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Effectiveness and costs of interventions to lower systolic blood pressure and cholesterol: a global and regional analysis on reduction of cardiovascular-disease risk

Cardiovascular disease accounts for much morbidity and mortality in developed countries and is becoming increasingly important in less developed regions. Systolic blood pressure above 115 mm Hg accounts for two-thirds of strokes and almost half of ischaemic heart disease cases, and cholesterol conce... Full description

Journal Title: The Lancet (British edition) 2003, Vol.361 (9359), p.717-725
Main Author: Murray, Christopher JL
Other Authors: Lauer, Jeremy A , Hutubessy, Raymond CW , Niessen, Louis , Tomijima, Niels , Rodgers, Anthony , Lawes, Carlene MM , Evans, David B
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: Elsevier Ltd
ID: ISSN: 0140-6736
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title: Effectiveness and costs of interventions to lower systolic blood pressure and cholesterol: a global and regional analysis on reduction of cardiovascular-disease risk
format: Article
creator:
  • Murray, Christopher JL
  • Lauer, Jeremy A
  • Hutubessy, Raymond CW
  • Niessen, Louis
  • Tomijima, Niels
  • Rodgers, Anthony
  • Lawes, Carlene MM
  • Evans, David B
subjects:
  • Abridged Index Medicus
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biological and medical sciences
  • Blood
  • Blood Pressure
  • Cardiovascular disease
  • Cardiovascular diseases
  • Cardiovascular Diseases - economics
  • Cardiovascular Diseases - prevention & control
  • Care and treatment
  • Child
  • Child mortality
  • Cholesterol
  • Cookery for hypertensives
  • Coronary artery disease
  • Cost analysis
  • Cost-Benefit Analysis
  • Costs
  • Developed countries
  • Developing Countries
  • Disease control
  • Disorders of blood lipids. Hyperlipoproteinemia
  • Epidemiology
  • Food processing
  • Global Health
  • Health education
  • Health Expenditures - standards
  • Health Promotion - economics
  • Health risk assessment
  • Health risks
  • Health services
  • Heart diseases
  • Humans
  • Hypercholesterolemia
  • Hypercholesterolemia - economics
  • Hypercholesterolemia - prevention & control
  • Hypertension
  • Hypertension - economics
  • Hypertension - prevention & control
  • Incidence
  • Intervention
  • Medical care, Cost of
  • Medical research
  • Medical sciences
  • Medicine, Experimental
  • Metabolic diseases
  • Middle Aged
  • Miscellaneous
  • Morbidity
  • Mortality
  • Personal health
  • Prevention
  • Public health. Hygiene
  • Public health. Hygiene-occupational medicine
  • Quality-Adjusted Life Years
  • Reduction
  • Regional analysis
  • Regional planning
  • Risk factors
  • Systematic review
ispartof: The Lancet (British edition), 2003, Vol.361 (9359), p.717-725
description: Cardiovascular disease accounts for much morbidity and mortality in developed countries and is becoming increasingly important in less developed regions. Systolic blood pressure above 115 mm Hg accounts for two-thirds of strokes and almost half of ischaemic heart disease cases, and cholesterol concentrations exceeding 3·8 mmol/L for 18% and 55%, respectively. We report estimates of the population health effects, and costs of selected interventions to reduce the risks associated with high cholesterol concentrations and blood pressure in areas of the world with differing epidemiological profiles. Effect sizes were derived from systematic reviews or meta-analyses, and the effect on health outcomes projected over time for populations with differing age, sex, and epidemiological profiles. Incidence data from estimates of burden of disease were used in a four-state longitudinal population model to calculate disability-adjusted life years (DALYs) averted and patients treated. Costs were taken from previous publications, or estimated by local experts, in 14 regions. Non-personal health interventions, including government action to stimulate a reduction in the salt content of processed foods, are cost-effective ways to limit cardiovascular disease and could avert over 21 million DALYs per year worldwide. Combination treatment for people whose risk of a cardiovascular event over the next 10 years is above 35% is also cost effective leading to substantial additional health benefits by averting an additional 63 million DALYs per year worldwide. The combination of personal and non-personal health interventions evaluated here could lower the global incidence of cardiovascular events by as much as 50%.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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titleEffectiveness and costs of interventions to lower systolic blood pressure and cholesterol: a global and regional analysis on reduction of cardiovascular-disease risk
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creatorMurray, Christopher JL ; Lauer, Jeremy A ; Hutubessy, Raymond CW ; Niessen, Louis ; Tomijima, Niels ; Rodgers, Anthony ; Lawes, Carlene MM ; Evans, David B
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descriptionCardiovascular disease accounts for much morbidity and mortality in developed countries and is becoming increasingly important in less developed regions. Systolic blood pressure above 115 mm Hg accounts for two-thirds of strokes and almost half of ischaemic heart disease cases, and cholesterol concentrations exceeding 3·8 mmol/L for 18% and 55%, respectively. We report estimates of the population health effects, and costs of selected interventions to reduce the risks associated with high cholesterol concentrations and blood pressure in areas of the world with differing epidemiological profiles. Effect sizes were derived from systematic reviews or meta-analyses, and the effect on health outcomes projected over time for populations with differing age, sex, and epidemiological profiles. Incidence data from estimates of burden of disease were used in a four-state longitudinal population model to calculate disability-adjusted life years (DALYs) averted and patients treated. Costs were taken from previous publications, or estimated by local experts, in 14 regions. Non-personal health interventions, including government action to stimulate a reduction in the salt content of processed foods, are cost-effective ways to limit cardiovascular disease and could avert over 21 million DALYs per year worldwide. Combination treatment for people whose risk of a cardiovascular event over the next 10 years is above 35% is also cost effective leading to substantial additional health benefits by averting an additional 63 million DALYs per year worldwide. The combination of personal and non-personal health interventions evaluated here could lower the global incidence of cardiovascular events by as much as 50%.
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languageeng
publisherLondon: Elsevier Ltd
subjectAbridged Index Medicus ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Blood ; Blood Pressure ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - economics ; Cardiovascular Diseases - prevention & control ; Care and treatment ; Child ; Child mortality ; Cholesterol ; Cookery for hypertensives ; Coronary artery disease ; Cost analysis ; Cost-Benefit Analysis ; Costs ; Developed countries ; Developing Countries ; Disease control ; Disorders of blood lipids. Hyperlipoproteinemia ; Epidemiology ; Food processing ; Global Health ; Health education ; Health Expenditures - standards ; Health Promotion - economics ; Health risk assessment ; Health risks ; Health services ; Heart diseases ; Humans ; Hypercholesterolemia ; Hypercholesterolemia - economics ; Hypercholesterolemia - prevention & control ; Hypertension ; Hypertension - economics ; Hypertension - prevention & control ; Incidence ; Intervention ; Medical care, Cost of ; Medical research ; Medical sciences ; Medicine, Experimental ; Metabolic diseases ; Middle Aged ; Miscellaneous ; Morbidity ; Mortality ; Personal health ; Prevention ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Quality-Adjusted Life Years ; Reduction ; Regional analysis ; Regional planning ; Risk factors ; Systematic review
ispartofThe Lancet (British edition), 2003, Vol.361 (9359), p.717-725
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6Lawes, Carlene MM
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0Effectiveness and costs of interventions to lower systolic blood pressure and cholesterol: a global and regional analysis on reduction of cardiovascular-disease risk
1The Lancet (British edition)
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descriptionCardiovascular disease accounts for much morbidity and mortality in developed countries and is becoming increasingly important in less developed regions. Systolic blood pressure above 115 mm Hg accounts for two-thirds of strokes and almost half of ischaemic heart disease cases, and cholesterol concentrations exceeding 3·8 mmol/L for 18% and 55%, respectively. We report estimates of the population health effects, and costs of selected interventions to reduce the risks associated with high cholesterol concentrations and blood pressure in areas of the world with differing epidemiological profiles. Effect sizes were derived from systematic reviews or meta-analyses, and the effect on health outcomes projected over time for populations with differing age, sex, and epidemiological profiles. Incidence data from estimates of burden of disease were used in a four-state longitudinal population model to calculate disability-adjusted life years (DALYs) averted and patients treated. Costs were taken from previous publications, or estimated by local experts, in 14 regions. Non-personal health interventions, including government action to stimulate a reduction in the salt content of processed foods, are cost-effective ways to limit cardiovascular disease and could avert over 21 million DALYs per year worldwide. Combination treatment for people whose risk of a cardiovascular event over the next 10 years is above 35% is also cost effective leading to substantial additional health benefits by averting an additional 63 million DALYs per year worldwide. The combination of personal and non-personal health interventions evaluated here could lower the global incidence of cardiovascular events by as much as 50%.
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0Abridged Index Medicus
1Adolescent
2Adult
3Aged
4Aged, 80 and over
5Biological and medical sciences
6Blood
7Blood Pressure
8Cardiovascular disease
9Cardiovascular diseases
10Cardiovascular Diseases - economics
11Cardiovascular Diseases - prevention & control
12Care and treatment
13Child
14Child mortality
15Cholesterol
16Cookery for hypertensives
17Coronary artery disease
18Cost analysis
19Cost-Benefit Analysis
20Costs
21Developed countries
22Developing Countries
23Disease control
24Disorders of blood lipids. Hyperlipoproteinemia
25Epidemiology
26Food processing
27Global Health
28Health education
29Health Expenditures - standards
30Health Promotion - economics
31Health risk assessment
32Health risks
33Health services
34Heart diseases
35Humans
36Hypercholesterolemia
37Hypercholesterolemia - economics
38Hypercholesterolemia - prevention & control
39Hypertension
40Hypertension - economics
41Hypertension - prevention & control
42Incidence
43Intervention
44Medical care, Cost of
45Medical research
46Medical sciences
47Medicine, Experimental
48Metabolic diseases
49Middle Aged
50Miscellaneous
51Morbidity
52Mortality
53Personal health
54Prevention
55Public health. Hygiene
56Public health. Hygiene-occupational medicine
57Quality-Adjusted Life Years
58Reduction
59Regional analysis
60Regional planning
61Risk factors
62Systematic review
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titleEffectiveness and costs of interventions to lower systolic blood pressure and cholesterol: a global and regional analysis on reduction of cardiovascular-disease risk
authorMurray, Christopher JL ; Lauer, Jeremy A ; Hutubessy, Raymond CW ; Niessen, Louis ; Tomijima, Niels ; Rodgers, Anthony ; Lawes, Carlene MM ; Evans, David B
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1Adolescent
2Adult
3Aged
4Aged, 80 and over
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6Blood
7Blood Pressure
8Cardiovascular disease
9Cardiovascular diseases
10Cardiovascular Diseases - economics
11Cardiovascular Diseases - prevention & control
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15Cholesterol
16Cookery for hypertensives
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26Food processing
27Global Health
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29Health Expenditures - standards
30Health Promotion - economics
31Health risk assessment
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36Hypercholesterolemia
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58Reduction
59Regional analysis
60Regional planning
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abstractCardiovascular disease accounts for much morbidity and mortality in developed countries and is becoming increasingly important in less developed regions. Systolic blood pressure above 115 mm Hg accounts for two-thirds of strokes and almost half of ischaemic heart disease cases, and cholesterol concentrations exceeding 3·8 mmol/L for 18% and 55%, respectively. We report estimates of the population health effects, and costs of selected interventions to reduce the risks associated with high cholesterol concentrations and blood pressure in areas of the world with differing epidemiological profiles. Effect sizes were derived from systematic reviews or meta-analyses, and the effect on health outcomes projected over time for populations with differing age, sex, and epidemiological profiles. Incidence data from estimates of burden of disease were used in a four-state longitudinal population model to calculate disability-adjusted life years (DALYs) averted and patients treated. Costs were taken from previous publications, or estimated by local experts, in 14 regions. Non-personal health interventions, including government action to stimulate a reduction in the salt content of processed foods, are cost-effective ways to limit cardiovascular disease and could avert over 21 million DALYs per year worldwide. Combination treatment for people whose risk of a cardiovascular event over the next 10 years is above 35% is also cost effective leading to substantial additional health benefits by averting an additional 63 million DALYs per year worldwide. The combination of personal and non-personal health interventions evaluated here could lower the global incidence of cardiovascular events by as much as 50%.
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pmid12620735
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