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Intrinsic extracellular matrix properties regulate stem cell differentiation

Abstract One of the recent paradigm shifts in stem cell biology has been the discovery that stem cells can begin to differentiate into mature tissue cells when exposed to intrinsic properties of the extracellular matrix (ECM), such as matrix structure, elasticity, and composition. These parameters a... Full description

Journal Title: Journal of biomechanics 2009, Vol.43 (1), p.55-62
Main Author: Reilly, Gwendolen C
Other Authors: Engler, Adam J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Ltd
ID: ISSN: 0021-9290
Link: https://www.ncbi.nlm.nih.gov/pubmed/19800626
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title: Intrinsic extracellular matrix properties regulate stem cell differentiation
format: Article
creator:
  • Reilly, Gwendolen C
  • Engler, Adam J
subjects:
  • Animals
  • Biochemistry
  • Biology
  • Biomechanics
  • Cell Differentiation - physiology
  • Cell Lineage
  • Differentiation
  • Dynamics
  • Elasticity
  • Electrochemical machining
  • Extracellular matrix
  • Extracellular Matrix - chemistry
  • Extracellular Matrix - metabolism
  • Extracellular Matrix - ultrastructure
  • Growth factors
  • Humans
  • Mechanical properties
  • Permeability
  • Physical Medicine and Rehabilitation
  • Proteins
  • Stem cells
  • Stem Cells - cytology
  • Stem Cells - metabolism
  • three-Dimensional
  • Topographical drawing
  • Topography
ispartof: Journal of biomechanics, 2009, Vol.43 (1), p.55-62
description: Abstract One of the recent paradigm shifts in stem cell biology has been the discovery that stem cells can begin to differentiate into mature tissue cells when exposed to intrinsic properties of the extracellular matrix (ECM), such as matrix structure, elasticity, and composition. These parameters are known to modulate the forces a cell can exert upon its matrix. Mechano-sensitive pathways subsequently convert these biophysical cues into biochemical signals that commit the cell to a specific lineage. Just as with well-studied growth factors, ECM parameters are extremely dynamic and are spatially- and temporally-controlled during development, suggesting that they play a morphogenetic role in guiding differentiation and arrangement of cells. Our ability to dynamically regulate the stem cell niche as the body does is likely a critical requirement for developing differentiated cells from stem cells for therapeutic applications. Here, we present the emergence of stem cell mechanobiology and its future challenges with new biomimetic, three-dimensional scaffolds that are being used therapeutically to treat disease.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0021-9290
fulltext: fulltext
issn:
  • 0021-9290
  • 1873-2380
url: Link


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descriptionAbstract One of the recent paradigm shifts in stem cell biology has been the discovery that stem cells can begin to differentiate into mature tissue cells when exposed to intrinsic properties of the extracellular matrix (ECM), such as matrix structure, elasticity, and composition. These parameters are known to modulate the forces a cell can exert upon its matrix. Mechano-sensitive pathways subsequently convert these biophysical cues into biochemical signals that commit the cell to a specific lineage. Just as with well-studied growth factors, ECM parameters are extremely dynamic and are spatially- and temporally-controlled during development, suggesting that they play a morphogenetic role in guiding differentiation and arrangement of cells. Our ability to dynamically regulate the stem cell niche as the body does is likely a critical requirement for developing differentiated cells from stem cells for therapeutic applications. Here, we present the emergence of stem cell mechanobiology and its future challenges with new biomimetic, three-dimensional scaffolds that are being used therapeutically to treat disease.
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subjectAnimals ; Biochemistry ; Biology ; Biomechanics ; Cell Differentiation - physiology ; Cell Lineage ; Differentiation ; Dynamics ; Elasticity ; Electrochemical machining ; Extracellular matrix ; Extracellular Matrix - chemistry ; Extracellular Matrix - metabolism ; Extracellular Matrix - ultrastructure ; Growth factors ; Humans ; Mechanical properties ; Permeability ; Physical Medicine and Rehabilitation ; Proteins ; Stem cells ; Stem Cells - cytology ; Stem Cells - metabolism ; three-Dimensional ; Topographical drawing ; Topography
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abstractAbstract One of the recent paradigm shifts in stem cell biology has been the discovery that stem cells can begin to differentiate into mature tissue cells when exposed to intrinsic properties of the extracellular matrix (ECM), such as matrix structure, elasticity, and composition. These parameters are known to modulate the forces a cell can exert upon its matrix. Mechano-sensitive pathways subsequently convert these biophysical cues into biochemical signals that commit the cell to a specific lineage. Just as with well-studied growth factors, ECM parameters are extremely dynamic and are spatially- and temporally-controlled during development, suggesting that they play a morphogenetic role in guiding differentiation and arrangement of cells. Our ability to dynamically regulate the stem cell niche as the body does is likely a critical requirement for developing differentiated cells from stem cells for therapeutic applications. Here, we present the emergence of stem cell mechanobiology and its future challenges with new biomimetic, three-dimensional scaffolds that are being used therapeutically to treat disease.
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