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Xanthohumol enhances antiviral effect of interferon alpha-2b against bovine viral diarrhea virus, a surrogate of hepatitis C virus

Xanthohumol (XN) is a natural compound with multifunctional potentials, including antiviral activity. In this study, the antiviral activity of addition of XN to interferon (IFN)-alpha was examined and compared with each compound alone using bovine viral diarrhea virus (BVDV), a surrogate model of he... Full description

Journal Title: Phytomedicine (Stuttgart) 2010-04, Vol.17 (5), p.310-316
Main Author: Zhang, Ni
Other Authors: Liu, Zhengwen , Han, Qunying , Chen, Jinghong , Lv, Yi
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Germany
ID: EISSN: 1618-095X
Link: https://www.ncbi.nlm.nih.gov/pubmed/19748253
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title: Xanthohumol enhances antiviral effect of interferon alpha-2b against bovine viral diarrhea virus, a surrogate of hepatitis C virus
format: Article
creator:
  • Zhang, Ni
  • Liu, Zhengwen
  • Han, Qunying
  • Chen, Jinghong
  • Lv, Yi
subjects:
  • Animals
  • Antiviral Agents - pharmacology
  • Antiviral Agents - therapeutic use
  • Cattle
  • Cell Line
  • Cytopathogenic Effect, Viral - drug effects
  • Diarrhea Viruses, Bovine Viral - drug effects
  • Drug Synergism
  • Drug Therapy, Combination
  • Flaviviridae Infections - drug therapy
  • Flaviviridae Infections - virology
  • Flavonoids - pharmacology
  • Flavonoids - therapeutic use
  • Hepacivirus
  • Humulus - chemistry
  • Interferon-alpha - therapeutic use
  • Male
  • Phytotherapy
  • Plant Extracts - pharmacology
  • Plant Extracts - therapeutic use
  • Propiophenones - pharmacology
  • Propiophenones - therapeutic use
  • Recombinant Proteins
  • RNA, Viral - metabolism
  • Testis
  • Viral Envelope Proteins - antagonists & inhibitors
ispartof: Phytomedicine (Stuttgart), 2010-04, Vol.17 (5), p.310-316
description: Xanthohumol (XN) is a natural compound with multifunctional potentials, including antiviral activity. In this study, the antiviral activity of addition of XN to interferon (IFN)-alpha was examined and compared with each compound alone using bovine viral diarrhea virus (BVDV), a surrogate model of hepatitis C virus (HCV). BVDV E2 protein and the viral RNA level were determined by immunofluorescence and quantitative real-time RT-PCR, respectively. The addition of XN to IFN-alpha significantly improved CPEs induced by the virus and inhibited BVDV E2 protein and viral RNA levels. The interaction between XN and IFN-alpha was significant (P
language: eng
source: Alma/SFX Local Collection
identifier: EISSN: 1618-095X
fulltext: fulltext
issn:
  • 1618-095X
url: Link


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descriptionXanthohumol (XN) is a natural compound with multifunctional potentials, including antiviral activity. In this study, the antiviral activity of addition of XN to interferon (IFN)-alpha was examined and compared with each compound alone using bovine viral diarrhea virus (BVDV), a surrogate model of hepatitis C virus (HCV). BVDV E2 protein and the viral RNA level were determined by immunofluorescence and quantitative real-time RT-PCR, respectively. The addition of XN to IFN-alpha significantly improved CPEs induced by the virus and inhibited BVDV E2 protein and viral RNA levels. The interaction between XN and IFN-alpha was significant (P<0.001). XN at 3.13 microg/ml in combination with IFN-alpha at 50 IU/ml showed greater inhibitory effect on the viral RNA level than each compound used alone at 6.25 microg/ml and 100 IU/ml, respectively, indicating synergistic effect on BVDV replication in this combination. The inhibitory activity in all the tested combinations of XN and IFN-alpha was stronger than that of each compound used alone at the corresponding concentration. These results suggest that XN in combination with IFN-alpha exhibited a greater in vitro antiviral effect compared with each compound used alone. Further studies are deserved to investigate the anti-HCV activity of XN and the potential of XN in formulating novel anti-HCV regimen.
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subjectAnimals ; Antiviral Agents - pharmacology ; Antiviral Agents - therapeutic use ; Cattle ; Cell Line ; Cytopathogenic Effect, Viral - drug effects ; Diarrhea Viruses, Bovine Viral - drug effects ; Drug Synergism ; Drug Therapy, Combination ; Flaviviridae Infections - drug therapy ; Flaviviridae Infections - virology ; Flavonoids - pharmacology ; Flavonoids - therapeutic use ; Hepacivirus ; Humulus - chemistry ; Interferon-alpha - therapeutic use ; Male ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Propiophenones - pharmacology ; Propiophenones - therapeutic use ; Recombinant Proteins ; RNA, Viral - metabolism ; Testis ; Viral Envelope Proteins - antagonists & inhibitors
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abstractXanthohumol (XN) is a natural compound with multifunctional potentials, including antiviral activity. In this study, the antiviral activity of addition of XN to interferon (IFN)-alpha was examined and compared with each compound alone using bovine viral diarrhea virus (BVDV), a surrogate model of hepatitis C virus (HCV). BVDV E2 protein and the viral RNA level were determined by immunofluorescence and quantitative real-time RT-PCR, respectively. The addition of XN to IFN-alpha significantly improved CPEs induced by the virus and inhibited BVDV E2 protein and viral RNA levels. The interaction between XN and IFN-alpha was significant (P<0.001). XN at 3.13 microg/ml in combination with IFN-alpha at 50 IU/ml showed greater inhibitory effect on the viral RNA level than each compound used alone at 6.25 microg/ml and 100 IU/ml, respectively, indicating synergistic effect on BVDV replication in this combination. The inhibitory activity in all the tested combinations of XN and IFN-alpha was stronger than that of each compound used alone at the corresponding concentration. These results suggest that XN in combination with IFN-alpha exhibited a greater in vitro antiviral effect compared with each compound used alone. Further studies are deserved to investigate the anti-HCV activity of XN and the potential of XN in formulating novel anti-HCV regimen.
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