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Marked Decrease in Plasma Antioxidants in Aged Osteoporotic Women: Results of a Cross-Sectional Study

Although recent epidemiological studies found a positive correlation between dietary vitamin C intake and bone mineral density, data on plasma levels of vitamin C or other antioxidants in osteoporotic subjects are scanty. The aim of this study was to evaluate whether antioxidant defenses are decreas... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2003-04, Vol.88 (4), p.1523-1527
Main Author: Maggio, Dario
Other Authors: Barabani, Mauro , Pierandrei, Marco , Polidori, M. Cristina , Catani, Marco , Mecocci, Patrizia , Senin, Umberto , Pacifici, Roberto , Cherubini, Antonio
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Bethesda, MD: Endocrine Society
ID: ISSN: 0021-972X
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recordid: cdi_proquest_miscellaneous_73167981
title: Marked Decrease in Plasma Antioxidants in Aged Osteoporotic Women: Results of a Cross-Sectional Study
format: Article
creator:
  • Maggio, Dario
  • Barabani, Mauro
  • Pierandrei, Marco
  • Polidori, M. Cristina
  • Catani, Marco
  • Mecocci, Patrizia
  • Senin, Umberto
  • Pacifici, Roberto
  • Cherubini, Antonio
subjects:
  • Abridged Index Medicus
  • Activities of Daily Living
  • Aged
  • Aging
  • Analysis. Health state
  • Antioxidants - administration & dosage
  • Antioxidants - analysis
  • Ascorbic Acid - blood
  • Biological and medical sciences
  • Body Mass Index
  • Bone and Bones - injuries
  • Cross-Sectional Studies
  • Diet
  • Diseases of the osteoarticular system
  • Epidemiology
  • Erythrocytes - enzymology
  • Female
  • Fractures, Bone - epidemiology
  • General aspects
  • Glutathione Peroxidase - blood
  • Humans
  • Lipid Peroxidation
  • Malondialdehyde - blood
  • Medical sciences
  • Middle Aged
  • Osteoporosis - blood
  • Osteoporosis - complications
  • Osteoporosis - physiopathology
  • Osteoporosis. Osteomalacia. Paget disease
  • Public health. Hygiene
  • Public health. Hygiene-occupational medicine
  • Superoxide Dismutase - blood
  • Uric Acid - blood
  • Vitamin A - blood
  • Vitamin E - blood
ispartof: The journal of clinical endocrinology and metabolism, 2003-04, Vol.88 (4), p.1523-1527
description: Although recent epidemiological studies found a positive correlation between dietary vitamin C intake and bone mineral density, data on plasma levels of vitamin C or other antioxidants in osteoporotic subjects are scanty. The aim of this study was to evaluate whether antioxidant defenses are decreased in elderly osteoporotic women and, if this is the case, to understand whether osteoporosis is a condition characterized by increased oxidative stress. To answer these questions, plasma vitamins C, E, and A; uric acid; and the enzymatic activities of superoxide dismutase in plasma and erythrocytes and of glutathione peroxidase in plasma were measured in 75 subjects with osteoporosis and 75 controls. Dietary and endogenous antioxidants were consistently lower in osteoporotic than in control subjects. On the other hand, plasma levels of malondialdehyde, a byproduct of lipid peroxidation, did not differ between groups. Our results reveal that antioxidant defenses are markedly decreased in osteoporotic women. The mechanisms underlying antioxidant depletion and its relevance to the pathogenesis of osteoporosis deserve further investigation.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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titleMarked Decrease in Plasma Antioxidants in Aged Osteoporotic Women: Results of a Cross-Sectional Study
creatorMaggio, Dario ; Barabani, Mauro ; Pierandrei, Marco ; Polidori, M. Cristina ; Catani, Marco ; Mecocci, Patrizia ; Senin, Umberto ; Pacifici, Roberto ; Cherubini, Antonio
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descriptionAlthough recent epidemiological studies found a positive correlation between dietary vitamin C intake and bone mineral density, data on plasma levels of vitamin C or other antioxidants in osteoporotic subjects are scanty. The aim of this study was to evaluate whether antioxidant defenses are decreased in elderly osteoporotic women and, if this is the case, to understand whether osteoporosis is a condition characterized by increased oxidative stress. To answer these questions, plasma vitamins C, E, and A; uric acid; and the enzymatic activities of superoxide dismutase in plasma and erythrocytes and of glutathione peroxidase in plasma were measured in 75 subjects with osteoporosis and 75 controls. Dietary and endogenous antioxidants were consistently lower in osteoporotic than in control subjects. On the other hand, plasma levels of malondialdehyde, a byproduct of lipid peroxidation, did not differ between groups. Our results reveal that antioxidant defenses are markedly decreased in osteoporotic women. The mechanisms underlying antioxidant depletion and its relevance to the pathogenesis of osteoporosis deserve further investigation.
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subjectAbridged Index Medicus ; Activities of Daily Living ; Aged ; Aging ; Analysis. Health state ; Antioxidants - administration & dosage ; Antioxidants - analysis ; Ascorbic Acid - blood ; Biological and medical sciences ; Body Mass Index ; Bone and Bones - injuries ; Cross-Sectional Studies ; Diet ; Diseases of the osteoarticular system ; Epidemiology ; Erythrocytes - enzymology ; Female ; Fractures, Bone - epidemiology ; General aspects ; Glutathione Peroxidase - blood ; Humans ; Lipid Peroxidation ; Malondialdehyde - blood ; Medical sciences ; Middle Aged ; Osteoporosis - blood ; Osteoporosis - complications ; Osteoporosis - physiopathology ; Osteoporosis. Osteomalacia. Paget disease ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Superoxide Dismutase - blood ; Uric Acid - blood ; Vitamin A - blood ; Vitamin E - blood
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descriptionAlthough recent epidemiological studies found a positive correlation between dietary vitamin C intake and bone mineral density, data on plasma levels of vitamin C or other antioxidants in osteoporotic subjects are scanty. The aim of this study was to evaluate whether antioxidant defenses are decreased in elderly osteoporotic women and, if this is the case, to understand whether osteoporosis is a condition characterized by increased oxidative stress. To answer these questions, plasma vitamins C, E, and A; uric acid; and the enzymatic activities of superoxide dismutase in plasma and erythrocytes and of glutathione peroxidase in plasma were measured in 75 subjects with osteoporosis and 75 controls. Dietary and endogenous antioxidants were consistently lower in osteoporotic than in control subjects. On the other hand, plasma levels of malondialdehyde, a byproduct of lipid peroxidation, did not differ between groups. Our results reveal that antioxidant defenses are markedly decreased in osteoporotic women. The mechanisms underlying antioxidant depletion and its relevance to the pathogenesis of osteoporosis deserve further investigation.
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4Analysis. Health state
5Antioxidants - administration & dosage
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7Ascorbic Acid - blood
8Biological and medical sciences
9Body Mass Index
10Bone and Bones - injuries
11Cross-Sectional Studies
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14Epidemiology
15Erythrocytes - enzymology
16Female
17Fractures, Bone - epidemiology
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19Glutathione Peroxidase - blood
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21Lipid Peroxidation
22Malondialdehyde - blood
23Medical sciences
24Middle Aged
25Osteoporosis - blood
26Osteoporosis - complications
27Osteoporosis - physiopathology
28Osteoporosis. Osteomalacia. Paget disease
29Public health. Hygiene
30Public health. Hygiene-occupational medicine
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32Uric Acid - blood
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29Public health. Hygiene
30Public health. Hygiene-occupational medicine
31Superoxide Dismutase - blood
32Uric Acid - blood
33Vitamin A - blood
34Vitamin E - blood
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abstractAlthough recent epidemiological studies found a positive correlation between dietary vitamin C intake and bone mineral density, data on plasma levels of vitamin C or other antioxidants in osteoporotic subjects are scanty. The aim of this study was to evaluate whether antioxidant defenses are decreased in elderly osteoporotic women and, if this is the case, to understand whether osteoporosis is a condition characterized by increased oxidative stress. To answer these questions, plasma vitamins C, E, and A; uric acid; and the enzymatic activities of superoxide dismutase in plasma and erythrocytes and of glutathione peroxidase in plasma were measured in 75 subjects with osteoporosis and 75 controls. Dietary and endogenous antioxidants were consistently lower in osteoporotic than in control subjects. On the other hand, plasma levels of malondialdehyde, a byproduct of lipid peroxidation, did not differ between groups. Our results reveal that antioxidant defenses are markedly decreased in osteoporotic women. The mechanisms underlying antioxidant depletion and its relevance to the pathogenesis of osteoporosis deserve further investigation.
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pubEndocrine Society
pmid12679433
doi10.1210/jc.2002-021496
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