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α-Lipoic acid supplementation enhances heat shock protein production and decreases post exercise lactic acid concentrations in exercised standardbred trotters

Heat shock protein (HSP) expression is an adaptive mechanism against the disruption of cell homeostasis during exercise. Several antioxidant supplementation strategies have been used to enhance tissue protection. In this study, we examined the effects of a redox modulator, α-lipoic acid (LA) on HSP... Full description

Journal Title: Research in veterinary science 2009, Vol.87 (3), p.462-467
Main Author: Kinnunen, S
Other Authors: Hyyppä, S , Oksala, N , Laaksonen, D.E , Hannila, M.-L , Sen, C.K , Atalay, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier India Pvt Ltd
ID: ISSN: 0034-5288
Link: https://www.ncbi.nlm.nih.gov/pubmed/19427659
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title: α-Lipoic acid supplementation enhances heat shock protein production and decreases post exercise lactic acid concentrations in exercised standardbred trotters
format: Article
creator:
  • Kinnunen, S
  • Hyyppä, S
  • Oksala, N
  • Laaksonen, D.E
  • Hannila, M.-L
  • Sen, C.K
  • Atalay, M
subjects:
  • Animal Feed
  • Animals
  • Diet - veterinary
  • Dietary Supplements
  • Exercise
  • Female
  • Heat-Shock Proteins - metabolism
  • Horse
  • Horses - physiology
  • Lactic Acid - blood
  • Lipoic acid
  • Male
  • Oxidative capacity
  • Physical Conditioning, Animal - adverse effects
  • Stress proteins
  • Thioctic Acid - pharmacology
ispartof: Research in veterinary science, 2009, Vol.87 (3), p.462-467
description: Heat shock protein (HSP) expression is an adaptive mechanism against the disruption of cell homeostasis during exercise. Several antioxidant supplementation strategies have been used to enhance tissue protection. In this study, we examined the effects of a redox modulator, α-lipoic acid (LA) on HSP responses in six standardbred trotters following intense aerobic exercise. DL–LA supplementation (25 mg kg −1 d −1) for five weeks increased the resting levels of HSP90 (1.02 ± 0.155 in control and 1.26 ± 0.090 after supplementation in arbitrary units) and the recovery levels of inducible HSP70 (0.89 ± 0.056 in control and 1.05 ± 0.089 after supplementation in arbitrary units) in skeletal muscle. Furthermore, LA increased skeletal muscle citrate synthase activity at rest and lowered the blood lactate concentration during exercise without any changes in the heart rate. LA had no effect on concentrations of HSP60, HSP25 or GRP75 in skeletal muscle. LA decreased the exercise-induced increases in plasma aspartate aminotransferase and creatine kinase concentrations during recovery. Our results suggest that LA supplementation may enhance tissue protection and increase oxidative capacity of the muscle in horse.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0034-5288
fulltext: fulltext
issn:
  • 0034-5288
  • 1532-2661
url: Link


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descriptionHeat shock protein (HSP) expression is an adaptive mechanism against the disruption of cell homeostasis during exercise. Several antioxidant supplementation strategies have been used to enhance tissue protection. In this study, we examined the effects of a redox modulator, α-lipoic acid (LA) on HSP responses in six standardbred trotters following intense aerobic exercise. DL–LA supplementation (25 mg kg −1 d −1) for five weeks increased the resting levels of HSP90 (1.02 ± 0.155 in control and 1.26 ± 0.090 after supplementation in arbitrary units) and the recovery levels of inducible HSP70 (0.89 ± 0.056 in control and 1.05 ± 0.089 after supplementation in arbitrary units) in skeletal muscle. Furthermore, LA increased skeletal muscle citrate synthase activity at rest and lowered the blood lactate concentration during exercise without any changes in the heart rate. LA had no effect on concentrations of HSP60, HSP25 or GRP75 in skeletal muscle. LA decreased the exercise-induced increases in plasma aspartate aminotransferase and creatine kinase concentrations during recovery. Our results suggest that LA supplementation may enhance tissue protection and increase oxidative capacity of the muscle in horse.
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subjectAnimal Feed ; Animals ; Diet - veterinary ; Dietary Supplements ; Exercise ; Female ; Heat-Shock Proteins - metabolism ; Horse ; Horses - physiology ; Lactic Acid - blood ; Lipoic acid ; Male ; Oxidative capacity ; Physical Conditioning, Animal - adverse effects ; Stress proteins ; Thioctic Acid - pharmacology
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abstractHeat shock protein (HSP) expression is an adaptive mechanism against the disruption of cell homeostasis during exercise. Several antioxidant supplementation strategies have been used to enhance tissue protection. In this study, we examined the effects of a redox modulator, α-lipoic acid (LA) on HSP responses in six standardbred trotters following intense aerobic exercise. DL–LA supplementation (25 mg kg −1 d −1) for five weeks increased the resting levels of HSP90 (1.02 ± 0.155 in control and 1.26 ± 0.090 after supplementation in arbitrary units) and the recovery levels of inducible HSP70 (0.89 ± 0.056 in control and 1.05 ± 0.089 after supplementation in arbitrary units) in skeletal muscle. Furthermore, LA increased skeletal muscle citrate synthase activity at rest and lowered the blood lactate concentration during exercise without any changes in the heart rate. LA had no effect on concentrations of HSP60, HSP25 or GRP75 in skeletal muscle. LA decreased the exercise-induced increases in plasma aspartate aminotransferase and creatine kinase concentrations during recovery. Our results suggest that LA supplementation may enhance tissue protection and increase oxidative capacity of the muscle in horse.
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doi10.1016/j.rvsc.2009.04.009