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Control of leaf morphogenesis by microRNAs

Plants with altered microRNA metabolism have pleiotropic developmental defects, but direct evidence for microRNAs regulating specific aspects of plant morphogenesis has been lacking. In a genetic screen, we identified the JAW locus, which produces a microRNA that can guide messenger RNA cleavage of... Full description

Journal Title: Nature 2003, Vol.425 (6955), p.257-263
Main Author: Carrington, James C
Other Authors: Weigel, Detlef , Palatnik, Javier F , Allen, Edwards , Wu, Xuelin , Schommer, Carla , Schwab, Rebecca
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: London: Nature Publishing
ID: ISSN: 0028-0836
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recordid: cdi_proquest_miscellaneous_743148307
title: Control of leaf morphogenesis by microRNAs
format: Article
creator:
  • Carrington, James C
  • Weigel, Detlef
  • Palatnik, Javier F
  • Allen, Edwards
  • Wu, Xuelin
  • Schommer, Carla
  • Schwab, Rebecca
subjects:
  • Arabidopsis - genetics
  • Arabidopsis Proteins - genetics
  • Base Sequence
  • Biological and medical sciences
  • Conserved Sequence
  • Fundamental and applied biological sciences. Psychology
  • Gene Expression Profiling
  • Gene Expression Regulation, Plant
  • Genes, Plant - genetics
  • MicroRNAs - genetics
  • MicroRNAs - metabolism
  • Molecular Sequence Data
  • Morphogenesis
  • Mutation
  • Oligonucleotide Array Sequence Analysis
  • Phenotype
  • Phylogeny
  • Plant growth. Development of the storage organs
  • Plant Leaves - genetics
  • Plant Leaves - growth & development
  • Plant physiology and development
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA Processing, Post-Transcriptional
  • RNA, Messenger - genetics
  • RNA, Messenger - metabolism
  • RNA, Plant - genetics
  • RNA, Plant - metabolism
  • Transgenes
  • Vegetative apparatus, growth and morphogenesis. Senescence
ispartof: Nature, 2003, Vol.425 (6955), p.257-263
description: Plants with altered microRNA metabolism have pleiotropic developmental defects, but direct evidence for microRNAs regulating specific aspects of plant morphogenesis has been lacking. In a genetic screen, we identified the JAW locus, which produces a microRNA that can guide messenger RNA cleavage of several TCP genes controlling leaf development. MicroRNA-guided cleavage of TCP4 mRNA is necessary to prevent aberrant activity of the TCP4 gene expressed from its native promoter. In addition, overexpression of wild-type and microRNA-resistant TCP variants demonstrates that mRNA cleavage is largely sufficient to restrict TCP function to its normal domain of activity. TCP genes with microRNA target sequences are found in a wide range of species, indicating that microRNA-mediated control of leaf morphogenesis is conserved in plants with very different leaf forms.
language: eng
source:
identifier: ISSN: 0028-0836
fulltext: no_fulltext
issn:
  • 0028-0836
  • 1476-4687
url: Link


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descriptionPlants with altered microRNA metabolism have pleiotropic developmental defects, but direct evidence for microRNAs regulating specific aspects of plant morphogenesis has been lacking. In a genetic screen, we identified the JAW locus, which produces a microRNA that can guide messenger RNA cleavage of several TCP genes controlling leaf development. MicroRNA-guided cleavage of TCP4 mRNA is necessary to prevent aberrant activity of the TCP4 gene expressed from its native promoter. In addition, overexpression of wild-type and microRNA-resistant TCP variants demonstrates that mRNA cleavage is largely sufficient to restrict TCP function to its normal domain of activity. TCP genes with microRNA target sequences are found in a wide range of species, indicating that microRNA-mediated control of leaf morphogenesis is conserved in plants with very different leaf forms.
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subjectArabidopsis - genetics ; Arabidopsis Proteins - genetics ; Base Sequence ; Biological and medical sciences ; Conserved Sequence ; Fundamental and applied biological sciences. Psychology ; Gene Expression Profiling ; Gene Expression Regulation, Plant ; Genes, Plant - genetics ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Molecular Sequence Data ; Morphogenesis ; Mutation ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Phylogeny ; Plant growth. Development of the storage organs ; Plant Leaves - genetics ; Plant Leaves - growth & development ; Plant physiology and development ; Reverse Transcriptase Polymerase Chain Reaction ; RNA Processing, Post-Transcriptional ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; RNA, Plant - genetics ; RNA, Plant - metabolism ; Transgenes ; Vegetative apparatus, growth and morphogenesis. Senescence
ispartofNature, 2003, Vol.425 (6955), p.257-263
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abstractPlants with altered microRNA metabolism have pleiotropic developmental defects, but direct evidence for microRNAs regulating specific aspects of plant morphogenesis has been lacking. In a genetic screen, we identified the JAW locus, which produces a microRNA that can guide messenger RNA cleavage of several TCP genes controlling leaf development. MicroRNA-guided cleavage of TCP4 mRNA is necessary to prevent aberrant activity of the TCP4 gene expressed from its native promoter. In addition, overexpression of wild-type and microRNA-resistant TCP variants demonstrates that mRNA cleavage is largely sufficient to restrict TCP function to its normal domain of activity. TCP genes with microRNA target sequences are found in a wide range of species, indicating that microRNA-mediated control of leaf morphogenesis is conserved in plants with very different leaf forms.
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