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The finished DNA sequence of human chromosome 12

Human chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome. Here we present the finished sequence of human chromosome 12,... Full description

Journal Title: Nature 2006-03-16, Vol.440 (7082), p.346-351
Main Author: Scherer, Steven E
Other Authors: Muzny, Donna M , Buhay, Christian J , Chen, Rui , Cree, Andrew , Ding, Yan , Dugan-Rocha, Shannon , Gill, Rachel , Gunaratne, Preethi , Harris, R. Alan , Hawes, Alicia C , Hernandez, Judith , Hodgson, Anne V , Hume, Jennifer , Jackson, Andrew , Khan, Ziad Mohid , Kovar-Smith, Christie , Lewis, Lora R , Lozado, Ryan J , Metzker, Michael L , Milosavljevic, Aleksandar , Miner, George R , Montgomery, Kate T , Morgan, Margaret B , Nazareth, Lynne V , Scott, Graham , Sodergren, Erica , Song, Xing-Zhi , Steffen, David , Lovering, Ruth C , Wheeler, David A , Worley, Kim C , Yuan, Yi , Zhang, Zhengdong , Adams, Charles Q , Ansari-Lari, M. Ali , Ayele, Mulu , Brown, Mary J , Chen, Guan , Chen, Zhijian , Clerc-Blankenburg, Kerstin P , Davis, Clay , Delgado, Oliver , Dinh, Huyen H , Draper, Heather , Gonzalez-Garay, Manuel L , Havlak, Paul , Jackson, Laronda R , Jacob, Leni S , Kelly, Susan H , Li, Li , Li, Zhangwan , Liu, Jing , Liu, Wen , Lu, Jing , Maheshwari, Manjula , Nguyen, Bao-Viet , Okwuonu, Geoffrey O , Pasternak, Shiran , Perez, Lesette M , Plopper, Farah J. H , Santibanez, Jireh , Shen, Hua , Tabor, Paul E , Verduzco, Daniel , Waldron, Lenee , Wang, Qiaoyan , Williams, Gabrielle A , Zhang, JingKun , Zhou, Jianling , Nelson, David , Kucherlapati, Raju , Weinstock, George , Gibbs, Richard A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: London: Nature Publishing
ID: ISSN: 0028-0836
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title: The finished DNA sequence of human chromosome 12
format: Article
creator:
  • Scherer, Steven E
  • Muzny, Donna M
  • Buhay, Christian J
  • Chen, Rui
  • Cree, Andrew
  • Ding, Yan
  • Dugan-Rocha, Shannon
  • Gill, Rachel
  • Gunaratne, Preethi
  • Harris, R. Alan
  • Hawes, Alicia C
  • Hernandez, Judith
  • Hodgson, Anne V
  • Hume, Jennifer
  • Jackson, Andrew
  • Khan, Ziad Mohid
  • Kovar-Smith, Christie
  • Lewis, Lora R
  • Lozado, Ryan J
  • Metzker, Michael L
  • Milosavljevic, Aleksandar
  • Miner, George R
  • Montgomery, Kate T
  • Morgan, Margaret B
  • Nazareth, Lynne V
  • Scott, Graham
  • Sodergren, Erica
  • Song, Xing-Zhi
  • Steffen, David
  • Lovering, Ruth C
  • Wheeler, David A
  • Worley, Kim C
  • Yuan, Yi
  • Zhang, Zhengdong
  • Adams, Charles Q
  • Ansari-Lari, M. Ali
  • Ayele, Mulu
  • Brown, Mary J
  • Chen, Guan
  • Chen, Zhijian
  • Clerc-Blankenburg, Kerstin P
  • Davis, Clay
  • Delgado, Oliver
  • Dinh, Huyen H
  • Draper, Heather
  • Gonzalez-Garay, Manuel L
  • Havlak, Paul
  • Jackson, Laronda R
  • Jacob, Leni S
  • Kelly, Susan H
  • Li, Li
  • Li, Zhangwan
  • Liu, Jing
  • Liu, Wen
  • Lu, Jing
  • Maheshwari, Manjula
  • Nguyen, Bao-Viet
  • Okwuonu, Geoffrey O
  • Pasternak, Shiran
  • Perez, Lesette M
  • Plopper, Farah J. H
  • Santibanez, Jireh
  • Shen, Hua
  • Tabor, Paul E
  • Verduzco, Daniel
  • Waldron, Lenee
  • Wang, Qiaoyan
  • Williams, Gabrielle A
  • Zhang, JingKun
  • Zhou, Jianling
  • Nelson, David
  • Kucherlapati, Raju
  • Weinstock, George
  • Gibbs, Richard A
subjects:
  • Animals
  • Base Composition
  • Biological and medical sciences
  • Chromosomes, Human, Pair 12 - genetics
  • Classical genetics, quantitative genetics, hybrids
  • CpG Islands - genetics
  • Evolution, Molecular
  • Expressed Sequence Tags
  • Fundamental and applied biological sciences. Psychology
  • Genes - genetics
  • Genetics of eukaryotes. Biological and molecular evolution
  • Human
  • Humans
  • Linkage Disequilibrium - genetics
  • Microsatellite Repeats - genetics
  • Molecular Sequence Data
  • Mutagenesis, Insertional - genetics
  • Pan troglodytes - genetics
  • Sequence Analysis, DNA
  • Sequence Deletion - genetics
  • Short Interspersed Nucleotide Elements - genetics
  • Synteny - genetics
ispartof: Nature, 2006-03-16, Vol.440 (7082), p.346-351
description: Human chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome. Here we present the finished sequence of human chromosome 12, which has been finished to high quality and spans approximately 132 megabases, representing ∼4.5% of the human genome. Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages. The rate of base substitutions in recent evolutionary history shows an overall slowing in hominids compared with primates and rodents.
language: eng
source:
identifier: ISSN: 0028-0836
fulltext: no_fulltext
issn:
  • 0028-0836
  • 1476-4687
  • 1476-4679
url: Link


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titleThe finished DNA sequence of human chromosome 12
creatorScherer, Steven E ; Muzny, Donna M ; Buhay, Christian J ; Chen, Rui ; Cree, Andrew ; Ding, Yan ; Dugan-Rocha, Shannon ; Gill, Rachel ; Gunaratne, Preethi ; Harris, R. Alan ; Hawes, Alicia C ; Hernandez, Judith ; Hodgson, Anne V ; Hume, Jennifer ; Jackson, Andrew ; Khan, Ziad Mohid ; Kovar-Smith, Christie ; Lewis, Lora R ; Lozado, Ryan J ; Metzker, Michael L ; Milosavljevic, Aleksandar ; Miner, George R ; Montgomery, Kate T ; Morgan, Margaret B ; Nazareth, Lynne V ; Scott, Graham ; Sodergren, Erica ; Song, Xing-Zhi ; Steffen, David ; Lovering, Ruth C ; Wheeler, David A ; Worley, Kim C ; Yuan, Yi ; Zhang, Zhengdong ; Adams, Charles Q ; Ansari-Lari, M. Ali ; Ayele, Mulu ; Brown, Mary J ; Chen, Guan ; Chen, Zhijian ; Clerc-Blankenburg, Kerstin P ; Davis, Clay ; Delgado, Oliver ; Dinh, Huyen H ; Draper, Heather ; Gonzalez-Garay, Manuel L ; Havlak, Paul ; Jackson, Laronda R ; Jacob, Leni S ; Kelly, Susan H ; Li, Li ; Li, Zhangwan ; Liu, Jing ; Liu, Wen ; Lu, Jing ; Maheshwari, Manjula ; Nguyen, Bao-Viet ; Okwuonu, Geoffrey O ; Pasternak, Shiran ; Perez, Lesette M ; Plopper, Farah J. H ; Santibanez, Jireh ; Shen, Hua ; Tabor, Paul E ; Verduzco, Daniel ; Waldron, Lenee ; Wang, Qiaoyan ; Williams, Gabrielle A ; Zhang, JingKun ; Zhou, Jianling ; Nelson, David ; Kucherlapati, Raju ; Weinstock, George ; Gibbs, Richard A
creatorcontribScherer, Steven E ; Muzny, Donna M ; Buhay, Christian J ; Chen, Rui ; Cree, Andrew ; Ding, Yan ; Dugan-Rocha, Shannon ; Gill, Rachel ; Gunaratne, Preethi ; Harris, R. Alan ; Hawes, Alicia C ; Hernandez, Judith ; Hodgson, Anne V ; Hume, Jennifer ; Jackson, Andrew ; Khan, Ziad Mohid ; Kovar-Smith, Christie ; Lewis, Lora R ; Lozado, Ryan J ; Metzker, Michael L ; Milosavljevic, Aleksandar ; Miner, George R ; Montgomery, Kate T ; Morgan, Margaret B ; Nazareth, Lynne V ; Scott, Graham ; Sodergren, Erica ; Song, Xing-Zhi ; Steffen, David ; Lovering, Ruth C ; Wheeler, David A ; Worley, Kim C ; Yuan, Yi ; Zhang, Zhengdong ; Adams, Charles Q ; Ansari-Lari, M. Ali ; Ayele, Mulu ; Brown, Mary J ; Chen, Guan ; Chen, Zhijian ; Clerc-Blankenburg, Kerstin P ; Davis, Clay ; Delgado, Oliver ; Dinh, Huyen H ; Draper, Heather ; Gonzalez-Garay, Manuel L ; Havlak, Paul ; Jackson, Laronda R ; Jacob, Leni S ; Kelly, Susan H ; Li, Li ; Li, Zhangwan ; Liu, Jing ; Liu, Wen ; Lu, Jing ; Maheshwari, Manjula ; Nguyen, Bao-Viet ; Okwuonu, Geoffrey O ; Pasternak, Shiran ; Perez, Lesette M ; Plopper, Farah J. H ; Santibanez, Jireh ; Shen, Hua ; Tabor, Paul E ; Verduzco, Daniel ; Waldron, Lenee ; Wang, Qiaoyan ; Williams, Gabrielle A ; Zhang, JingKun ; Zhou, Jianling ; Nelson, David ; Kucherlapati, Raju ; Weinstock, George ; Gibbs, Richard A ; Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
descriptionHuman chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome. Here we present the finished sequence of human chromosome 12, which has been finished to high quality and spans approximately 132 megabases, representing ∼4.5% of the human genome. Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages. The rate of base substitutions in recent evolutionary history shows an overall slowing in hominids compared with primates and rodents.
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languageeng
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subjectAnimals ; Base Composition ; Biological and medical sciences ; Chromosomes, Human, Pair 12 - genetics ; Classical genetics, quantitative genetics, hybrids ; CpG Islands - genetics ; Evolution, Molecular ; Expressed Sequence Tags ; Fundamental and applied biological sciences. Psychology ; Genes - genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Human ; Humans ; Linkage Disequilibrium - genetics ; Microsatellite Repeats - genetics ; Molecular Sequence Data ; Mutagenesis, Insertional - genetics ; Pan troglodytes - genetics ; Sequence Analysis, DNA ; Sequence Deletion - genetics ; Short Interspersed Nucleotide Elements - genetics ; Synteny - genetics
ispartofNature, 2006-03-16, Vol.440 (7082), p.346-351
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0Scherer, Steven E
1Muzny, Donna M
2Buhay, Christian J
3Chen, Rui
4Cree, Andrew
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6Dugan-Rocha, Shannon
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8Gunaratne, Preethi
9Harris, R. Alan
10Hawes, Alicia C
11Hernandez, Judith
12Hodgson, Anne V
13Hume, Jennifer
14Jackson, Andrew
15Khan, Ziad Mohid
16Kovar-Smith, Christie
17Lewis, Lora R
18Lozado, Ryan J
19Metzker, Michael L
20Milosavljevic, Aleksandar
21Miner, George R
22Montgomery, Kate T
23Morgan, Margaret B
24Nazareth, Lynne V
25Scott, Graham
26Sodergren, Erica
27Song, Xing-Zhi
28Steffen, David
29Lovering, Ruth C
30Wheeler, David A
31Worley, Kim C
32Yuan, Yi
33Zhang, Zhengdong
34Adams, Charles Q
35Ansari-Lari, M. Ali
36Ayele, Mulu
37Brown, Mary J
38Chen, Guan
39Chen, Zhijian
40Clerc-Blankenburg, Kerstin P
41Davis, Clay
42Delgado, Oliver
43Dinh, Huyen H
44Draper, Heather
45Gonzalez-Garay, Manuel L
46Havlak, Paul
47Jackson, Laronda R
48Jacob, Leni S
49Kelly, Susan H
50Li, Li
51Li, Zhangwan
52Liu, Jing
53Liu, Wen
54Lu, Jing
55Maheshwari, Manjula
56Nguyen, Bao-Viet
57Okwuonu, Geoffrey O
58Pasternak, Shiran
59Perez, Lesette M
60Plopper, Farah J. H
61Santibanez, Jireh
62Shen, Hua
63Tabor, Paul E
64Verduzco, Daniel
65Waldron, Lenee
66Wang, Qiaoyan
67Williams, Gabrielle A
68Zhang, JingKun
69Zhou, Jianling
70Nelson, David
71Kucherlapati, Raju
72Weinstock, George
73Gibbs, Richard A
74Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
title
0The finished DNA sequence of human chromosome 12
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descriptionHuman chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome. Here we present the finished sequence of human chromosome 12, which has been finished to high quality and spans approximately 132 megabases, representing ∼4.5% of the human genome. Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages. The rate of base substitutions in recent evolutionary history shows an overall slowing in hominids compared with primates and rodents.
subject
0Animals
1Base Composition
2Biological and medical sciences
3Chromosomes, Human, Pair 12 - genetics
4Classical genetics, quantitative genetics, hybrids
5CpG Islands - genetics
6Evolution, Molecular
7Expressed Sequence Tags
8Fundamental and applied biological sciences. Psychology
9Genes - genetics
10Genetics of eukaryotes. Biological and molecular evolution
11Human
12Humans
13Linkage Disequilibrium - genetics
14Microsatellite Repeats - genetics
15Molecular Sequence Data
16Mutagenesis, Insertional - genetics
17Pan troglodytes - genetics
18Sequence Analysis, DNA
19Sequence Deletion - genetics
20Short Interspersed Nucleotide Elements - genetics
21Synteny - genetics
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8Gunaratne, Preethi
9Harris, R. Alan
10Hawes, Alicia C
11Hernandez, Judith
12Hodgson, Anne V
13Hume, Jennifer
14Jackson, Andrew
15Khan, Ziad Mohid
16Kovar-Smith, Christie
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18Lozado, Ryan J
19Metzker, Michael L
20Milosavljevic, Aleksandar
21Miner, George R
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26Sodergren, Erica
27Song, Xing-Zhi
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29Lovering, Ruth C
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31Worley, Kim C
32Yuan, Yi
33Zhang, Zhengdong
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titleThe finished DNA sequence of human chromosome 12
authorScherer, Steven E ; Muzny, Donna M ; Buhay, Christian J ; Chen, Rui ; Cree, Andrew ; Ding, Yan ; Dugan-Rocha, Shannon ; Gill, Rachel ; Gunaratne, Preethi ; Harris, R. Alan ; Hawes, Alicia C ; Hernandez, Judith ; Hodgson, Anne V ; Hume, Jennifer ; Jackson, Andrew ; Khan, Ziad Mohid ; Kovar-Smith, Christie ; Lewis, Lora R ; Lozado, Ryan J ; Metzker, Michael L ; Milosavljevic, Aleksandar ; Miner, George R ; Montgomery, Kate T ; Morgan, Margaret B ; Nazareth, Lynne V ; Scott, Graham ; Sodergren, Erica ; Song, Xing-Zhi ; Steffen, David ; Lovering, Ruth C ; Wheeler, David A ; Worley, Kim C ; Yuan, Yi ; Zhang, Zhengdong ; Adams, Charles Q ; Ansari-Lari, M. Ali ; Ayele, Mulu ; Brown, Mary J ; Chen, Guan ; Chen, Zhijian ; Clerc-Blankenburg, Kerstin P ; Davis, Clay ; Delgado, Oliver ; Dinh, Huyen H ; Draper, Heather ; Gonzalez-Garay, Manuel L ; Havlak, Paul ; Jackson, Laronda R ; Jacob, Leni S ; Kelly, Susan H ; Li, Li ; Li, Zhangwan ; Liu, Jing ; Liu, Wen ; Lu, Jing ; Maheshwari, Manjula ; Nguyen, Bao-Viet ; Okwuonu, Geoffrey O ; Pasternak, Shiran ; Perez, Lesette M ; Plopper, Farah J. H ; Santibanez, Jireh ; Shen, Hua ; Tabor, Paul E ; Verduzco, Daniel ; Waldron, Lenee ; Wang, Qiaoyan ; Williams, Gabrielle A ; Zhang, JingKun ; Zhou, Jianling ; Nelson, David ; Kucherlapati, Raju ; Weinstock, George ; Gibbs, Richard A
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1Base Composition
2Biological and medical sciences
3Chromosomes, Human, Pair 12 - genetics
4Classical genetics, quantitative genetics, hybrids
5CpG Islands - genetics
6Evolution, Molecular
7Expressed Sequence Tags
8Fundamental and applied biological sciences. Psychology
9Genes - genetics
10Genetics of eukaryotes. Biological and molecular evolution
11Human
12Humans
13Linkage Disequilibrium - genetics
14Microsatellite Repeats - genetics
15Molecular Sequence Data
16Mutagenesis, Insertional - genetics
17Pan troglodytes - genetics
18Sequence Analysis, DNA
19Sequence Deletion - genetics
20Short Interspersed Nucleotide Elements - genetics
21Synteny - genetics
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1Muzny, Donna M
2Buhay, Christian J
3Chen, Rui
4Cree, Andrew
5Ding, Yan
6Dugan-Rocha, Shannon
7Gill, Rachel
8Gunaratne, Preethi
9Harris, R. Alan
10Hawes, Alicia C
11Hernandez, Judith
12Hodgson, Anne V
13Hume, Jennifer
14Jackson, Andrew
15Khan, Ziad Mohid
16Kovar-Smith, Christie
17Lewis, Lora R
18Lozado, Ryan J
19Metzker, Michael L
20Milosavljevic, Aleksandar
21Miner, George R
22Montgomery, Kate T
23Morgan, Margaret B
24Nazareth, Lynne V
25Scott, Graham
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27Song, Xing-Zhi
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31Worley, Kim C
32Yuan, Yi
33Zhang, Zhengdong
34Adams, Charles Q
35Ansari-Lari, M. Ali
36Ayele, Mulu
37Brown, Mary J
38Chen, Guan
39Chen, Zhijian
40Clerc-Blankenburg, Kerstin P
41Davis, Clay
42Delgado, Oliver
43Dinh, Huyen H
44Draper, Heather
45Gonzalez-Garay, Manuel L
46Havlak, Paul
47Jackson, Laronda R
48Jacob, Leni S
49Kelly, Susan H
50Li, Li
51Li, Zhangwan
52Liu, Jing
53Liu, Wen
54Lu, Jing
55Maheshwari, Manjula
56Nguyen, Bao-Viet
57Okwuonu, Geoffrey O
58Pasternak, Shiran
59Perez, Lesette M
60Plopper, Farah J. H
61Santibanez, Jireh
62Shen, Hua
63Tabor, Paul E
64Verduzco, Daniel
65Waldron, Lenee
66Wang, Qiaoyan
67Williams, Gabrielle A
68Zhang, JingKun
69Zhou, Jianling
70Nelson, David
71Kucherlapati, Raju
72Weinstock, George
73Gibbs, Richard A
74Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
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8Gunaratne, Preethi
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14Jackson, Andrew
15Khan, Ziad Mohid
16Kovar-Smith, Christie
17Lewis, Lora R
18Lozado, Ryan J
19Metzker, Michael L
20Milosavljevic, Aleksandar
21Miner, George R
22Montgomery, Kate T
23Morgan, Margaret B
24Nazareth, Lynne V
25Scott, Graham
26Sodergren, Erica
27Song, Xing-Zhi
28Steffen, David
29Lovering, Ruth C
30Wheeler, David A
31Worley, Kim C
32Yuan, Yi
33Zhang, Zhengdong
34Adams, Charles Q
35Ansari-Lari, M. Ali
36Ayele, Mulu
37Brown, Mary J
38Chen, Guan
39Chen, Zhijian
40Clerc-Blankenburg, Kerstin P
41Davis, Clay
42Delgado, Oliver
43Dinh, Huyen H
44Draper, Heather
45Gonzalez-Garay, Manuel L
46Havlak, Paul
47Jackson, Laronda R
48Jacob, Leni S
49Kelly, Susan H
50Li, Li
51Li, Zhangwan
52Liu, Jing
53Liu, Wen
54Lu, Jing
55Maheshwari, Manjula
56Nguyen, Bao-Viet
57Okwuonu, Geoffrey O
58Pasternak, Shiran
59Perez, Lesette M
60Plopper, Farah J. H
61Santibanez, Jireh
62Shen, Hua
63Tabor, Paul E
64Verduzco, Daniel
65Waldron, Lenee
66Wang, Qiaoyan
67Williams, Gabrielle A
68Zhang, JingKun
69Zhou, Jianling
70Nelson, David
71Kucherlapati, Raju
72Weinstock, George
73Gibbs, Richard A
aucorpBaylor College of Medicine Human Genome Sequencing Center Sequence Production Team
formatjournal
genrearticle
ristypeJOUR
atitleThe finished DNA sequence of human chromosome 12
jtitleNature
addtitleNature
date2006-03-16
risdate2006
volume440
issue7082
spage346
epage351
pages346-351
issn0028-0836
eissn
01476-4687
11476-4679
codenNATUAS
abstractHuman chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome. Here we present the finished sequence of human chromosome 12, which has been finished to high quality and spans approximately 132 megabases, representing ∼4.5% of the human genome. Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages. The rate of base substitutions in recent evolutionary history shows an overall slowing in hominids compared with primates and rodents.
copLondon
pubNature Publishing
pmid16541075
doi10.1038/nature04569
tpages6
oafree_for_read