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Anti-inflammatory effect of atorvastatin (80 mg) in unstable angina pectoris and non–Q-wave acute myocardial infarction

In this randomized trial, C-reactive protein increased during the first 5 days of an acute coronary syndrome in patients treated with placebo, but this phenomenon was not observed in those randomized to atorvastatin 80 mg/day. This suggests that short-term statin therapy inhibits inflammation in pat... Full description

Journal Title: The American journal of cardiology 2003, Vol.92 (3), p.298-301
Main Author: Correia, Luis C.L
Other Authors: Spósito, Andrei C , Lima, José C , Magalhães, Luiz P , Passos, Luiz C.S , Rocha, Mário S , D’Oliveira, Argemiro , Esteves, J.Péricles
Format: Electronic Article Electronic Article
Language: English
Subjects:
Abridged Index Medicus
Aged
Angina pectoris
Angina, Unstable - blood
Angina, Unstable - drug therapy
Anti-Inflammatory Agents - therapeutic use
Antianginal agents. Coronary vasodilator agents
Anticholesteremic Agents - therapeutic use
Atorvastatin
Biological and medical sciences
Biomarkers - blood
C-Reactive Protein - drug effects
C-Reactive Protein - metabolism
Cardiovascular system
Cholesterol - blood
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Drug therapy
Effects
Female
Heart attacks
Heptanoic Acids - therapeutic use
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Male
Medical sciences
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - drug therapy
Pharmacology. Drug treatments
Pyrroles - therapeutic use
Syndrome
Treatment Outcome
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0002-9149
Zum Text:
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recordid: cdi_proquest_miscellaneous_73524786
title: Anti-inflammatory effect of atorvastatin (80 mg) in unstable angina pectoris and non–Q-wave acute myocardial infarction
format: Article
creator:
  • Correia, Luis C.L
  • Spósito, Andrei C
  • Lima, José C
  • Magalhães, Luiz P
  • Passos, Luiz C.S
  • Rocha, Mário S
  • D’Oliveira, Argemiro
  • Esteves, J.Péricles
subjects:
  • Abridged Index Medicus
  • Aged
  • Angina pectoris
  • Angina, Unstable - blood
  • Angina, Unstable - drug therapy
  • Anti-Inflammatory Agents - therapeutic use
  • Antianginal agents. Coronary vasodilator agents
  • Anticholesteremic Agents - therapeutic use
  • Atorvastatin
  • Biological and medical sciences
  • Biomarkers - blood
  • C-Reactive Protein - drug effects
  • C-Reactive Protein - metabolism
  • Cardiovascular system
  • Cholesterol - blood
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Administration Schedule
  • Drug therapy
  • Effects
  • Female
  • Heart attacks
  • Heptanoic Acids - therapeutic use
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
  • Male
  • Medical sciences
  • Middle Aged
  • Myocardial Infarction - blood
  • Myocardial Infarction - drug therapy
  • Pharmacology. Drug treatments
  • Pyrroles - therapeutic use
  • Syndrome
  • Treatment Outcome
ispartof: The American journal of cardiology, 2003, Vol.92 (3), p.298-301
description: In this randomized trial, C-reactive protein increased during the first 5 days of an acute coronary syndrome in patients treated with placebo, but this phenomenon was not observed in those randomized to atorvastatin 80 mg/day. This suggests that short-term statin therapy inhibits inflammation in patients with non–ST-elevation acute coronary syndromes.
language: eng
source:
identifier: ISSN: 0002-9149
fulltext: no_fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


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titleAnti-inflammatory effect of atorvastatin (80 mg) in unstable angina pectoris and non–Q-wave acute myocardial infarction
creatorCorreia, Luis C.L ; Spósito, Andrei C ; Lima, José C ; Magalhães, Luiz P ; Passos, Luiz C.S ; Rocha, Mário S ; D’Oliveira, Argemiro ; Esteves, J.Péricles
creatorcontribCorreia, Luis C.L ; Spósito, Andrei C ; Lima, José C ; Magalhães, Luiz P ; Passos, Luiz C.S ; Rocha, Mário S ; D’Oliveira, Argemiro ; Esteves, J.Péricles
descriptionIn this randomized trial, C-reactive protein increased during the first 5 days of an acute coronary syndrome in patients treated with placebo, but this phenomenon was not observed in those randomized to atorvastatin 80 mg/day. This suggests that short-term statin therapy inhibits inflammation in patients with non–ST-elevation acute coronary syndromes.
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languageeng
publisherNew York, NY: Elsevier Inc
subjectAbridged Index Medicus ; Aged ; Angina pectoris ; Angina, Unstable - blood ; Angina, Unstable - drug therapy ; Anti-Inflammatory Agents - therapeutic use ; Antianginal agents. Coronary vasodilator agents ; Anticholesteremic Agents - therapeutic use ; Atorvastatin ; Biological and medical sciences ; Biomarkers - blood ; C-Reactive Protein - drug effects ; C-Reactive Protein - metabolism ; Cardiovascular system ; Cholesterol - blood ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Administration Schedule ; Drug therapy ; Effects ; Female ; Heart attacks ; Heptanoic Acids - therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - drug therapy ; Pharmacology. Drug treatments ; Pyrroles - therapeutic use ; Syndrome ; Treatment Outcome
ispartofThe American journal of cardiology, 2003, Vol.92 (3), p.298-301
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descriptionIn this randomized trial, C-reactive protein increased during the first 5 days of an acute coronary syndrome in patients treated with placebo, but this phenomenon was not observed in those randomized to atorvastatin 80 mg/day. This suggests that short-term statin therapy inhibits inflammation in patients with non–ST-elevation acute coronary syndromes.
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3Angina, Unstable - blood
4Angina, Unstable - drug therapy
5Anti-Inflammatory Agents - therapeutic use
6Antianginal agents. Coronary vasodilator agents
7Anticholesteremic Agents - therapeutic use
8Atorvastatin
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11C-Reactive Protein - drug effects
12C-Reactive Protein - metabolism
13Cardiovascular system
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21Heart attacks
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2Lima, José C
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6D’Oliveira, Argemiro
7Esteves, J.Péricles
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titleAnti-inflammatory effect of atorvastatin (80 mg) in unstable angina pectoris and non–Q-wave acute myocardial infarction
authorCorreia, Luis C.L ; Spósito, Andrei C ; Lima, José C ; Magalhães, Luiz P ; Passos, Luiz C.S ; Rocha, Mário S ; D’Oliveira, Argemiro ; Esteves, J.Péricles
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1Aged
2Angina pectoris
3Angina, Unstable - blood
4Angina, Unstable - drug therapy
5Anti-Inflammatory Agents - therapeutic use
6Antianginal agents. Coronary vasodilator agents
7Anticholesteremic Agents - therapeutic use
8Atorvastatin
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11C-Reactive Protein - drug effects
12C-Reactive Protein - metabolism
13Cardiovascular system
14Cholesterol - blood
15Dose-Response Relationship, Drug
16Double-Blind Method
17Drug Administration Schedule
18Drug therapy
19Effects
20Female
21Heart attacks
22Heptanoic Acids - therapeutic use
23Humans
24Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
25Male
26Medical sciences
27Middle Aged
28Myocardial Infarction - blood
29Myocardial Infarction - drug therapy
30Pharmacology. Drug treatments
31Pyrroles - therapeutic use
32Syndrome
33Treatment Outcome
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1Spósito, Andrei C
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1Spósito, Andrei C
2Lima, José C
3Magalhães, Luiz P
4Passos, Luiz C.S
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6D’Oliveira, Argemiro
7Esteves, J.Péricles
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atitleAnti-inflammatory effect of atorvastatin (80 mg) in unstable angina pectoris and non–Q-wave acute myocardial infarction
jtitleThe American journal of cardiology
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date2003
risdate2003
volume92
issue3
spage298
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pages298-301
issn0002-9149
eissn1879-1913
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abstractIn this randomized trial, C-reactive protein increased during the first 5 days of an acute coronary syndrome in patients treated with placebo, but this phenomenon was not observed in those randomized to atorvastatin 80 mg/day. This suggests that short-term statin therapy inhibits inflammation in patients with non–ST-elevation acute coronary syndromes.
copNew York, NY
pubElsevier Inc
pmid12888137
doi10.1016/S0002-9149(03)00630-1