schliessen

Filtern

 

Bibliotheken

Impact of Blood Pressure Lowering on Cardiovascular Outcomes in Normal Weight, Overweight, and Obese Individuals: The Perindopril Protection Against Recurrent Stroke Study Trial

There is considerable uncertainty regarding the efficacy of blood pressure–lowering therapy in reducing cardiovascular risk in obese people. In this report we examine the effects of blood pressure lowering according to baseline body mass index (kilograms per meter squared) in the Perindopril Protect... Full description

Journal Title: Hypertension (Dallas Tex. 1979), 2010, Vol.55 (5), p.1193-1198
Main Author: Czernichow, Sébastien
Other Authors: Ninomiya, Toshiharu , Huxley, Rachel , Kengne, André-Pascal , Batty, G David , Grobbee, Diederick E , Woodward, Mark , Neal, Bruce , Chalmers, John
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: American Heart Association, Inc
ID: ISSN: 0194-911X
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_733105200
title: Impact of Blood Pressure Lowering on Cardiovascular Outcomes in Normal Weight, Overweight, and Obese Individuals: The Perindopril Protection Against Recurrent Stroke Study Trial
format: Article
creator:
  • Czernichow, Sébastien
  • Ninomiya, Toshiharu
  • Huxley, Rachel
  • Kengne, André-Pascal
  • Batty, G David
  • Grobbee, Diederick E
  • Woodward, Mark
  • Neal, Bruce
  • Chalmers, John
subjects:
  • Aged
  • Antihypertensive Agents - therapeutic use
  • Arterial hypertension. Arterial hypotension
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Body Weight
  • Cardiology. Vascular system
  • Cardiovascular Diseases - epidemiology
  • Cardiovascular Diseases - prevention & control
  • Clinical manifestations. Epidemiology. Investigative techniques. Etiology
  • Female
  • Humans
  • Ischemic Attack, Transient - complications
  • Ischemic Attack, Transient - epidemiology
  • Male
  • Medical sciences
  • Middle Aged
  • Obesity - complications
  • Obesity - epidemiology
  • Obesity - physiopathology
  • Overweight - complications
  • Overweight - epidemiology
  • Overweight - physiopathology
  • Perindopril - therapeutic use
  • Placebos
  • Proportional Hazards Models
  • Recurrence
  • Risk Reduction Behavior
  • Stroke - epidemiology
  • Stroke - prevention & control
ispartof: Hypertension (Dallas, Tex. 1979), 2010, Vol.55 (5), p.1193-1198
description: There is considerable uncertainty regarding the efficacy of blood pressure–lowering therapy in reducing cardiovascular risk in obese people. In this report we examine the effects of blood pressure lowering according to baseline body mass index (kilograms per meter squared) in the Perindopril Protection Against Recurrent Stroke Study. A total of 6105 participants with cerebrovascular disease were randomized to perindopril-based blood pressure–lowering therapy or placebo. The overall mean difference in systolic/diastolic blood pressure between participants assigned active therapy or placebo was 9/4 mm Hg (SE0.5/0.3 mm Hg), with no difference by body mass index quarters (
language: eng
source:
identifier: ISSN: 0194-911X
fulltext: no_fulltext
issn:
  • 0194-911X
  • 1524-4563
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.3661296
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_cross
recordidTN_cdi_proquest_miscellaneous_733105200
sourceformatXML
sourcesystemPC
sourcerecordid733105200
originalsourceidFETCH-LOGICAL-13833-8ff97ee9cb0b0a09b8e4b9e960fd54e456b6685bce065f2b44bf96f4b0fcaf470
addsrcrecordideNpdkd2O0zAQhSMEYsvCKyALCXFDythx_vauVIVWqtpqtwi4ihxn3Jp14mInrfaxeEO8agGJC2ts65tz7DlR9IbCmNKMfph_38xut7PV3WK9mswnYwrlmHLIGH8SjWjKeMzTLHkajYCWPC4p_XYVvfD-BwDlnOfPoysGjDKW01H0a9EehOyJVeSjsbYhG4feDw7J0p7Q6W5HbEemwjXaHoWXgxGOrIde2hY90R1ZWdcKQ76i3u3792R9RHe67EXXkHWNHsmia_RRN4Mw_oZs90g2j9KNPThtgqPtUfY6-Ex2Qne-J7coB-ew68ld7-w9hjI0D2TrtDAvo2cq6OCrS72OvnyabafzeLn-vJhOljFNiiSJC6XKHLGUNdQgoKwL5HWJZQaqSTmGCdVZVqS1RMhSxWrOa1VmitegpFA8h-vo3Vn34OzPAX1ftdpLNEZ0aAdf5UlCIWUAgbw5k9JZ7x2qKvyrFe6holA9Jlb9l1i4L6tzYqH59cVmqFts_rb-iSgAby9AGL8wyolOav-PYzlQWiaB42fuZE2Pzt-bIQRY7VGYfl-FZwJnWREzoABpOMVhsQR-A9ILtC0
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid733105200
display
typearticle
titleImpact of Blood Pressure Lowering on Cardiovascular Outcomes in Normal Weight, Overweight, and Obese Individuals: The Perindopril Protection Against Recurrent Stroke Study Trial
creatorCzernichow, Sébastien ; Ninomiya, Toshiharu ; Huxley, Rachel ; Kengne, André-Pascal ; Batty, G David ; Grobbee, Diederick E ; Woodward, Mark ; Neal, Bruce ; Chalmers, John
creatorcontribCzernichow, Sébastien ; Ninomiya, Toshiharu ; Huxley, Rachel ; Kengne, André-Pascal ; Batty, G David ; Grobbee, Diederick E ; Woodward, Mark ; Neal, Bruce ; Chalmers, John
descriptionThere is considerable uncertainty regarding the efficacy of blood pressure–lowering therapy in reducing cardiovascular risk in obese people. In this report we examine the effects of blood pressure lowering according to baseline body mass index (kilograms per meter squared) in the Perindopril Protection Against Recurrent Stroke Study. A total of 6105 participants with cerebrovascular disease were randomized to perindopril-based blood pressure–lowering therapy or placebo. The overall mean difference in systolic/diastolic blood pressure between participants assigned active therapy or placebo was 9/4 mm Hg (SE0.5/0.3 mm Hg), with no difference by body mass index quarters (<23.1, 23.1 to 25.3, 25.4 to 27.8, and ≥27.9 kg/m). A consistent treatment benefit was demonstrated for protection against major vascular events across quarters with the following hazard ratios (95% CIs)0.80 (0.62 to 1.02), 0.78 (0.61 to 1.01), 0.67 (0.53 to 0.86), 0.69 (0.54 to 0.88), and 0.74 (0.66 to 0.84; P for heterogeneity=0.16). Similar results were apparent for stroke and stroke subtypes (all P for heterogeneity ≥0.07) or with the standard definitions of overweight and obesity (<25, 25 to 29, and ≥30 kg/m; all P for heterogeneity ≥0.28). The absolute effects of treatment were, however, more than twice that in the highest compared with the lowest body mass index quartile. Across increasing quarters of body mass index over 5 years, active therapy prevented 1 major vascular event among every 28, 23, 13, and 13 patients treated. In conclusion, blood pressure–lowering therapy produced comparable risk reductions in vascular disease across the whole range of body mass indices in participants with a history of stroke. However, the greater baseline level of cardiovascular risk in those with higher body mass index meant that these patients obtained the greatest benefit.
identifier
0ISSN: 0194-911X
1EISSN: 1524-4563
2DOI: 10.1161/HYPERTENSIONAHA.109.140624
3PMID: 20212271
4CODEN: HPRTDN
languageeng
publisherHagerstown, MD: American Heart Association, Inc
subjectAged ; Antihypertensive Agents - therapeutic use ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Body Weight ; Cardiology. Vascular system ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - prevention & control ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Female ; Humans ; Ischemic Attack, Transient - complications ; Ischemic Attack, Transient - epidemiology ; Male ; Medical sciences ; Middle Aged ; Obesity - complications ; Obesity - epidemiology ; Obesity - physiopathology ; Overweight - complications ; Overweight - epidemiology ; Overweight - physiopathology ; Perindopril - therapeutic use ; Placebos ; Proportional Hazards Models ; Recurrence ; Risk Reduction Behavior ; Stroke - epidemiology ; Stroke - prevention & control
ispartofHypertension (Dallas, Tex. 1979), 2010, Vol.55 (5), p.1193-1198
rights
02010 American Heart Association, Inc.
12015 INIST-CNRS
lds50peer_reviewed
oafree_for_read
citesFETCH-LOGICAL-13833-8ff97ee9cb0b0a09b8e4b9e960fd54e456b6685bce065f2b44bf96f4b0fcaf470
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22701193$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20212271$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Czernichow, Sébastien
1Ninomiya, Toshiharu
2Huxley, Rachel
3Kengne, André-Pascal
4Batty, G David
5Grobbee, Diederick E
6Woodward, Mark
7Neal, Bruce
8Chalmers, John
title
0Impact of Blood Pressure Lowering on Cardiovascular Outcomes in Normal Weight, Overweight, and Obese Individuals: The Perindopril Protection Against Recurrent Stroke Study Trial
1Hypertension (Dallas, Tex. 1979)
addtitleHypertension
descriptionThere is considerable uncertainty regarding the efficacy of blood pressure–lowering therapy in reducing cardiovascular risk in obese people. In this report we examine the effects of blood pressure lowering according to baseline body mass index (kilograms per meter squared) in the Perindopril Protection Against Recurrent Stroke Study. A total of 6105 participants with cerebrovascular disease were randomized to perindopril-based blood pressure–lowering therapy or placebo. The overall mean difference in systolic/diastolic blood pressure between participants assigned active therapy or placebo was 9/4 mm Hg (SE0.5/0.3 mm Hg), with no difference by body mass index quarters (<23.1, 23.1 to 25.3, 25.4 to 27.8, and ≥27.9 kg/m). A consistent treatment benefit was demonstrated for protection against major vascular events across quarters with the following hazard ratios (95% CIs)0.80 (0.62 to 1.02), 0.78 (0.61 to 1.01), 0.67 (0.53 to 0.86), 0.69 (0.54 to 0.88), and 0.74 (0.66 to 0.84; P for heterogeneity=0.16). Similar results were apparent for stroke and stroke subtypes (all P for heterogeneity ≥0.07) or with the standard definitions of overweight and obesity (<25, 25 to 29, and ≥30 kg/m; all P for heterogeneity ≥0.28). The absolute effects of treatment were, however, more than twice that in the highest compared with the lowest body mass index quartile. Across increasing quarters of body mass index over 5 years, active therapy prevented 1 major vascular event among every 28, 23, 13, and 13 patients treated. In conclusion, blood pressure–lowering therapy produced comparable risk reductions in vascular disease across the whole range of body mass indices in participants with a history of stroke. However, the greater baseline level of cardiovascular risk in those with higher body mass index meant that these patients obtained the greatest benefit.
subject
0Aged
1Antihypertensive Agents - therapeutic use
2Arterial hypertension. Arterial hypotension
3Biological and medical sciences
4Blood and lymphatic vessels
5Body Weight
6Cardiology. Vascular system
7Cardiovascular Diseases - epidemiology
8Cardiovascular Diseases - prevention & control
9Clinical manifestations. Epidemiology. Investigative techniques. Etiology
10Female
11Humans
12Ischemic Attack, Transient - complications
13Ischemic Attack, Transient - epidemiology
14Male
15Medical sciences
16Middle Aged
17Obesity - complications
18Obesity - epidemiology
19Obesity - physiopathology
20Overweight - complications
21Overweight - epidemiology
22Overweight - physiopathology
23Perindopril - therapeutic use
24Placebos
25Proportional Hazards Models
26Recurrence
27Risk Reduction Behavior
28Stroke - epidemiology
29Stroke - prevention & control
issn
00194-911X
11524-4563
fulltextfalse
rsrctypearticle
creationdate2010
recordtypearticle
recordideNpdkd2O0zAQhSMEYsvCKyALCXFDythx_vauVIVWqtpqtwi4ihxn3Jp14mInrfaxeEO8agGJC2ts65tz7DlR9IbCmNKMfph_38xut7PV3WK9mswnYwrlmHLIGH8SjWjKeMzTLHkajYCWPC4p_XYVvfD-BwDlnOfPoysGjDKW01H0a9EehOyJVeSjsbYhG4feDw7J0p7Q6W5HbEemwjXaHoWXgxGOrIde2hY90R1ZWdcKQ76i3u3792R9RHe67EXXkHWNHsmia_RRN4Mw_oZs90g2j9KNPThtgqPtUfY6-Ex2Qne-J7coB-ew68ld7-w9hjI0D2TrtDAvo2cq6OCrS72OvnyabafzeLn-vJhOljFNiiSJC6XKHLGUNdQgoKwL5HWJZQaqSTmGCdVZVqS1RMhSxWrOa1VmitegpFA8h-vo3Vn34OzPAX1ftdpLNEZ0aAdf5UlCIWUAgbw5k9JZ7x2qKvyrFe6holA9Jlb9l1i4L6tzYqH59cVmqFts_rb-iSgAby9AGL8wyolOav-PYzlQWiaB42fuZE2Pzt-bIQRY7VGYfl-FZwJnWREzoABpOMVhsQR-A9ILtC0
startdate201005
enddate201005
creator
0Czernichow, Sébastien
1Ninomiya, Toshiharu
2Huxley, Rachel
3Kengne, André-Pascal
4Batty, G David
5Grobbee, Diederick E
6Woodward, Mark
7Neal, Bruce
8Chalmers, John
general
0American Heart Association, Inc
1Lippincott Williams & Wilkins
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
97X8
sort
creationdate201005
titleImpact of Blood Pressure Lowering on Cardiovascular Outcomes in Normal Weight, Overweight, and Obese Individuals: The Perindopril Protection Against Recurrent Stroke Study Trial
authorCzernichow, Sébastien ; Ninomiya, Toshiharu ; Huxley, Rachel ; Kengne, André-Pascal ; Batty, G David ; Grobbee, Diederick E ; Woodward, Mark ; Neal, Bruce ; Chalmers, John
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-13833-8ff97ee9cb0b0a09b8e4b9e960fd54e456b6685bce065f2b44bf96f4b0fcaf470
rsrctypearticles
prefilterarticles
languageeng
creationdate2010
topic
0Aged
1Antihypertensive Agents - therapeutic use
2Arterial hypertension. Arterial hypotension
3Biological and medical sciences
4Blood and lymphatic vessels
5Body Weight
6Cardiology. Vascular system
7Cardiovascular Diseases - epidemiology
8Cardiovascular Diseases - prevention & control
9Clinical manifestations. Epidemiology. Investigative techniques. Etiology
10Female
11Humans
12Ischemic Attack, Transient - complications
13Ischemic Attack, Transient - epidemiology
14Male
15Medical sciences
16Middle Aged
17Obesity - complications
18Obesity - epidemiology
19Obesity - physiopathology
20Overweight - complications
21Overweight - epidemiology
22Overweight - physiopathology
23Perindopril - therapeutic use
24Placebos
25Proportional Hazards Models
26Recurrence
27Risk Reduction Behavior
28Stroke - epidemiology
29Stroke - prevention & control
toplevelpeer_reviewed
creatorcontrib
0Czernichow, Sébastien
1Ninomiya, Toshiharu
2Huxley, Rachel
3Kengne, André-Pascal
4Batty, G David
5Grobbee, Diederick E
6Woodward, Mark
7Neal, Bruce
8Chalmers, John
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8MEDLINE - Academic
jtitleHypertension (Dallas, Tex. 1979)
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Czernichow, Sébastien
1Ninomiya, Toshiharu
2Huxley, Rachel
3Kengne, André-Pascal
4Batty, G David
5Grobbee, Diederick E
6Woodward, Mark
7Neal, Bruce
8Chalmers, John
formatjournal
genrearticle
ristypeJOUR
atitleImpact of Blood Pressure Lowering on Cardiovascular Outcomes in Normal Weight, Overweight, and Obese Individuals: The Perindopril Protection Against Recurrent Stroke Study Trial
jtitleHypertension (Dallas, Tex. 1979)
addtitleHypertension
date2010-05
risdate2010
volume55
issue5
spage1193
epage1198
pages1193-1198
issn0194-911X
eissn1524-4563
codenHPRTDN
abstractThere is considerable uncertainty regarding the efficacy of blood pressure–lowering therapy in reducing cardiovascular risk in obese people. In this report we examine the effects of blood pressure lowering according to baseline body mass index (kilograms per meter squared) in the Perindopril Protection Against Recurrent Stroke Study. A total of 6105 participants with cerebrovascular disease were randomized to perindopril-based blood pressure–lowering therapy or placebo. The overall mean difference in systolic/diastolic blood pressure between participants assigned active therapy or placebo was 9/4 mm Hg (SE0.5/0.3 mm Hg), with no difference by body mass index quarters (<23.1, 23.1 to 25.3, 25.4 to 27.8, and ≥27.9 kg/m). A consistent treatment benefit was demonstrated for protection against major vascular events across quarters with the following hazard ratios (95% CIs)0.80 (0.62 to 1.02), 0.78 (0.61 to 1.01), 0.67 (0.53 to 0.86), 0.69 (0.54 to 0.88), and 0.74 (0.66 to 0.84; P for heterogeneity=0.16). Similar results were apparent for stroke and stroke subtypes (all P for heterogeneity ≥0.07) or with the standard definitions of overweight and obesity (<25, 25 to 29, and ≥30 kg/m; all P for heterogeneity ≥0.28). The absolute effects of treatment were, however, more than twice that in the highest compared with the lowest body mass index quartile. Across increasing quarters of body mass index over 5 years, active therapy prevented 1 major vascular event among every 28, 23, 13, and 13 patients treated. In conclusion, blood pressure–lowering therapy produced comparable risk reductions in vascular disease across the whole range of body mass indices in participants with a history of stroke. However, the greater baseline level of cardiovascular risk in those with higher body mass index meant that these patients obtained the greatest benefit.
copHagerstown, MD
pubAmerican Heart Association, Inc
pmid20212271
doi10.1161/HYPERTENSIONAHA.109.140624
oafree_for_read