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Redistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: Comparison of dopamine, dobutamine and isoproterenol

The effects of dopamine, dobutamine and isoproterenol on coronary hemodynamics, severity of stenosis, distal bed resistance and transmural myocardial perfusion gradients with radioactive microspheres were studied in dogs with a mild obstruction of the left circumflex coronary artery anesthetized wit... Full description

Journal Title: The American journal of cardiology 1981, Vol.48 (2), p.269-279
Main Author: Warltier, David C
Other Authors: Zyvoloski, Mark , Gross, Garrett J , Hardman, Harold F , Brooks, Harold L
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0002-9149
Link: https://www.ncbi.nlm.nih.gov/pubmed/7270436
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recordid: cdi_proquest_miscellaneous_73636656
title: Redistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: Comparison of dopamine, dobutamine and isoproterenol
format: Article
creator:
  • Warltier, David C
  • Zyvoloski, Mark
  • Gross, Garrett J
  • Hardman, Harold F
  • Brooks, Harold L
subjects:
  • Abridged Index Medicus
  • Animals
  • Catecholamines - pharmacology
  • Coronary Circulation - drug effects
  • Coronary Disease - physiopathology
  • Coronary Vessels - physiopathology
  • Diastole - drug effects
  • Dobutamine - pharmacology
  • Dogs
  • Dopamine - pharmacology
  • Hemodynamics - drug effects
  • Isoproterenol - pharmacology
  • Models, Biological
  • Time Factors
  • Vascular Resistance - drug effects
ispartof: The American journal of cardiology, 1981, Vol.48 (2), p.269-279
description: The effects of dopamine, dobutamine and isoproterenol on coronary hemodynamics, severity of stenosis, distal bed resistance and transmural myocardial perfusion gradients with radioactive microspheres were studied in dogs with a mild obstruction of the left circumflex coronary artery anesthetized with morphine-chloralose. Changes in transmural blood flow were related to the ratio of the diastolic aortic pressure-time Index to tension-time index (DPTI/TTI) and the ratio of the distal diastolic coronary pressure-time index to tension-time index (DDPT1/TTI). At doses of 5 gmg/kg per min, dopamine had no significant effect on DPTI/TTI, DDPTI/TTI or endocardial/epicardial flow ratio; however, dobutamine produced a slight decrease in this flow ratio and in DDPTI/TTI. At doses of 10 gmg/kg per min, both drugs produced a significant (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0002-9149
fulltext: fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


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titleRedistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: Comparison of dopamine, dobutamine and isoproterenol
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creatorWarltier, David C ; Zyvoloski, Mark ; Gross, Garrett J ; Hardman, Harold F ; Brooks, Harold L
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descriptionThe effects of dopamine, dobutamine and isoproterenol on coronary hemodynamics, severity of stenosis, distal bed resistance and transmural myocardial perfusion gradients with radioactive microspheres were studied in dogs with a mild obstruction of the left circumflex coronary artery anesthetized with morphine-chloralose. Changes in transmural blood flow were related to the ratio of the diastolic aortic pressure-time Index to tension-time index (DPTI/TTI) and the ratio of the distal diastolic coronary pressure-time index to tension-time index (DDPT1/TTI). At doses of 5 gmg/kg per min, dopamine had no significant effect on DPTI/TTI, DDPTI/TTI or endocardial/epicardial flow ratio; however, dobutamine produced a slight decrease in this flow ratio and in DDPTI/TTI. At doses of 10 gmg/kg per min, both drugs produced a significant (p <0.05) reduction in diastolic coronary pressure distal to the stenosis, DDPTI/TTI and endocardial/epicardial flow ratio without change in DPTI/TTI. In comparison, isoproterenol (0.01 and 0.05 gmg/kg per min) produced dose-related decreases in endocardial/epicardial flow ratio, DDPTI/TTI and DPTI/TTI. During infusion of each sympathomimetic agent, there was a corresponding reduction in distal bed vascular resistance but a concomitant increase in stenosis resistance. The results also show that dopamine and dobutamine, as well as isoproterenol, are capable of producing a maldistribution of coronary blood flow distal to a mild coronary arterial stenosis and that such a redistribution of flow is dependent on dose, reduction of the distal diastolic coronary pressure-time index and decrease in DDPTI/TTI. It Is further concluded that hemodynamic changes distal to a coronary arterial stenosis seriously jeopardize the usefulness of DPTI/TTI; however, DDPTI/TTI can be used to predict drug effects on the endocardial/epicardial flow ratio in an ischemie area. This study demonstrates that “fixed” stenoses can undergo dynamic processes and sympathomlmetic amines increase the resistance to flow through a stenotic coronary artery in the nonfailing heart.
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languageeng
publisherUnited States: Elsevier Inc
subjectAbridged Index Medicus ; Animals ; Catecholamines - pharmacology ; Coronary Circulation - drug effects ; Coronary Disease - physiopathology ; Coronary Vessels - physiopathology ; Diastole - drug effects ; Dobutamine - pharmacology ; Dogs ; Dopamine - pharmacology ; Hemodynamics - drug effects ; Isoproterenol - pharmacology ; Models, Biological ; Time Factors ; Vascular Resistance - drug effects
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0Redistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: Comparison of dopamine, dobutamine and isoproterenol
1The American journal of cardiology
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descriptionThe effects of dopamine, dobutamine and isoproterenol on coronary hemodynamics, severity of stenosis, distal bed resistance and transmural myocardial perfusion gradients with radioactive microspheres were studied in dogs with a mild obstruction of the left circumflex coronary artery anesthetized with morphine-chloralose. Changes in transmural blood flow were related to the ratio of the diastolic aortic pressure-time Index to tension-time index (DPTI/TTI) and the ratio of the distal diastolic coronary pressure-time index to tension-time index (DDPT1/TTI). At doses of 5 gmg/kg per min, dopamine had no significant effect on DPTI/TTI, DDPTI/TTI or endocardial/epicardial flow ratio; however, dobutamine produced a slight decrease in this flow ratio and in DDPTI/TTI. At doses of 10 gmg/kg per min, both drugs produced a significant (p <0.05) reduction in diastolic coronary pressure distal to the stenosis, DDPTI/TTI and endocardial/epicardial flow ratio without change in DPTI/TTI. In comparison, isoproterenol (0.01 and 0.05 gmg/kg per min) produced dose-related decreases in endocardial/epicardial flow ratio, DDPTI/TTI and DPTI/TTI. During infusion of each sympathomimetic agent, there was a corresponding reduction in distal bed vascular resistance but a concomitant increase in stenosis resistance. The results also show that dopamine and dobutamine, as well as isoproterenol, are capable of producing a maldistribution of coronary blood flow distal to a mild coronary arterial stenosis and that such a redistribution of flow is dependent on dose, reduction of the distal diastolic coronary pressure-time index and decrease in DDPTI/TTI. It Is further concluded that hemodynamic changes distal to a coronary arterial stenosis seriously jeopardize the usefulness of DPTI/TTI; however, DDPTI/TTI can be used to predict drug effects on the endocardial/epicardial flow ratio in an ischemie area. This study demonstrates that “fixed” stenoses can undergo dynamic processes and sympathomlmetic amines increase the resistance to flow through a stenotic coronary artery in the nonfailing heart.
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1Animals
2Catecholamines - pharmacology
3Coronary Circulation - drug effects
4Coronary Disease - physiopathology
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6Diastole - drug effects
7Dobutamine - pharmacology
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13Time Factors
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titleRedistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: Comparison of dopamine, dobutamine and isoproterenol
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abstractThe effects of dopamine, dobutamine and isoproterenol on coronary hemodynamics, severity of stenosis, distal bed resistance and transmural myocardial perfusion gradients with radioactive microspheres were studied in dogs with a mild obstruction of the left circumflex coronary artery anesthetized with morphine-chloralose. Changes in transmural blood flow were related to the ratio of the diastolic aortic pressure-time Index to tension-time index (DPTI/TTI) and the ratio of the distal diastolic coronary pressure-time index to tension-time index (DDPT1/TTI). At doses of 5 gmg/kg per min, dopamine had no significant effect on DPTI/TTI, DDPTI/TTI or endocardial/epicardial flow ratio; however, dobutamine produced a slight decrease in this flow ratio and in DDPTI/TTI. At doses of 10 gmg/kg per min, both drugs produced a significant (p <0.05) reduction in diastolic coronary pressure distal to the stenosis, DDPTI/TTI and endocardial/epicardial flow ratio without change in DPTI/TTI. In comparison, isoproterenol (0.01 and 0.05 gmg/kg per min) produced dose-related decreases in endocardial/epicardial flow ratio, DDPTI/TTI and DPTI/TTI. During infusion of each sympathomimetic agent, there was a corresponding reduction in distal bed vascular resistance but a concomitant increase in stenosis resistance. The results also show that dopamine and dobutamine, as well as isoproterenol, are capable of producing a maldistribution of coronary blood flow distal to a mild coronary arterial stenosis and that such a redistribution of flow is dependent on dose, reduction of the distal diastolic coronary pressure-time index and decrease in DDPTI/TTI. It Is further concluded that hemodynamic changes distal to a coronary arterial stenosis seriously jeopardize the usefulness of DPTI/TTI; however, DDPTI/TTI can be used to predict drug effects on the endocardial/epicardial flow ratio in an ischemie area. This study demonstrates that “fixed” stenoses can undergo dynamic processes and sympathomlmetic amines increase the resistance to flow through a stenotic coronary artery in the nonfailing heart.
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pmid7270436
doi10.1016/0002-9149(81)90607-X