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Gastrointestinal stromal tumor and gastric adenocarcinoma collision tumors

Summary Gastrointestinal stromal tumors sometimes occur together with gastric carcinoma, but true collision tumors featuring these 2 components are very rare. The authors describe here 2 collision tumors containing a gastrointestinal stromal tumor with intermingling elements of gastric adenocarcinom... Full description

Journal Title: Human pathology 2010, Vol.41 (7), p.1034-1039
Main Author: Kleist, Britta, MD
Other Authors: Lasota, Jerzy, MD , Miettinen, Markku, MD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0046-8177
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recordid: cdi_proquest_miscellaneous_733345717
title: Gastrointestinal stromal tumor and gastric adenocarcinoma collision tumors
format: Article
creator:
  • Kleist, Britta, MD
  • Lasota, Jerzy, MD
  • Miettinen, Markku, MD
subjects:
  • Adenocarcinoma
  • Adenocarcinoma - metabolism
  • Adenocarcinoma - pathology
  • Aged
  • Aged, 80 and over
  • Anoctamin-1
  • Antigens, CD34 - metabolism
  • Biological and medical sciences
  • Carcinogens
  • Chloride Channels
  • Collision tumor
  • Fatal Outcome
  • Female
  • Gastroenterology. Liver. Pancreas. Abdomen
  • Gastrointestinal Stromal Tumors - metabolism
  • Gastrointestinal Stromal Tumors - pathology
  • GIST
  • Humans
  • Immunohistochemistry
  • Investigative techniques, diagnostic techniques (general aspects)
  • Keratin
  • Male
  • Medical sciences
  • Membrane Proteins - metabolism
  • Mutation
  • Mutation analysis
  • Neoplasm Proteins - metabolism
  • Neoplasms, Multiple Primary - metabolism
  • Neoplasms, Multiple Primary - pathology
  • Pathogenesis
  • Pathology
  • Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
  • Proto-Oncogene Proteins c-kit - genetics
  • Proto-Oncogene Proteins c-kit - metabolism
  • Stomach cancer
  • Stomach Neoplasms - metabolism
  • Stomach Neoplasms - pathology
  • Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
  • Tomography
  • Tumors
ispartof: Human pathology, 2010, Vol.41 (7), p.1034-1039
description: Summary Gastrointestinal stromal tumors sometimes occur together with gastric carcinoma, but true collision tumors featuring these 2 components are very rare. The authors describe here 2 collision tumors containing a gastrointestinal stromal tumor with intermingling elements of gastric adenocarcinoma. The gastrointestinal stromal tumors were 5.5 to 6 cm spindle cell tumors, and one patient had an additional prepyloric stromal tumor (2.5 cm). All gastrointestinal stromal tumors had low mitotic counts less than 5/50 high-power fields and were positive for KIT, DOG1, and CD34. Different KIT exon 11 mutations (single nucleotide substitution, complex insertion-duplication) in all tumors indicated that the 2 gastrointestinal stromal tumors in one patient were independent primary tumors. The adenocarcinoma components displayed gland-forming intestinal type to signet ring cell morphology with focally accompanying dysplastic epithelium, immunohistochemical positivity for CDX2, and varying keratin 7/20 expression. We hypothesize that development of gastric adenocarcinoma within a gastrointestinal stromal tumor may be based on displaced gastric epithelium in a long-standing stromal tumor with events of intermittent ulceration and epithelial regeneration.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0046-8177
fulltext: fulltext
issn:
  • 0046-8177
  • 1532-8392
url: Link


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descriptionSummary Gastrointestinal stromal tumors sometimes occur together with gastric carcinoma, but true collision tumors featuring these 2 components are very rare. The authors describe here 2 collision tumors containing a gastrointestinal stromal tumor with intermingling elements of gastric adenocarcinoma. The gastrointestinal stromal tumors were 5.5 to 6 cm spindle cell tumors, and one patient had an additional prepyloric stromal tumor (2.5 cm). All gastrointestinal stromal tumors had low mitotic counts less than 5/50 high-power fields and were positive for KIT, DOG1, and CD34. Different KIT exon 11 mutations (single nucleotide substitution, complex insertion-duplication) in all tumors indicated that the 2 gastrointestinal stromal tumors in one patient were independent primary tumors. The adenocarcinoma components displayed gland-forming intestinal type to signet ring cell morphology with focally accompanying dysplastic epithelium, immunohistochemical positivity for CDX2, and varying keratin 7/20 expression. We hypothesize that development of gastric adenocarcinoma within a gastrointestinal stromal tumor may be based on displaced gastric epithelium in a long-standing stromal tumor with events of intermittent ulceration and epithelial regeneration.
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subjectAdenocarcinoma ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Aged ; Aged, 80 and over ; Anoctamin-1 ; Antigens, CD34 - metabolism ; Biological and medical sciences ; Carcinogens ; Chloride Channels ; Collision tumor ; Fatal Outcome ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal Stromal Tumors - metabolism ; Gastrointestinal Stromal Tumors - pathology ; GIST ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Keratin ; Male ; Medical sciences ; Membrane Proteins - metabolism ; Mutation ; Mutation analysis ; Neoplasm Proteins - metabolism ; Neoplasms, Multiple Primary - metabolism ; Neoplasms, Multiple Primary - pathology ; Pathogenesis ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Proto-Oncogene Proteins c-kit - genetics ; Proto-Oncogene Proteins c-kit - metabolism ; Stomach cancer ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tomography ; Tumors
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descriptionSummary Gastrointestinal stromal tumors sometimes occur together with gastric carcinoma, but true collision tumors featuring these 2 components are very rare. The authors describe here 2 collision tumors containing a gastrointestinal stromal tumor with intermingling elements of gastric adenocarcinoma. The gastrointestinal stromal tumors were 5.5 to 6 cm spindle cell tumors, and one patient had an additional prepyloric stromal tumor (2.5 cm). All gastrointestinal stromal tumors had low mitotic counts less than 5/50 high-power fields and were positive for KIT, DOG1, and CD34. Different KIT exon 11 mutations (single nucleotide substitution, complex insertion-duplication) in all tumors indicated that the 2 gastrointestinal stromal tumors in one patient were independent primary tumors. The adenocarcinoma components displayed gland-forming intestinal type to signet ring cell morphology with focally accompanying dysplastic epithelium, immunohistochemical positivity for CDX2, and varying keratin 7/20 expression. We hypothesize that development of gastric adenocarcinoma within a gastrointestinal stromal tumor may be based on displaced gastric epithelium in a long-standing stromal tumor with events of intermittent ulceration and epithelial regeneration.
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1Adenocarcinoma - metabolism
2Adenocarcinoma - pathology
3Aged
4Aged, 80 and over
5Anoctamin-1
6Antigens, CD34 - metabolism
7Biological and medical sciences
8Carcinogens
9Chloride Channels
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12Female
13Gastroenterology. Liver. Pancreas. Abdomen
14Gastrointestinal Stromal Tumors - metabolism
15Gastrointestinal Stromal Tumors - pathology
16GIST
17Humans
18Immunohistochemistry
19Investigative techniques, diagnostic techniques (general aspects)
20Keratin
21Male
22Medical sciences
23Membrane Proteins - metabolism
24Mutation
25Mutation analysis
26Neoplasm Proteins - metabolism
27Neoplasms, Multiple Primary - metabolism
28Neoplasms, Multiple Primary - pathology
29Pathogenesis
30Pathology
31Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
32Proto-Oncogene Proteins c-kit - genetics
33Proto-Oncogene Proteins c-kit - metabolism
34Stomach cancer
35Stomach Neoplasms - metabolism
36Stomach Neoplasms - pathology
37Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
38Tomography
39Tumors
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34Stomach cancer
35Stomach Neoplasms - metabolism
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38Tomography
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abstractSummary Gastrointestinal stromal tumors sometimes occur together with gastric carcinoma, but true collision tumors featuring these 2 components are very rare. The authors describe here 2 collision tumors containing a gastrointestinal stromal tumor with intermingling elements of gastric adenocarcinoma. The gastrointestinal stromal tumors were 5.5 to 6 cm spindle cell tumors, and one patient had an additional prepyloric stromal tumor (2.5 cm). All gastrointestinal stromal tumors had low mitotic counts less than 5/50 high-power fields and were positive for KIT, DOG1, and CD34. Different KIT exon 11 mutations (single nucleotide substitution, complex insertion-duplication) in all tumors indicated that the 2 gastrointestinal stromal tumors in one patient were independent primary tumors. The adenocarcinoma components displayed gland-forming intestinal type to signet ring cell morphology with focally accompanying dysplastic epithelium, immunohistochemical positivity for CDX2, and varying keratin 7/20 expression. We hypothesize that development of gastric adenocarcinoma within a gastrointestinal stromal tumor may be based on displaced gastric epithelium in a long-standing stromal tumor with events of intermittent ulceration and epithelial regeneration.
copNew York, NY
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pmid20381123
doi10.1016/j.humpath.2009.11.017