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Angiogenesis in cancer and other diseases

Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases. Concentrated efforts in this area of research are leading to the discovery of a growing number of pro- and anti-angiogenic molecules, some of which are already in clinical trials. The complex interacti... Full description

Journal Title: Nature (London) 2000-09-14, Vol.407 (6801), p.249-257
Main Author: Carmeliet, Peter
Other Authors: Jain, Rakesh K
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: England: Nature Publishing Group
ID: ISSN: 0028-0836
Link: https://www.ncbi.nlm.nih.gov/pubmed/11001068
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title: Angiogenesis in cancer and other diseases
format: Article
creator:
  • Carmeliet, Peter
  • Jain, Rakesh K
subjects:
  • Animals
  • Disease
  • Endothelial Growth Factors - physiology
  • Humans
  • Lymphokines - physiology
  • Neoplasms - blood supply
  • Neoplasms - genetics
  • Neovascularization, Pathologic - drug therapy
  • Neovascularization, Pathologic - genetics
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
ispartof: Nature (London), 2000-09-14, Vol.407 (6801), p.249-257
description: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases. Concentrated efforts in this area of research are leading to the discovery of a growing number of pro- and anti-angiogenic molecules, some of which are already in clinical trials. The complex interactions among these molecules and how they affect vascular structure and function in different environments are now beginning to be elucidated. This integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases. But owing to several unanswered questions, caution is needed.
language: eng
source:
identifier: ISSN: 0028-0836
fulltext: no_fulltext
issn:
  • 0028-0836
  • 1476-4687
url: Link


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descriptionPathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases. Concentrated efforts in this area of research are leading to the discovery of a growing number of pro- and anti-angiogenic molecules, some of which are already in clinical trials. The complex interactions among these molecules and how they affect vascular structure and function in different environments are now beginning to be elucidated. This integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases. But owing to several unanswered questions, caution is needed.
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subjectAnimals ; Disease ; Endothelial Growth Factors - physiology ; Humans ; Lymphokines - physiology ; Neoplasms - blood supply ; Neoplasms - genetics ; Neovascularization, Pathologic - drug therapy ; Neovascularization, Pathologic - genetics ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors
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abstractPathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases. Concentrated efforts in this area of research are leading to the discovery of a growing number of pro- and anti-angiogenic molecules, some of which are already in clinical trials. The complex interactions among these molecules and how they affect vascular structure and function in different environments are now beginning to be elucidated. This integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases. But owing to several unanswered questions, caution is needed.
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