schliessen

Filtern

 

Bibliotheken

Cover Image

Redistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: Comparison of dopamine, dobutamine and isoproterenol

The effects of dopamine, dobutamine and isoproterenol on coronary hemodynamics, severity of stenosis, distal bed resistance and transmural myocardial perfusion gradients with radioactive microspheres were studied in dogs with a mild obstruction of the left circumflex coronary artery anesthetized wit... Full description

Journal Title: The American journal of cardiology 1981, Vol.48 (2), p.269-279
Main Author: Warltier, David C
Other Authors: Zyvoloski, Mark , Gross, Garrett J , Hardman, Harold F , Brooks, Harold L
Format: Electronic Article Electronic Article
Language: English
Subjects:
Abridged Index Medicus
Animals
Catecholamines - pharmacology
Coronary Circulation - drug effects
Coronary Disease - physiopathology
Coronary Vessels - physiopathology
Diastole - drug effects
Dobutamine - pharmacology
Dogs
Dopamine - pharmacology
Hemodynamics - drug effects
Isoproterenol - pharmacology
Models, Biological
Time Factors
Vascular Resistance - drug effects
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0002-9149
Link: https://www.ncbi.nlm.nih.gov/pubmed/7270436
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_73636656
title: Redistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: Comparison of dopamine, dobutamine and isoproterenol
format: Article
creator:
  • Warltier, David C
  • Zyvoloski, Mark
  • Gross, Garrett J
  • Hardman, Harold F
  • Brooks, Harold L
subjects:
  • Abridged Index Medicus
  • Animals
  • Catecholamines - pharmacology
  • Coronary Circulation - drug effects
  • Coronary Disease - physiopathology
  • Coronary Vessels - physiopathology
  • Diastole - drug effects
  • Dobutamine - pharmacology
  • Dogs
  • Dopamine - pharmacology
  • Hemodynamics - drug effects
  • Isoproterenol - pharmacology
  • Models, Biological
  • Time Factors
  • Vascular Resistance - drug effects
ispartof: The American journal of cardiology, 1981, Vol.48 (2), p.269-279
description: The effects of dopamine, dobutamine and isoproterenol on coronary hemodynamics, severity of stenosis, distal bed resistance and transmural myocardial perfusion gradients with radioactive microspheres were studied in dogs with a mild obstruction of the left circumflex coronary artery anesthetized with morphine-chloralose. Changes in transmural blood flow were related to the ratio of the diastolic aortic pressure-time Index to tension-time index (DPTI/TTI) and the ratio of the distal diastolic coronary pressure-time index to tension-time index (DDPT1/TTI). At doses of 5 gmg/kg per min, dopamine had no significant effect on DPTI/TTI, DDPTI/TTI or endocardial/epicardial flow ratio; however, dobutamine produced a slight decrease in this flow ratio and in DDPTI/TTI. At doses of 10 gmg/kg per min, both drugs produced a significant (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0002-9149
fulltext: fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK1.5104268
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_pubme
recordidTN_cdi_proquest_miscellaneous_73636656
sourceformatXML
sourcesystemPC
sourcerecordid73636656
originalsourceidFETCH-LOGICAL-e253t-866f330e59641080ed6dcbd8d9db773b459747a04fdaaa7bb7b670bc04d03a6f3
addsrcrecordideNo9Udtq3DAQFaUh3ab9gxT0VFKoW2llS3YeAmHJpRAolBbyJnQZExXb2kraFP9QvzPj3aVPGs05c2Y4h5Bzzr5wxuVXxti66njdXbT8U8ckU9XjK7Lireoq3nHxmqz-U96Qtzn_xi_njTwlp2qtWC3kivz7AT7kkoLdlRAnGns6ztGZ5IMZqB1i9LQf4l-6sLBTIjXUz5MZg6MupjiZNFOTCqRlIBeYYg6Z2pnmedya8hTHMEJBNo5MkC_pJmI_hXzY5uN2D3zGCm_Y19RMniJhmyLqouLwjpz0Zsjw_viekV-3Nz8399XD97tvm-uHCtaNKFUrZS8Eg6aTNWctAy-9s771nbdKCVs3naqVYXXvjTHKWmWlYtax2jNhcPaMfDzo4uo_O8hFjyE7GAYzQdxlrYQUUjYSiR-OxJ0dwettCiM6oY_GIn51wAGvfQ6QdHYBJoduJ3BF-xg0Z3oJUi8p6SUl3XK9D1I_ihf9YZR3
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid73636656
display
typearticle
titleRedistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: Comparison of dopamine, dobutamine and isoproterenol
sourceAlma/SFX Local Collection
creatorWarltier, David C ; Zyvoloski, Mark ; Gross, Garrett J ; Hardman, Harold F ; Brooks, Harold L
creatorcontribWarltier, David C ; Zyvoloski, Mark ; Gross, Garrett J ; Hardman, Harold F ; Brooks, Harold L
descriptionThe effects of dopamine, dobutamine and isoproterenol on coronary hemodynamics, severity of stenosis, distal bed resistance and transmural myocardial perfusion gradients with radioactive microspheres were studied in dogs with a mild obstruction of the left circumflex coronary artery anesthetized with morphine-chloralose. Changes in transmural blood flow were related to the ratio of the diastolic aortic pressure-time Index to tension-time index (DPTI/TTI) and the ratio of the distal diastolic coronary pressure-time index to tension-time index (DDPT1/TTI). At doses of 5 gmg/kg per min, dopamine had no significant effect on DPTI/TTI, DDPTI/TTI or endocardial/epicardial flow ratio; however, dobutamine produced a slight decrease in this flow ratio and in DDPTI/TTI. At doses of 10 gmg/kg per min, both drugs produced a significant (p <0.05) reduction in diastolic coronary pressure distal to the stenosis, DDPTI/TTI and endocardial/epicardial flow ratio without change in DPTI/TTI. In comparison, isoproterenol (0.01 and 0.05 gmg/kg per min) produced dose-related decreases in endocardial/epicardial flow ratio, DDPTI/TTI and DPTI/TTI. During infusion of each sympathomimetic agent, there was a corresponding reduction in distal bed vascular resistance but a concomitant increase in stenosis resistance. The results also show that dopamine and dobutamine, as well as isoproterenol, are capable of producing a maldistribution of coronary blood flow distal to a mild coronary arterial stenosis and that such a redistribution of flow is dependent on dose, reduction of the distal diastolic coronary pressure-time index and decrease in DDPTI/TTI. It Is further concluded that hemodynamic changes distal to a coronary arterial stenosis seriously jeopardize the usefulness of DPTI/TTI; however, DDPTI/TTI can be used to predict drug effects on the endocardial/epicardial flow ratio in an ischemie area. This study demonstrates that “fixed” stenoses can undergo dynamic processes and sympathomlmetic amines increase the resistance to flow through a stenotic coronary artery in the nonfailing heart.
identifier
0ISSN: 0002-9149
1EISSN: 1879-1913
2DOI: 10.1016/0002-9149(81)90607-X
3PMID: 7270436
languageeng
publisherUnited States: Elsevier Inc
subjectAbridged Index Medicus ; Animals ; Catecholamines - pharmacology ; Coronary Circulation - drug effects ; Coronary Disease - physiopathology ; Coronary Vessels - physiopathology ; Diastole - drug effects ; Dobutamine - pharmacology ; Dogs ; Dopamine - pharmacology ; Hemodynamics - drug effects ; Isoproterenol - pharmacology ; Models, Biological ; Time Factors ; Vascular Resistance - drug effects
ispartofThe American journal of cardiology, 1981, Vol.48 (2), p.269-279
rights1981
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7270436$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Warltier, David C
1Zyvoloski, Mark
2Gross, Garrett J
3Hardman, Harold F
4Brooks, Harold L
title
0Redistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: Comparison of dopamine, dobutamine and isoproterenol
1The American journal of cardiology
addtitleAm J Cardiol
descriptionThe effects of dopamine, dobutamine and isoproterenol on coronary hemodynamics, severity of stenosis, distal bed resistance and transmural myocardial perfusion gradients with radioactive microspheres were studied in dogs with a mild obstruction of the left circumflex coronary artery anesthetized with morphine-chloralose. Changes in transmural blood flow were related to the ratio of the diastolic aortic pressure-time Index to tension-time index (DPTI/TTI) and the ratio of the distal diastolic coronary pressure-time index to tension-time index (DDPT1/TTI). At doses of 5 gmg/kg per min, dopamine had no significant effect on DPTI/TTI, DDPTI/TTI or endocardial/epicardial flow ratio; however, dobutamine produced a slight decrease in this flow ratio and in DDPTI/TTI. At doses of 10 gmg/kg per min, both drugs produced a significant (p <0.05) reduction in diastolic coronary pressure distal to the stenosis, DDPTI/TTI and endocardial/epicardial flow ratio without change in DPTI/TTI. In comparison, isoproterenol (0.01 and 0.05 gmg/kg per min) produced dose-related decreases in endocardial/epicardial flow ratio, DDPTI/TTI and DPTI/TTI. During infusion of each sympathomimetic agent, there was a corresponding reduction in distal bed vascular resistance but a concomitant increase in stenosis resistance. The results also show that dopamine and dobutamine, as well as isoproterenol, are capable of producing a maldistribution of coronary blood flow distal to a mild coronary arterial stenosis and that such a redistribution of flow is dependent on dose, reduction of the distal diastolic coronary pressure-time index and decrease in DDPTI/TTI. It Is further concluded that hemodynamic changes distal to a coronary arterial stenosis seriously jeopardize the usefulness of DPTI/TTI; however, DDPTI/TTI can be used to predict drug effects on the endocardial/epicardial flow ratio in an ischemie area. This study demonstrates that “fixed” stenoses can undergo dynamic processes and sympathomlmetic amines increase the resistance to flow through a stenotic coronary artery in the nonfailing heart.
subject
0Abridged Index Medicus
1Animals
2Catecholamines - pharmacology
3Coronary Circulation - drug effects
4Coronary Disease - physiopathology
5Coronary Vessels - physiopathology
6Diastole - drug effects
7Dobutamine - pharmacology
8Dogs
9Dopamine - pharmacology
10Hemodynamics - drug effects
11Isoproterenol - pharmacology
12Models, Biological
13Time Factors
14Vascular Resistance - drug effects
issn
00002-9149
11879-1913
fulltexttrue
rsrctypearticle
creationdate1981
recordtypearticle
recordideNo9Udtq3DAQFaUh3ab9gxT0VFKoW2llS3YeAmHJpRAolBbyJnQZExXb2kraFP9QvzPj3aVPGs05c2Y4h5Bzzr5wxuVXxti66njdXbT8U8ckU9XjK7Lireoq3nHxmqz-U96Qtzn_xi_njTwlp2qtWC3kivz7AT7kkoLdlRAnGns6ztGZ5IMZqB1i9LQf4l-6sLBTIjXUz5MZg6MupjiZNFOTCqRlIBeYYg6Z2pnmedya8hTHMEJBNo5MkC_pJmI_hXzY5uN2D3zGCm_Y19RMniJhmyLqouLwjpz0Zsjw_viekV-3Nz8399XD97tvm-uHCtaNKFUrZS8Eg6aTNWctAy-9s771nbdKCVs3naqVYXXvjTHKWmWlYtax2jNhcPaMfDzo4uo_O8hFjyE7GAYzQdxlrYQUUjYSiR-OxJ0dwettCiM6oY_GIn51wAGvfQ6QdHYBJoduJ3BF-xg0Z3oJUi8p6SUl3XK9D1I_ihf9YZR3
startdate1981
enddate1981
creator
0Warltier, David C
1Zyvoloski, Mark
2Gross, Garrett J
3Hardman, Harold F
4Brooks, Harold L
generalElsevier Inc
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
67X8
sort
creationdate1981
titleRedistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: Comparison of dopamine, dobutamine and isoproterenol
authorWarltier, David C ; Zyvoloski, Mark ; Gross, Garrett J ; Hardman, Harold F ; Brooks, Harold L
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-e253t-866f330e59641080ed6dcbd8d9db773b459747a04fdaaa7bb7b670bc04d03a6f3
rsrctypearticles
prefilterarticles
languageeng
creationdate1981
topic
0Abridged Index Medicus
1Animals
2Catecholamines - pharmacology
3Coronary Circulation - drug effects
4Coronary Disease - physiopathology
5Coronary Vessels - physiopathology
6Diastole - drug effects
7Dobutamine - pharmacology
8Dogs
9Dopamine - pharmacology
10Hemodynamics - drug effects
11Isoproterenol - pharmacology
12Models, Biological
13Time Factors
14Vascular Resistance - drug effects
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Warltier, David C
1Zyvoloski, Mark
2Gross, Garrett J
3Hardman, Harold F
4Brooks, Harold L
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6MEDLINE - Academic
jtitleThe American journal of cardiology
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Warltier, David C
1Zyvoloski, Mark
2Gross, Garrett J
3Hardman, Harold F
4Brooks, Harold L
formatjournal
genrearticle
ristypeJOUR
atitleRedistribution of myocardial blood flow distal to a dynamic coronary arterial stenosis by sympathomimetic amines: Comparison of dopamine, dobutamine and isoproterenol
jtitleThe American journal of cardiology
addtitleAm J Cardiol
date1981
risdate1981
volume48
issue2
spage269
epage279
pages269-279
issn0002-9149
eissn1879-1913
abstractThe effects of dopamine, dobutamine and isoproterenol on coronary hemodynamics, severity of stenosis, distal bed resistance and transmural myocardial perfusion gradients with radioactive microspheres were studied in dogs with a mild obstruction of the left circumflex coronary artery anesthetized with morphine-chloralose. Changes in transmural blood flow were related to the ratio of the diastolic aortic pressure-time Index to tension-time index (DPTI/TTI) and the ratio of the distal diastolic coronary pressure-time index to tension-time index (DDPT1/TTI). At doses of 5 gmg/kg per min, dopamine had no significant effect on DPTI/TTI, DDPTI/TTI or endocardial/epicardial flow ratio; however, dobutamine produced a slight decrease in this flow ratio and in DDPTI/TTI. At doses of 10 gmg/kg per min, both drugs produced a significant (p <0.05) reduction in diastolic coronary pressure distal to the stenosis, DDPTI/TTI and endocardial/epicardial flow ratio without change in DPTI/TTI. In comparison, isoproterenol (0.01 and 0.05 gmg/kg per min) produced dose-related decreases in endocardial/epicardial flow ratio, DDPTI/TTI and DPTI/TTI. During infusion of each sympathomimetic agent, there was a corresponding reduction in distal bed vascular resistance but a concomitant increase in stenosis resistance. The results also show that dopamine and dobutamine, as well as isoproterenol, are capable of producing a maldistribution of coronary blood flow distal to a mild coronary arterial stenosis and that such a redistribution of flow is dependent on dose, reduction of the distal diastolic coronary pressure-time index and decrease in DDPTI/TTI. It Is further concluded that hemodynamic changes distal to a coronary arterial stenosis seriously jeopardize the usefulness of DPTI/TTI; however, DDPTI/TTI can be used to predict drug effects on the endocardial/epicardial flow ratio in an ischemie area. This study demonstrates that “fixed” stenoses can undergo dynamic processes and sympathomlmetic amines increase the resistance to flow through a stenotic coronary artery in the nonfailing heart.
copUnited States
pubElsevier Inc
pmid7270436
doi10.1016/0002-9149(81)90607-X