
  • Schmaltz, A.
  • Schönian, U.
  • Schwab, M. D.
subjects:
  • Adult
  • ardiomyopathy
  • atural
  • Autoantibodies - chemistry
  • Autoantibodies - immunology
  • Basement Membrane - immunology
  • Biological and medical sciences
  • Cardiology. Vascular system
  • Cardiomyopathy, Dilated - immunology
  • Child
  • Child, Preschool
  • Coxsackievirus Infections - immunology
  • Cross Reactions
  • ctivity
  • Enterovirus B, Human
  • erimyocarditis
  • erum
  • Female
  • Heart
  • Humans
  • ilated
  • Immunoglobulin A - analysis
  • Immunoglobulin A - biosynthesis
  • Immunoglobulin G - analysis
  • Immunoglobulin G - biosynthesis
  • Infant
  • Laminin - immunology
  • Male
  • Medical sciences
  • Middle Aged
  • Myocarditis - immunology
  • Myocarditis. Cardiomyopathies
  • ntibodies
  • ntimyolemmal
  • ntisarcolemmal
  • Sarcolemma - immunology
  • yocarditis
  • ytolytic
ispartof: Basic research in cardiology, 1991, Vol.86, p.101-114
description: Antisarcolemmal (ASAs) and in particular antimyolemmal antibodies (AMLAs) are a serologic hallmark of inflammatory heart muscle disease and its sequelae. Since they may also occur to a much lesser incidence with increasing age, it was examined whether they also possess properties of “natural antibodies”. As natural antibodies, AMLAs and ASAs have specificity for conserved structures on the membrane. They possess cross-reactivity and increase with age. In contrast to natural antibodies, however, they occur most frequently after viral stimulation, and are more often of the IgG- and IgA- than of the IgM-isotype and fix complement in the acute stage of the disease. They also exhibit cytolytic and cytotoxic properties when incubated in vitro with isolated heart muscle cells. In addition, antigenic mimicry has been demonstrated to be operative, since they are cross-reactive to viral proteins.
language: eng
source:
identifier: ISSN: 0300-8428
fulltext: no_fulltext
issn:
  • 0300-8428
  • 1435-1803
url: Link


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titleAre antisarcolemmal (ASAs) and antimyolemmal antibodies (AMLAs) “natural” antibodies?
creatorMaisch, Bernhard ; Drude, L. ; Hengstenberg, C. ; Herzum, M. ; Hufnagel, G. ; Kochsiek, K. ; Schmaltz, A. ; Schönian, U. ; Schwab, M. D.
creatorcontribMaisch, Bernhard ; Drude, L. ; Hengstenberg, C. ; Herzum, M. ; Hufnagel, G. ; Kochsiek, K. ; Schmaltz, A. ; Schönian, U. ; Schwab, M. D.
descriptionAntisarcolemmal (ASAs) and in particular antimyolemmal antibodies (AMLAs) are a serologic hallmark of inflammatory heart muscle disease and its sequelae. Since they may also occur to a much lesser incidence with increasing age, it was examined whether they also possess properties of “natural antibodies”. As natural antibodies, AMLAs and ASAs have specificity for conserved structures on the membrane. They possess cross-reactivity and increase with age. In contrast to natural antibodies, however, they occur most frequently after viral stimulation, and are more often of the IgG- and IgA- than of the IgM-isotype and fix complement in the acute stage of the disease. They also exhibit cytolytic and cytotoxic properties when incubated in vitro with isolated heart muscle cells. In addition, antigenic mimicry has been demonstrated to be operative, since they are cross-reactive to viral proteins.
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1ISBN: 9783798508941
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3EISSN: 1435-1803
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languageeng
publisherHeidelberg: Steinkopff
subjectAdult ; ardiomyopathy ; atural ; Autoantibodies - chemistry ; Autoantibodies - immunology ; Basement Membrane - immunology ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiomyopathy, Dilated - immunology ; Child ; Child, Preschool ; Coxsackievirus Infections - immunology ; Cross Reactions ; ctivity ; Enterovirus B, Human ; erimyocarditis ; erum ; Female ; Heart ; Humans ; ilated ; Immunoglobulin A - analysis ; Immunoglobulin A - biosynthesis ; Immunoglobulin G - analysis ; Immunoglobulin G - biosynthesis ; Infant ; Laminin - immunology ; Male ; Medical sciences ; Middle Aged ; Myocarditis - immunology ; Myocarditis. Cardiomyopathies ; ntibodies ; ntimyolemmal ; ntisarcolemmal ; Sarcolemma - immunology ; yocarditis ; ytolytic
ispartofBasic research in cardiology, 1991, Vol.86, p.101-114
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1Basic research in cardiology
addtitleBasic Res Cardiol
descriptionAntisarcolemmal (ASAs) and in particular antimyolemmal antibodies (AMLAs) are a serologic hallmark of inflammatory heart muscle disease and its sequelae. Since they may also occur to a much lesser incidence with increasing age, it was examined whether they also possess properties of “natural antibodies”. As natural antibodies, AMLAs and ASAs have specificity for conserved structures on the membrane. They possess cross-reactivity and increase with age. In contrast to natural antibodies, however, they occur most frequently after viral stimulation, and are more often of the IgG- and IgA- than of the IgM-isotype and fix complement in the acute stage of the disease. They also exhibit cytolytic and cytotoxic properties when incubated in vitro with isolated heart muscle cells. In addition, antigenic mimicry has been demonstrated to be operative, since they are cross-reactive to viral proteins.
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1ardiomyopathy
2atural
3Autoantibodies - chemistry
4Autoantibodies - immunology
5Basement Membrane - immunology
6Biological and medical sciences
7Cardiology. Vascular system
8Cardiomyopathy, Dilated - immunology
9Child
10Child, Preschool
11Coxsackievirus Infections - immunology
12Cross Reactions
13ctivity
14Enterovirus B, Human
15erimyocarditis
16erum
17Female
18Heart
19Humans
20ilated
21Immunoglobulin A - analysis
22Immunoglobulin A - biosynthesis
23Immunoglobulin G - analysis
24Immunoglobulin G - biosynthesis
25Infant
26Laminin - immunology
27Male
28Medical sciences
29Middle Aged
30Myocarditis - immunology
31Myocarditis. Cardiomyopathies
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36yocarditis
37ytolytic
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titleAre antisarcolemmal (ASAs) and antimyolemmal antibodies (AMLAs) “natural” antibodies?
authorMaisch, Bernhard ; Drude, L. ; Hengstenberg, C. ; Herzum, M. ; Hufnagel, G. ; Kochsiek, K. ; Schmaltz, A. ; Schönian, U. ; Schwab, M. D.
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1ardiomyopathy
2atural
3Autoantibodies - chemistry
4Autoantibodies - immunology
5Basement Membrane - immunology
6Biological and medical sciences
7Cardiology. Vascular system
8Cardiomyopathy, Dilated - immunology
9Child
10Child, Preschool
11Coxsackievirus Infections - immunology
12Cross Reactions
13ctivity
14Enterovirus B, Human
15erimyocarditis
16erum
17Female
18Heart
19Humans
20ilated
21Immunoglobulin A - analysis
22Immunoglobulin A - biosynthesis
23Immunoglobulin G - analysis
24Immunoglobulin G - biosynthesis
25Infant
26Laminin - immunology
27Male
28Medical sciences
29Middle Aged
30Myocarditis - immunology
31Myocarditis. Cardiomyopathies
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34ntisarcolemmal
35Sarcolemma - immunology
36yocarditis
37ytolytic
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1Drude, L.
2Hengstenberg, C.
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4Hufnagel, G.
5Kochsiek, K.
6Schmaltz, A.
7Schönian, U.
8Schwab, M. D.
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0Maisch, Bernhard
1Drude, L.
2Hengstenberg, C.
3Herzum, M.
4Hufnagel, G.
5Kochsiek, K.
6Schmaltz, A.
7Schönian, U.
8Schwab, M. D.
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atitleAre antisarcolemmal (ASAs) and antimyolemmal antibodies (AMLAs) “natural” antibodies?
jtitleBasic research in cardiology
addtitleBasic Res Cardiol
date1991
risdate1991
volume86
spage101
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pages101-114
issn0300-8428
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isbn
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13798508941
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codenBRCAB7
abstractAntisarcolemmal (ASAs) and in particular antimyolemmal antibodies (AMLAs) are a serologic hallmark of inflammatory heart muscle disease and its sequelae. Since they may also occur to a much lesser incidence with increasing age, it was examined whether they also possess properties of “natural antibodies”. As natural antibodies, AMLAs and ASAs have specificity for conserved structures on the membrane. They possess cross-reactivity and increase with age. In contrast to natural antibodies, however, they occur most frequently after viral stimulation, and are more often of the IgG- and IgA- than of the IgM-isotype and fix complement in the acute stage of the disease. They also exhibit cytolytic and cytotoxic properties when incubated in vitro with isolated heart muscle cells. In addition, antigenic mimicry has been demonstrated to be operative, since they are cross-reactive to viral proteins.
copHeidelberg
pubSteinkopff
pmid1664204
doi10.1007/978-3-662-30769-4_10