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Arterial stiffness in chronic kidney disease: causes and consequences

Chronic kidney disease is associated with elevated cardiovascular risk, and heart failure and arrhythmias are the biggest causes of cardiovascular death in this population. Increased arterial stiffness is a hallmark of chronic kidney disease and is associated with adverse alterations in cardiac stru... Full description

Journal Title: Heart 2010-06, Vol.96 (11), p.817-823
Main Author: Chue, Colin D
Other Authors: Townend, Jonathan N , Steeds, Richard P , Ferro, Charles J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: BMJ Publishing Group Ltd and British Cardiovascular Society
ID: ISSN: 1355-6037
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title: Arterial stiffness in chronic kidney disease: causes and consequences
format: Article
creator:
  • Chue, Colin D
  • Townend, Jonathan N
  • Steeds, Richard P
  • Ferro, Charles J
subjects:
  • Abridged Index Medicus
  • Arterial stiffness
  • Arteriosclerosis - etiology
  • Arteriosclerosis - mortality
  • Arteriosclerosis - physiopathology
  • Atherosclerosis
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Blood pressure
  • Cardiology. Vascular system
  • Cardiovascular system
  • Causes of
  • chronic kidney disease
  • Chronic kidney failure
  • Complications and side effects
  • diastolic dysfunction
  • Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
  • Heart attacks
  • heart failure
  • Humans
  • Kidney Failure, Chronic - complications
  • Kidney Failure, Chronic - mortality
  • Kidney Failure, Chronic - physiopathology
  • Kidneys
  • left ventricular hypertrophy
  • Medical sciences
  • Mortality
  • Nephrology. Urinary tract diseases
  • Nephropathies. Renovascular diseases. Renal failure
  • renal disease
  • Renal failure
  • Risk Factors
  • Rodents
  • Urinary system involvement in other diseases. Miscellaneous
ispartof: Heart, 2010-06, Vol.96 (11), p.817-823
description: Chronic kidney disease is associated with elevated cardiovascular risk, and heart failure and arrhythmias are the biggest causes of cardiovascular death in this population. Increased arterial stiffness is a hallmark of chronic kidney disease and is associated with adverse alterations in cardiac structure and function that may predispose to an increased risk of cardiovascular death. These changes are already apparent in early kidney disease, which is highly prevalent in the developed world. The mechanisms underlying increased arterial stiffness in chronic kidney disease are undoubtedly complex, but an understanding is paramount to enable the development of novel therapeutic strategies to prevent or reverse this pathophysiology and therefore reduce the cardiovascular disease burden in this high-risk cohort.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1355-6037
fulltext: fulltext
issn:
  • 1355-6037
  • 1468-201X
url: Link


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descriptionChronic kidney disease is associated with elevated cardiovascular risk, and heart failure and arrhythmias are the biggest causes of cardiovascular death in this population. Increased arterial stiffness is a hallmark of chronic kidney disease and is associated with adverse alterations in cardiac structure and function that may predispose to an increased risk of cardiovascular death. These changes are already apparent in early kidney disease, which is highly prevalent in the developed world. The mechanisms underlying increased arterial stiffness in chronic kidney disease are undoubtedly complex, but an understanding is paramount to enable the development of novel therapeutic strategies to prevent or reverse this pathophysiology and therefore reduce the cardiovascular disease burden in this high-risk cohort.
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subjectAbridged Index Medicus ; Arterial stiffness ; Arteriosclerosis - etiology ; Arteriosclerosis - mortality ; Arteriosclerosis - physiopathology ; Atherosclerosis ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood pressure ; Cardiology. Vascular system ; Cardiovascular system ; Causes of ; chronic kidney disease ; Chronic kidney failure ; Complications and side effects ; diastolic dysfunction ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Heart attacks ; heart failure ; Humans ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - mortality ; Kidney Failure, Chronic - physiopathology ; Kidneys ; left ventricular hypertrophy ; Medical sciences ; Mortality ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; renal disease ; Renal failure ; Risk Factors ; Rodents ; Urinary system involvement in other diseases. Miscellaneous
ispartofHeart, 2010-06, Vol.96 (11), p.817-823
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abstractChronic kidney disease is associated with elevated cardiovascular risk, and heart failure and arrhythmias are the biggest causes of cardiovascular death in this population. Increased arterial stiffness is a hallmark of chronic kidney disease and is associated with adverse alterations in cardiac structure and function that may predispose to an increased risk of cardiovascular death. These changes are already apparent in early kidney disease, which is highly prevalent in the developed world. The mechanisms underlying increased arterial stiffness in chronic kidney disease are undoubtedly complex, but an understanding is paramount to enable the development of novel therapeutic strategies to prevent or reverse this pathophysiology and therefore reduce the cardiovascular disease burden in this high-risk cohort.
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