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Levels of urinary transforming growth factor β-1 in children with D+ hemolytic uremic syndrome

About 25–50% of survivors of the acute phase of postdiarrheal hemolytic uremic syndrome (D+ HUS) develop chronic renal disease. Transforming growth factor β-1 (TGFβ-1) is the main fibrogenic growth factor in humans, and there is a significant correlation between its levels and the grade of interstit... Full description

Journal Title: Pediatric nephrology (Berlin West), 2010, Vol.25 (6), p.1177-1180
Main Author: Caletti, María Gracia
Other Authors: Balestracci, Alejandro , Roy, Adriana Haydeé
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0931-041X
Link: https://www.ncbi.nlm.nih.gov/pubmed/20157739
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title: Levels of urinary transforming growth factor β-1 in children with D+ hemolytic uremic syndrome
format: Article
creator:
  • Caletti, María Gracia
  • Balestracci, Alejandro
  • Roy, Adriana Haydeé
subjects:
  • Adolescent
  • Brief Report
  • Child
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hemolytic-Uremic Syndrome - complications
  • Hemolytic-Uremic Syndrome - urine
  • Humans
  • Infant
  • Kidney Failure, Chronic - etiology
  • Kidney Failure, Chronic - urine
  • Male
  • Medicine
  • Medicine & Public Health
  • Nephrology
  • Pediatrics
  • Transforming Growth Factor beta1 - urine
  • Urology
ispartof: Pediatric nephrology (Berlin, West), 2010, Vol.25 (6), p.1177-1180
description: About 25–50% of survivors of the acute phase of postdiarrheal hemolytic uremic syndrome (D+ HUS) develop chronic renal disease. Transforming growth factor β-1 (TGFβ-1) is the main fibrogenic growth factor in humans, and there is a significant correlation between its levels and the grade of interstitial fibrosis in chronic nephropathies. We hypothesized that increased urinary TGFβ-1 may be an early indicator of sequelae in D+ HUS patients who show no sign of renal damage as determined by conventional diagnostic tests. We therefore compared the levels of TGFβ-1 in urine collected from healthy controls (HC) ( n  = 18) with that from patients with a past history of D+ HUS ( n  = 39). We found that TGFβ-1 excretion was significantly higher ( p  
language: eng
source:
identifier: ISSN: 0931-041X
fulltext: no_fulltext
issn:
  • 0931-041X
  • 1432-198X
url: Link


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descriptionAbout 25–50% of survivors of the acute phase of postdiarrheal hemolytic uremic syndrome (D+ HUS) develop chronic renal disease. Transforming growth factor β-1 (TGFβ-1) is the main fibrogenic growth factor in humans, and there is a significant correlation between its levels and the grade of interstitial fibrosis in chronic nephropathies. We hypothesized that increased urinary TGFβ-1 may be an early indicator of sequelae in D+ HUS patients who show no sign of renal damage as determined by conventional diagnostic tests. We therefore compared the levels of TGFβ-1 in urine collected from healthy controls (HC) ( n  = 18) with that from patients with a past history of D+ HUS ( n  = 39). We found that TGFβ-1 excretion was significantly higher ( p  < 0.001) in the patient group (median level 73 pg/mg creatinine) than in the HC (median level 28 pg/mg creatinine). TGFβ-1 excretion did not correlate with age, white blood cell count, length of oligoanuric period, maximum creatinine at the acute stage, or length of the follow-up. Since TGFβ-1 excretion may reflect ongoing renal tissue damage, our results emphasize the need for the lifelong follow-up of patients with a past history of D+ HUS, even those showing apparent recovery. Long-term monitoring of this cohort is necessary to determine the clinical utility of our findings.
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subjectAdolescent ; Brief Report ; Child ; Child, Preschool ; Enzyme-Linked Immunosorbent Assay ; Female ; Hemolytic-Uremic Syndrome - complications ; Hemolytic-Uremic Syndrome - urine ; Humans ; Infant ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - urine ; Male ; Medicine ; Medicine & Public Health ; Nephrology ; Pediatrics ; Transforming Growth Factor beta1 - urine ; Urology
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abstractAbout 25–50% of survivors of the acute phase of postdiarrheal hemolytic uremic syndrome (D+ HUS) develop chronic renal disease. Transforming growth factor β-1 (TGFβ-1) is the main fibrogenic growth factor in humans, and there is a significant correlation between its levels and the grade of interstitial fibrosis in chronic nephropathies. We hypothesized that increased urinary TGFβ-1 may be an early indicator of sequelae in D+ HUS patients who show no sign of renal damage as determined by conventional diagnostic tests. We therefore compared the levels of TGFβ-1 in urine collected from healthy controls (HC) ( n  = 18) with that from patients with a past history of D+ HUS ( n  = 39). We found that TGFβ-1 excretion was significantly higher ( p  < 0.001) in the patient group (median level 73 pg/mg creatinine) than in the HC (median level 28 pg/mg creatinine). TGFβ-1 excretion did not correlate with age, white blood cell count, length of oligoanuric period, maximum creatinine at the acute stage, or length of the follow-up. Since TGFβ-1 excretion may reflect ongoing renal tissue damage, our results emphasize the need for the lifelong follow-up of patients with a past history of D+ HUS, even those showing apparent recovery. Long-term monitoring of this cohort is necessary to determine the clinical utility of our findings.
copBerlin/Heidelberg
pubSpringer-Verlag
pmid20157739
doi10.1007/s00467-009-1434-0