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Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies

The plasma amino acid profiles of 36 children with autism spectrum disorders were reviewed to determine the impact of diet on amino acid patterns. Ten of the children were on gluten and casein restricted diets administered by parents, while the other 26 consumed unrestricted diets. No amino acid pro... Full description

Journal Title: Journal of autism and developmental disorders 2003, Vol.33 (4), p.449-454
Main Author: ARNOLD, Georgianne L
Other Authors: HYMAN, Susan L , MOONEY, Robert A , KIRBY, Russell S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Heidelberg: Springer
ID: ISSN: 0162-3257
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recordid: cdi_proquest_miscellaneous_73617435
title: Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies
format: Article
creator:
  • ARNOLD, Georgianne L
  • HYMAN, Susan L
  • MOONEY, Robert A
  • KIRBY, Russell S
subjects:
  • Amino acids
  • Amino Acids - blood
  • Amino Acids, Essential - blood
  • Amino Acids, Essential - deficiency
  • Autism
  • Autistic children
  • Autistic Disorder - blood
  • Autistic Disorder - diet therapy
  • Biological and medical sciences
  • Caseins - administration & dosage
  • Child
  • Child clinical studies
  • Child Development Disorders, Pervasive - blood
  • Child Development Disorders, Pervasive - diet therapy
  • Developmental disorders
  • Diet
  • Glutens - administration & dosage
  • Humans
  • Infantile autism
  • Medical sciences
  • Nutrition Assessment
  • Nutrition disorders
  • Nutritional Requirements
  • Plasma levels
  • Protein Deficiency - blood
  • Protein Deficiency - etiology
  • Proteins
  • Psychology. Psychoanalysis. Psychiatry
  • Psychopathology. Psychiatry
  • Retrospective Studies
  • Risk Factors
ispartof: Journal of autism and developmental disorders, 2003, Vol.33 (4), p.449-454
description: The plasma amino acid profiles of 36 children with autism spectrum disorders were reviewed to determine the impact of diet on amino acid patterns. Ten of the children were on gluten and casein restricted diets administered by parents, while the other 26 consumed unrestricted diets. No amino acid profile specific to autism was identified. However, children with autism had more essential amino acid deficiencies consistent with poor protein nutrition than an age/gender matched control group. There was a trend for children with autism who were on restricted diets to have an increased prevalence of essential amino acid deficiencies and lower plasma levels of essential acids including the neurotransmitter precursors tyrosine and tryptophan than both controls and children with autism on unrestricted diets. These data indicate that larger, more focused studies of protein nutrition in children with autism are needed in order to determine the extent to which restricted diets might place the developing brains of children with autism at risk from protein malnutrition. The high rate of tryptophan and tyrosine deficiency in this group is also of concern given their role as neurotransmitter precursors.
language: eng
source:
identifier: ISSN: 0162-3257
fulltext: no_fulltext
issn:
  • 0162-3257
  • 1573-3432
url: Link


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descriptionThe plasma amino acid profiles of 36 children with autism spectrum disorders were reviewed to determine the impact of diet on amino acid patterns. Ten of the children were on gluten and casein restricted diets administered by parents, while the other 26 consumed unrestricted diets. No amino acid profile specific to autism was identified. However, children with autism had more essential amino acid deficiencies consistent with poor protein nutrition than an age/gender matched control group. There was a trend for children with autism who were on restricted diets to have an increased prevalence of essential amino acid deficiencies and lower plasma levels of essential acids including the neurotransmitter precursors tyrosine and tryptophan than both controls and children with autism on unrestricted diets. These data indicate that larger, more focused studies of protein nutrition in children with autism are needed in order to determine the extent to which restricted diets might place the developing brains of children with autism at risk from protein malnutrition. The high rate of tryptophan and tyrosine deficiency in this group is also of concern given their role as neurotransmitter precursors.
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subjectAmino acids ; Amino Acids - blood ; Amino Acids, Essential - blood ; Amino Acids, Essential - deficiency ; Autism ; Autistic children ; Autistic Disorder - blood ; Autistic Disorder - diet therapy ; Biological and medical sciences ; Caseins - administration & dosage ; Child ; Child clinical studies ; Child Development Disorders, Pervasive - blood ; Child Development Disorders, Pervasive - diet therapy ; Developmental disorders ; Diet ; Glutens - administration & dosage ; Humans ; Infantile autism ; Medical sciences ; Nutrition Assessment ; Nutrition disorders ; Nutritional Requirements ; Plasma levels ; Protein Deficiency - blood ; Protein Deficiency - etiology ; Proteins ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Retrospective Studies ; Risk Factors
ispartofJournal of autism and developmental disorders, 2003, Vol.33 (4), p.449-454
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descriptionThe plasma amino acid profiles of 36 children with autism spectrum disorders were reviewed to determine the impact of diet on amino acid patterns. Ten of the children were on gluten and casein restricted diets administered by parents, while the other 26 consumed unrestricted diets. No amino acid profile specific to autism was identified. However, children with autism had more essential amino acid deficiencies consistent with poor protein nutrition than an age/gender matched control group. There was a trend for children with autism who were on restricted diets to have an increased prevalence of essential amino acid deficiencies and lower plasma levels of essential acids including the neurotransmitter precursors tyrosine and tryptophan than both controls and children with autism on unrestricted diets. These data indicate that larger, more focused studies of protein nutrition in children with autism are needed in order to determine the extent to which restricted diets might place the developing brains of children with autism at risk from protein malnutrition. The high rate of tryptophan and tyrosine deficiency in this group is also of concern given their role as neurotransmitter precursors.
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2Amino Acids, Essential - blood
3Amino Acids, Essential - deficiency
4Autism
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6Autistic Disorder - blood
7Autistic Disorder - diet therapy
8Biological and medical sciences
9Caseins - administration & dosage
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12Child Development Disorders, Pervasive - blood
13Child Development Disorders, Pervasive - diet therapy
14Developmental disorders
15Diet
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21Nutrition disorders
22Nutritional Requirements
23Plasma levels
24Protein Deficiency - blood
25Protein Deficiency - etiology
26Proteins
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29Retrospective Studies
30Risk Factors
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1HYMAN, Susan L
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atitlePlasma amino acids profiles in children with autism: potential risk of nutritional deficiencies
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date2003
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abstractThe plasma amino acid profiles of 36 children with autism spectrum disorders were reviewed to determine the impact of diet on amino acid patterns. Ten of the children were on gluten and casein restricted diets administered by parents, while the other 26 consumed unrestricted diets. No amino acid profile specific to autism was identified. However, children with autism had more essential amino acid deficiencies consistent with poor protein nutrition than an age/gender matched control group. There was a trend for children with autism who were on restricted diets to have an increased prevalence of essential amino acid deficiencies and lower plasma levels of essential acids including the neurotransmitter precursors tyrosine and tryptophan than both controls and children with autism on unrestricted diets. These data indicate that larger, more focused studies of protein nutrition in children with autism are needed in order to determine the extent to which restricted diets might place the developing brains of children with autism at risk from protein malnutrition. The high rate of tryptophan and tyrosine deficiency in this group is also of concern given their role as neurotransmitter precursors.
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